Cyclin-dependent kinase-2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H

European Journal of Biochemistry

Volumn 237, Issue 2, 1996, Pages 460-467

  Higashi, Hideaki ^a   Suzuki Takahashi, Ikuko ^a   Saitoh, Shio ^a   Segawa, Kaoru ^b   Taya, Yoichi ^c   Okuyama, Akira ^a   Nishimura, Susumu ^a   Kitagawa, Masatoshi ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Cdk activating kinase (CAK); Cell cycle; Cyclin dependent kinase; Post translational modification; Protein kinase

Indexed keywords

CYCLIN A; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 7; CYCLIN E; CYCLIN H; CYCLINE; UNCLASSIFIED DRUG;

ARTICLE; BACULOVIRUS; CELL CYCLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0029915265     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1996.0460k.x     Document Type: Article

References (34)

1. Pines, J. (1993) Cyclins and cyclin-dependent kinases: take your partners. Trends Biochem. Sci. 18, 195-197.
2. Kishimoto, T. (1994) Cell reproduction: induction of M-phase events by cyclin-dependent cdc2 kinase, Int. J. Dev. Biol. 38, 185-191.
3. Morgan, D. O. (1995) Principles of CDK regulation, Nature 374, 131-134.
4. Lees, E. (1995) Cyclin dependent kinase regulation. Curr. Opin. Cell Biol. 7, 773-780.
5. Pagano, M., Pepperkok, R., Lukas, J., Baldin, V., Ansorge, W., Bartek, J. & Draetta, G. (1993) Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts, J. Cell Biol. 121, 101-111.
6. 1-S phase protein kinase. Science 257, 1958-1960.
7. Koff, A., Giordano, A., Desai, D., Yamashita, K., Harper, J. W., Elledge, S., Nishimoto, T., Morgan, D. O., Franza, B. R. & Roberts, J. M. (1992) Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle, Science 257, 1689-1694.
8. Ohtsubo, M. & Roberts J. M. (1993) Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science 259, 1908-1911.
9. Fisher, R. P. & Morgan, D. O. (1994) A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase, Cell 78, 713-724.
10. Makela, T. P., Tassan, J.-P., Nigg, E. A., Frutiger, S., Hughes, G. J. & Weinberg, R. A. (1994) A cyclin associated with the CDK-activating kinase MO15, Nature 371, 254-257.
11. Weinberg, R. A. (1995) The retinoblastoma protein and cell cycle control, Cell 81, 323-330.
12. PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell 71, 323-334.
13. Kato, J., Matsushime, H., Scott, W. H., Ewen, M. E. & Sherr, C. J. (1993) Direct binding of cyclin D to the retinoblastoma gene product (pRB) and pRB phosphorylation by the cyclin D-dependent kinase CDK4, Genes & Dev. 7, 331-342.
14. Motokura, T. & Arnold, A. (1993) Cyclins and oncogenesis, Biochim. Biophys. Acta 1155, 63-78.
15. Lucibello, F. C., Sewing, A., Brüsselbach, S., Bürger, C. & Müller, R. (1993) Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts. J. Cell Sci. 105, 123-133.
16. 1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-cdk2 and cyclin D1-cdk2 complexes, Proc. Natl Acad. Sci. USA 90, 11034-11038.
17. Xiong, Y., Zhang, H. & Beach, D. (1992) D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA, Cell 71, 505-514.
18. Bates, S., Bonetta, L., MacAllan, D., Parry, D., Holder, A., Dickson, C. & Peters, G. (1994) CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1, Oncogene 9, 71-79.
19. Meyerson, M. & Harlow, E. (1994) Identification of G1 kinase activity for cdk6, a novel cyclin D partner, Mol. Cell. Biol. 14, 2077-2086.
20. Ewen, M. E., Sluss, H. K., Sherr, C. J., Matsushime, H., Kato, J. & Livingston, D. M. (1993) Functional interactions of the retinoblastoma protein with mammalian D-type cyclins, Cell 73, 487-497.
21. Matsushime, H., Quelle, D. E., Shurtleff, S. A., Shibuya, M., Sherr, C. J. & Kato, J. (1994) D-type cyclin-dependent kinase activity in mammalian cells, Mol. Cell. Biol. 14, 2066-2076.
22. Taya, Y., Yasuda, H., Kamijyo, M., Nakaya, K., Nakamura, Y., Ohba, Y. & Nishimura, S. (1989) In vitro phosphorylation of the tumor suppressor gene RB protein by mitosis-specific histone H1 kinase, Biochem. Biophys. Res. Commun. 164, 580-586.
23. Kitagawa, M., Saitoh, S., Ogino, H., Okabe, T., Matsumoto, H., Okuyama, A., Tamai, K., Ohba, Y., Yasuda, H., Nishimura, S. & Taya, Y. (1992) cdc2-like kinase is associated with the retinoblastoma protein, Oncogene 7, 1067-1074.
24. Kitagawa, M., Higashi, H., Takahashi, I.-S., Segawa, K., Hanks, S. K., Taya, Y., Nishimura, S. & Okuyama, A. (1995) Phosphorylation of E2F-1 by cyclin A-cdk2, Oncogene 10, 229-236.
25. Kitagawa, M., Okabe, T., Ogino, H., Matsumoto, H., Takahashi, I.-S., Kokubo, T., Higashi, H., Saitoh, S., Taya, Y., Yasuda, H., Ohba, Y., Nishimura, S. & Okuyama, A. (1993) Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase, Oncogene 8, 2425-2432.
26. Kitagawa, M., Higashi, H., Takahashi, I.-S., Okabe, T., Ogino, H., Taya, Y., Nishimura, S. & Okuyama, A. (1994) A cyclin-dependent kinase inhibitor, butyrolactone I, inhibits phosphorylation of RB protein and cell cycle progression, Oncogene 9, 2549-2557.
27. 2 phase of the cell cycle and associates with cyclin A. Proc. Natl Acad. Sci. USA 89, 2824-2828.
28. cdc2 and its companion cyclin-dependent kinases. Trends Cell Biol. 3, 296-301.
29. Nigg, E. A. (1993) Targets of cyclin-dependent protein kinases, Curr. Opin. Cell Biol. 5, 187-193.
30. Peters, G. (1994) Stifled by inhibition. Nature 371, 204-205.
31. Sherr, C. J. & Roberts, J. M. (1995) Inhibitors of mammalian G, cyclin-dependent kinases, Genes & Dev. 9, 1149-1163.
32. Xiong, Y., Menninger, J., Beach, D. & Ward, D. C. (1992) Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins, Genomics 13, 575-584.
33. Tam, S. W., Theodoras, A. M., Shay, J. W., Draetta, G. F. & Pagano, M. (1994) Differential expression and regulation of cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for cyclin D1 function in G1 progression. Oncogene 9, 2663-2674.
34. 1-to-S phase transition, Mol. Cell. Biol. 15, 2612-2624.