Voltage dependence of mouse acetylcholine receptor gating: Different charge movements in di-, mono- and unliganded receptors

Journal of Physiology

Volumn 494, Issue 1, 1996, Pages 155-170

  Auerbach, Anthony ^a   Sigurdson, Wade ^a   Chen, Jian ^a   Akk, Gustav ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; NICOTINIC RECEPTOR; RECOMBINANT PROTEIN; VOLTAGE GATED CHANNEL FORMING PROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CHANNEL GATING; CONTROLLED STUDY; HYPERPOLARIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

EID: 0029934560     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.1996.sp021482     Document Type: Article

References (39)

1. ACKERS, G. K., DOYLE, M. L., MYERS, D. & DAUGHERTY, M. A. (1992). Molecular code for cooperativity in hemoglobin. Science 255, 54-63.
2. AKABAS, M. H., STAUFFER D. A., XU, M. & KARLIN, A. (1992). Acetylcholine receptor channel structure probed in cysteine-substitution mutants. Science 258, 307-310.
3. AKK, G. & AUERBACH, A. (1996). Inorganic monovalent cations compete with agonists for the transmitter binding site of nicotinic acetylcholine receptors. Biophysical Journal 70, 2652-2658.
4. AUERBACH, A. (1993). A statistical analysis of acetylcholine receptor activation in Xenopus myocytes: stepwise vs. concerted models of gating. Journal of Physiology 461, 339-378.
5. CHANGEUX, J.-P. & EDELSTEIN, S. J. (1994). On allosteric mechanisms and acetylcholine receptors. Trends in Biochemical Sciences 19, 399-400.
6. CHEN, J., ZHANG, Y., AKK, G., SINE, S. & AUERBACH, A. (1995). Activation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of α-subunit tyrosine 190 affect both binding and gating. Biophysical Journal 69, 849-859.
7. COLQUHOUN, D., DREYER, F. & SHERIDAN, R. E. (1979). The actions of tubocurarine at the frog neuromuscular junction. Journal of Physiology 293, 247-284.
8. COLQUHOUN, D. & HAWKES, A. G. (1977). Relaxation and fluctuation in membrane currents that flow through drug-operated channels. Proceedings of the Royal Society B 199, 231-262.
9. COLQUHOUN, D. & SAKMANN, B. (1985). Fast events in single channel currents activated by acetylcholine and its analogues of the frog muscle end-plate. Journal of Physiology 369, 501-557.
10. HILLE, B. (1992). Ionic Channels of Excitable Membranes, 2nd edn. Sinauer Associates Inc., Sunderland, MA, USA.
11. IMOTO, K., BUSCH, C., SAKMANN, B., MISHINA, M., MORI, Y., KONNO, T., FUKUDA, K., KURASAKI, M., BUJO, H., FUJITA, Y. & NUMA, S. (1986). Location of a δ-subunit region determining ion transport through the acetylcholine receptor channel. Nature 324, 670-674.
12. JACKSON, M. B. (1986). Kinetics of unliganded acetylcholine receptor channel gating. Biophysical Journal 49, 663-672.
13. JACKSON, M. B. (1988). Dependence of acetylcholine receptor channel kinetics on agonist concentration in cultured mouse muscle fibres. Journal of Physiology 397, 555-583.
14. JACKSON, M. B. (1989). Perfection of asynaptic receptor: kinetics and energetics of the acetylcholine receptor. Proceedings of the National Academy of Sciences of the USA 86, 2199-2203.
15. KARLIN, A. (1967). On the application of "a plausible model" of allosteric proteins to the receptor for acetylcholine. Journal of Theoretical Biology 16, 306-320.
16. KOSHLAND, D. E. JR, NEMETHY, G. & FILMER, D. (1966). Comparison of experimental binding data and theoretical models in proteins containing subunits. Biochemistry 5, 365-385.
17. LABARCA, C., NOWAK, M. W., ZHANG, H., TANG, L., DESHPANDE, P. & LESTER, H. A. (1995). Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Nature 376, 514-516.
18. MACHONOCHIE, D. J., FLETCHER, G. H. & STEINBACH, J. H. (1995). The conductance of the muscle nicotinic receptor channel changes rapidly upon gating. Biophysical Journal 68, 483-490.
19. MACHONOCHIE, D. J. & STEINBACH, J. H. (1992). Adult and foetal acetylcholine receptor channel opening rates. Biophysical Journal 61, A143.
