Molecular mechanisms of retinoid action in acute promyelocytic leukemia (review)

International Journal of Oncology

Volumn 11, Issue 2, 1997, Pages 397-414

  Garattini, Enrico ^a   Fortino, Ida ^a   Terao, Mineko ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

APL; PML RAR ; Retinoic acid; Retinoid

Indexed keywords

CYCLIC AMP; GRANULOCYTE COLONY STIMULATING FACTOR; INTERFERON; RETINOIC ACID; RETINOID;

ACUTE MYELOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; BLOOD CLOTTING DISORDER; CELL ADHESION; CELL DIFFERENTIATION; CYTOLOGY; GENE CONTROL; GENE EXPRESSION; NEUTROPHIL; ONCOGENE; PRIORITY JOURNAL; REMISSION;

EID: 0030875477     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.11.2.397     Document Type: Article

References (18)

1. Kantarjian HM, Keating MJ, Walters RS, Estey EH, McCredie KB, Smith TL, Dalton WT Jr, Cork A, Trujillo JM and Freireich EJ: Acute promyelocytic leukemia. M.D. Anderson Hospital experience. Am J Med 80: 789-797, 1997.
2. Grignani F, Fagioli M, Ferrucci PF, Alcalay M and Pelicci PG: The molecular genetics of acute promyelocytic leukemia. Blood Rev 7: 87-93, 1993.
3. Warrell RP Jr, Maslak P, Eardley A, Heller G, Miller WH Jr and Frankel SR: Treatment of acute promyelocytic leukemia with all-trans retinoic acid: an update of the New York experience. Leukemia 8 (Suppl 2): S33-S37, 1994.
4. De Thé H, Chomienne C, Lanotte M, Degos L and Dejean A: The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus. Nature 347: 558-561, 1990.
5. Borrow J, Goddard AD, Sheer D and Solomon E: Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science 249: 1577-1580, 1990.
6. Kakizuka A, Miller WH Jr, Umesono K, Warrell RP Jr, Frankel SR, Murty VV, Dmitrovsky E and Evans RM: Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell 66: 663-674, 1991.
7. Chen SJ, Zhu YJ, Tong JH, Dong S, Huang W, Chen Y, Xiang WM, Zhang L, Li XS, Qian GQ, et al: Rearrangements in the second intron of the RARA gene are present in a large majority of patients with acute promyelocytic leukemia and are used as molecular marker for retinoic acid-induced leukemic cell differentiation. Blood 78: 2696-2701, 1991.
8. De Thé H, Lavau C, Marchio A, Chomienne C, Degos L and Dejean A: The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 66: 675-684, 1991.
9. Alcalay M, Zangrilli D, Pandolfi PP, Longo L, Mencarelli A, Giacomucci A, Rocchi M, Biondi A, Rambaldi A, Lo Coco F, et al: Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus. Proc Natl Acad Sci USA 88: 1977-1981, 1991.
10. Kastner P, Perez A, Lutz Y, Rochette Egly C, Gaub MP, Durand B, Lanotte M, Berger R and Chambon P: Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins. EMBO J 11: 629-642, 1992.
11. Gillard EF and Solomon E: Acute promyelocytic leukaemia and the t(15;17) translocation. Semin Cancer Biol 4: 359-367, 1993.
12. Geng JP, Tong JH, Dong S, Wang ZY, Chen SJ, Chen Z, Zelent A, Berger R and Larsen CJ: Localization of the chromosome 15 breakpoints and expression of multiple PML-RAR alpha transcripts in acute promyelocytic leukemia: a study of 28 Chinese patients. Leukemia 7: 20-26, 1993.
13. Pandolfi PP, Grignani F, Alcalay M, Mencarelli A, Biondi A, Lococo F and Pelicci PG: Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties. Oncogene 6: 1285-1292, 1991.
14. Fagioli M, Alcalay M, Pandolfi PP, Venturini L, Mencarelli A, Simeone A, Acampora D, Grignani F and Pelicci PG: Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms. Oncogene 7: 1083-1091, 1992.
15. Mu ZM, Chin KV, Liu JH, Lozano G and Chang KS: PML, a growth suppressor disrupted in acute promyelocytic leukemia. Mol Cell Biol 14: 6858-6867, 1994.
16. Le X-F, Yang P and Chang KS: Analysis of the growth and transformation suppressor domains of promyelocytic leukemia gene. J Biol Chem 271: 130-135, 1997.
17. Petkovich M, Brand NJ, Krust A and Chambon P: A human retionic acid receptor which belongs to the family of nuclear receptors. Nature 330: 444-450, 1987.
18. Weis K, Rambaud S, Lavau C, Jansen J, Carvalho T, Carmo Fonseca M, Lamond A and Dejean A: Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells. Cell 76: 345-356, 1994.