메뉴 건너뛰기




Volumn 11, Issue 4, 1999, Pages 261-276

Thrombopoietin: An update on therapeutic potential

Author keywords

[No Author keywords available]

Indexed keywords

THROMBOPOIETIN;

EID: 0032925287     PISSN: 11738804     EISSN: None     Source Type: Journal    
DOI: 10.2165/00063030-199911040-00005     Document Type: Review
Times cited : (6)

References (110)
  • 1
    • 0000009286 scopus 로고
    • Demonstration and some properties of human thrombopoietin in thrombocythaemic sera
    • 1. Keleman E, Cserhati I, Tanos B. Demonstration and some properties of human thrombopoietin in thrombocythaemic sera. Acta Haematol (Basel) 1958; 20: 350-5
    • (1958) Acta Haematol (Basel) , vol.20 , pp. 350-355
    • Keleman, E.1    Cserhati, I.2    Tanos, B.3
  • 2
    • 0023891872 scopus 로고
    • Thrombopoietin: Its biology, purification and characterisation
    • 2. McDonald TP. Thrombopoietin: its biology, purification and characterisation. Exp Hematol 1988; 16: 201-5
    • (1988) Exp Hematol , vol.16 , pp. 201-205
    • McDonald, T.P.1
  • 3
    • 0022624954 scopus 로고
    • A retrovirus complex inducing an acute myeloproliferative leukemia disorder in mice
    • 3. Wendling F, Varlet P, Charon M, et al. A retrovirus complex inducing an acute myeloproliferative leukemia disorder in mice. Virology 1986; 149: 242
    • (1986) Virology , vol.149 , pp. 242
    • Wendling, F.1    Varlet, P.2    Charon, M.3
  • 4
    • 0025674093 scopus 로고
    • A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic precursors
    • 4. Souyri M, Vigon I, Penciolelli JF, et al. A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic precursors. Cell 1990; 63: 1137
    • (1990) Cell , vol.63 , pp. 1137
    • Souyri, M.1    Vigon, I.2    Penciolelli, J.F.3
  • 5
    • 0026684707 scopus 로고
    • Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of the hematopoietic growth factor receptor superfamily
    • 5. Vigon I, Mornon JP, Cocault L, et al. Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci USA 1992; 89: 5640
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5640
    • Vigon, I.1    Mornon, J.P.2    Cocault, L.3
  • 6
    • 0027225872 scopus 로고
    • Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis
    • 6. Methia N, Louache F, Vainchencker W, et al. Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 1993; 82: 1395
    • (1993) Blood , vol.82 , pp. 1395
    • Methia, N.1    Louache, F.2    Vainchencker, W.3
  • 7
    • 0028302409 scopus 로고
    • Stimulation of megakaryocytopoiesis and thrombocytopoeisis by the c-Mpl ligand
    • 7. Je Sauvage FJ, Mass PE, Spencer SD, et al. Stimulation of megakaryocytopoiesis and thrombocytopoeisis by the c-Mpl ligand. Nature 1994; 369: 533-8
    • (1994) Nature , vol.369 , pp. 533-538
    • Je Sauvage, F.J.1    Mass, P.E.2    Spencer, S.D.3
  • 8
    • 0028199208 scopus 로고
    • Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
    • 8. Lok S, Kaushansky K, Holly RD, et al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 1994; 369: 565-8
    • (1994) Nature , vol.369 , pp. 565-568
    • Lok, S.1    Kaushansky, K.2    Holly, R.D.3
  • 9
    • 0028343099 scopus 로고
    • Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor mpl
    • 9. Bartley TD, Bogenberger J, Hunt P, et al. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor mpl. Cell 1994; 77: 1117-24
    • (1994) Cell , vol.77 , pp. 1117-1124
    • Bartley, T.D.1    Bogenberger, J.2    Hunt, P.3
  • 10
    • 0027992924 scopus 로고
    • Molecular cloning and chromosomal localisation of human thrombopoietin gene
    • 10. SohmaY, Akahori H, Seki N, et al. Molecular cloning and chromosomal localisation of human thrombopoietin gene. FEBS Lett 1994; 353: 57-61
    • (1994) FEBS Lett , vol.353 , pp. 57-61
    • Akahori, H.1    Seki, N.2
  • 11
    • 0003296021 scopus 로고
    • Purification and characterization of thrombopoietin derived from thrombocytopenic rat plasma
    • 11. Kato T, Iwamatsu A, Shimada Y. Purification and characterization of thrombopoietin derived from thrombocytopenic rat plasma [abstract]. Blood 1994; 84 Suppl. 1: 329a
    • (1994) Blood , vol.84 , Issue.SUPPL. 1
    • Kato, T.1    Iwamatsu, A.2    Shimada, Y.3
  • 12
    • 0028117771 scopus 로고
    • The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production
    • 12. Kuter DJ, Beeler DL, Rosenburg RD. The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci USA 1994; 91: 1104
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 1104
    • Kuter, D.J.1    Beeler, D.L.2    Rosenburg, R.D.3
  • 13
    • 0028109434 scopus 로고
    • The structure, biology and therapeutic applications of recombinant thrombopoietin
    • 13. Lok S, Foster D. The structure, biology and therapeutic applications of recombinant thrombopoietin. Stem Cells 1994; 12: 586-98
    • (1994) Stem Cells , vol.12 , pp. 586-598
    • Lok, S.1    Foster, D.2
  • 14
    • 0028899548 scopus 로고
    • Genomic structure, chromosomal characterization and conserved alternative splice forms of thrombopoietin
    • 14. Gurney AL, Kuang WJ, Xie MH, et al. Genomic structure, chromosomal characterization and conserved alternative splice forms of thrombopoietin. Blood 1995; 85: 981-8
    • (1995) Blood , vol.85 , pp. 981-988
    • Gurney, A.L.1    Kuang, W.J.2    Xie, M.H.3
  • 15
    • 4243432426 scopus 로고
    • Effects of recombinant human thrombopoietin (rhTPO) on human haematopoietic cells
    • 15. Solberg LA Jr, Wilson D, De Sauvage F, et al. Effects of recombinant human thrombopoietin (rhTPO) on human haematopoietic cells [abstract]. Blood 1994; 84: 330a
