Discrimination between drug candidates using models for evaluation of intestinal absorption

Advanced Drug Delivery Reviews

Volumn 23, Issue 1-3, 1997, Pages 27-45

  Stewart, Barbra H ^a   Chan, O Helen ^a   Jezyk, Nancy ^b   Fleisher, David ^b  

^a PFIZER INC   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

cell uptake; intestinal absorption; lipophilicity; permeability; stability

Indexed keywords

CELL MEMBRANES; CELLS; COMPUTATIONAL METHODS; DRUG THERAPY; MATHEMATICAL MODELS; STABILITY; TISSUE;

CELL UPTAKE; INTESTINAL ABSORPTION; INTESTINAL CELLS; ISOLATED TISSUE; LIPOPHILICITY; MEMBRANE PARTITIONING; NEW CHEMICAL ENTITIES; ORGAN PERFUSION; PHYSICOCHEMICAL MEASUREMENTS; SUBCELLULAR MEMBRANE FRACTIONS;

DRUG PRODUCTS;

CEFDINIR; GABAPENTIN; HYDROCORTISONE; MANNITOL; NEW DRUG; PHENYLALANINE; PHENYTOIN;

CELL CULTURE; CELL FRACTIONATION; DRUG DESIGN; DRUG SOLUBILITY; DRUG UPTAKE; HUMAN; INTESTINE ABSORPTION; INTESTINE CELL; LIPOPHILICITY; MEMBRANE PERMEABILITY; MODEL; NONHUMAN; PARTITION COEFFICIENT; PERFUSION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW; TECHNIQUE;

EID: 0031024172     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(96)00424-3     Document Type: Review

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