Daidzein and genistein concentrations in human milk after soy consumption

Clinical Chemistry

Volumn 42, Issue 6 SUPPL., 1996, Pages 955-964

  Franke, Adrian A ^a   Custer, Laurie J ^a  

^a UNIVERSITY OF HAWAII CANCER CENTER   (United States)

Author keywords

Breast feeding; Cancer prevention; Equol; Isoflavonoids; Newborns; O desmethylangolensin; Phytoestrogens

Indexed keywords

ACETIC ACID ETHYL ESTER; DAIDZEIN; EQUOL; GENISTEIN; ISOFLAVONE DERIVATIVE; NORANGOLENSIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BREAST MILK; DIETARY INTAKE; FEMALE; FLUOROMETRY; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HYDROLYSIS; MASS SPECTROMETRY; NORMAL HUMAN; SOYBEAN; URINE;

EID: 0029952307     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/42.6.955     Document Type: Article

References (34)

1. Messina M, Persky V, Setchell KDR, Barnes S. Soy intake and cancer risk: a review of in vitro and in vivo data. Nutr Cancer 1994;21:113-31.
2. Messina M, Barnes S. The role of soy products in reducing risk of cancer. J Natl Cancer Inst 1991;83:541-6.
3. Barnes S, Peterson TG. Biochemical targets of the isoflavone genistein in tumor cell lines. Proc Soc Exp Biol Med 1995;208: 103-8.
4. Wei H, Bowen R, Cai Q, Barnes S, Wang Y. Antioxidant and antipromotional effects of the soybean isoflavone genistein. Proc Soc Exp Biol Med 1995;208:124-30.
5. Mousavi Y, Adlercreutz H. Genistein is an effective stimulator of sex hormone-binding globulin production in hepatocarcinoma human liver cancer cells and suppresses proliferation of these cells in culture. Steroids 1993;58:301-4.
6. Adlercreutz H, Bannwart C, Wähälä K, Mäkelä T, Brunow G, Hase T, et al. Inhibition of human aromatase by mammalian lignans and isoflavonoid phytoestrogens. J Steroid Biochem Mol Biol 1993; 44:147-53.
7. Makela SI, Pylkkanen LH, Santti RSS, Adlercreutz H. Dietary soybean may be antiestrogenic in male mice. J Nutr 1995;125: 437-45.
8. Cassidy A, Bingham S, Setchell KDR. Biological effect of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. Am J Clin Nutr 1994;60:333-40.
9. Hirano T, Gotoh M, Oka K. Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells. Life Sci 1994;55:1061-9.
10. Constantinou A, Huberman E. Genistein as an inducer of tumor cell differentiation: possible mechanisms of action. Proc Soc Exp Biol Med 1995;208:109-15.
11. Fotsis T, Pepper M, Adlercreutz H, Hase T, Montesano R, Schweigerer L Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis. J Nutr 1995;125(Suppl): 790-7.
12. Uckun FM, Evans E, Forsyth CJ, Waddick KG, Ahlgren LT, Chestrom LM, et al. Biotherapy of B-cell precursor leukemia by targeting genistein to CDl9-associated tyrosine kinases. Science 1995;267:886-91.
13. Lamartiniere CA, Moore J, Holland M, Barnes S. Neonatal genistein chemoprevents mammary cancer. Proc Soc Exp Biol Med 1995;208:120-3.
14. Barnes S, Peterson TG, Grubbs C, Setchell KDR. Diet and cancer: markers, prevention and treatment. New York: Plenum Press, 1994;135-47.
15. Adlercreutz H, Honjo H, Higashi A, Fotsis T, Hamalainen E, Hasegawa T, et al. Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet. Am J Clin Nutr 1991;54:1093-100.
16. Adlercreutz H, Markkanen H, Watanabe S. Plasma concentrations of phyto-oestrogens in Japanese men. Lancet 1993;342:1209-10.
17. Franke AA, Custer U, Cerna CM, Narala KK. Quantitation of phytoestrogens in legumes by HPLC. J Agric Food Chem 1994;42: 1905-13.