    • (1994) Blood , vol.84
    • Solberg L.A., Jr.1    Wilson, D.2    De Sauvage, F.3
  • 16
    • 0030307588 scopus 로고    scopus 로고
    • Biological roles for the second domain of thrombopoietin
    • 16. Foster D, Lok S. Biological roles for the second domain of thrombopoietin. Stem Cells 1996; 14 Suppl. 1: 102-7
    • (1996) Stem Cells , vol.14 , Issue.SUPPL. 1 , pp. 102-107
    • Foster, D.1    Lok, S.2
  • 17
    • 0028899548 scopus 로고
    • Genomic structure, chromosomal localisation and conserved alternative splice forms of thrombopoietin
    • 17. Gurney AL, Kuang W-K, Xie M-H, et al. Genomic structure, chromosomal localisation and conserved alternative splice forms of thrombopoietin. Blood 1995; 85: 981-8
    • (1995) Blood , vol.85 , pp. 981-988
    • Gurney, A.L.1    Kuang, W.-K.2    Xie, M.-H.3
  • 18
    • 0028803099 scopus 로고
    • Peglylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice
    • 18. Hokom MM, Lacey D, Kinstler OB, et al. Peglylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice. Blood 1995; 86 (12): 4486-92
    • (1995) Blood , vol.86 , Issue.12 , pp. 4486-4492
    • Hokom, M.M.1    Lacey, D.2    Kinstler, O.B.3
  • 19
    • 0030966361 scopus 로고    scopus 로고
    • Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer
    • 19. Vadhan-Raj S, Murray LJ, Buesos-Ramos C, et al. Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer. Ann Intern Med 1997; 126 (9): 673-81
    • (1997) Ann Intern Med , vol.126 , Issue.9 , pp. 673-681
    • Vadhan-Raj, S.1    Murray, L.J.2    Buesos-Ramos, C.3
  • 20
    • 0030307622 scopus 로고    scopus 로고
    • The physiology of platelet production
    • 20. Kuter DJ. The physiology of platelet production. Stem Cells 1996; 14 Suppl. 1: 88-101
    • (1996) Stem Cells , vol.14 , Issue.SUPPL. 1 , pp. 88-101
    • Kuter, D.J.1
  • 21
    • 0001885491 scopus 로고
    • The reproducibility and constancy of the platelet count
    • 21. Brecher G, Scneiderman M, Cronkite EP. The reproducibility and constancy of the platelet count. Am J Clin Pathol 1953; 23: 15-26
    • (1953) Am J Clin Pathol , vol.23 , pp. 15-26
    • Brecher, G.1    Scneiderman, M.2    Cronkite, E.P.3
  • 22
    • 0019401772 scopus 로고
    • The platelet count and mean platelet volume
    • 22. Giles C. The platelet count and mean platelet volume. Br J Haematol 1981; 48: 31-7
    • (1981) Br J Haematol , vol.48 , pp. 31-37
    • Giles, C.1
  • 23
    • 0016782782 scopus 로고
    • Mediterranean macrothrombocytopenia
    • 23. von Behrens WE. Mediterranean macrothrombocytopenia. Blood 1975; 46: 199-208
    • (1975) Blood , vol.46 , pp. 199-208
    • Von Behrens, W.E.1
  • 24
    • 0019463843 scopus 로고
    • The inverse relation of platelet size and count in normal subjects and an artefact of other particles
    • 24. Bessman JD, Williams LJ, Gilmer PR. The inverse relation of platelet size and count in normal subjects and an artefact of other particles. Am J Clin Pathol 1981; 76: 289-93
    • (1981) Am J Clin Pathol , vol.76 , pp. 289-293
    • Bessman, J.D.1    Williams, L.J.2    Gilmer, P.R.3
  • 25
    • 0022511291 scopus 로고
    • From precursor to product: How do megakaryocytes produce platelets?
    • 25. Thompson CB. From precursor to product: how do megakaryocytes produce platelets? Prog Clin Biol Res 1986; 215: 361-71
    • (1986) Prog Clin Biol Res , vol.215 , pp. 361-371
    • Thompson, C.B.1
  • 26
    • 0014264397 scopus 로고
    • Kinetics of thrombocytopoiesis
    • 26. Harker LA. Kinetics of thrombocytopoiesis. J Clin Invest 1968; 47: 458-65
    • (1968) J Clin Invest , vol.47 , pp. 458-465
    • Harker, L.A.1
  • 27
    • 0021320037 scopus 로고
    • Two-color flow cytometric measurement of DNA distribution of rat megakaryocytes in unfixed, unfractionated marrow cell suspensions
    • 27. Jackson JW, Brown LK, Somerville BC, et al. Two-color flow cytometric measurement of DNA distribution of rat megakaryocytes in unfixed, unfractionated marrow cell suspensions. Blood 1984; 63: 768-78
    • (1984) Blood , vol.63 , pp. 768-778
    • Jackson, J.W.1    Brown, L.K.2    Somerville, B.C.3
  • 28
    • 0025177216 scopus 로고
    • Regulation of megakaryocyte ploidy in vivo in the rat
    • 28. Kuter DJ, Rosenburg RD. Regulation of megakaryocyte ploidy in vivo in the rat. Blood 1990; 75: 74-81
    • (1990) Blood , vol.75 , pp. 74-81
    • Kuter, D.J.1    Rosenburg, R.D.2
  • 29
    • 0028557354 scopus 로고
    • Human thrombopoietin: Gene structure, cDNA sequence, expression and chromosomal localization
    • 29. Foster D, Sprecher CA, Grant FJ, et al. Human thrombopoietin: gene structure, cDNA sequence, expression and chromosomal localization. Proc Natl Acad Sci 1994; 91: 13023-7
    • (1994) Proc Natl Acad Sci , vol.91 , pp. 13023-13027
    • Foster, D.1    Sprecher, C.A.2    Grant, F.J.3
  • 30
    • 0028985426 scopus 로고
    • The mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets
    • 30. Debili N, Wendling F, Cosman D, et al. The mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets. Blood 1995; 85: 391-401
    • (1995) Blood , vol.85 , pp. 391-401
    • Debili, N.1    Wendling, F.2    Cosman, D.3
  • 31
    • 0030968519 scopus 로고    scopus 로고
    • Human platelets display high-affinity receptors for thrombopoietin
    • 31. Broudy VC, Lin NL, Sabath DF, et al. Human platelets display high-affinity receptors for thrombopoietin. Blood 1997; 89: 1896-904
    • (1997) Blood , vol.89 , pp. 1896-1904
    • Broudy, V.C.1    Lin, N.L.2    Sabath, D.F.3
  • 32
    • 0027257805 scopus 로고
