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Volumn 19, Issue 1, 1999, Pages 49-59

Adenovirus-mediated gene therapy of liver diseases

Author keywords

Adenoviral vectors; Gene therapy; Hepatic malignancies; Hereditary diseases; Infectious diseases

Indexed keywords

BETA GALACTOSIDASE; BILIRUBIN; FUMARYLACETOACETASE; GLUCURONOSYLTRANSFERASE; LOW DENSITY LIPOPROTEIN RECEPTOR; NEUTRALIZING ANTIBODY; ORNITHINE CARBAMOYLTRANSFERASE; PROTEIN P53; VIRUS DNA;

EID: 0032948552     PISSN: 02728087     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-1007097     Document Type: Review
Times cited : (46)

References (86)
  • 1
    • 0000557447 scopus 로고    scopus 로고
    • Adenoviridae: The viruses and their replication
    • Fields BN, Knipe DM, Howley PM (eds). Philadelphia: Lippincott-Raven
    • Shenk T. Adenoviridae: The viruses and their replication. In: Fields BN, Knipe DM, Howley PM (eds). Fields Virology. 3rd ed. Philadelphia: Lippincott-Raven, 1996, pp 2111-2148
    • (1996) Fields Virology. 3rd Ed. , pp. 2111-2148
    • Shenk, T.1
  • 2
    • 0031975745 scopus 로고    scopus 로고
    • The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses
    • Bergelson JM, Krithivas A, Cell L, et al. The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses. J Virol 1998;72:415-419
    • (1998) J Virol , vol.72 , pp. 415-419
    • Bergelson, J.M.1    Krithivas, A.2    Cell, L.3
  • 4
    • 0030024402 scopus 로고    scopus 로고
    • Characterization of 911: A new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors
    • Fallaux FJ, Kranenburg O, Cramer SJ, et al. Characterization of 911: A new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors. Hum Gene Ther 1996; 7:215-222
    • (1996) Hum Gene Ther , vol.7 , pp. 215-222
    • Fallaux, F.J.1    Kranenburg, O.2    Cramer, S.J.3
  • 5
    • 0030971781 scopus 로고    scopus 로고
    • High level of transgene expression in cell cultures and in the mouse by replication-incompetent adenoviruses harboring modified VAI genes
    • liot M, Adam M, Gallais I, et al. High level of transgene expression in cell cultures and in the mouse by replication-incompetent adenoviruses harboring modified VAI genes. J Virol 1997;71: 5375-5381
    • (1997) J Virol , vol.71 , pp. 5375-5381
    • Liot, M.1    Adam, M.2    Gallais, I.3
  • 6
    • 0029834562 scopus 로고    scopus 로고
    • Evaluation of promoter strength for hepatic gene expression in vivo following adenovirus-mediated gene transfer
    • Guo ZS, Wang LH, Eisensmith RC, et al. Evaluation of promoter strength for hepatic gene expression in vivo following adenovirus-mediated gene transfer. Gene Ther 1996;9:802-810
    • (1996) Gene Ther , vol.9 , pp. 802-810
    • Guo, Z.S.1    Wang, L.H.2    Eisensmith, R.C.3
  • 7
    • 0029924662 scopus 로고    scopus 로고
    • Evaluation of HBV promoter for use in hepatic gene therapy
    • Loser P, Sandig V, Kirillova I, et al. Evaluation of HBV promoter for use in hepatic gene therapy. Biol Chem Hoppe Seyler 1996;377:187-193
    • (1996) Biol Chem Hoppe Seyler , vol.377 , pp. 187-193
    • Loser, P.1    Sandig, V.2    Kirillova, I.3
  • 8
    • 0029861452 scopus 로고    scopus 로고
    • Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo
    • Lieber A, He CY, Kirillova I, et al. Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo. J Virol 1996;70:8944-8960
    • (1996) J Virol , vol.70 , pp. 8944-8960
    • Lieber, A.1    He, C.Y.2    Kirillova, I.3
  • 9
    • 0031666610 scopus 로고    scopus 로고
    • Efficient fas-ligand gene expression in rodent liver after intravenous injection of a recombinant adenovirus by the use of a Cre-mediated switching system
    • kuyama T, Fujino M, Li X-K, et al. Efficient Fas-ligand gene expression in rodent liver after intravenous injection of a recombinant adenovirus by the use of a Cre-mediated switching system. Gene Ther 1998;5:1047-1053
    • (1998) Gene Ther , vol.5 , pp. 1047-1053
    • Kuyama, T.1    Fujino, M.2    Li, X.-K.3
  • 10
    • 0032539762 scopus 로고    scopus 로고
    • Enhanced and specific gene expression via tissue-specific production of Cre recombinase using adenovirus vector
    • Sato Y, Tanaka K, Lee G, et al. Enhanced and specific gene expression via tissue-specific production of Cre recombinase using adenovirus vector. Biochem Biophys Res Commun 1998;244:455-462
    • (1998) Biochem Biophys Res Commun , vol.244 , pp. 455-462
    • Sato, Y.1    Tanaka, K.2    Lee, G.3
  • 12
    • 0030917202 scopus 로고    scopus 로고
    • ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
