Phagocytosis of Gram-negative bacteria by a unique CD14-dependent mechanism

Journal of Leukocyte Biology

Volumn 62, Issue 6, 1997, Pages 786-794

  Schiff, Deborah E ^a   Kline, Lois ^a   Soldau, Katrin ^a   Lee, J D ^a   Pugin, Jerome ^a   Tobias, Peter S ^a   Ulevitch, Richard J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Glycophosphatidylinositol anchor; Lipopolysaccharide; Lipopolysaccharide binding protein; Wortmannin

Indexed keywords

BINDING PROTEIN; BISINDOLYLMALEIMIDE; CD14 ANTIGEN; IMMUNOGLOBULIN F(AB')2 FRAGMENT; LIPOPOLYSACCHARIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; TYRPHOSTIN; WORTMANNIN;

ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; ESCHERICHIA COLI; GRAM NEGATIVE INFECTION; HOST RESISTANCE; HUMAN; HUMAN CELL; MYCOBACTERIUM TUBERCULOSIS; OPSONIZATION; PHAGOCYTOSIS; PRIORITY JOURNAL;

EID: 0031458256     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.62.6.786     Document Type: Article

References (30)

1. Wright, S. D., Ramos, R. A., Tobias, P. S., Ulevitch, R. J., Mathison, J. C. (1990) CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding proteins. Science 249, 1431-1433.
2. Pugin, J., Heumann, D., Tomasz, A., Kravchenko, V., Akamatsu, Y., Nishijima, M., Glauser, M.-P., Tobias, P. S., Ulevitch, R. J. (1994) CD14 is a pattern recognition receptor. Immunity 1, 509-516.
3. Peterson, P. K., Gekker, G., Hu, S., Anderson, W. R., Ulevitch, R. J., Tobias, P. S., Gustafson, K. V., Molitor, T. W., Chao, C. C. (1995) CD14 receptor-mediated uptake of nonopsonized Mycobacterium tuberculosis by human microglia. Infect. Immun. 63, 1598-1602.
4. Wright, S. D., Tobias, P. S., Ulevitch, R. J., Ramos, R. A. (1989) Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. J. Exp. Med. 170, 1231-1241.
5. Wright, S. D., Ramos, R. A., Hermanowski-Vosatka, A., Rockwell, P., Detmers, P. A. (1991) Activation of the adhesive capacity of CR3 on neutrophils by endotoxin: Dependence on lipopolysaccharide binding protein and CD14. J. Exp. Med. 173, 1281-1286.
6. Tobias, P. S., Soldau, K., Gegner, J. A., Mintz, D., Ulevitch, R. J. (1995) Lipopolysaccharide binding protein-mediated complexation of lipopolysaccharide with soluble CD14. J. Biol. Chem. 270, 10482-10488.
7. Yu, B., Wright, S. D. (1996) Catalytic properties of lipopolysaccharide (LPS) binding protein. Transfer of LPS to soluble CD14. J. Biol. Chem. 271, 4100-4105.
8. Luchi, M., Munford, R. S. (1993) Binding, internalization, and deacylation of bacterial lipopolysaccharide by human neutrophils. J. Immunol. 151, 959-969.
9. Kirkland, T. N., Finley, F., Letureq, D., Moriarty, A., Lee, J.-D., Ulevitch, R. J., Tobias, P. S. (1993) Analysis of lipopolysaccharide binding by CD14. J. Biol. Chem. 268, 24818-24823.
10. Gegner, J. A., Ulevitch, R. J., Tobias, P. S. (1995) LPS signal transduction and clearance. Dual roles for LBP and mCD14. J. Biol. Chem. 270, 5320-5325.
11. Grunwald, U., Fan, X., Jack, R. S., Workalemahu, G., Kallies, A., Stelter, F., Schutt, C. (1996) Monocytes can phagocytose gram-negative bacteria by a CD14-dependent mechanism. J. Immunol. 157, 4119-4125.
12. Lee, J.-D., Kato, K., Tobias, P. S., Kirkland, T. N., Ulevitch, R. J. (1992) Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaceharide (LPS) and LPS binding protein. J. Exp. Med. 175, 1697-1705.