    • Expression of the c-mpl protooncogene in human hematologic malignancies
    • 32. Vigon I, Dreyfus F, Melie J. Expression of the c-mpl protooncogene in human hematologic malignancies. Blood 1993; 82: 877-83
    • (1993) Blood , vol.82 , pp. 877-883
    • Vigon, I.1    Dreyfus, F.2    Melie, J.3
  • 33
    • 0029129618 scopus 로고
    • Thrombopoietin receptor expression in human cancer cell lines and primary tissues
    • 33. Columbyova L, Loda M, Scadden DT. Thrombopoietin receptor expression in human cancer cell lines and primary tissues. Cancer Res 1995; 55: 3509-12
    • (1995) Cancer Res , vol.55 , pp. 3509-3512
    • Columbyova, L.1    Loda, M.2    Scadden, D.T.3
  • 34
    • 0028332474 scopus 로고
    • Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin
    • 34. Kaushansky K, Lok K, Holly R, et al. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 1994; 369 (6481): 568-71
    • (1994) Nature , vol.369 , Issue.6481 , pp. 568-571
    • Kaushansky, K.1    Lok, K.2    Holly, R.3
  • 35
    • 0028114123 scopus 로고
    • In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells
    • 35. Zeigler FC, De Sauvage F, Widmer HR, et al. In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood 1994; 84: 4045-52
    • (1994) Blood , vol.84 , pp. 4045-4052
    • Zeigler, F.C.1    De Sauvage, F.2    Widmer, H.R.3
  • 36
    • 0028909690 scopus 로고
    • Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro
    • 36. Broudy VC, Lin NL, Kaushansky K. Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 1995; 85: 1719-26
    • (1995) Blood , vol.85 , pp. 1719-1726
    • Broudy, V.C.1    Lin, N.L.2    Kaushansky, K.3
  • 37
    • 0029046966 scopus 로고
    • Megakaryocyte growth and development factor
    • 37. Nichol JL, Hokom MM, Hornkohl A, et al. Megakaryocyte growth and development factor. J Clin Invest 1995; 95: 2973-8
    • (1995) J Clin Invest , vol.95 , pp. 2973-2978
    • Nichol, J.L.1    Hokom, M.M.2    Hornkohl, A.3
  • 38
    • 0029121283 scopus 로고
    • Modulation of megakaryocytopoiesis by thrombopoietin: The c-Mpl ligand
    • 38. Banu N, Wang JF, Deng B, et al. Modulation of megakaryocytopoiesis by thrombopoietin: the c-Mpl ligand. Blood 1995; 86 (4): 1331
    • (1995) Blood , vol.86 , Issue.4 , pp. 1331
    • Banu, N.1    Wang, J.F.2    Deng, B.3
  • 39
    • 0028928884 scopus 로고
    • Platelets generated in vivo from pro-platelets displaying human megakaryocytes are functional
    • 39. Choi ES, Nichol JL, Hokom MM, et al. Platelets generated in vivo from pro-platelets displaying human megakaryocytes are functional. Blood 1995; 85: 402-13
    • (1995) Blood , vol.85 , pp. 402-413
    • Choi, E.S.1    Nichol, J.L.2    Hokom, M.M.3
  • 40
    • 0029983852 scopus 로고    scopus 로고
    • Effects of recombinant human thrombopoietin on megakaryocyte colony formation and megakaryocyte ploidy by human CD34+ cells in a serum-free system
    • 40. Angchaisuksiri P, Carlson PL, Dessypris EN. Effects of recombinant human thrombopoietin on megakaryocyte colony formation and megakaryocyte ploidy by human CD34+ cells in a serum-free system. Br J Haematol 1996; 93: 13-7
    • (1996) Br J Haematol , vol.93 , pp. 13-17
    • Angchaisuksiri, P.1    Carlson, P.L.2    Dessypris, E.N.3
  • 41
    • 0029037953 scopus 로고
    • The mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors
    • 41. Debili N, Wendling F, Katz A, et al. The mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors. Blood 1995; 86 (7): 2516-25
    • (1995) Blood , vol.86 , Issue.7 , pp. 2516-2525
    • Debili, N.1    Wendling, F.2    Katz, A.3
  • 42
    • 0031052063 scopus 로고    scopus 로고
    • Thrombopoietin: The primary regulator of megakaryocytopoiesis and thrombopoiesis
    • 42. Eaton DL, De Sauvage F. Thrombopoietin: the primary regulator of megakaryocytopoiesis and thrombopoiesis. Exp Hematol 1997; 25: 1-7
    • (1997) Exp Hematol , vol.25 , pp. 1-7
    • Eaton, D.L.1    De Sauvage, F.2
  • 43
    • 0029051730 scopus 로고
    • Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice
    • 43. Ulich TR, del Castillo J, Yin S, et al. Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood 1995; 86 (3): 971-6
    • (1995) Blood , vol.86 , Issue.3 , pp. 971-976
    • Ulich, T.R.1    Del Castillo, J.2    Yin, S.3
  • 44
    • 0029030356 scopus 로고
    • The reciprocol relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulphan-induced thrombocytopenia in the rabbit
    • 44. Kuter DJ, Rosenberg RD. The reciprocol relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulphan-induced thrombocytopenia in the rabbit. Blood 1995; 85: 2720-30
    • (1995) Blood , vol.85 , pp. 2720-2730
    • Kuter, D.J.1    Rosenberg, R.D.2
  • 45
    • 0028022980 scopus 로고
    • Appearance of a megakaryocyte growth-promoting factor, megapoietin, during acute thrombocytopenia in the rabbit
    • 45. Kuter DJ, Rosenberg RD. Appearance of a megakaryocyte growth-promoting factor, megapoietin, during acute thrombocytopenia in the rabbit. Blood 1994; 84: 1464-72
    • (1994) Blood , vol.84 , pp. 1464-1472
    • Kuter, D.J.1    Rosenberg, R.D.2
  • 46
    • 0028176283 scopus 로고
    • C-mpl ligand is a humoral regulator of megakaryopoiesis
    • 46. Wendling F, Maraskovsky E, Debili N. C-mpl ligand is a humoral regulator of megakaryopoiesis. Nature 1994; 369: 571-4
    • (1994) Nature , vol.369 , pp. 571-574
    • Wendling, F.1    Maraskovsky, E.2    Debili, N.3
  • 47
    • 0030024685 scopus 로고    scopus 로고
    • Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin
    • 47. De Sauvage F, Carver-Moore K, Luoh SM, et al. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J Exp Med 1996; 183: 651-6
    • (1996) J Exp Med , vol.183 , pp. 651-656
    • De Sauvage, F.1    Carver-Moore, K.2    Luoh, S.M.3
  • 48
    • 0029865443 scopus 로고    scopus 로고
    • Regulation of thrombopoietin levels by c-mpl mediated binding to platelets
    • 48. Fielder PJ, Gurney AL, Stefanich E, et al. Regulation of thrombopoietin levels by c-mpl mediated binding to platelets. Blood 1996; 87: 2154-61
    • (1996) Blood , vol.87 , pp. 2154-2161
    • Fielder, P.J.1    Gurney, A.L.2    Stefanich, E.3
  • 49
    • 0030048887 scopus 로고    scopus 로고
    • Thrombopoietin in thrombocytopenic mice: Evidence against regulation at the mRNA level and for a direct regulatory role of platelets
    • 49. Stoffel R, Wiestner A, Skoda RC. Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood 1996; 87: 567-73
    • (1996) Blood , vol.87 , pp. 567-573
    • Stoffel, R.1    Wiestner, A.2    Skoda, R.C.3
  • 50
    • 0028086542 scopus 로고
    • Thrombocytopenia in c-mpl-deficient mice
    • 50. Gurney AL, Carver-Moore K, De Sauvage F, et al. Thrombocytopenia in c-mpl-deficient mice. Science 1994; 265: 1445-7
    • (1994) Science , vol.265 , pp. 1445-1447
    • Gurney, A.L.1    Carver-Moore, K.2    De Sauvage, F.3
  • 51
    • 0029960265 scopus 로고    scopus 로고
    • Deficiencies in progenitor cells of multiple hemopoietic lineages and defective megakaryopoiesis in mice lacking the thrombopoietin receptor c-mpl
    • 51. Alexander WS, Roberts AW, Nicola NA, et al. Deficiencies in progenitor cells of multiple hemopoietic lineages and defective megakaryopoiesis in mice lacking the thrombopoietin receptor c-mpl. Blood 1996; 87: 2162-70
    • (1996) Blood , vol.87 , pp. 2162-2170
    • Alexander, W.S.1    Roberts, A.W.2    Nicola, N.A.3
  • 52
    • 0029684417 scopus 로고    scopus 로고
    • Low levels of erythroid and myeloid progenitors in thrombopoietin and c-mpl deficient mice
    • 52. Carver-Moore K, Broxmeyer HE, Luoh SM, et al. Low levels of erythroid and myeloid progenitors in thrombopoietin and c-mpl deficient mice. Blood 1996; 88: 803-8
    • (1996) Blood , vol.88 , pp. 803-808
    • Carver-Moore, K.1    Broxmeyer, H.E.2    Luoh, S.M.3
  • 53
    • 0029864161 scopus 로고    scopus 로고
    • Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice
    • 53. Kaushansky K, Lin NL, Grossman A, et al. Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice. Exp Hematol 1996; 24: 254-69
    • (1996) Exp Hematol , vol.24 , pp. 254-269
    • Kaushansky, K.1    Lin, N.L.2    Grossman, A.3
  • 54
    • 0030942587 scopus 로고    scopus 로고
    • A single injection of pegylated murine megakaryocyte growth and development factor (MGDF) into mice is sufficient to produce a profound stimulation of megakaryocyte frequency, size and ploidy
    • 54. Arnold JT, Daw NC, Stenberg PE, et al. A single injection of pegylated murine megakaryocyte growth and development factor (MGDF) into mice is sufficient to produce a profound stimulation of megakaryocyte frequency, size and ploidy. Blood 1997; 89 (3): 823-33
    • (1997) Blood , vol.89 , Issue.3 , pp. 823-833
    • Arnold, J.T.1    Daw, N.C.2    Stenberg, P.E.3
  • 55
    • 0029150347 scopus 로고
    • Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy
    • 55. Kaushansky K, Broudy VC, Grossman A, et al. Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. J Clin Invest 1995; 96: 1683-7
    • (1995) J Clin Invest , vol.96 , pp. 1683-1687
    • Kaushansky, K.1    Broudy, V.C.2    Grossman, A.3
  • 56
    • 0029928021 scopus 로고    scopus 로고
    • Insights into the cellular mechanisms of erythropoietin-thrombopoietin synergy
    • Apr
    • 56. Papayannopoulou T, Brice M, Farrer D, et al. Insights into the cellular mechanisms of erythropoietin-thrombopoietin synergy. Exp Hematol 1996 Apr: 24 (5): 660-9
    • (1996) Exp Hematol , vol.24 , Issue.5 , pp. 660-669
    • Papayannopoulou, T.1    Brice, M.2    Farrer, D.3
  • 57
    • 4243860087 scopus 로고
    • Recombinant human thrombopoietin stimulates platelet responses in cynomologous monkeys
    • 57. Sprugel KH, Ren HP, Osherhoff M. Recombinant human thrombopoietin stimulates platelet responses in cynomologous monkeys. Blood 1995; 86 Suppl. 1: 20a
    • (1995) Blood , vol.86 , Issue.SUPPL. 1
    • Sprugel, K.H.1    Ren, H.P.2    Osherhoff, M.3
  • 58
    • 0029062371 scopus 로고
    • Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates
    • 58. Farese M, Hunt P, Boone T, et al. Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates. Blood 1995; 86 (1): 54-9
    • (1995) Blood , vol.86 , Issue.1 , pp. 54-59
    • Farese, M.1    Hunt, P.2    Boone, T.3
  • 59
    • 0030068687 scopus 로고    scopus 로고
    • Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates
    • 59. Harker LA, Hunt P, Marzec U, et al. Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates. Blood 1996; 87 (5): 1833-44
    • (1996) Blood , vol.87 , Issue.5 , pp. 1833-1844
    • Harker, L.A.1    Hunt, P.2    Marzec, U.3
  • 60
    • 0029943307 scopus 로고    scopus 로고
    • Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates
    • 60. Harker LA, Marzec U, Hunt P, et al. Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates. Blood 1996; 88 (2): 511-21
    • (1996) Blood , vol.88 , Issue.2 , pp. 511-521
    • Harker, L.A.1    Marzec, U.2    Hunt, P.3
  • 61
    • 0041446036 scopus 로고
    • Recombinant thrombopoietin induces a dose response increase in reticulated platelets which precedes the increase in platelet count, and does not affect platelet lifespan in mice
