Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit

Blood

Volumn 88, Issue 6, 1996, Pages 2026-2032

  Broudy, Virginia C ^a   Lin, Nancy L ^b   Fox, Norma ^b   Taga, Tetsuya ^b   Saito, Mikiyoshi ^b   Kaushansky, Kenneth ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GLYCOPROTEIN; LEUKEMIA INHIBITORY FACTOR; MONOCLONAL ANTIBODY; ONCOSTATIN M; RECEPTOR SUBUNIT; RECOMBINANT INTERLEUKIN 11; RECOMBINANT INTERLEUKIN 3; RECOMBINANT INTERLEUKIN 6; RECOMBINANT THROMBOPOIETIN;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL PROLIFERATION; COLONY FORMING UNIT; DNA CONTENT; FLOW CYTOMETRY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THROMBOCYTE COUNT;

EID: 0029794750     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.6.2026.bloodjournal8862026     Document Type: Article

References (44)

1. Zucker-Franklin D, Petursson S: Thrombocytopoiesis - analysis by membrane tracer and freeze-fracture studies on fresh human and cultured mouse megakaryocytes. J Cell Biol 99:390, 1984
2. Choi ES, Nichol JL, Hokom MM, Hornkohl AC, Hunt P: Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional. Blood 85:402, 1995
3. Segal GM, Stueve T, Adamson JW: Analysis of murine megakaryocyte colony size and ploidy: Effects of interleukin-3. J Cell Physiol 137:537, 1988
4. Briddell RA. Bruno E, Cooper RJ, Brandt JE, Hoffman R: Effect of c-kit ligand on in vitro human megakaryopoiesis. Blood 78:2854, 1991
5. Ishibashi T, Kimura H, Uchida T, Kariyone S, Friese P, Burstein SA: Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro. Proc Natl Acad Sci USA 86:5953, 1989
6. Burstein SA, Mei R-L, Henthorn J, Friese P, Turner K: Leukemia inhibitory factor and interleukin-11 promote maturation of murine and human megakaryocytes in vitro. J Cell Physiol 153:305, 1992
7. Wallace PM, MacMaster JF, Rillema JR, Peng J, Burstein SA, Shoyab M: Thrombocytopoietic properties of oncostatin M. Blood 86:1310, 1995
8. Broudy VC, Lin NL, Kaushansky K: Throinbopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 85:1719, 1995
9. Debili N, Wendling F, Katz A, Guichard J, Breton-Gorius J, Hunt P, Vainchenker W: The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors. Blood 86:2516, 1995
10. Nichol JL, Hokom MM, Hornkohl A, Sheridan WP, Ohashi H, Kato T, Li YS, Bartley TD, Choi E, Bogenberger J, Skrine JD, Knudten A, Chen J, Trail G, Sleeman L, Cole S, Grampp G, Hunt P: Megakaryocyte growth and development factor. Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia. J Clin Invest 95:2973, 1995
11. Patterson PH: Leukemia inhibitory factor, a cytokine at the interface between neurobiology and immunology. Proc Natl Acad Sci USA 91:7833, 1994
12. Pennica D, Shaw KJ, Swanson TA, Moore MW, Shelton DL, Zioncheck KA, Rosenthal A, Taga T, Paoni NF, Wood WL: Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex. J Biol Chem 270:10915, 1995
13. Taga T, Hibi M, Hirata Y. Yamasaki K, Yasukawa K, Matsuda T, Hirano T. Kishimoto T: Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp 130, Cell 58:573, 1989
14. Kishimoto T, Akira S, Narazaki M, Taga T: Interleukin-6 family of cytokines and gp 130. Blood 86:1243, 1995
15. Saito M, Yoshida K, Hibi M, Taga T, Kishimoto T: Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo. J Immunol 148:4066, 1992
16. Kaushansky K: Thrombopoietin: The primary regulator of platelet production. Blood 86:419, 1995
17. Hunt P, Li Y-S, Nichol JL, Hokom MM, Bogenberger JM, Swift SE, Skrine JD, Hornkohl AC, Lu H, Clogston C. Merewether LA. Johnson MJ, Parker V, Knudten A, Farese A, Hsu RY, Garcia A, Stead R. Bosselman RA, Bartley TD: Purification and biologic characterization of plasma-derived megakaryocyte growth and development factor. Blood 86:540, 1995
18. Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Dort PJ, Hagen FS, Roth GJ, Papayannopoulou T, Foster DC: Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 369:568, 1994
19. Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW: Thrombocytopenia in c-mpl-deficient mice. Science 265:1445, 1994
20. Vigon I, Mornon J-P, Cocault L, Mitjavila M-T, Tambourin P, Gisselbrecht S, Souyri M: Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci USA 89:5640, 1992
21. Vigon I, Florindo C, Fichelson S, Guener J-L, Mattei M-G, Souyri M, Cosman D, Gisselbrecht S: Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: Molecular cloning, chromosomal location and evidence for a function in cell growth. Oncogene 8:2607, 1993
22. Cosman D: The hematopoietin receptor superfamily. Cytokine 5:95, 1993
