The yeast C-type cyclin Ctk2p is phosphorylated and rapidly degraded by the ubiquitin-proteasome pathway

Molecular and Cellular Biology

Volumn 19, Issue 4, 1999, Pages 2527-2534

  Hautbergue, Guillaume ^a,b   Goguel, Valérie ^a,b  

^a ECOLE NORMALE SUPÉRIEURE   (France)

^b CEA SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLINE; PROTEASOME; UBIQUITIN;

ARTICLE; CELL CYCLE; GROWTH REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION;

SACCHAROMYCES CEREVISIAE;

EID: 0032936709     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.4.2527     Document Type: Article

References (69)

1. Balciunas, D., and H. Ronne. 1995. Three subunits of the RNA polymerase II mediator complex are involved in glucose repression. Nucleic Acids Res. 23:4421-4425.
2. Biederer, T., C. Volkwein, and T. Sommer. 1996. Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway. EMBO J. 15:2069-2076.
3. Bonneaud, N., O. Ozier-Kalogeropoulos, G. Li, M. Labouesse, L. Minvielle-Sebastia, and F. Lacroute. 1991. A family of low and high copy replicative, integrative and single-stranded S. cerevisiae/E. coli shuttle vectors. Yeast 7:609-615.
4. Chardin, P., J. H. Camomis, N. W. Gale, L. Van Aelst, J. Schlessinger, M. Wigler, and D. Bar-Sagi. 1993. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to Grb2. Science 260:1338-1343.
5. Chau, V., J. W. Tobias, A. Bachmair, D. Marriott, D. J. Ecker, D. K. Gonda, and A. Varshavsky. 1989. A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. Science 243:1576-1583.
6. Cooper, K. F., M. J. Mallory, J. B. Smith, and R. Strich. 1997. Stress and developmental regulation of the yeast C-type cyclin Ume3p (Srb11p/Ssn8p). EMBO J. 16:4665-4675.
7. Cross, F. R., and C. M. Blake. 1993. The yeast Cln3 protein is an unstable activator of Cdc28. Mol. Cell. Biol. 13:3266-3271.
8. Dahmus, M. E. 1996. Reversible phosphorylation of the C-terminal domain of RNA polymerase II. J. Biol. Chem. 271:19009-19012.
9. 1 cyclin Cln2p by a Cdc34p-dependent pathway. EMBO J. 14:303-312.
10. Ecker, D. J., M. I. Khan, J. Marsh, T. R. Butt, and S. T. Crooke. 1987. Chemical synthesis and expression of a cassette adapted ubiquitin gene. J. Biol. Chem. 262:3524-3527.
11. Ellison, M. J., and M. Hochstrasser. 1991. Epitope-tagged ubiquitin. J. Biol. Chem. 266:21150-21157.
12. Faye, G., M. Simon, J.-G. Valay, D. Fesquet, and C. Facca. 1997. Rig2, a RING finger protein that interacts with the Kin28/Cc11 CTD kinase in yeast. Mol. Gen. Genet. 255:460-466.
13. Finley, D., S. Sadis, B. P. Monia, P. Boucher, D. J. Ecker, S. T. Crooke, and V. Chau. 1994. Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant. Mol. Cell. Biol. 14:5501-5509.
14. +, a second essential C-type cyclin gene in Schizosacchromyces pombe. J. Biol. Chem. 272:12100-12106.
15. Galan, J. M., and R. Haguenauer-Tsapis. 1997. Ubiquitin Lys63 is involved in ubiquitination of a yeast plasma membrane protein. EMBO J. 16:5847-5854.
16. Glotzer, M., A. W. Murray, and M. W. Kirschner. 1991. Cyclin is degraded by the ubiquitin pathway. Nature 349:132-138.
17. Heinmeyer, W., J. Kleinschmidt, J. Saidowsky, C. Escher, and D. Wolf. 1991. Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival. EMBO J. 10:555-562.
18. Hilt, W., and D. H. Wolf. 1996. Proteasomes: destruction as a programme. Trends Biochem. Sci. 21:96-102.
19. Hochstrasser, M. 1995. Ubiquitin, proteasomes, and the regulation of intracellular protein degradation. Curr. Opin. Cell Biol. 7:215-223.
20. Hochstrasser, M. 1996. Ubiquitin-dependent protein degradation. Annu. Rev. Genet. 30:405-439.
21. Hochstrasser, M., M. J. Ellison, V. Chau, and A. Varshavsky. 1991. The short-lived MATα2 transcriptional regulator is ubiquitinated in vivo. Proc. Natl. Acad. Sci. USA 88:4606-4610.