    • 61. Ault K, Knowles C. Recombinant thrombopoietin induces a dose response increase in reticulated platelets which precedes the increase in platelet count, and does not affect platelet lifespan in mice [abstract]. Blood 1995; 86 Suppl. 1: 367a
    • (1995) Blood , vol.86 , Issue.SUPPL. 1
    • Ault, K.1    Knowles, C.2
  • 62
    • 0031019748 scopus 로고    scopus 로고
    • Prevention of thrombocytopenia and neutropenia in a nonhuman primate model of marrow suppressive chemotherapy by combining pegylated recombinant human megakaryocyte growth and development factor and recombinant human granulocyte colony-stimulating factor
    • 62. Harker LA, Marzec UM, Kelly AB, et al. Prevention of thrombocytopenia and neutropenia in a nonhuman primate model of marrow suppressive chemotherapy by combining pegylated recombinant human megakaryocyte growth and development factor and recombinant human granulocyte colony-stimulating factor. Blood 1997; 89 (1): 155-65
    • (1997) Blood , vol.89 , Issue.1 , pp. 155-165
    • Harker, L.A.1    Marzec, U.M.2    Kelly, A.B.3
  • 63
    • 0029963122 scopus 로고    scopus 로고
    • Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation induced marrow aplasia
    • 63. Farese AM, Hunt P, Grab LB, et al. Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation induced marrow aplasia. J Clin Invest 1996; 97 (9): 2145-51
    • (1996) J Clin Invest , vol.97 , Issue.9 , pp. 2145-2151
    • Farese, A.M.1    Hunt, P.2    Grab, L.B.3
  • 64
    • 9544248772 scopus 로고    scopus 로고
    • Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy-induced thrombocytopenia
    • 64. Akahori H, Shibuya K, Obuchi M, et al. Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy-induced thrombocytopenia. Br J Haematol 1996; 94: 722-8
    • (1996) Br J Haematol , vol.94 , pp. 722-728
    • Akahori, H.1    Shibuya, K.2    Obuchi, M.3
  • 65
    • 0029796257 scopus 로고    scopus 로고
    • Thrombopoietin accelerates platelet, red blood cell and neutrophil recovery in myelosuppressed mice
    • 65. Grossman A, Lenox J, Ren HP, et al. Thrombopoietin accelerates platelet, red blood cell and neutrophil recovery in myelosuppressed mice. Exp Hematol 1996; 24: 1238-46
    • (1996) Exp Hematol , vol.24 , pp. 1238-1246
    • Grossman, A.1    Lenox, J.2    Ren, H.P.3
  • 66
    • 0029992540 scopus 로고    scopus 로고
    • Synergistic effects of thrombopoietin and granulocyte colony-stimulating factor on neutrophil recovery in myelosuppressed mice
    • 66. Grossman A, Lenox J, Deisher TA, et al. Synergistic effects of thrombopoietin and granulocyte colony-stimulating factor on neutrophil recovery in myelosuppressed mice. Blood 1996; 88 (9): 3363-70
    • (1996) Blood , vol.88 , Issue.9 , pp. 3363-3370
    • Grossman, A.1    Lenox, J.2    Deisher, T.A.3
  • 67
    • 0030443702 scopus 로고    scopus 로고
    • Improvement of thrombocytopenia following bone marrow transplantation by pegylated recombinant human megakaryocyte growth and development factor in mice
    • 67. Kabaya K, Shibuya K, Torii Y, et al. Improvement of thrombocytopenia following bone marrow transplantation by pegylated recombinant human megakaryocyte growth and development factor in mice. Bone Marrow Transplant 1996; 18: 1035-41
    • (1996) Bone Marrow Transplant , vol.18 , pp. 1035-1041
    • Kabaya, K.1    Shibuya, K.2    Torii, Y.3
  • 68
    • 0028787175 scopus 로고
    • Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice
    • 68. Fibbe WE, Heemskerk DPM, Laterveer L, et al. Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice. Blood 1995; 86 (9): 3308-13
    • (1995) Blood , vol.86 , Issue.9 , pp. 3308-3313
    • Fibbe, W.E.1    Heemskerk, D.P.M.2    Laterveer, L.3
  • 69
    • 0029999474 scopus 로고    scopus 로고
    • Megakaryocyte growth and development factor accelerates platelet recovery in peripheral blood progenitor cell transplant recipients
    • 69. Molineux G, Hartley C, McElroy P, et al. Megakaryocyte growth and development factor accelerates platelet recovery in peripheral blood progenitor cell transplant recipients. Blood 1996; 88 (1): 336-76
    • (1996) Blood , vol.88 , Issue.1 , pp. 336-376
    • Molineux, G.1    Hartley, C.2    McElroy, P.3
  • 70
    • 0029027918 scopus 로고
    • Recombinant human thrombopoietin (mpl ligand) enhances proliferation of erythroid progenitors
    • 70. Koyabashi M, Laver JH, Kato T, et al. Recombinant human thrombopoietin (mpl ligand) enhances proliferation of erythroid progenitors. Blood 1995; 86: 2494-9
    • (1995) Blood , vol.86 , pp. 2494-2499
    • Koyabashi, M.1    Laver, J.H.2    Kato, T.3
  • 71
    • 0028820319 scopus 로고
    • Regulation of platelet activation in vitro by c-Mpl ligand, thrombopoietin
    • 71. Chen J, Herceg-Harjacek L, Groopman J, et al. Regulation of platelet activation in vitro by c-Mpl ligand, thrombopoietin. Blood 1995; 86 (11): 4054-62
    • (1995) Blood , vol.86 , Issue.11 , pp. 4054-4062
    • Chen, J.1    Herceg-Harjacek, L.2    Groopman, J.3
  • 72
    • 0029619105 scopus 로고
    • Modulation of platelet activation in vitro by thrombopoietin
    • 72. Kojima H, Hamazaki Y, Nagata Y, et al. Modulation of platelet activation in vitro by thrombopoietin. Thromb Haemost 1995; 74 (6): 1541-5
    • (1995) Thromb Haemost , vol.74 , Issue.6 , pp. 1541-1545
    • Kojima, H.1    Hamazaki, Y.2    Nagata, Y.3
  • 73
    • 0029080417 scopus 로고
    • Megakaryocyte growth and development factor (MGDF) moderately enhances in-vitro platelet aggregation
