Proteolytic processing of Alzheimer's disease associated proteins

Journal of Neural Transmission, Supplement

Volumn , Issue 53, 1998, Pages 159-167

  Haass, C ^a   Grunberg J ^a   Capell, A ^a   Wild Bode, C ^a   Leimer, U ^a   Walter, J ^a   Yamazaki, T ^b   Ihara, I ^b   Zweckbronner, I ^c   Jakubek, C ^c   Baumeister, R ^c  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; MEMBRANE PROTEIN; NERVE PROTEIN; PRESENILIN 1; PRESENILIN 2; PROTEINASE; PSEN1 PROTEIN, HUMAN; PSEN2 PROTEIN, HUMAN;

ALZHEIMER DISEASE; ANIMAL MODEL; ARTICLE; CAENORHABDITIS ELEGANS; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; SENILE PLAQUE; AMINO ACID SEQUENCE; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; REVIEW;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; ENDOPEPTIDASES; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PRESENILIN-1; PRESENILIN-2;

EID: 0031596263     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6467-9_14     Document Type: Article

References (39)

1. Baumeister R, Leimer U, Zweckbronner I, Jakubek C, Grünberg J, Haass C (1997) Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate caenorhabditis elegans notch signaling independently of proteolytic processing. Genes Function 1: 149-159
2. Borchelt D, Thinakaran G, Eckman C, Lee M, Davenport F, Ratovitsky T, Prada C-M, Kim G, Seekins S, Yager D, Slunt H, Wang R, Seeger M, Levey A, Gandy S, Copeland N, Jenkins N, Price D, Younkin S, Sisodia SS (1996) Familial Alzheimer's disease-linked presenilin-1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron 17: 1005-10013
3. Capell A, Saffrich R, Olivo J-C, Meyn L, Walter J, Grünberg J, Dotti C, Haass C (1997) Expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation. J Neurochem 69: 2432-2440
4. Citron M, Westaway D, Xia W, Carlson G, Diehl TS, Levesque G, Johnson-Wood K, Lee, M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, Strome R, Lieberburg I, Rommens J, Kim S, Schenk D, Fraser P, St. George-Hyslop P, Selkoe DJ (1997) Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nature Med 3: 67-72
5. Cook DG, Sung JC, Golde TE, Felsenstein KM, Wojczyk BS, Tanzi RE, Trojanowski JQ, Lee V M-Y, Doms RW (1996) Expression and analysis of presenilin 1 in a human neuronal system: Localization in cell bodies and dendrites. Proc Natl Acad Sci USA 93: 9223-9228
6. Cook DG, Forman MS, Sung JC, Leight S, Kolson DL, Iwatsubo T, Lee V M-Y, Doms RW (1997) Alzheimer's Aβ (1-42) is generated in the endoplasmic reticulum / intermediate compartment of NT2N cells. Nature Med 3: 1021-1023
7. De Strooper B, Beullens M, Contreras B, Levesque L, Craessaerts K, Cordell B, Moechars D, Bollen M , Fraser P, St. George-Hyslop P, Van Leuven F (1997) Phosphorylation, subcellular localization and membrane orientation of the Alzheimer's disease-associated presenilins. J Biol Chem 272: 3590-3598
8. Duff K, Eckman C, Zehr C, Yu X, Prada CM, Perez-Tur J, Hutton M, Buee L, Harigaya Y, Yager D, Morgan D, Gordon MN, Holcomb L, Refolo L, Zenk B, Hardy J, Younkin SG (1996) Increased amyloid-β42 (43) in brains of mice expressing mutant presenilin 1. Nature 383: 710-713
9. Grünberg J, Walter J, Hendriks L, van Broeckhoven C, Loetscher H, Deuschle U, Jacobsen H, Haass C (1998) Alternative processing of the Alzheimer's disease associated presenilin-1 involving proteases of the caspase family. Biochemistry (in press)
10. Haass C (1997) Presenilins: genes for life and death. Neuron 18: 687-690
11. Haass C, Selkoe DJ (1993) Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide. Cell 75: 1039-1042
12. Hartmann T, Bieger SC, Brühl B, Tienari PJ, Ida N, Allsop D, Roberts GW, Masters CL, Dotti CG, Unsicker K, Beyreuther K (1997) Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides. Nature Med 3: 1016-1020
13. Hartmann H, Busciglio J, Baumann K-H, Staufenbiel M, Yankner B (1997) Developmental regulation of presenilin-1 processing in the brain suggests a role in neuronal differentiation. J Biol Chem 272: 14505-14508
14. Kim T-W, Pettingell H, Jung Y-K, Kovacs D, Tanzi R (1997) Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 277: 373-376
15. Kovacs DM, Fausett HJ, Page K J, Kim TW, Moir RD, Merriam DE, Hollister RD, Hallmark OG, Mancini R, Felsenstein KM, Hyman BT, Tanzi RE, Wasco W (1996) Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nature Med 2: 224-229
16. Levy-Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, Yu C, Jondro PD, Schmidt SD, Wang K, Crowley AC, Fu Y-H, Guenette SY, Galas D, Nemens E, Wijsman EM, Bird TD, Schellenberg GD, Tanzi RE (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269: 973-977