    • Heise C, Sampson-Johannes A, Williams A. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat Med 1997;3:639-645
    • (1997) Nat Med , vol.3 , pp. 639-645
    • Heise, C.1    Sampson-Johannes, A.2    Williams, A.3
  • 13
    • 0031697770 scopus 로고    scopus 로고
    • P53-dependent cell death/apoptosis is required for a productive adenovirus infection
    • Hall AR, Dix BR, O'Carroll SJ, et al. P53-dependent cell death/apoptosis is required for a productive adenovirus infection. Nat Med 1998;4:1068-1072
    • (1998) Nat Med , vol.4 , pp. 1068-1072
    • Hall, A.R.1    Dix, B.R.2    O'Carroll, S.J.3
  • 14
    • 0028937785 scopus 로고
    • Cellular and humoral immune responses to viral antigen create barriers to lung-directed gene therapy with recombinant adenoviruses
    • Yang Y, Li Q, Ertl HCJ, Wilson JM. Cellular and humoral immune responses to viral antigen create barriers to lung-directed gene therapy with recombinant adenoviruses. J Virol 1995;67:2004-2015
    • (1995) J Virol , vol.67 , pp. 2004-2015
    • Yang, Y.1    Li, Q.2    Ertl, H.C.J.3    Wilson, J.M.4
  • 15
    • 0003354726 scopus 로고    scopus 로고
    • Adenoviruses
    • Fields BN, Knipe DM, Howley PM (eds). Philadelphia: Lippincott-Raven
    • Horwitz MS. Adenoviruses. In: Fields BN, Knipe DM, Howley PM (eds). Fields Virology, 3rd ed. Philadelphia: Lippincott-Raven, 1996, pp 2149-2171
    • (1996) Fields Virology, 3rd Ed. , pp. 2149-2171
    • Horwitz, M.S.1
  • 16
    • 0028934815 scopus 로고
    • Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long term expression
    • Dai Y, Schwarz EM, Gu D, et al. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long term expression. Proc Natl Acad Sci U S A 1995;92:1401-1405
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 1401-1405
    • Dai, Y.1    Schwarz, E.M.2    Gu, D.3
  • 17
    • 0029944988 scopus 로고    scopus 로고
    • Transient immuneblockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver
    • Yang Y, Greenough K, Wilson JM. Transient immuneblockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver. Gene Ther 1996;3:412-420
    • (1996) Gene Ther , vol.3 , pp. 412-420
    • Yang, Y.1    Greenough, K.2    Wilson, J.M.3
  • 18
    • 0030865752 scopus 로고    scopus 로고
    • Transient immunosuppression with FK506 permits long term expression of therapeutic genes introduced into the liver using recombinant adenoviruses
    • Ilan Y, Jona VK, Sengupta K, et al. Transient immunosuppression with FK506 permits long term expression of therapeutic genes introduced into the liver using recombinant adenoviruses. Hepatology 1997;26:949-956
    • (1997) Hepatology , vol.26 , pp. 949-956
    • Ilan, Y.1    Jona, V.K.2    Sengupta, K.3
  • 19
    • 85038173452 scopus 로고    scopus 로고
    • Long term adenovirus directed gene therapy in rats and rabbits using transient FK-506 treatment
    • Ilan Y, Jona VK, Prakash R, et al. Long term adenovirus directed gene therapy in rats and rabbits using transient FK-506 treatment. Hepatology 1996;24:48A
    • (1996) Hepatology , vol.24
    • Ilan, Y.1    Jona, V.K.2    Prakash, R.3
  • 20
    • 0028979466 scopus 로고
    • New prospectives of CD28-B7 mediated T cell costimulation
    • Bluestone JA. New prospectives of CD28-B7 mediated T cell costimulation. Immunity 1995;2:555-559
    • (1995) Immunity , vol.2 , pp. 555-559
    • Bluestone, J.A.1
  • 21
    • 0027761138 scopus 로고
    • Comparative analysis of B7-1 and B7-2 costimulatory ligands: Expression and function
    • Hathcock KS, Laszlo G, Dickler HB, et al. Comparative analysis of B7-1 and B7-2 costimulatory ligands: Expression and function. Science 1993;262:905-909
    • (1993) Science , vol.262 , pp. 905-909
    • Hathcock, K.S.1    Laszlo, G.2    Dickler, H.B.3
  • 22
    • 0029100024 scopus 로고
    • Antigen-dependent clonal expansion of a trace population of antigen-specific CD4 T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA4
    • Kearne ER, Walunas TL, Karr RW. Antigen-dependent clonal expansion of a trace population of antigen-specific CD4 T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA4. J Immunol 1995;155:1032-1036
    • (1995) J Immunol , vol.155 , pp. 1032-1036
    • Kearne, E.R.1    Walunas, T.L.2    Karr, R.W.3
  • 23
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in CTLA4
    • Waterhouse P, Penninger JM, Timms E, et al. Lymphoproliferative disorders with early lethality in mice deficient in CTLA4. Science 1995;270:985-988
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouse, P.1    Penninger, J.M.2    Timms, E.3
  • 24
    • 0029060729 scopus 로고