    • 73. Toombs CF, Young CH, Glaspy JA, et al. Megakaryocyte growth and development factor (MGDF) moderately enhances in-vitro platelet aggregation. Thromb Res 1995; 80 (1): 23-33
    • (1995) Thromb Res , vol.80 , Issue.1 , pp. 23-33
    • Toombs, C.F.1    Young, C.H.2    Glaspy, J.A.3
  • 74
    • 0029912139 scopus 로고    scopus 로고
    • Effects of recombinant human megakaryocyte growth and development factor on platelet activation
    • 74. Montrucchio G, Brizzi MF, Calosso G, et al. Effects of recombinant human megakaryocyte growth and development factor on platelet activation. Blood 1996; 87 (7): 2762-8
    • (1996) Blood , vol.87 , Issue.7 , pp. 2762-2768
    • Montrucchio, G.1    Brizzi, M.F.2    Calosso, G.3
  • 75
    • 0029979883 scopus 로고    scopus 로고
    • Thrombopoietin potentiates activation of human platelets in association with JAK2 and TYK2 phophorylation
    • 75. Rodriguez-Linares B, Watson SP. Thrombopoietin potentiates activation of human platelets in association with JAK2 and TYK2 phophorylation. Biochem J 1996; 316: 93-8
    • (1996) Biochem J , vol.316 , pp. 93-98
    • Rodriguez-Linares, B.1    Watson, S.P.2
  • 76
    • 9444287622 scopus 로고    scopus 로고
    • Thrombopoietin modulates platelet activation in vitro through protein-tyrosine phosphorylation
    • 76. Kobuta Y, Arai T, Tanka T, et al. Thrombopoietin modulates platelet activation in vitro through protein-tyrosine phosphorylation. Stem Cells 1996; 14: 439-44
    • (1996) Stem Cells , vol.14 , pp. 439-444
    • Kobuta, Y.1    Arai, T.2    Tanka, T.3
  • 77
    • 9344225757 scopus 로고    scopus 로고
    • Thrombopoietin primes human platelet aggregation induced by shear stress and by multiple agonists
    • 77. Oda A, MiYakawa Y, Druker B, et al. Thrombopoietin primes human platelet aggregation induced by shear stress and by multiple agonists. Blood 1996; 87 (11): 4664-70
    • (1996) Blood , vol.87 , Issue.11 , pp. 4664-4670
    • Oda, A.1    Miyakawa, Y.2    Druker, B.3
  • 78
    • 0029794750 scopus 로고    scopus 로고
    • Thrombopoietin stimulates colony-forming unit megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit
    • 78. Broudy VC, Lin NL, Kox N, et al. Thrombopoietin stimulates colony-forming unit megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit. Blood 1996; 88: 2026-32
    • (1996) Blood , vol.88 , pp. 2026-2032
    • Broudy, V.C.1    Lin, N.L.2    Kox, N.3
  • 79
    • 0030982911 scopus 로고    scopus 로고
    • Ultrastructure of platelet formation by human megakaryocytes cultured with the Mpl ligand
    • 79. Cramer, Norol F, Guichard J, et al. Ultrastructure of platelet formation by human megakaryocytes cultured with the Mpl ligand. Blood 1997; 89: 2336-46
    • (1997) Blood , vol.89 , pp. 2336-2346
    • Cramer, N.F.1    Guichard, J.2
  • 80
    • 0031057949 scopus 로고    scopus 로고
    • Action of thrombopoietin at the megakaryocyte progenitor level is critical for the subsequent proplatelet production
    • 80. Horie K, Miyazaki H, Hagiwara T, et al. Action of thrombopoietin at the megakaryocyte progenitor level is critical for the subsequent proplatelet production. Exp Hematol 1997; 25: 169-76
    • (1997) Exp Hematol , vol.25 , pp. 169-176
    • Horie, K.1    Miyazaki, H.2    Hagiwara, T.3
  • 81
    • 0028843848 scopus 로고
    • Chronic exposure to retroviral encoded MGDF (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice
    • 81. Yan XQ, Lacey D, Fletcher F et al. Chronic exposure to retroviral encoded MGDF (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice. Blood 1995; 86 (11): 4025-33
    • (1995) Blood , vol.86 , Issue.11 , pp. 4025-4033
    • Yan, X.Q.1    Lacey, D.2    Fletcher, F.3
  • 82
    • 0030753987 scopus 로고    scopus 로고
    • Cellular localization of thrombopoietin mRNA in the liver by in-situ hybridization
    • 82. Nomura S, Ogami K, Kawamura K, et al. Cellular localization of thrombopoietin mRNA in the liver by in-situ hybridization. Exp Hematol 1997; 25: 565-72
    • (1997) Exp Hematol , vol.25 , pp. 565-572
    • Nomura, S.1    Ogami, K.2    Kawamura, K.3
  • 83
    • 0031035555 scopus 로고    scopus 로고
    • Localization and regulation of thrombopoietin mRNA expression in human kidney, liver, bone marrow,and spleen using in situ hybridization
    • 83. Sungaran R, Markovic B, Chong BH. Localization and regulation of thrombopoietin mRNA expression in human kidney, liver, bone marrow,and spleen using in situ hybridization. Blood 1997; 89: 101-7
    • (1997) Blood , vol.89 , pp. 101-107
    • Sungaran, R.1    Markovic, B.2    Chong, B.H.3
  • 84
    • 0031020240 scopus 로고    scopus 로고
    • Transgenic mice overexpressing human c-mpl ligand exhibit chronic thrombocytosis and display enhanced recovery from 5-fluorouracil or antiplatelet serum treatment
    • Mar
    • 84. Zhou W, Toombs CF, Zou T, et al. Transgenic mice overexpressing human c-mpl ligand exhibit chronic thrombocytosis and display enhanced recovery from 5-fluorouracil or antiplatelet serum treatment. Blood 1997 Mar; 89: 1551-9
    • (1997) Blood , vol.89 , pp. 1551-1559
    • Zhou, W.1    Toombs, C.F.2    Zou, T.3
  • 85
    • 10344235968 scopus 로고    scopus 로고
    • Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer
    • 85. Basser R, Rasko JEJ, Clarke K, et al. Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer. Lancet 1996; 348; 1279
    • (1996) Lancet , vol.348 , pp. 1279
    • Basser, R.1    Rasko, J.E.J.2    Clarke, K.3
  • 86
    • 0028961058 scopus 로고
    • Thrombopoietic effects and toxicity of interleukin-6 in patients with ovarian cancer before and after chemotherapy: A multicentric placebo controlled, randomized phase Ib study