18. Wang H, Murphy PA. Isoflavone composition of American and Japanese soybeans in Iowa: effects of variety, crop year, and location. J Agric Food Chem 1994;42:1674-7.
19. Tsukamoto C, Shimada S, Igita K, Kudou S, Kokubun M, Okubo K, et al. Factors affecting isoflavone content in soybean seeds: changes in isoflavones, saponins, and composition of fatty acids at different temperatures during seed development. J Agric Food Chem 1995;43:1184-92.
20. Barnes S, Kirk M, Coward L. Isoflavones and their conjugates in soy foods: extraction conditions and analysis by HPLC-mass spectrometry. J Agric Food Chem 1994;42:2466-74.
21. Coward L, Barnes NC, Setchell KDR, Barnes S. The antitumor isoflavones, genistein and daidzein, in soybean foods of American and Asian diets. J Agric Food Chem 1993;41:1961-7.
22. Adlercreutz H, Fotsis T, Bannwart C, Wähälä K, Brunow G, Hase T. Isotope dilution gas chromatographic-mass spectrometric method for the determination of lignans and isoflavonoids in human urine, including identification of genistein. Clin Chim Acta 1991;199:263-78.
23. Kelly GE, Nelson C, Waring MA, Joannou GE, Reeder AY. Metabolites of dietary (soya) isoflavones in human urine. Clin Chim Acta 1993;223:9-22.
24. Adlercreutz H, Fotsis T, Lampe J, Wähälä T, Mäkelä T, Brunow G, et al. Quantitative determination of lignans and isoflavonoids in plasma of omnivorous and vegetarian women by isotope dilution gas chromatography-mass spectrometry. Scand J Clin Lab Invest 1993;53:5-18.
25. Kurzer MS, Lampe JW, Martini MC, Adlercreutz H. Fecal lignan and isoflavonoid excretion in premenopausal women consuming flaxseed powder. Cancer Epidemiol Biomarkers Prev 1995;4:353-8.
26. Adlercreutz H, Fotsis T, Kurzer MS, Wähälä K, Mäkelä T, Hase T. Isotope dilution gas chromatographic-mass spectrometric method for the determination of unconjugated lignans and isoflavonoids in human feces, with preliminary results in omnivorous and vegetarian women. Anal Biochem 1995;225:101-8. .
27. Franke AA, Custer LJ. High-performance liquid chromatography assay of isoflavonoids and coumestrol from human urine. J Chromatogr B 1994;662:47-60.
28. Xu X, Wang H-J, Murphy PA, Cook L, Hendrich S. Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women. J Nutr 1994;124:825-32.
29. Bannwart C, Adlercreutz H, Fotsis T, Wähälä K, Hase T, Brunow G. Identification of isoflavonic phyto-oestrogens and of lignans in human urine and in cow milk by GC-MS. In: Todd JFJ, ed. Advances in mass spectrometry 1985. Proceedings of the 10th International Conference on Mass Spectrometry. Chichester, UK: John Wiley, 1986:661-2.
30. Bannwart C, Adlercreutz H, Wähälä K, Kotiaho T, Hesso A, Brunow G, et al. Identification of the phyto-oestrogen 3',7-dihydroxyisoflavan, an isomer of equol, in human urine and cow's milk. Biomed Environ Mass Spectrom 1988;17:l-6.
31. Donike M. Steroid profiling in Cologne. In: Donike M, Geyer H, Gotzmann A, Mareck-Engelke U, Rauth S, eds. 10th Cologne Workshop on Dope Analysis. Köln: Sport und Buch Strauβ, 1993:1-5.
32. 2 [Abstract]. 86th Meeting of American Association for Cancer Research, March 18-22,1995, Toronto, Canada. Abstract # 741.
33. Sfakianos J, Barnes S. The isoflavone genistein (GEN) undergoes an enterohepatic circulation. Hepatology 1996;23:in press.
34. Cunniff P. Method 932.05. In: Official methods of analysis of AOAC International, 16th ed. Arlington, VA: AOAC International, 1995.