    • Induction and reversal of long-lived specific unresponsiveness to a T-dependent antigen following cTLA4Ig treament
    • Wallace PM, Rodgers JN, Leytze GM, et al. Induction and reversal of long-lived specific unresponsiveness to a T-dependent antigen following CTLA4Ig treament. J Immunol 1995;154: 5885-5895
    • (1995) J Immunol , vol.154 , pp. 5885-5895
    • Wallace, P.M.1    Rodgers, J.N.2    Leytze, G.M.3
  • 25
    • 0030984335 scopus 로고    scopus 로고
    • Transient immunomoclulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver
    • Kay MA, Meuse L, Gown AM, et al. Transient immunomoclulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver. Proc Natl Acad Sci U S A 1997;94:4686-4691
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 4686-4691
    • Kay, M.A.1    Meuse, L.2    Gown, A.M.3
  • 26
    • 0029970829 scopus 로고    scopus 로고
    • Induction of tolerance to recombinant adenoviruses by injection into newborn rats: Long term amelioration of hyperbilirubinemia in Gunn rats
    • Takahashi M, Ilan Y, Sengupta K, et al. Induction of tolerance to recombinant adenoviruses by injection into newborn rats: Long term amelioration of hyperbilirubinemia in Gunn rats. J Biol Chem 1996;271:26536-26542
    • (1996) J Biol Chem , vol.271 , pp. 26536-26542
    • Takahashi, M.1    Ilan, Y.2    Sengupta, K.3
  • 27
    • 85038177756 scopus 로고    scopus 로고
    • Prenatal tolerization to recombinant adenovirus permits long term correction of bilirubin glucuronidation defect in Gunn rats by repeated adenovirus-mediated gene therapy
    • Ilan Y, Sauter B, Roy Chowdhury N, et al. Prenatal tolerization to recombinant adenovirus permits long term correction of bilirubin glucuronidation defect in Gunn rats by repeated adenovirus-mediated gene therapy. Gastroenterology 1998;114:261 A
    • (1998) Gastroenterology , vol.114
    • Ilan, Y.1    Sauter, B.2    Roy Chowdhury, N.3
  • 28
    • 0026688642 scopus 로고
    • Prenatal diagnosis of bilirubin UDP glucuronusyl transferase deficiency in rats by genomic DNA analysis
    • Huang TJ, Roy Chowdhury J, Lahiri P, et al. Prenatal diagnosis of bilirubin UDP glucuronusyl transferase deficiency in rats by genomic DNA analysis. Hepatology 1992;16:756-762
    • (1992) Hepatology , vol.16 , pp. 756-762
    • Huang, T.J.1    Roy Chowdhury, J.2    Lahiri, P.3
  • 30
    • 0029849639 scopus 로고    scopus 로고
    • Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long term gene therapy in Gunn rats
    • Ilan Y, Attavar P, Takahashi M, et al. Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long term gene therapy in Gunn rats. J Clin Invest 1996;98:2640-2647
    • (1996) J Clin Invest , vol.98 , pp. 2640-2647
    • Ilan, Y.1    Attavar, P.2    Takahashi, M.3
  • 32
    • 0030847054 scopus 로고    scopus 로고
    • Oral tolerance: Immune mechanisms and treatment of autoimmune diseases
    • Weiner HL. Oral tolerance: Immune mechanisms and treatment of autoimmune diseases. Immunol Today 1997;18:335-343
    • (1997) Immunol Today , vol.18 , pp. 335-343
    • Weiner, H.L.1
  • 33
    • 0029123992 scopus 로고
    • Exquisite peptide specificity of oral tolerance in experimental autoimmune encephalomyelitis
    • Javed NH, Gienapp IE, Cox KL, et al. Exquisite peptide specificity of oral tolerance in experimental autoimmune encephalomyelitis. J Immunol 1995;155:1599-1605
    • (1995) J Immunol , vol.155 , pp. 1599-1605
    • Javed, N.H.1    Gienapp, I.E.2    Cox, K.L.3
  • 34
    • 0027467440 scopus 로고
    • Double-blind pilot trial of oral tolerization with myelin antigen in multiple sclerosis
    • Weiner HL, Mackin GA, Matsui M, et al. Double-blind pilot trial of oral tolerization with myelin antigen in multiple sclerosis. Science 1993;261:1321-1324
    • (1993) Science , vol.261 , pp. 1321-1324
    • Weiner, H.L.1    Mackin, G.A.2    Matsui, M.3
  • 35
    • 0029959955 scopus 로고    scopus 로고
    • Dose-dependent activation and deletion of antigen-specific T cells following oral tolerance
    • Chen YH, Weiner HL. Dose-dependent activation and deletion of antigen-specific T cells following oral tolerance. Ann N Y Acad Sci 1996;778:111-121
    • (1996) Ann N Y Acad Sci , vol.778 , pp. 111-121
    • Chen, Y.H.1    Weiner, H.L.2
  • 36
    • 0030951645 scopus 로고    scopus 로고
    • Oral tolerization to adenoviral antigens permits long term gene expression using recombinant adenoviral vectors
    • Ian Y, Prakash R, Davidson A, et al. Oral tolerization to adenoviral antigens permits long term gene expression using recombinant adenoviral vectors. J Clin Invest 1997;99:1098-1106
