Activation of P2X receptors for adenosine triphosphate evokes cardiorespiratory reflexes in anaesthetized rats

Journal of Physiology

Volumn 507, Issue 3, 1998, Pages 843-855

  McQueen, D S ^a   Bond, S M ^a   Moores, C ^a   Chessell, I ^b   Humphrey, P P A ^b   Dowd, E ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; ATROPINE; PENTOBARBITAL; PURINE P2X RECEPTOR; SURAMIN; PURINERGIC P2X RECEPTOR; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; APNEA; ARTICLE; BRADYCARDIA; CAROTID BODY CHEMORECEPTOR; CHEMORECEPTOR; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPRESSOR RESPONSE; DESENSITIZATION; HEART FUNCTION; HOMEOSTASIS; HYPERVENTILATION; HYPOTENSION; LUNG INFLATION; MALE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; RESPIRATION CONTROL; RESPIRATORY FUNCTION; SENSORY NERVE; VAGOTOMY; VAGUS NERVE; BEZOLD JARISCH DEPRESSOR REFLEX; CARDIORESPIRATORY REFLEX; CARDIOVASCULAR FUNCTION; CHEMORECEPTOR REFLEX; DRUG POTENCY; ED50; MECHANORECEPTOR; PULMONARY INFLATION RECEPTOR; REFLEX BRADYCARDIA;

ADENOSINE TRIPHOSPHATE; AFFERENT PATHWAYS; ANIMALS; APNEA; BLOOD PRESSURE; CAROTID BODY; CHEMORECEPTORS; HEART RATE; HYPERVENTILATION; MALE; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2; REFLEX; RESPIRATION; RESPIRATION, ARTIFICIAL; TRACHEA; VAGOTOMY; VAGUS NERVE;

EID: 0032521367     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1998.843bs.x     Document Type: Article

References (42)

