MEIC Evaluation of Acute Systemic Toxicity: Part III. In Vitro Results from 16 Additional Methods Used to Test the First 30 Reference Chemicals and a Comparative Cytotoxicity Analysis

ATLA Alternatives to Laboratory Animals

Volumn 26 SUPPL. 1, Issue , 1998, Pages 93-129

  Clemedson, Cecilia ^a   Barile, Frank A ^a   Ekwall, Barbro ^a   Gómez Lechón, Maria José ^a   Hall, Tony ^a   Imai, Koichi ^a   Kahru, Anne ^a   Logemann, Pam ^a   Monaco, Francesca ^a   Ohno, Tadao ^a   Segner, Helmut ^a   Sjöström, Michael ^a   Valentino, Matteo ^a   Walum, Erik ^a   Wang, Xianhai ^a   Ekwall, Björn ^a  

^a CTLU   (Sweden)

Author keywords

Alternatives; Basal cytotoxicity; Biostatistics; Comparative cell toxicology; Cultured cells; Cytotoxicity endpoints; Differential cytotoxicity; Evaluation; In vitro cytotoxicity; MEIC; Multwartate analysis; Organ specific toxicity; Toxicity testing; Validation

Indexed keywords

EID: 2542620018     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (41)

1. Bondesson, I., Ekwall, B., Hellberg, S., Romert, L., Stenberg, K. & Walum, E (1989). MEIC: a new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests. Cell Biology and Toxicology 5, 331-347.
2. Ekwall, B (1992). Features and prospects of the MEIC cytotoxicity evaluation project. AATEX 1, 231-237.
3. Clemedson, C. et al. (1996). MEIC evaluation of acute systemic toxicity, I. Methodology of 68 in vitro toxicity assays used to test the first 30 reference chemicals. ATLA 24, Suppl. 1, 249-272
4. Clemedson, C et al. (1996) MEIC evaluation of acute systemic toxicity. II. In vitro results from 68 toxicity assays used to test the first 30 reference chemicals and a comparative cytotoxicity analysis. ATLA 24, Suppl. 1, 273-311.
5. Hellberg, S., Enksson, L., Jonsson, J., Lindgren, F , Sjöström, M., Wold, S., Ekwall, B., GómezLechón, M J., Clothier, R., Accomando, N.J., Grimes, A., Barile, F A., Nordin, M , Tyson, C A , Dierickx, P., Shrivastava, R.S, Tingsleff-Skaanild, M., Garza-Ocañas, L. & Fiskesjö, G (1990). Analogy models for prediction of human toxicity. ATLA 18, 103-116.
6. Doostdar, H., Duthie, S.J., Burke, M.D , Melvin, W.T. & Grant, M.H. (1988). The influence of culture medium composition on drug metabolising enzyme activities of the human liver derived Hep G2 cell line. FEBS Letters 241, 15-18.
7. Hall, T.J , James, P.R. & Cambridge, G (1993). Development of an in vitro hepatotoxicity assay for assessing the effects of chronic drug exposure. Research Communications in Chemical Pathology and Pharmacology 79, 249-256.
8. Barile, F.A., Arjtin, S. & Hopkinson, D. (1993). In vitro cytotoxicity testing: biological and statistical significance. Toxicology in Vitro 7, 111-116.
9. Barile, F.A. (1994). Introduction to In Vitro Cytotoxicology: Mechanisms and Methods. Boca Raton, FL, USA: CRC Press.
10. Wang, X., Sasaki, T., Matsudo, T , Saijo-Kurita, K. & Ohno, T. (1993). Correlation of in vitro toxicities of MEIC chemicals determined by lactate dehydrogenase release assay with in vivo toxicities to animals and humans. AATEX 2, 115-126.
11. Imai, K., Nakamura, F., Takoka, Y. & Nakamura, M. (1988). Cytotoxicity of metal ions from the viewpoint of cell recovery, Journal of Dental Technology 16, 980-983.
12. Imai, K., Nakamura, M., Matsumoto, R. & Kokita, K. (1992). Cytotoxicity test using cell recovery test method Medicine and Biology 125, 109-112.
13. Imai, K., Nakamura, M , Meng, A. & Zhang. J. (1993). Cytotoxicity of metal ions extracted in artificial saliva by cell recovery. The Journal of the Japanese Society for Dental Materials and Devices 12, 412-417.