    • (1997) J Clin Invest , vol.99 , pp. 1098-1106
    • Ian, Y.1    Prakash, R.2    Davidson, A.3
  • 37
    • 0000899510 scopus 로고    scopus 로고
    • A critical role of the liver in inducing oral tolerance to adenoviral vectors for long term gene therapy
    • Ilan Y, Roy Chowdhury N, Sauter B, et al. A critical role of the liver in inducing oral tolerance to adenoviral vectors for long term gene therapy. Gastroenterology 1998;114:260A
    • (1998) Gastroenterology , vol.114
    • Ilan, Y.1    Roy Chowdhury, N.2    Sauter, B.3
  • 38
    • 17344370857 scopus 로고    scopus 로고
    • Oral tolerization to adenoviral proteins permits repeated adenovirus-mediated gene therapy in rats with preexisting immunity to adenovirus
    • Ilan Y, Sauter B, Roy Chowdhury N, et al. Oral tolerization to adenoviral proteins permits repeated adenovirus-mediated gene therapy in rats with preexisting immunity to adenovirus. Hepatology 1998;27:1368-1376
    • (1998) Hepatology , vol.27 , pp. 1368-1376
    • Ilan, Y.1    Sauter, B.2    Roy Chowdhury, N.3
  • 39
    • 0001464534 scopus 로고    scopus 로고
    • Adoptive transfer of tolerance from rats tolerized to adenoviral antigens allows long term adenovirus-mediated gene therapy in Gunn rats
    • Ilan Y, Prakash R, Jona VK, et al. Adoptive transfer of tolerance from rats tolerized to adenoviral antigens allows long term adenovirus-mediated gene therapy in Gunn rats. Hepatology 1996; 24:304
    • (1996) Hepatology , vol.24 , pp. 304
    • Ilan, Y.1    Prakash, R.2    Jona, V.K.3
  • 40
    • 0028229147 scopus 로고
    • Inactivation of E2a in recombinant adenoviruses limits cellular immunity and improves the prospect of gene therapy of cystic fibrosis
    • Yang Y, Nunes FA, Berencsi K, et al. Inactivation of E2a in recombinant adenoviruses limits cellular immunity and improves the prospect of gene therapy of cystic fibrosis. Proc Natl Acad Sci U S A 1994;7:362-369
    • (1994) Proc Natl Acad Sci U S A , vol.7 , pp. 362-369
    • Yang, Y.1    Nunes, F.A.2    Berencsi, K.3
  • 41
    • 0029966514 scopus 로고    scopus 로고
    • Recombinant adenovirus deleted of all viral genes for genes for gene therapy of cystic fibrosis
    • Fisher KJ, Choi H, Burda J, et al. Recombinant adenovirus deleted of all viral genes for genes for gene therapy of cystic fibrosis. Virology 1996;217:11-22
    • (1996) Virology , vol.217 , pp. 11-22
    • Fisher, K.J.1    Choi, H.2    Burda, J.3
  • 42
    • 0031778879 scopus 로고    scopus 로고
    • Role of E4 in eliciting CD4 T cell and B cell responses to adenovirus vectors delivered to murine and nonhuman primate lungs
    • Chirmule N, Hughes JV, Gao GP, et al. Role of E4 in eliciting CD4 T cell and B cell responses to adenovirus vectors delivered to murine and nonhuman primate lungs. J Virol 1998;72: 6138-6145
    • (1998) J Virol , vol.72 , pp. 6138-6145
    • Chirmule, N.1    Hughes, J.V.2    Gao, G.P.3
  • 43
    • 0032530110 scopus 로고    scopus 로고
    • Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: Implications for gene therapy
    • Kafri T, Morgan D, Krahl T, et al. Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: Implications for gene therapy. Proc Natl Acad Sci U S A 1998;95:11377-11382
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 11377-11382
    • Kafri, T.1    Morgan, D.2    Krahl, T.3
  • 44
    • 0029147645 scopus 로고
    • Model systems for studying the effects of adenovirus E3 genes on virulence in vivo
    • Horwitz MS, Tufariello J. Grunhaus A, et al. Model systems for studying the effects of adenovirus E3 genes on virulence in vivo. Curr Top Microbiol Immunol 1995;199:195-211
    • (1995) Curr Top Microbiol Immunol , vol.199 , pp. 195-211
    • Horwitz, M.S.1    Tufariello, J.2    Grunhaus, A.3
  • 45
    • 0029030001 scopus 로고
    • The constitutive expression of the immunodulatory gp 19K protein in E1-, E3-adenoviral vectors strongly reduces the host cytotoxic T cell response against the vector
    • Lee MG, Abina MA, Haddada H, et al. The constitutive expression of the immunodulatory gp 19K protein in E1-, E3-adenoviral vectors strongly reduces the host cytotoxic T cell response against the vector. Gene Ther 1995;2:256-262
    • (1995) Gene Ther , vol.2 , pp. 256-262
    • Lee, M.G.1    Abina, M.A.2    Haddada, H.3
  • 46
    • 0028141978 scopus 로고
    • Identification of amino acids within the MHC molecule important for the interaction with the adenovirus protein E3/19K
    • Feuerbach D, Etteldorf S, Ebenau-Jehle C, et al. Identification of amino acids within the MHC molecule important for the interaction with the adenovirus protein E3/19K. J Immunol 1994;153: 1626-1636