20. MAGLEBY, K. L. & STEVENS, C. F. (1972a). A quantitative description of end-plate currents. Journal of Physiology 223, 173-197.
21. MAGLEBY, K. L. & STEVENS, C. F. (1972b). The effect of voltage on the time course of end-plate currents. Journal of Physiology 223, 151-171.
22. MONOD, J., WYMAN, J. & CHANGEUX, J.-P. (1965). On the nature of allosteric transition: a plausible model. Journal of Molecular Biology 12, 88-118.
23. NEHER, E. & SAKMANN, B. (1976). Single channel currents recorded from membrane of denervated frog muscle fibres. Nature 260, 799-802.
24. OHNO, K., HUTCHINSON, D. O., MILONE, M., BERGMAM, J. M., BOUZAT, C., SINE, S. M. & ENGEL, A. G. (1995). Congenital myasthenic syndrome caused by prolonged acetylcholine receptor openings due to a mutation in the M2 domain of the ε-subunit. Proceedings of the National Academy of Sciences of the USA 92, 758-762.
25. REVAH, F., BERTRAND, D., GALZI, J.-L., DEVILLERS-THIÉRY, A., MULLE, C., HUSSY, N., BERTRAND, S., BALLIVET, M. & CHANGEUX, J.-P. (1991). Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor. Nature 353, 846-849.
26. ROHRBOUGH, J. & KIDOKORO, Y. (1990). Changes in kinetics of acetylcholine receptor channels after initial expression in Xenopus myocyte culture. Journal of Physiology 425, 245-269.
27. SHERIDAN, R. E. & LESTER, H. A. (1977). Rates and equilibria at the acetylcholine receptor of electrophorus electroplaques: a study of neurally evoked postsynaptic currents and of voltage-jump relaxations. Journal of General Physiology 70, 187-219.
28. SIGURDSON, W. & AUERBACH, A. (1994). Frequent, long-lived spontaneous and mono-liganded openings of nicotinic acetylcholine receptors with M2 mutations. Neuroscience Society Annual Meeting Abstract 20, 1132.
29. SIGURDSON, W., CHEN., J., AKABAS, M. & AUERHACH, A. (1994). Single channel kinetics of mouse AChR M2 mutants αL251C and αS248C. Biophysical Journal 66, A212.
30. SIGWORTH, F. J. & SINE, S. M. (1987). Data transformations for improved display and fitting of single-channel dwell time histograms. Biophysical Journal 52, 1047-1054.
31. SINE, S. M. (1994). Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of residues that determine curare selectivity. Proceedings of the National Academy of Sciences of the USA 90, 9436-9440.
32. SINE, S. M., CLAUDIO, T. & SIGSWORTH, F. (1990). Activation of Torpedo acetylcholine receptors expressed in mouse fibroblasts. Journal of General Physiology 96, 395-437.
33. SINE, S. M., OHNO, K., BOUZAT, C., AUERBACH, A., MILONE, M., PRUITT, J. & ENGEL, A. G. (1995). Mutation of the acetylcholine receptor α-subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity. Neuron 15, 229-239.
34. SINE, S. M., QUIRAM, P., PAPANIKOLAOU, F., KREIENKAMP, H.-J. & TAYLOR, P. (1994). Conserved tyrosines in the alpha subunit of the nicotinic acetylcholine receptor stabilize quaternary ammonium groups of agonists and curariform antagonists. Journal of Biological Chemistry 269, 8808-8816.
35. UNWIN, N. (1993). Nicotinic acetylcholine receptor at 9 Å resolution. Journal of Molecular Biology 229, 1101-1124.
36. UNWIN, N. (1995). Acetylcholine receptor channel imaged in the open state. Nature 273, 37-43.
37. VALENZUELA, C. F., WEIGN, E. P., YGUERABIDE, J. & JOHSON, D. A. (1994). Transverse distance between the membrane and agonist binding sites on the Torpedo acetylcholine receptor: a fluorescence study. Biophysical Journal 66, 674-682.
38. YOUNG, H. S., SKITA, V. & HERBETTE, L. G. (1995). Location of the α-bungarotoxin binding sites on the nicotinic acetylcholine receptor superstructure: a low angle X-ray diffraction study. Biophysical Journal 68, A233.
39. ZHANG, Y., CHEN, J. & AUERBACH, A. (1995). Activation of recombinant mouse acetylcholine receptors by acetylcholine, carbamylcholine and tetramethylammonium. Journal of Physiology 486, 189-206.