Bryostatin 1 enhances paclitaxel-induced mitochondrial dysfunction and apoptosis in human leukemia cells (U937) ectopically expressing Bcl-x(L)

Leukemia

Volumn 13, Issue 10, 1999, Pages 1564-1573

  Wang, S ^a   Wang, Z ^a   Boise, L H ^b   Dent, P ^b   Grant, S ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Bcl x(L); Bryostatin 1; Leukemia; MAP kinase; Paclitaxel

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BRYOSTATIN 1; CASPASE 3; CYCLIN DEPENDENT KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PACLITAXEL; PROTEIN BCL X; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR;

APOPTOSIS; ARTICLE; CELL CYCLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0032876984     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401532     Document Type: Article

References (45)

1. Rowinsky EK, Onetto N, Canetta RM, Arbuck SG. Taxol: the first of the taxanes, an important new class of antitumor agents. Semin Oncol 1992; 19: 646-662.
2. Bhalla K, Ibrado AM, Tourkina E, Tang CQ, Mahoney ME, Huang Y. Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells. Leukemia 1993; 7: 563-568.
3. Horwitz SB. Mechanism of action of Taxol. Trends Pharmacol Sci 1992; 13: 134-136.
4. Donaldson KL, Goolsby G, Kiener PA, Wahl AF. Activation of p 34cdc2 coincident with Taxol-induced apoptosis. Cell Growth Diff 1994; 5: 1041-1050.
5. Yang E, Korsmeyer SJ. Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood 1996; 88: 386-401.
6. Oltvai ZN, Korsmeyer SJ. Checkpoints of dueling dimers foil death wishes. Cell 1994; 79: 189-192.
7. Boise L, Gonzalez-Garcia M, Postema C, Ding L, Lindsten T, Turka L, Mao X, Nunez G, Thompson C. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of cell death. Cell 1993; 74: 597-608.
8. Marchetti P, Castedo M, Susin SA, Zamzami N, Hirsch T, Machio A, Haeffner A, Hirsch F, Geuskens M, Kroemer G. Mitochondrial permeability transition is a central coordinating event of apoptosis. J Exp Med 1996; 184: 1155-1160.
9. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng T-I, Jones DP, Wang X. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 1997; 275: 1129-1132.
10. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade. Cell 1997; 91: 479-489.
11. L overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human myeloid leukemia HL-60 cells. Cancer Res 1997; 57: 1109-1115.
12. Schmitt E, Cimoli G, Steyaert A, Bertrand R. Bcl-xL modulates apoptosis induced by anticancer drugs and delays DEVDase and DNA fragmentation-promoting activities. Exp Cell Res 1998; 240: 107-121.
13. Grant S, Roberts J, Bear HD, Poplin E, Tombes M, Kyle B. Phase Ib pharmacodynamic trial of bryostatin 1 in patients with advanced malignancies. Clin Cancer Res 1998; 4: 611-618.
14. Grant S, Turner A, Freemerman A, Wang J, Kramer L, larvis WD. Modulation of PKC activity and calcium-sensitive isoform expression in human myeloid leukemia cells: relationship to differentiation and ara-C-induced apoptosis. Exp Cell Res 1996; 228: 65-75.
15. Wang S, Vrana JA, Bartimole T, Freemerman AJ, Jarvis WD, Kramer LB, Krystal G, Dent P, Grant S. Agents that downregulate or inhibit protein kinase C circumvent resistance to 1-β-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells overexpressing Bcl-2. Mol Pharmacol 1997; 52: 1000-1009.
16. Simonian PL, Grillot DAM, Nunez G. Bcl-2 and Bcl-XL can differentially block chemotherapy-induced cell death. Blood 1997; 90: 1208-1216.
17. Wang S, Guo Y, Castillo T, Dent P, Grant S. Potentiation of taxol-induced apoptosis and antiproliferative effects in human myeloid leukemia cells (U937) by bryostatin 1. Biochem Pharmacol 1998; 56: 635-644.
18. Jarvis WD, Gewirtz D, Povirk L, Turner A, Traylor R, Pettit GR, Grant S. Effect of bryostatin 1 and other activators of protein kinase C on 1-β-D-arabinofuranosylcytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells. Biochem Pharmacol 1994; 47: 839-852.
19. Marchetti P, Castedo M, Susin SA, Zamzami N, Hirsch T, Machio A, Haeffner A, Hirsch F, Geuskens M, Kroemer G. Mitochondrial permeability transition is a central coordinating event of apoptosis. J Exp Med 1996; 184: 1155-1160.