23. Kaushansky K, Shoemaker SG, Broudy VC, Lin NL, Matous JV, Alderman EM, Aghajanian JD, Szklut PJ, VanDyke RE, Pearce MK, Abrams JS: Structure-function relationships of interleukin-3. An analysis based on the function and binding characteristics of a series of interspecies chimera of gibbon and murine interleukin-3. J Clin Invest 90:1879, 1992
24. Kaushansky K, Broudy VC, Lin N, Jorgensen MJ, McCarty J, Fox N, Zucker-Franklin D, Lofton-Day C: Thrombopoietin, the Mpl ligand, is essential for full megakaryocyte development. Proc Natl Acad Sci USA 92:3234, 1995
25. Paul SR, Bennett F, Calvetti JA, Kelleher K, Wood CR, O'Hara RM Jr, Leary AC, Sibley B, Clark SC, Williams DA, Yang Y-C: Molecular cloning of cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and haematopoietic cytokine. Proc Natl Acad Sci USA 87:7512, 1990
26. Sabath DF, Drachman JG, Kaushansky K, Broudy VC: Development of a cell line dependent on Mp1 ligand for proliferation. Blood 84:325a, 1994 (suppl 1)
27. Burstein SA, Friese P, Downs T, Mei R-L: Characteristics of a novel rat anti-mouse platelet monoclonal antibody: Application to studies of megakaryocytes. Exp Hematol 20:1170, 1992
28. Takada K, Saito M, Kaneko H, lizuka K, Kokai Y, Fujimoto J: Novel monoclonal antibody reactive with thrombin-sensitive 74-kDa glycoproteins present on platelets and megakaryocytes both from mouse and rat. Hybridoma 14:361, 1995
29. KishimotoT: The biology of interleukin-6. Blood 74:1, 1989
30. Du XX, Williams DA: Interleukin-11: A multifunctional growth factor derived from the hematopoietic microenvironment. Blood 83:2023, 1994
31. Jiang S, Levine JD, Fu Y, Deng B, London R, Groopman JE, Avraham H: Cytokine production by primary bone marrow megakaryocytes. Blood 84:4151, 1994
32. Wickenhauser C, Lorenzen J, Thiele J, Hillienhof A, Jungheim K, Schmitz B, Hansmann M-L, Fischer R: Secretion of cytokines (interleukin-1α, -3, and -6 and granulocyte-macrophage colony-stimulating factor) by normal human bone marrow megakaryocytes. Blood 85:685, 1995
33. Souyri M, Vigon I, Penciolelli J-F, Heard J-M, Tambourin P, Wendung F: A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hemalopoietic progenitors. Cell 63:1137, 1990
34. de Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC. Henzel WJ, Wong SC, Kuang WJ, Oles KJ, Hultgren B, Solberg LA Jr, Goeddel DV, Eaton DL: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369:533, 1994
35. Bartley TD, Bogenberger J, Hut P, Li Y-S, Lu HS, Martin F, Chang M-S, Nichol JL, Swift S, Johnson MJ, Hsu R-Y, Parker VP, Suggs S, Skrine JD. Merewether LA, Clogston C, Hsu E, Hokom MM, Hornkohl A, Choi E, Pangelinan M, Sun Y, Mar V, McNinch J, Simonet L, Jacobsen F, Xie C, Shutter J, Chute H, Basu R, Selander L, Trollinger D, Sieu L, Padilla D, Trail G, Elliott G, Izumi R, Covey T, Crouse J, Garcia A, Xu W, Del Castillo J, Biron J, Cole S, Hu MC-T, Pacifici R, Ponting I, Saris C, Wen D, Yung YP, Lin H, Bosselman RA: Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77:1117, 1994
36. Lok S, Kaushansky K. Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Helpel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AFT, Mathewes SL, Bailey MC, Forstrom JW, Buddle MM, Osborn SG, Evans SJ, Sheppard PO, Presnell SR, O'Hara PJ, Hagen FS, Roth GJ, Foster DC: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565, 1994
37. Kuter DJ, Beeler DL, Rosenberg RD: The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci USA 91:11104, 1994
38. Sohma Y, Akahori H, Seki N, Hori T, Ogami K, Kato T, Shimada Y, Kawamura K, Miyazaki H: Molecular cloning and chromosomal localization of the human thrombopoietin gene. FEBS Lett 353:57, 1994
39. Zucker-Franklin D, Kaushansky K: The effect of thrombopoietin on the development of megakaryocytes and platelets. An ultrastructural analysis. Blood (in press)
40. Skoda RC, Seldin DC, Chiang M-K, Peichel CL, Vogt TF, Leder P: Murine c-mpl: A member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. EMBO J 12:2645, 1993
41. Morella KK, Bruno E, Kumaki S, Lai C-F, Fu J, Wang H-M, Murray L, Hoffman R, Timour M, Benit L, Giesselbrecht S, Zhuang H, Wojchowski DM, Baumann H, Gearing DP: Signal transduction by the receptors for thrombopoietin (c-mpl) and interleukin-3 in hematopoietic and nonhematopoietic cells. Blood 86:557, 1995
42. Gurney AL, Wong SC, Henzel WJ, de Sauvage FJ: Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and She phosphorylation. Proc Natl Acad Sci USA 92:5292, 1995
43. Banu N, Wang J, Deng B, Groopman JE, Avraham H: Modulation of megakaryocytopoiesis by thrombopoietin: The C-Mpl ligand. Blood 86:1331, 1995
44. Lotem J, Shabo Y, Sachs L: Regulation of megakaryocyte development by interleukin-6. Blood 74:1545, 1989