    • (1994) J Immunol , vol.153 , pp. 1626-1636
    • Feuerbach, D.1    Etteldorf, S.2    Ebenau-Jehle, C.3
  • 47
    • 0344912858 scopus 로고    scopus 로고
    • Interaction of an adenovirus 14.7 kDa protein inhibitor of TNF acytolysis with a new member of the GT-Pase superfamily of signal transducers
    • Li Y, Kang J, Horwitz MS. Interaction of an adenovirus 14.7 kDa protein inhibitor of TNF acytolysis with a new member of the GT-Pase superfamily of signal transducers. J Virol 1996;56: 734-741
    • (1996) J Virol , vol.56 , pp. 734-741
    • Li, Y.1    Kang, J.2    Horwitz, M.S.3
  • 48
    • 0028139267 scopus 로고
    • Adenovirus E3 14.7-kilodalton protein, an antagonist of tumor necrosis factor cytolis, increases the virulence of vcaccinia virus in severe combined immunodeficient mice
    • Turariello, JM, Sangho C, Horwitz M.S. Adenovirus E3 14.7-kilodalton protein, an antagonist of tumor necrosis factor cytolis, increases the virulence of vcaccinia virus in severe combined immunodeficient mice. Proc Natl Acad Sci U S A 1994;91: 10987-10991
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10987-10991
    • Turariello, J.M.1    Sangho, C.2    Horwitz, M.S.3
  • 49
    • 0029125671 scopus 로고
    • Prolonged survival of pancreatic islet allograft mediated by adenovirus immunoregulatory transgenes
    • Efrat S, Fejer M, Brownlee G, et al. Prolonged survival of pancreatic islet allograft mediated by adenovirus immunoregulatory transgenes. Proc Natl Acad Sci U S A 1995;92:6947-6951
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 6947-6951
    • Efrat, S.1    Fejer, M.2    Brownlee, G.3
  • 50
    • 0030005390 scopus 로고    scopus 로고
    • Stabilization of transgene expression by incorporation of E3 region genes into an adenoviral factor IX vector and by transient anti-CD4 treatment of the host
    • Polier W, Schneider-Rasp S, Liebert U, et al. Stabilization of transgene expression by incorporation of E3 region genes into an adenoviral factor IX vector and by transient anti-CD4 treatment of the host. Gene Ther 1996;63:521-530
    • (1996) Gene Ther , vol.63 , pp. 521-530
    • Polier, W.1    Schneider-Rasp, S.2    Liebert, U.3
  • 51
    • 0030988482 scopus 로고    scopus 로고
    • Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression
    • Ilan Y, Droguett, G, Roy Chowdhury N, et al. Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression. Proc Natl Acad Sci U S A 1997;94: 2587-2592
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 2587-2592
    • Ilan, Y.1    Droguett, G.2    Roy Chowdhury, N.3
  • 52
    • 0000377241 scopus 로고    scopus 로고
    • Expression of adenoviral E3 gene production in normal rat hepatocytes prevents their rejection upon transplantation into allogeneic Gunn rats
    • Ilan Y, Sauter B, Roy Chowdhury N, et al. Expression of adenoviral E3 gene production in normal rat hepatocytes prevents their rejection upon transplantation into allogeneic Gunn rats. Hepatology 1997;26:490A
    • (1997) Hepatology , vol.26
    • Ilan, Y.1    Sauter, B.2    Roy Chowdhury, N.3
  • 53
    • 0028276410 scopus 로고
    • Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man
    • Bosma PJ, Seppen J, Goldhoorn B, et al. Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man. J Biol Chem 1994;269:17960-17964
    • (1994) J Biol Chem , vol.269 , pp. 17960-17964
    • Bosma, P.J.1    Seppen, J.2    Goldhoorn, B.3
  • 54
    • 0028791598 scopus 로고
    • Molecular biology of bilirubin metabolism
    • Boyer JL, Ockner RK (eds). Philadelphia: WB Saunders
    • Jansen PLM, Bosma PJ, Roy-Chowdhury J. Molecular biology of bilirubin metabolism. In: Boyer JL, Ockner RK (eds). Progress in Liver Diseases. Vol. XIII. Philadelphia: WB Saunders, 1995, pp 125-150
    • (1995) Progress in Liver Diseases. , vol.13 , pp. 125-150
    • Jansen, P.L.M.1    Bosma, P.J.2    Roy-Chowdhury, J.3
  • 55
    • 0031019586 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer and expression of human β-glucuronidase gene in the liver, spleen, and central nervous system in mucopolysaccharidosis type VlI mice
    • Ohashi T, Watabe K, Uehara K, et al. Adenovirus-mediated gene transfer and expression of human β-glucuronidase gene in the liver, spleen, and central nervous system in mucopolysaccharidosis type VlI mice. Proc Natl Acad Sci U S A 1997;94: 1287-1292
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 1287-1292
    • Ohashi, T.1    Watabe, K.2    Uehara, K.3
  • 56
    • 0030917824 scopus 로고    scopus 로고