14. Valentino, M , Monaco, F , Pizzichini, M.A & Governa, M (1993) The use of the vitality and chemotaxis of human polymorphonuclear leukocytes for the in vitro estimation of the acute toxicity of the first ten chemicals from the MEIC list. ATLA 21, 73-80.
15. Valentino, M., Monaco, F. & Clemedson, C. (1993) Test di citotossicita in vitro del progetto MEIC: Possibilita' di considerare alcuni end point dei leucociti polimorfo-nucleati quali elementi per predire l'effetto tossico sull'uomo. In Proceedings of 56th Congresso Nazionale della Società Italiana di Medicina del Lavoro ed Igiene Industriale, pp. 591-594
16. Jover, R , Ponsoda, X, Castell, J.V. & Gómez-Lechón, M.J (1994), Acute cytotoxicity of ten chemicals in human and rat cultured hepatocytes and in cell lines correlation between in vitro data and human lethal concentrations Toxicology in Vitro 8, 47-54
17. Jover, R , Ponsoda, X , Castell, J.V. & Gómez-Lechón, M J. (1992) Evaluation of the cytotoxicity of ten chemicals on human cultured hepatocytes predictability of human toxicity and comparison with rodent cell culture systems Toxicology in Vitro 6, 47-52
18. Ponsoda, X , Jover, R , Núǹez, C , Rovo, M , Castell, J V & Gómez-Lechón, M J (1995) Evaluation of cytotoxicity of ten chemicals in human and rat hepatocytes and in cell lines correlation between in vitro data and human lethal concentrations Toxicology in Vitro 9, 959-966
19. Triglia, D , Sherard Braa, S , Yonan, C & Naughton, G K (1991) In vitro toxicity of various classes of test agents using the neutral red assay on a human three-dimensional physiologic skin model. In Vitro Cellular Development and Biology: Animal 27, 239-244.
20. Mosmann, T (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays Journal of Immunological Methods 65, 55-63.
21. Hall, T.J. & Heckel, C. (1990). Lack of effect of verapamil and MDL 646, a cytoprotective PGE1 analogue on cyclosporin A nephrotoxicity in vitro. Research Communications in Chemical Pathology and Pharmacology 67, 293-296.
22. Lenz, D., Segner, H. & Hanke, W. (1993). Comparison of different endpoint methods for acute cytotoxicity tests with the R1-cell line. In Fish Ecotoxicology and Ecophysiology (ed. T. Braunbeck, W Hanke & H. Segner), pp. 93-102. Weinheim, Germany: VCH Verlag.
23. Kahru, A. & Borehardt, B. (1994). Toxicity of 39 MEIC chemicals to bio luminescent photobacteria (the Biotox™ test): correlation with other test systems. ATLA 22, 147-160.
24. Jolliffe, I.T. (1986). Principal Components Analysis. New York: Springer Verlag.
25. Jackson, J E. (1991). A Users Guide to Principal Components. New York: John Wiley and Sons.
26. Wold, S. (1978). Cross-validatory estimation components in factor analysis and principal components models Technometrics 20, 397-405.
27. Wold, S., Esbensen, K. & Geladi, P (1987). Principal components analysis. Chemometric and Intelligent Laboratory Systems 2, 37-52
28. Wold, H. (1966) Estimation of principal components and related models by iterative least squares. In Multivariate Analysis (ed. P.R. Krishnaiah), pp. 391-420 New York Academic Press
29. Wold, S., Albano, C., Dunn, W J. 3rd, Esbensen, K., Hellberg, S., Johansson, E. & Sjoström, M. (1983) Pattern recognition, finding and using regularities in multivariate data. In Food Research and Data Analysis (ed. H Martens & H. Russworm), pp. 147-188 London: Applied Science Publishers
30. Newbold, P. (1991). Statistics for Business and Economics, 3rd edn. Urbana-Champaign. IL, USA. Prentice-Hall.
31. Daniel, W W (1978) Biostatistics A Foundation for Analysis in the Health Sciences, 2nd edn New York: John Wiley