22. Ito, H., Y. Fukuda, K. Murata, and A. Kumura. 1983. Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153:163-168.
23. King, R. W., R. J. Deshaies, J.-M. Peters, and M. W. Kirschner. 1996. How proteolysis drives the cell cycle. Science 274:1652-1659.
24. King, R. W., M. Glotzer, and M. W. Kirschner. 1996. Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates. Mol. Cell. Biol. 7:1343-1357.
25. Kobayashi, H., E. Stewart, R. Poon, J. P. Adamczewski, J. Gannon, and T. Hunt. 1992. Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits. Mol. Biol. Cell 3:1279-1294.
26. Kuchin, S., and M. Carlson. 1998. Functional relationships of Srb10-Srb11 kinase, carboxy-terminal domain kinase CTDK-I, and transcriptional corepressor Ssn6-Tup1. Mol. Cell. Biol. 18:1163-1171.
27. Kuchin, S., P. Yeghiayan, and M. Carlson. 1995. Cyclin-dependent protein kinase and cyclin homologs SSN3 and SSN8 contribute to transcriptional control in yeast. Proc. Natl. Acad. Sci. USA 92:4006-4010.
28. 1 cyclin Cln2 induced by CDK-dependent phosphorylation. Science 271:1597-1601.
29. Lee, J. M., and A. L. Greenleaf. 1989. A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II. Proc. Natl. Acad. Sci. USA 86:3624-3628.
30. Lee, J. M., and A. L. Greenleaf. 1991. CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae. Gene Expr. 1:149-167.
31. Lee, J. M., and A. L. Greenleaf. 1997. Modulation of RNA polymerase II elongation efficiency by C-terminal heptapeptide repeat domain kinase I. J. Biol. Chem. 272:10990-10993.
32. Lees, E. M. and E. Harlow. 1993. Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase. Mol. Cell. Biol. 13:1194-1201.
33. Léopold, P., and P. H. O'Farrell. 1991. An evolutionary conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins. Cell 66:1207-1216.
34. Lew, D. J., V. Dulic, and S. I. Reed. 1991. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell 66:1197-1206.
35. Liao, S.-M., J. Zhang, D. A. Jeffery, A. J. Koleske, C. M. Thompson, D. M. Chao, M. Viljoen, H. J. J. van Vuuren, and R. A. Young. 1995. A kinase-cyclin pair in the RNA polymerase II holoenzyme. Nature 374:193-196.
36. Liu, Z.-J., T. Ueda, T. Miyazaki, N. Tanaka, S. Mine, Y. Tanaka, T. Taniguchi, H. Yamamura, and Y. Minami. 1998. A critical role for cyclin C in promotion of the hematopoietic cell cycle by cooperation with c-Myc. Mol. Cell. Biol. 18:3445-3454.
37. Lu, H., L. Zawel, L. Fisher, J.-M. Egly, and D. Reinberg. 1992. Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II. Nature 358:641-645.
38. Marshall, N. F., and D. H. Price. 1995. Purification of P-TEFb, a transcription factor required for the transition into productive elongation. J. Biol. Chem. 270:12335-12338.
39. Molz, L., and D. Beach. 1993. Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity. EMBO J. 12:1723-1732.
40. Morgan, D. O. 1995. Principles of CDK regulation. Nature 374:131-134.
41. Morgan, D. O. 1997. Cyclin-dependent kinases: engines, clocks, and micro-processors. Annu. Rev. Cell Dev. Biol. 13:261-291.
42. Murray, A. W., M. J. Solomon, and M. W. Kirschner. 1989. The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. Nature 339:280-286.
43. Nasmyth, K. 1993. Control of the yeast cell cycle by the Cdc28 protein kinase. Curr. Opin. Cell Biol. 5:166-179.
44. Nigg, E. A. 1996. Cyclin-dependent kinase 7: at the cross-roads of transcription. DNA repair and cell cycle control? Curr. Opin. Cell Biol. 8:312-317.
45. Papa, F. R., and M. Hochstrasser. 1993. The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene. Nature 366:313-319.
46. Patturajan, M., R. J. Schulte, B. M. Sefton, R. Berezney, M. Vincent, O. Bensaude, S. L. Warren, and J. L. Corden. 1998. Growth-related changes in phosphorylation of yeast RNA polymerase II. J. Biol. Chem. 273:4689-4694.