    • 86. D'Hondt V, Humblet Y, Guillame T, et al. Thrombopoietic effects and toxicity of interleukin-6 in patients with ovarian cancer before and after chemotherapy: a multicentric placebo controlled, randomized phase Ib study. Blood 1995; 85: 2347-5
    • (1995) Blood , vol.85 , pp. 2347-2355
    • D'Hondt, V.1    Humblet, Y.2    Guillame, T.3
  • 87
    • 0027469684 scopus 로고
    • The effects of treatment with interleukin-1α on platelet recovery after high-dose carboplatin
    • 87. Smith JW, Longo DL, Alvord WG, et al. The effects of treatment with interleukin-1α on platelet recovery after high-dose carboplatin. N Engl J Med 1993; 328: 756-61
    • (1993) N Engl J Med , vol.328 , pp. 756-761
    • Smith, J.W.1    Longo, D.L.2    Alvord, W.G.3
  • 88
    • 15844395460 scopus 로고    scopus 로고
    • A phase i trial of recombinant human interleukin-11 (Neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy
    • 88. Gordon MS, McCaskill-Stevens WJ, Battiato LA, et al. A phase I trial of recombinant human interleukin-11 (Neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy. Blood 1996; 87: 3615-24
    • (1996) Blood , vol.87 , pp. 3615-3624
    • Gordon, M.S.1    McCaskill-Stevens, W.J.2    Battiato, L.A.3
  • 89
    • 0026761309 scopus 로고
    • Effects of interleukin-3 after chemotherapy for advanced ovarian cancer
    • 89. Biesma B, Willemse PH, Mulder NH, et al. Effects of interleukin-3 after chemotherapy for advanced ovarian cancer. Blood 1992; 80: 1141-8
    • (1992) Blood , vol.80 , pp. 1141-1148
    • Biesma, B.1    Willemse, P.H.2    Mulder, N.H.3
  • 90
    • 0029147155 scopus 로고
    • Toxicity and efficacy of escalating doses of recombinant human interleukin-6 after chemotherapy in patients with breast cancer or non-small cell lung cancer
    • 90. Veldhuis GJ, Willemse PH, Sleijfer DT, et al. Toxicity and efficacy of escalating doses of recombinant human interleukin-6 after chemotherapy in patients with breast cancer or non-small cell lung cancer. J Clin Oncol 1995; 13: 2585-93
    • (1995) J Clin Oncol , vol.13 , pp. 2585-2593
    • Veldhuis, G.J.1    Willemse, P.H.2    Sleijfer, D.T.3
  • 91
    • 0013479411 scopus 로고
    • Effects of P1XY321, a granulocyte-macrophage colony stimulating factor/interleukin-3 fusion protein, on chemotherapy-induced multilineage myelosuppression in patients with sarcoma
    • 91. Vadhan-Raj S. Papadopoulous NE, Burgess MA, et al. Effects of P1XY321, a granulocyte-macrophage colony stimulating factor/interleukin-3 fusion protein, on chemotherapy-induced multilineage myelosuppression in patients with sarcoma. J Clin Oncol 1994; 13: 2585-93
    • (1994) J Clin Oncol , vol.13 , pp. 2585-2593
    • Vadhan-Raj, S.1    Papadopoulous, N.E.2    Burgess, M.A.3
  • 92
    • 9244234420 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of recombinant interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy
    • 92. Tepler I, Elias L, Smith JW, et al. A randomized placebo-controlled trial of recombinant interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy. Blood 1996; 87: 3607-14
    • (1996) Blood , vol.87 , pp. 3607-3614
    • Tepler, I.1    Elias, L.2    Smith, J.W.3
  • 93
    • 0031049879 scopus 로고    scopus 로고
    • Effects of polyethyleneglycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer
    • 93. Fanucchi MH, Glaspy J, Garst J, et al. Effects of polyethyleneglycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. N Engl J Med 1997; 336 (6): 404-9
    • (1997) N Engl J Med , vol.336 , Issue.6 , pp. 404-409
    • Fanucchi, M.H.1    Glaspy, J.2    Garst, J.3
  • 94
    • 17944389931 scopus 로고    scopus 로고
    • Randomised, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) with filgrastim after dose-intensive chemotherapy in patients with advanced cancer
    • 94. Basser RL, Clarke K, Rasko JEJ, et al. Randomised, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) with filgrastim after dose-intensive chemotherapy in patients with advanced cancer. Blood 1997; 89: 3118-28
    • (1997) Blood , vol.89 , pp. 3118-3128
    • Basser, R.L.1    Clarke, K.2    Rasko, J.E.J.3
  • 95
    • 0024359117 scopus 로고
    • Treatment of chemotherapy-induced neutropenia by subcutaneously administered granulocyte colony-stimulating factor with optimization of dose and duration of therapy
    • 95. Morstyn G, Campbell L, Lieschke G, et al. Treatment of chemotherapy-induced neutropenia by subcutaneously administered granulocyte colony-stimulating factor with optimization of dose and duration of therapy. J Clin Oncol 1989; 7: 1554-62
    • (1989) J Clin Oncol , vol.7 , pp. 1554-1562
    • Morstyn, G.1    Campbell, L.2    Lieschke, G.3
  • 96
    • 8544258752 scopus 로고    scopus 로고
    • Multilineage mobilization of peripheral blood progenitor cells following administration of PEG-rHUMGDF
    • 96. Rasko JEJ, Basser RL, Boyd J, et al. Multilineage mobilization of peripheral blood progenitor cells following administration of PEG-rHUMGDF. Br J Haematol 1997; 97: 871-80
    • (1997) Br J Haematol , vol.97 , pp. 871-880
    • Rasko, J.E.J.1    Basser, R.L.2    Boyd, J.3
  • 97
    • 0026504705 scopus 로고
    • Effect of peripheral-blood progenitor cells mobilised by filgrastim (G-CSF) on platelet recovery after high-dose chemotherapy
    • 97. Sheridan WP, Begley CG, Juttner C, et al. Effect of peripheral-blood progenitor cells mobilised by filgrastim (G-CSF) on platelet recovery after high-dose chemotherapy. Lancet 1992; 339: 640-4
    • (1992) Lancet , vol.339 , pp. 640-644