    • Adenovirus-mediated gene therapy in a mouse model of hereditary tyrostnemia type I
    • Overturf K, al Dhalimy M, Ou CN, et al. Adenovirus-mediated gene therapy in a mouse model of hereditary tyrostnemia type I. Hum Gene Ther 1997;8:513-521
    • (1997) Hum Gene Ther , vol.8 , pp. 513-521
    • Overturf, K.1    Al Dhalimy, M.2    Ou, C.N.3
  • 57
    • 0029967430 scopus 로고    scopus 로고
    • Correction of ornithine transcarbamylase deficiency in adult spfash mice and OTC-deficient human hepatocytes with recombinant adenoviruses bearing the CAG promoter
    • Kiwaki K, Kanegae Y, Saito I, et al. Correction of ornithine transcarbamylase deficiency in adult spfash mice and OTC-deficient human hepatocytes with recombinant adenoviruses bearing the CAG promoter. Hum Gene Ther 1996;7:821-830
    • (1996) Hum Gene Ther , vol.7 , pp. 821-830
    • Kiwaki, K.1    Kanegae, Y.2    Saito, I.3
  • 58
    • 17344366287 scopus 로고    scopus 로고
    • Correction of hypertriglyceridemia and impaired fat tolerance in lipoprotein lipase-deficient mice by adenovirus-mediated expression of human lipoprotein lipase
    • Excoffon KJ, Liu G, Miao L, et al. Correction of hypertriglyceridemia and impaired fat tolerance in lipoprotein lipase-deficient mice by adenovirus-mediated expression of human lipoprotein lipase. Arteriosclerosis Thromb Vasc Biol 1997;17: 2532-2539
    • (1997) Arteriosclerosis Thromb Vasc Biol , vol.17 , pp. 2532-2539
    • Excoffon, K.J.1    Liu, G.2    Miao, L.3
  • 59
    • 16944362700 scopus 로고    scopus 로고
    • Efficient adenovirus-mediated ectopic gene expression of human lipoprotein lipase in human hepatic (HepG2) cells
    • Liu G, Excoffon KJ, Benoit P, et al. Efficient adenovirus-mediated ectopic gene expression of human lipoprotein lipase in human hepatic (HepG2) cells. Hum Gene Ther 1997;8:205-214
    • (1997) Hum Gene Ther , vol.8 , pp. 205-214
    • Liu, G.1    Excoffon, K.J.2    Benoit, P.3
  • 60
    • 0029988465 scopus 로고    scopus 로고
    • Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene
    • Kozarsky KF, Joose K, Donahee M, et al. Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene. Nat Genet 1996;13:54-62
    • (1996) Nat Genet , vol.13 , pp. 54-62
    • Kozarsky, K.F.1    Joose, K.2    Donahee, M.3
  • 61
    • 0030666462 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer of human lipoprotein lipase ameliorates the hyperlipidemias associated with apolipoprotein E and LDL receptor deficiencies in mice
    • Zsigmond E, Kobayashi K, Tzung KW, et al. Adenovirus-mediated gene transfer of human lipoprotein lipase ameliorates the hyperlipidemias associated with apolipoprotein E and LDL receptor deficiencies in mice. Hum Gene Ther 1997;8:1921-1933
    • (1997) Hum Gene Ther , vol.8 , pp. 1921-1933
    • Zsigmond, E.1    Kobayashi, K.2    Tzung, K.W.3
  • 62
    • 0030960169 scopus 로고    scopus 로고
    • Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels
    • Kozarsky K, Donahee MH, Rigotti A, et al. Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels. Nature 1997;387:414-417
    • (1997) Nature , vol.387 , pp. 414-417
    • Kozarsky, K.1    Donahee, M.H.2    Rigotti, A.3
  • 63
    • 0029962807 scopus 로고    scopus 로고
    • Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor
    • Kobayashi K, Oka K, Forte T, et al. Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor. J Biol Chem 1996;271:6852-6860
    • (1996) J Biol Chem , vol.271 , pp. 6852-6860
    • Kobayashi, K.1    Oka, K.2    Forte, T.3
  • 64
    • 0029794714 scopus 로고    scopus 로고
    • Hepatic gene transfer of the catalytic subunit of the apolypoprotein B mRNA editing enzyme, APOBEC-1, leads to reduction of ldl in normal and watanabe heritable hyperlipidemic rabbits
    • Greeve J, Jona VK, Roy-Chowdhury N, et al. Hepatic gene transfer of the catalytic subunit of the apolypoprotein B mRNA editing enzyme, APOBEC-1, leads to reduction of LDL in normal and Watanabe heritable hyperlipidemic rabbits. J Lipid Res 1996;37:2001-2017
    • (1996) J Lipid Res , vol.37 , pp. 2001-2017
    • Greeve, J.1    Jona, V.K.2    Roy-Chowdhury, N.3
  • 65
    • 0029953004 scopus 로고    scopus 로고
    • Use of dominant negative mutants of the hepadnaviral core protein as antiviral agents
    • Scaglioni P, Melegari M, Takahashi M, et al. Use of dominant negative mutants of the hepadnaviral core protein as antiviral agents. Hepatology 1996;24:1010-1017
    • (1996) Hepatology , vol.24 , pp. 1010-1017
    • Scaglioni, P.1    Melegari, M.2    Takahashi, M.3
  • 66
    • 0029957795 scopus 로고    scopus 로고