17. Levitan D, Greenwald I (1995) Facilitation of Iin-12-mediated signaling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377: 351-354
18. Levitan D, Doyle T, Brousseau D, Lee M, Thinakaran G, Slunt H, Sisodia S, Greenwald I (1996) Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc Natl Acad Sci USA 93: 14940-14944
19. Loetscher H, Deuschle U, Brockhaus M, Reinhardt D, Nelboeck P, Mous J, Grünberg J, Haass C, Jacobsen H (1997) Presenilins are processed by caspase-type proteases. J Biol Chem 272: 20655-20659
20. Perez-Tur J, Froehlich S, Prihar G, Crook R, Baker M, Duff K, Wragg M, Busfield F, Lendon C, Clark RF, Roques P, Fuldner RA, Johnston J, Cowburn R, Forsell C, Axelman K, Lilius L, Houlden H, Karran E, Roberts GW, Rossor M, Adams MD, Hardy J, Goate A, Lannfelt L, Hutton M (1995) A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene. NeuroReport 7: 297-301
21. Podlisny M, Citron M, Amarante P, Sherringron R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo E, Seubert P, St. George-Hyslop P, Teplow D, Selkoe D (1997) Presenilins proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue. Neurobiol Dis 3: 325-337
22. Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holamn K, Tsuda T, Mar L, Sorbi S, Nacmias B, Piacentini S, Amaducci L, Chumakkov I, Cohen D, Lannfelt L, Fraser PE, Rommens JM, St. George-Hyslop PH (1995) Familial Alzheimer's disease kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376: 775-778
23. Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe DJ, Younkin S (1996) Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med 2: 864-870
24. Selkoe DJ (1996) Amyloid β-protein and the genetics of Alzheimer's disease. J Biol Chem 271: 18295-18298
25. Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S (1997) Skeletal and CNS defects in presenilin-1-deficient mice. Cell 89: 629-639
26. Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin J-F, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, da Silva HAR, Haines JL, Pericak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375: 754-760
27. 717) mutants. Science 264: 1336-1340
28. Tanzi RE, Kovacs DM, Kim T-W, Moir R, Guenette SY, Wasco W (1996) The gene defects responsible for Alzheimer's disease. Neurobiol Dis 3: 159-168
29. Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, Ratovitsky T, Davenport F, Nordstedt C, Seeger M, Hardy J, Levey AI, Gandy SE, Jenkins NA, Copeland, NG, Pric, DL Sisodia SS (1996) Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17: 181-190
30. Tomita T, Maruyama K, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J, Grünberg J, Haass C, Iwatsubo T, Obata K (1997) The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue. Proc Natl Acad Sci USA 94: 2025-2030
31. +-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science 271: 521-525
32. Vito P, Wolozin B, Ganjei JK, Iwasaki K, Lacana E, D'Adamio L (1996b) Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. J Biol Chem 271: 31025-31028
33. Walter J, Capell A, Grünberg J, Pesold B, Schindzielorz A, Prior R, Podlisny MB, Fraser P, St.George-Hyslop P, Selkoe DJ, Haass C (1996) The Alzheimer's disease - associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Mol Med 2: 673-691
34. Weidemann A, Paliga K, Dürrwang U, Czech C, Evin G, Masters C, Beyreuther K (1997) Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and β-amyloid precursor protein. Nature Med 3: 328-332
35. Wild-Bode C, Yamazaki T, Capell A, Leimer U, Steiner H, Ihara Y, Haass C (1997) Intracellular generation and accumulation of Amyloid β-peptide terminating at amino acid 42. J Biol Chem 272: 16085-16088
36. Wolozin B, Iwasaki K, Vito P, Ganjei JK, Lacana E, Sunderland T, Zhao B, Kusiak JW, Wasco W, D'Adamio L (1996) Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation. Science 274: 1710-1713
37. Wong PC, Zheng H, Chen H, Becher MW, Sirinathsinghji DJS, Trumbauer ME, Chen HY, Price DL, Van der Ploeg LHT, Sisodia SS (1997) Presenilin 1 is required for Notchl and D//1 expression in the paraxial mesoderm. Nature 387: 288-292
38. Xia W, Zhang J, Kholodenko D, Citron M, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ (1997) Enhanced production and oligomeraization of the 42-residue amyloid β-protein by CHO cells stably expressing mutant presenilins. J Biol Chem 272: 7977-7982
39. Xia W, Zhang J, Perez R, Koo EH, Selkoe DJ (1997) Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer's disease. Proc Natl Acad Sci USA 94: 8208-8213