    • Sheridan, W.P.1    Begley, C.G.2    Juttner, C.3
  • 98
    • 0026439358 scopus 로고
    • Prior chemotherapy does not prevent effective mobilisation by G-CSF of peripheral blood progenitor cells
    • 98. De Luca E, Sheridan WP, Watson D, et al. Prior chemotherapy does not prevent effective mobilisation by G-CSF of peripheral blood progenitor cells. Br J Cancer 1992; 66: 893-9
    • (1992) Br J Cancer , vol.66 , pp. 893-899
    • De Luca, E.1    Sheridan, W.P.2    Watson, D.3
  • 99
    • 0028174971 scopus 로고
    • Effects of interleukin-1α on carboplatin-induced thrombocytopenia in patients with recurrent ovarian cancer
    • 99. Vadhan-Raj S, Kudelka AP, Garrison L, et al. Effects of interleukin-1α on carboplatin-induced thrombocytopenia in patients with recurrent ovarian cancer. J Clin Oncol 1994; 12: 707-14
    • (1994) J Clin Oncol , vol.12 , pp. 707-714
    • Vadhan-Raj, S.1    Kudelka, A.P.2    Garrison, L.3
  • 100
    • 0013512570 scopus 로고
    • Mobilization of PBPC by priming with stem cell factor (SCF) before filgrastim compared to concurrent administration
    • 100. Basser RL, Begley CG, Mansfield R, et al. Mobilization of PBPC by priming with stem cell factor (SCF) before filgrastim compared to concurrent administration [abstract]. Blood 1995; 86 Suppl. 1: 687a
    • (1995) Blood , vol.86 , Issue.SUPPL. 1
    • Basser, R.L.1    Begley, C.G.2    Mansfield, R.3
  • 101
    • 10344238601 scopus 로고    scopus 로고
    • Administration of pegylated recombinant human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vivo activation
    • 101. O'Malley CJ, Rasko JEJ, Basser R, et al. Administration of pegylated recombinant human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vivo activation. Blood 1996; 88: 3288-98
    • (1996) Blood , vol.88 , pp. 3288-3298
    • O'Malley, C.J.1    Rasko, J.E.J.2    Basser, R.3
  • 102
    • 0026728713 scopus 로고
    • Effects of recombinant human interleukin-3 in patients with relapsed small-cell lung cancer treated with chemotherapy: A dose finding study
    • 102. Postmus P, Gietma JA, Damsma O, et al. Effects of recombinant human interleukin-3 in patients with relapsed small-cell lung cancer treated with chemotherapy: a dose finding study. J Clin Oncol 1992; 10: 1131-40
    • (1992) J Clin Oncol , vol.10 , pp. 1131-1140
    • Postmus, P.1    Gietma, J.A.2    Damsma, O.3
  • 104
    • 4243860082 scopus 로고    scopus 로고
    • Safety and activity of recombinant human thrombopoietin (rhTPO) in patients receiving autologous bone marrow transplant (ABMT): Preliminary results of a phase I/II trial
    • 104. Wolff S, Lynch J, Herzig R, et al. Safety and activity of recombinant human thrombopoietin (rhTPO) in patients receiving autologous bone marrow transplant (ABMT): preliminary results of a phase I/II trial [abstract]. Proc Am Soc Clin Oncol 1997; 16: 109a
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Wolff, S.1    Lynch, J.2    Herzig, R.3
  • 105
    • 0344073862 scopus 로고    scopus 로고
    • A randomised, double-blind, placebo-controlled study using PEG-rHuMGDF as an adjunct to chemotherapy for adults with denovo acute myeloid leukaemia: Early results
    • 105. Archimbaud E, Ottmann O, Liu Yin JA, et al. A randomised, double-blind, placebo-controlled study using PEG-rHuMGDF as an adjunct to chemotherapy for adults with denovo acute myeloid leukaemia: early results [abstract]. Blood 1997; 88 (10 Suppl. 1): 447a
    • (1997) Blood , vol.88 , Issue.10 SUPPL. 1
    • Archimbaud, E.1    Ottmann, O.2    Liu Yin, J.A.3
  • 106
    • 0028900601 scopus 로고
    • The use of rHuEpo in the treatment of anaemia related to myelodysplasia (MDS)
    • 106. Rose EH, Abels RI, Nelson RA, et al. The use of rHuEpo in the treatment of anaemia related to myelodysplasia (MDS). Br J Haematol 1995; 89: 931
    • (1995) Br J Haematol , vol.89 , pp. 931
    • Rose, E.H.1    Abels, R.I.2    Nelson, R.A.3
  • 107
    • 0023571993 scopus 로고
    • Effects of recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndromes
    • 107. Vadhan-Raj S, Keating M, LeMaistre A, et al. Effects of recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndromes. N Engl J Med 1987; 317: 1545
    • (1987) N Engl J Med , vol.317 , pp. 1545
    • Vadhan-Raj, S.1    Keating, M.2    LeMaistre, A.3
  • 108
    • 84867008669 scopus 로고
    • Treatment of myelodysplastic syndromes with recombinant human granulocyte colony-stimulating factor
    • 108. Negrin RS, Hauber DH, Nagler A. Treatment of myelodysplastic syndromes with recombinant human granulocyte colony-stimulating factor. Ann Intern Med 1992; 110: 976
    • (1992) Ann Intern Med , vol.110 , pp. 976
    • Negrin, R.S.1    Hauber, D.H.2    Nagler, A.3
  • 109
    • 0029858508 scopus 로고    scopus 로고
    • Differential mechanisms in the regukation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: Insight into the regulation of platelet production
    • 109. Chang M, Suen Y, Meng G, et al. Differential mechanisms in the regukation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: insight into the regulation of platelet production. Blood 1996; 88: 3354-62
    • (1996) Blood , vol.88 , pp. 3354-3362
    • Chang, M.1    Suen, Y.2    Meng, G.3
  • 110
    • 0024559068 scopus 로고
    • Human immunodeficiency virus-associated autoimmune thrombocytopenic purpura: A review
    • 110. Ratner L. Human immunodeficiency virus-associated autoimmune thrombocytopenic purpura: a review. Am J Med 1989; 86: 194
    • (1989) Am J Med , vol.86 , pp. 194
    • Ratner, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.