    • Costimulatory protein B7-1 enhances the cytotoxic T cell response and antibody response to hepatitis B surface antigen
    • He XS, Chen HS, Chu K, Rivkina M, Robinson WS. Costimulatory protein B7-1 enhances the cytotoxic T cell response and antibody response to hepatitis B surface antigen. Proc Natl Acad Sci U S A 1996;93:7274-7278
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 7274-7278
    • He, X.S.1    Chen, H.S.2    Chu, K.3    Rivkina, M.4    Robinson, W.S.5
  • 67
    • 0029970824 scopus 로고    scopus 로고
    • Elimination of hepatitis C virus RNA in infected human hepatocytes by adenovirus-mediated expression of ribozymes
    • Lieber A, He CY, Polyak SJ, et al. Elimination of hepatitis C virus RNA in infected human hepatocytes by adenovirus-mediated expression of ribozymes. J Virol 1996;70:8782-8791
    • (1996) J Virol , vol.70 , pp. 8782-8791
    • Lieber, A.1    He, C.Y.2    Polyak, S.J.3
  • 68
  • 69
    • 0030798508 scopus 로고    scopus 로고
    • Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma
    • Qian C, Idoate M, Bilbao R, et al. Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma. Hum Gene Ther 1997;8:349-358
    • (1997) Hum Gene Ther , vol.8 , pp. 349-358
    • Qian, C.1    Idoate, M.2    Bilbao, R.3
  • 70
    • 0030686481 scopus 로고    scopus 로고
    • Adenoviral-mediated herpes simplex virus thymidine kinase gene transfer: Regression of hepatic metastasis of pancreatic tumors
    • Block A, Chen SH, Kosai K, et al. Adenoviral-mediated herpes simplex virus thymidine kinase gene transfer: Regression of hepatic metastasis of pancreatic tumors. Pancreas 1997;15:25-34
    • (1997) Pancreas , vol.15 , pp. 25-34
    • Block, A.1    Chen, S.H.2    Kosai, K.3
  • 71
    • 0030817590 scopus 로고    scopus 로고
    • Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo
    • Pederson LC, Buchsbaum DJ, Vickers SM, et al. Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo. Cancer Res 1997;57:4325-4332
    • (1997) Cancer Res , vol.57 , pp. 4325-4332
    • Pederson, L.C.1    Buchsbaum, D.J.2    Vickers, S.M.3
  • 72
    • 0028936342 scopus 로고
    • Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: Development of a combined chemotherapy/cancer gene therapy strategy
    • Chen L, Waxman DJ. Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: Development of a combined chemotherapy/cancer gene therapy strategy. Cancer Res 1995; 55:581-589
    • (1995) Cancer Res , vol.55 , pp. 581-589
    • Chen, L.1    Waxman, D.J.2
  • 73
    • 0030810198 scopus 로고    scopus 로고
    • Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene
    • Chen L, Yu LJ, Waxman DJ. Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene. Cancer Res 1997;57:4830-4837
    • (1997) Cancer Res , vol.57 , pp. 4830-4837
    • Chen, L.1    Yu, L.J.2    Waxman, D.J.3
  • 74
    • 85038184050 scopus 로고    scopus 로고
    • Efficient tumor cell killing and pronounced bystander effect by adenovirus mediated transfer of the E. Coli purine nucleoside phosphorylase gene to hepatocellular carcinoma cells
    • Mohr L, Shankara S, Roberts B, et al. Efficient tumor cell killing and pronounced bystander effect by adenovirus mediated transfer of the E. coli purine nucleoside phosphorylase gene to hepatocellular carcinoma cells. Hepatology 1998;28:504A
    • (1998) Hepatology , vol.28
    • Mohr, L.1    Shankara, S.2    Roberts, B.3
  • 75
    • 0029972263 scopus 로고    scopus 로고
    • Gene therapy for hepatocellular carcinoma: Long-term remission of primary and metastatic tumors in mice by interleukin-2 gene therapy in vivo
    • Huang H, Chen SH, Kosai K, Finegold MJ, Woo SL. Gene therapy for hepatocellular carcinoma: Long-term remission of primary and metastatic tumors in mice by interleukin-2 gene therapy in vivo. Gene Ther 1996;3:980-987
    • (1996) Gene Ther , vol.3 , pp. 980-987
    • Huang, H.1    Chen, S.H.2    Kosai, K.3    Finegold, M.J.4    Woo, S.L.5
  • 76
    • 0031564326 scopus 로고    scopus 로고
    • In vivo therapy of hepatocellular carcinoma with a tumor-specific adenoviral vector expressing interleukin-2
    • Bui LA, Butterfield LH, Kim JY, et al. In vivo therapy of hepatocellular carcinoma with a tumor-specific adenoviral vector expressing interleukin-2. Hum Gene Ther 1997;8:2173-2182
    • (1997) Hum Gene Ther , vol.8 , pp. 2173-2182
    • Bui, L.A.1    Butterfield, L.H.2    Kim, J.Y.3
  • 77
    • 0030057511 scopus 로고    scopus 로고
    • Construction of a double recombinant adenovirus vector expressing a heterodimeric cytokine: In vitro and in vivo production of biologically active interleukin-12