13. Lee, J.-D., Kravchenko, V., Kirkland, T. N., Han, J., Mackman, N., Moriarty, A., Leturcq, D., Tobias, P. S., Ulevitch, R. J. (1993) GPI-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin. Proc. Natl. Acad. Sci. USA 90, 9930-9934.
14. Theofan, G., Horwitz, A. H., Williams, R. E., Liu, P., Chan, I., Birr, C., Carroll, S. F., Meszaros, K., Parent, J. B., Kasler, H., Aberle, S., Trown, P. W., Gazzano-Santoro, H. (1994) An amino-terminal fragment of human lipopolysaccharide-binding protein retains lipid A binding but not CD14-stimulatory activity. J. Immunol. 152, 3623-3629.
15. Wan, C. P., Park, C. S., Lau, B. H. S. (1993) A rapid and simple microfluorometric phagocytosis assay. J. Immunol. Meth. 162, 1-7.
16. Bjerknes, R., Bassoe, C.-F. (1984) Phagocyte C3-mediated attachment and internalization: Flow cytometric studies using a fluorescence quenching technique. Blut 49, 315-323.
17. Martin, R. J., Kusel, J. R., Robertson, S. J., Minta, A., Haugland, R. P. (1992) Distribution of a fluorescent ivermectin probe, bodipy ivermectin, in tissues of the nematode parasite Ascaris suum. Parasitol. Res. 78, 341-348.
18. Martin, R. J., Kusel, J. R. (1992) On the distribution of a fluorescent ivermectin probe (4″ 5,7 dimethyl-bodipy proprionylivermectin) in Ascaris membranes. Parastiol. 104, 549-555.
19. Low, M. G. (1989) Glycosyl-phosphatidynositol: a versatile anchor for cell surface proteins. FASEB J. 3, 1600-1608.
20. Viriyakosol, S., Kirkland, T. N. (1995) A region of human CD14 required for lipopolysaccharide binding. J. Biol. Chem. 270, 361-368.
21. Jack, R. S., Grunwald, U., Stelter, F., Workalemahu, G., Schutt, C. (1995) Both membrane-bound and soluble forms of CD14 bind to Gram-negative bacteria. Eur. J. Immunol. 25, 1436-1441.
22. Ninomiya, N., Hazeki, K., Fukui, Y., Seya, T., Okada, T., Hazeki, O., Ui, M. (1994) Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling. J. Biol. Chem. 269, 22732-22737.
23. Indik, Z. K., Park, J.-C., Hunter, S., Schreiber, A. D. (1996) The molecular dissection of Fc gamma receptor mediated phagocytosis. Blood 86, 4389-4399.
24. Powis, G., Bonjouklian, K., Berggren, M. M., Gallegos, A., Abraham, R., Ashendel, C., Zalkow, L., Matter, W. F., Dodge, J., Grindey, G., Vlahos, C. J. (1994) Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Cancer Res. 54, 2419-2423.
25. Arearo, A., Wymann, M. P. (1993) Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem. J. 296, 297-301.
26. Araki, N., Johnson, M. T., Swanson, J. A. (1996) A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages. J. Cell Biol. 135, 1249-1260.
27. Park, J.-G., Murray, R. K., Chien, P., Darby, C., Schreiber, A. D. (1993) Conserved cytoplasmic tyrosine residues of the gamma subunit are required for a phagocytic signal mediated by FcγRIIIA. J. Clin. Invest. 92, 2073-2079.
28. Indik, Z. K., Pan, X. Q., Huang, M.-M., McKenzie, S. E., Levinson, A. I., Schreiber, A. D. (1994) Insertion of cytoplasmic tyrosine sequences into the nonphagocytic receptor FcγRIIB establishes phagocytic function. Blood 83, 2072-2080.
29. Bonnema, J. D., Karnitz, L. M., Schoon, R. A., Abraham, R. T., Leibson, P. J. (1994) Fc receptor stimulation of phosphatidylinositol 3-kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity. J. Exp. Med. 180, 1427-1435.
30. Toullec, D., Pianetti, P., Coste, H., Bellevergue, P., Grand-Perret, T., Ajakane, M., Baudet, V., Boissin, P., Boursier, E., Loriolle, F., Duhamel, L., Charon, D., Kirilovsky, J. (1991) The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 266, 15771-15779.