47. Pickart, C. M. 1997. Targeting of substrates to the 26S proteasome. FASEB J. 11:1055-1066.
48. Richter-Ruoff, B., D. H. Wolf, and M. Hochstrasser. 1994. Degradation of the yeast MAT alpha 2 transcriptional regulator is mediated by the proteasome. FEBS Lett. 354:50-52.
49. Rogers, S., R. Wells, and M. Rechsteiner. 1986. Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis. Science 234: 364-368.
50. Rothstein, R. J. 1983. One step gene disruption in yeast. Methods Enzymol. 101:202-211.
51. Salama, S. R., K. B. Hendricks, and J. Thorner. 1994. G1 cyclin degradation: the PEST motif of yeast Cln2 is necessary, but not sufficient, for rapid protein turnover. Mol. Cell. Biol. 14:7953-7966.
52. Schork, S. M., M. Thumm, and D. H. Wolf. 1995. Catabolite inactivation of Fructose-1,6-biphosphatase of Saccharomyces cerevisiae. J. Biol. Chem. 270: 26446-26450.
53. Seufert, W., B. Futcher, and S. Jentsch. 1995. Role of a ubiquitin-conjugating enzyme in degradation of S-and M-phase cyclins. Nature 373:78-81.
54. Singer, J. D., B. M. Manning, and T. Formosa. 1996. Coordinating DNA replication to produce one copy of the genome requires genes that act in ubiquitin metabolism. Mol. Cell. Biol. 16:1356-1366.
55. Song, W. and M. Carlson. 1998. Srb/mediator proteins interact functionally and physically with transcriptional repressor Sfl1. EMBO J. 17:5757-5765.
56. Sterner, D. E., J. Moon Lee, S. E. Hardin, and A. L. Greenleaf. 1995. The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex. Mol. Cell. Biol. 15:5716-5724.
57. Surosky, R. T., R. Strich, and R. E. Esposito. 1994. The yeast UME5 gene regulates the stability of meiotic mRNAs in response to glucose. Mol. Cell. Biol. 14:3446-3458.
58. Svejstrup, J. Q., P. Vichi, and J.-M. Egly. 1996. The multiple roles of transcription/repair factor TFIIH. Trends Biochem. Sci. 21:346-350.
59. Tassan, J.-P., M. Jaquenoud, P. Léopold, S. J. Schultz, and E. A. Nigg. 1995. Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. Proc. Natl. Acad. Sci. USA 92:8871-8875.
60. Tyers, M., G. Tokiwa, R. Nash, and B. Futcher. 1992. The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation. EMBO J. 11:1773-1784.
61. Valay, J.-G., M.-F. Dubois, O. Bensaude, and G. Faye. 1996. Cell, a cyclin associated with protein kinase Kin28, controls the phosphorylation of RNA polymerase II largest subunit and mRNA transcription. C. R. Acad. Sci. (Paris) 319:183-189.
62. Valay, J.-G., M. Simon, M.-F. Dubois, O. Bensaude, C. Facca, and G. Faye. 1995. The KIN28 gene is required both for RNA polymerase II mediated transcription and phosphorylation of the Rpb1p CTD. J. Mol. Biol. 249:535-544.
63. Van Den Hazel, H. B., M. C. Kielland-Brandt, and J. R. Winther. 1996. Review: biosynthesis and function of yeast vacuolar proteases. Yeast 12:1-16.
64. Van Nocker, S., and R. D. Vierstra. 1993. Multiubiquitin chains linked through lysine 48 are abundant in vivo and are competent intermediates in the ubiquitin proteolytic pathway. J. Biol. Chem. 268:24766-24773.
65. Wahi, M., and A. D. Johnson. 1995. Identification of genes required for α2 repression in Saccharomyces cerevisiae. Genetics 140:79-90.
66. Wei, P., M. E. Garber, S.-M. Fang, W. H. Fischer, and K. A. Jones. 1998. A novel Cdk9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell 92:451-462.
67. Willems, A. R., S. Lanker, E. E. Patton, K. L. Craig, T. F. Nason, N. Mathias, R. Kobayashi, C. Wittenberg, and M. Tyers. 1996. Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway. Cell 86:453-463.
68. Cdc28-mediated control of Cln3 cyclin degradation. Mol. Cell. Biol. 15:731-741.
69. Zhu, Y., T. Pe'ery, J. Peng, Y. Ramanathan, N. Marshall, T. Marshall, B. Amendt, M. B. Mathews, and D. H. Price. 1997. Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro. Genes Dev. 11:2622-2632.