1. BEZOLD, A. VON & HIRT, L. (1867). Über die physiologischen Wirkungendes des essigsauren Veratrins. Untersuchungen Physiologisches Laboratorium Würzburg 1, 75-156.
2. BO, X., ZHANG, Y., NASSAR, M., BURNSTOCK, G. & SCHOEPFER, R. (1995). A P2X purinoceptor cDNA conferring a novel pharmacological profile. FEBS Letters 375, 129-133.
3. BUELL, G., COLLO, G. & RASSENDREN, F. (1996). P2X receptors - an emerging channel family. European Journal of Neuroscience 8, 2221-2228.
4. BURNSTOCK, G. (1988). Sympathetic purinergic transmission in small blood vessels. Trends in Pharmacological Science 9, 116-117.
5. (6) receptors and the distribution and properties of an extended family of ATP-gated ion channels. Journal of Neuroscience 16, 2495-2507.
6. COOK, S. P., VULCHANOVA, L., HARGREAVES, M. N., ELDE, R. & MCCLESKEY, E. W. (1997). Distinct ATP receptors on pain-sensing and stretch-sensing neurons. Nature 387, 505-508.
7. COX, B. F. & SMITS, G. J. (1996). Regional hemodynamic effects of purinergic P2 receptor subtype agonists in rats. Journal of Pharmacology and Experimental Therapeutics 277, 1492-1500.
8. DAWES, G. S. (1947). Studies on veratrum alkaloids. VII. Receptor areas in the coronary arteries and elsewhere as revealed by the use of veratridine. Journal of Pharmacology and Experimental Therapeutics 89, 325-342.
9. DAWES, G. S. & COMROE, J. H. JR (1954). Chemoreflexes from the heart and lungs. Physiological Reviews 34, 167-201.
10. DOWD, E., MCQUEEN, D. S., CHESSELL, I. P. & HUMPHREY, P. P. A. (1997). Activation by P2X purinoceptor agonists of sensory nerves innervating the rat knee joint. British Journal of Pharmacology 122, 286P.
11. DRURY, A. N. & SZENT-GYÖRGYI, A. (1929). The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart. Journal of Physiology 68, 213-237.
12. EMMELIN, N. & FELDBERG, W. (1948). Systemic effects of adenosine triphosphate. British Journal of Pharmacology 3, 273-284.
13. EVANS, R. J. & SUPRENANT, A. (1996). P2X receptors in autonomie and sensory neurons. Seminars in the Neurosciences 8, 217-223.
14. FOZARD, J. R. (1984). MDL 72222, a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors. Naunyn-Schmiedeberg's Archives of Pharmacology 326, 36-44.
15. GILLESPIE, J. S. & MUIR, T. C. (1967). A method of stimulating the complete sympathetic outflow from the spinal cord of the pithed rat. British Journal of Pharmacology 30, 78-87.
16. HAINSWORTH, R. (1991). Reflexes from the heart. Physiological Reviews 71, 617-658.
17. HOLTON, P. (1959). The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves. Journal of Physiology 145, 494-504.
18. HUMPHREY, P. P. A., BUELL, G., KENNEDY, I., KHAHK, B. J., MICHEL, A. D., SUPRENANT, A. & TREZISE, D. J. (1995). New insights on P2X receptors. Naunyn-Schmiedeberg's Archives of Pharmacology 351, 1-12.
19. HURT, C. M., WANG, L., XU, J., STERIOUS, W. & PELLEG, A. (1994). Electrophysiological-anatomic correlates of ATP-triggered vagal reflexes in dogs. 2. Vagal afferent traffic. American Journal of Physiology 267, H1093-1097.
20. JARISCH, A. (1941). Kreislaufsteuerung durch das Herz. Klinische Wochenschrift 20, 1045-1048.
21. JARISCH, A., LANDGREN, S., NEIL, E. & ZOTTERMAN, G. (1952). Impulse activity in the carotid sinus nerve following intracarotid injection of potassium chloride, veratrine, sodium citrate, adenosine triphosphate and α-dinitrophenol. Acta Physiologica Scandinavica 25, 195-211.
22. KHAHK, B. S., HUMPHREY, P. P. A. & SUPRENANT, A. (1995). Electrophysiological properties of P2X purinoceptors in rat superior cervical, nodose and guinea-pig celiac neurons. Journal of Physiology 484, 385-395.
23. KIDD, E. J., GRAHAMES, C. B. A., SIMON, J., MICHEL, A. D., BARNARD, E. A. & HUMPHREY, P. P. A. (1995). Localization of P2X purinoceptor transcripts in the rat nervous system. Molecular Pharmacology 48, 569-573.
24. LINDEN, R. J. (1973). Function of cardiac receptors. Circulation 48, 463-480.
25. MCQUEEN, D. S., DASHWOOD, M. R., COBB, V. J., MARR, C. G., BOND, S. M. & SPYER, K. M. (1995). Endothelins and rat carotid body : autoradiographic and functional pharmacological studies. Journal of the Autonomic Nervous System 53, 115-125.
26. MCQUEEN, D. S., MOORES, C., DOWD, E., BOND, S. M., CHESSELL, I. P. & HUMPHREY, P. P. A. (1997). P2X receptor activation evokes a Bezold-Jarisch like reflex in anaesthetised rats. British Journal of Pharmacology 122, 246P.
27. MCQUEEN, D. S. & RIBEIRO, J. A. (1983). On the specificity and type of receptor involved in carotid body chemoreceptor activation by adenosine in the cat. British Journal of Pharmacology 80, 347-354.
28. NORTH, R. A. (1996). P2X purinoceptor plethora. Seminars in the Neurosciences 8, 187-194.
29. PAINTAL, A. S. (1955). A study of ventricular pressure receptors and their role in the Bezold effect. Quarterly Journal of Experimental Physiology 40, 348-363.
30. PELLEG, A. & HURT, C. M. (1996). Mechanism of action of ATP on canine pulmonary vagal C-fiber nerve terminals. Journal of Physiology 490, 265-275.
31. PELLEG, A., HURT, C. M. & MICHELSON, E. L. (1990). Cardiac effects of adenosine and ATP. Annals of the New York Academy of Sciences 603, 19-30.
32. REID, P. G., WATT, A. H., PENNY, W. J., NEWBY, A. C., SMITH, A. P. & ROUTLEDGE, P. A. (1991). Plasma adenosine concentrations during adenosine-induced respiratory stimulation in man. European Journal of Clinical Pharmacology 40, 175-180.
33. RONGEN, G. A., FLORAS, J. S., LENDERS, J. W. M. & SMITS, P. (1997). Cardiovascular pharmacology of purines. Clinical Science 92, 13-24.
34. SCHLICKER, E., URBANEK, E. & GOTHERT, M. (1989). ATP, α,β-methylene ATP and suramin as tools for characterization of vascular P2X receptors in the pithed rat. Journal of Autonomic Pharmacology 9, 357-366.
35. SPERGEL, D. & LAHIRI, S. (1993). Differential modulation by extracellular ATP of carotid chemosensory responses. Journal of Applied Physiology 74, 3052-3056.
36. 7). Science 272, 735-738.
37. TANEYAMA, C., BENSON, K. T., HILD, P. G. & GOTO, H. (1997). Adenosine triphosphate attenuates renal sympathetic nerve activity through left ventricular chemosensitive receptors. Journal of Pharmacology and Experimental Therapeutics 280, 570-575.
38. TREZISE, D. J., BELL, N. J., KENNEDY, I. & HUMPHREY, P. P. A. (1994). Effects of divalent cations on the potency of ATP and related agonists in the rat isolated vagus nerve - implications for P-2 purinoceptor classification. British Journal of Pharmacology 113, 463-470.
39. TREZISE, D. J., KENNEDY, I. & HUMPHREY, P. P. A. (1993). Characterization of purinoceptors mediating depolarisation of rat isolated vagus nerve. British Journal of Pharmacology 110, 1055-1060.
40. 3]alpha, beta-methylene-ATP binding sites in medulla oblongata and spinal cord of the rat. Neurochemistry International 30, 159-169.
41. VELERA, A., HUSSY, N., EVANS, R. J., ADAMI, N., NORTH, R. A., SUPRENANT, A. & BUELL, G. (1994). A new class of ligand-gated ion channel denned by P2X receptor for extracellular ATP. Nature 371, 516-519.
42. ZIMMERMANN, H (1994). Signalling via ATP in the nervous system. Trends in Neurosciences 17, 420-426.