32. Gad, S. & Weil, C S. (1988) Statistics and Experimental Design for Toxicologists, 2nd edn Caldwell, NJ, USA Telford Press
33. Ekwall, B , Barile, F.A , Chesné, C , Clothier, R., Curren, R , Dierickx, P , Ekwall, O , Ferro, M , Fiskesjo, G , Garza-Ocan̄as, L , Gav, R , Gómez-Lechón, M J , Gülden, M . Hellberg, S , Imai, K , Isomaa, B , Kristen, U , Kunimoto, M , Kärenlampi, S , Lewan, L , Malmsten, A , Persoone, G , Romert, L , Sandberg, M , Sawyer, T , Seibert, H . Shrivastava, R , Stammati, A , Tanaka, N , Triglia, D & Walum, E (1992) Further MEIC evaluation acute lethal toxicity in man of reference chemicals 11-30 predicted by 60 in vitro toxicity assays and by oral LD50 in rodents Abstract In Proceedings of INVITOX 92, De Haan, Belgium, October 5-9, 1992
34. Ekwall, B , Barile, F A , Bondesson, I , Clemedson, C , Clothier, R , Curren, R , Dierickx, P , Fiskesjo, G , Garza-Ocan̄as, L , Gómez-Lechón, M.J., Gülden, M., Imai, K , Janus, J., Kristen, U., Kummoto, M., Kärenlampi, S , Lavrijsen, K., Lewan, L , Malmsten, A., Miura, T., Nakamura, M., Ohno, T., Ono, H., Persoone, G., Roguet, R., Romert, L., Sandberg, M , Sawyer, T , Seibert, H , Shrivastava, R , Sjöström, M., Stammati, A., Tanaka, N., Walum, E., Wang, X. & Zucco, F. (1992). Acute lethal toxicity in man predicted by cytotoxicity in 52 cellular assays and by oral LD50 tests in rodents for the Erst 30 MEIC chemicals. In Proceedings of the 6th Meeting of the Japanese Society for Alternatives to Animal Experiments, Tokyo, Japan, 17-18 December 1992, pp. 114-115.
35. Ekwall, B. & Acosta, D. (1982). In vitro comparative toxicity of selected drugs and chemicals in HeLa cells, Chang liver cells, and rat hepatocytes. Drug and Chemical Toxicology 5, 219-231
36. Ekwall, B. & Ekwall, K. (1988). Comments on the use of diverse cell systems in toxicity testing. ATLA 15, 193-200.
37. Fry, J.R., Hammond, A.H., Garle, M.J. & Lal, K. (1993). Comparison of xenobiotic-mediated cytotoxicity in rat cultured hepatocytes and the V79 Chinese hamster lung fibroblast cell line: can metabolically-activated hepatotoxins be identified by selective cytotoxicity to hepatocytes? ATLA 21, 8-13.
38. Ekwall, B., Clemedson, C , Barile, F., Calleja, M C , Castell, J., Chesné, C., Clothier, R., Curren, R , Dierickx, P., McFarlane-Abdulla, E., Ferro, M., Fiskesjö, G., Garza-Ocańas, L., Gómez-Lechón, M.J., Gülden, M , Isomaa, B., Janus, J., Kerszman, G., Kristen, U., Kunimoto, M , Kärenlampi, S., Lavrijsen, K., Lewan, L , Ohno, T., Persoone, G., Roguet, R., Romert, L., Sawyer, T., Seibert, H., Shrivastava, R., Stadtlander, K , Stammati, A., Tanaka, N., Triglia, D., Valentino, M., Walum, E., Wang, X., Zucco, F., Harvell, J.D. & Maibach, H. (1994). Comparison between human skin irritancy and in vitro toxicity from 77 systems for the first 12 MEIC chemicals. In Vitro Toxicology 7, 156.
39. Ekwall, B. (1992). Validation of in vitro cytotoxicity tests. In In Vitro Alternatives to Animal Pharmaco-toxicology (ed. J.V. Castell & M.J. Gómez-Lechón), pp. 361-390. Madrid: Farmaindustria.
40. Ekwall, B. (1083) Screening of toxic compounds in mammalian cell cultures. In Annals of the New York Academy of Sciences, Vol. 407, Cellular Systems for Toxicity Testing (ed. G.M. Williams, V C. Dunkel & V.A. Ray), pp. 64-77. New York: The New York Academy of Sciences.
41. Ekwall, B. (1994). The basal cytotoxicity concept. In Alternative Methods in Toxicology and the Life Sciences, Vol. 11, The World Congress on Alternatives and Animal Use in the Life Sciences: Education, Research, Testing (ed. A.M. Goldberg & L.F.M. van Zupthen), pp. 721-725. New York: Mary Ann Liebert.