    • Bramson J, Hitt M, Gallichan WS, et al. Construction of a double recombinant adenovirus vector expressing a heterodimeric cytokine: In vitro and in vivo production of biologically active interleukin-12. Hum Gene Ther 1996;7:333-342
    • (1996) Hum Gene Ther , vol.7 , pp. 333-342
    • Bramson, J.1    Hitt, M.2    Gallichan, W.S.3
  • 78
    • 0029848051 scopus 로고    scopus 로고
    • Direct intratumoral injection of an adenovirus expressing interleukin-12 induces regression and long-lasting immunity that is associated with highly localized expression of interleukin-12
    • Bramson J, Hitt M, Addison CL, et al. Direct intratumoral injection of an adenovirus expressing interleukin-12 induces regression and long-lasting immunity that is associated with highly localized expression of interleukin-12. Hum Gene Ther 1996;7: 1995-2002
    • (1996) Hum Gene Ther , vol.7 , pp. 1995-2002
    • Bramson, J.1    Hitt, M.2    Addison, C.L.3
  • 79
    • 0031178963 scopus 로고    scopus 로고
    • Eradication of murine bladder carcinoma by intratumor injection of a bicistronic adenoviral vector carrying cDNAs for the IL-12 heterodimer and its inhibition by the IL-12 p40 subunit homodimer
    • Chen L, Chen D, Block E, et al. Eradication of murine bladder carcinoma by intratumor injection of a bicistronic adenoviral vector carrying cDNAs for the IL-12 heterodimer and its inhibition by the IL-12 p40 subunit homodimer. J Immunol 1997; 159:351-359
    • (1997) J Immunol , vol.159 , pp. 351-359
    • Chen, L.1    Chen, D.2    Block, E.3
  • 80
    • 0029859405 scopus 로고    scopus 로고
    • Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma
    • Caruso M, Pham Nguyen K, Kwong YL, et al. Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma. Proc Natl Acad Sci U S A 1996;92:11302-11306
    • (1996) Proc Natl Acad Sci U S A , vol.92 , pp. 11302-11306
    • Caruso, M.1    Pham Nguyen, K.2    Kwong, Y.L.3
  • 81
    • 0032101974 scopus 로고    scopus 로고
    • T cell and NK cell-independent inhibition of hepatic metastases by systemic administration of an IL-12-expressing recombinant adenovirus
    • Siders WM, Wright PW, Hixon JA, et al. T cell and NK cell-independent inhibition of hepatic metastases by systemic administration of an IL-12-expressing recombinant adenovirus. J Immunol 1998;160:5465-5474
    • (1998) J Immunol , vol.160 , pp. 5465-5474
    • Siders, W.M.1    Wright, P.W.2    Hixon, J.A.3
  • 82
    • 0031018829 scopus 로고    scopus 로고
    • Isolated-organ perfusion for local gene delivery: Efficient adenovirus-mediated gene transfer into the liver
    • de Roos WK, Fallaux FJ, Marinelli AAWKS, et al. Isolated-organ perfusion for local gene delivery: Efficient adenovirus-mediated gene transfer into the liver. Gene Ther 1997;4:55-62
    • (1997) Gene Ther , vol.4 , pp. 55-62
    • De Roos, W.K.1    Fallaux, F.J.2    Marinelli, A.A.W.K.S.3
  • 83
    • 0031906191 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer into cold-preserved liver allografts: Survival pattern and unresponsiveness following transduction with CTLA4Ig
    • Olthoff KM, Judge TA, Gelman AE, et al. Adenovirus-mediated gene transfer into cold-preserved liver allografts: Survival pattern and unresponsiveness following transduction with CTLA4Ig. Nat Med 1998;4:194-200
    • (1998) Nat Med , vol.4 , pp. 194-200
    • Olthoff, K.M.1    Judge, T.A.2    Gelman, A.E.3
  • 84
    • 0029836780 scopus 로고    scopus 로고
    • Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy
    • Mittereder N, March KL, Trapnell BC. Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy. J Virol 1996;70:7498-7509
    • (1996) J Virol , vol.70 , pp. 7498-7509
    • Mittereder, N.1    March, K.L.2    Trapnell, B.C.3
  • 85
    • 0029968305 scopus 로고    scopus 로고
    • Circumventing the immune resposne to adenovirus-mediated gene therapy
    • Eiseler KA, Leinwand L, Gall J, et al. Circumventing the immune resposne to adenovirus-mediated gene therapy. Gene Ther 1996;3:154-162
    • (1996) Gene Ther , vol.3 , pp. 154-162
    • Eiseler, K.A.1    Leinwand, L.2    Gall, J.3
  • 86
    • 0030806875 scopus 로고    scopus 로고
    • Adenoviral/retroviral vector chimeras: A novel strategy to achieve high-efficiency stable transduction in vivo
    • Bilbao G, Feng M, Rancourt C, et al. Adenoviral/retroviral vector chimeras: A novel strategy to achieve high-efficiency stable transduction in vivo. FASEB J 1997;11:624-634
    • (1997) FASEB J , vol.11 , pp. 624-634
    • Bilbao, G.1    Feng, M.2    Rancourt, C.3


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