20. Jarvis WD, Fornari FA, Tombes RM, Martin HA, Erkulla RK, Bittman R, Schwartz GK, Dent P, Grant S. Evidence for involvement of MAPK, rather than SAPK, in potentiation of 1-β-D-arabinofuranosylcytosine-induced apoptosis by interruption of the PKC pathway. Mol Pharm 1998; 54: 844-856.
21. Takenaka K, Moriguchi T, Nishida E. Activation of the protein kinase p 38 in the spindle assembly checkpoint and mitotic arrest. Science 1998; 280: 599-602.
22. Shimizu S, Eguchi Y, Kamiike W, Funahahsi Y, Mignon A, Lacronique V, Matsuda H, Tsujimoto Y. Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux. Proc Natl Acad Sci USA 1998; 95: 1455-1459.
23. L antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents. Cancer Res 1997; 57: 62-67.
24. Medina V, Edmonds B, Young GP, James R, Appleton S, Zalewski PD. Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway. Cancer Res 1997; 57: 3697-3707.
25. WAF1/CIP1.MDA6. Exp Cell Res 1998; 244: 105-116.
26. L, and Apaf-1 form a ternary complex. J Biol Chem 1998; 273: 5841-5845.
27. L interacts with apaf-1 and inhibits apaf-1-dependent caspase 9 activation. Proc Natl Acad Sci USA 1998; 95: 4386-4391.
28. L and Bcl-2. EMBO J 1997; 16: 968-977.
29. Marzo I, Brenner C, Zamzami N, Jugensmeier JM, Susin SA, Vieira HLA, Prevost M-C, Xie Z, Matsuyama S, Reed JC, Kroemer G. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science 1998; 281: 2027-2031.
30. Haldar S, Chintapalli J, Croce CM. Taxol induces bcl-2 phosphorylation and death of prostate cancer cells. Cancer Res 1996; 56: 1253-1255.
31. L is phosphorylated in malignant cells following microtubule disruption. Cancer Res 1998; 58: 3331-3338.
32. Hu Z-B, Minden MD, McCulloch EA. Phosphorylation of BCL-2 after exposure of human leukemic cells to retinoic acid. Blood 1998; 92: 1768-1775.
33. Blagosklonny MV, Giannakakou P, El-Diery WS, Kingston DG, Higgs PI, Neckers L, Fojo T. Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death. Cancer Res 1997; 57: 130-135.
34. Ling YH, Tornos C, Perez-Soler R. Phosphorylation of Bcl-2 is a marker of M-phase events and not a determinant of apoptosis. J Biol Chem 1998; 273: 18984-18991.
35. Fang G, Chang BS, Kim CN, Perkins C, Thompson CB, Bhalla KN. 'Loop' domain is necessary for taxol-induced mobility shift and phosphorylation as well as for inhibiting taxol-induced cytosolic accumulation of cytochrome c and apoptosis. Cancer Res 1998; 58: 3202-3208.
36. May WS, Tyler G, Ito T, Armstrong DK, Qatsha KA, Davidson NE. Interleukin-3 and bryostatin 1 mediate hyperphosphorylation of BCL2α in association with suppression of apoptosis. J Biol Chem 1994; 269: 26865-26870.
37. Ruvolo PP, Deng X, Carr BK, May WS. A functional role for mitochondrial protein kinase Cα in Bcl-2 phosphorylation and suppression of apoptosis. J Biol Chem 1998; 273: 25436-25442.
38. Wang X, Martindale JL, Liu Y, Holbrook NJ. The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J 1998; 333: 291-300.
39. Xia Z, Dickens M, Raingeaud J, Davis R, Greenberg ME. Opposing effects of ERK and JNK-p 38 MAP kinases on apoptosis. Science 1995; 270: 1326-1331.
40. Lieu C-H, Liu C-C, Y T-H, Chen K-D, Chang Y-N, Lai Y-K. Role of mitogen-activiated protein kinase in taxol-induced apoptosis in human leukemic U937 cells. Cell Growth Diff 1998; 9: 767-776.
41. Torres K, Horowitz SB. Mechanisms of taxol-induced cell death are concentration-dependent. Cancer Res 1998; 58: 3620-3626.
42. Watanabe N, Broome M, Hunter T. Regulation of the human WEE1-CDKI tyrosine 15-kinase during the cell cycle. EMBO J 1995; 14: 1878-1891.
43. Guadagno TM, Ferrell JE. Requirement for MAPK activation for normal mitotic progression in Xenopus egg extracts. Science 1998; 282: 1312-1315.
44. Wang X, Zhai Y, Ferrell J. A role for mitogen-activated protein kinase in the spindle assembly checkpoint in XTC cells. J Cell Biol 1997; 137: 433-443.
45. Vrana JA, Auer KL, Dent TM, Grant S, Dent P. Inhibition of the MAPK pathway abrogates Bcl-2-mediated leukemic cell survival after exposure of HL-60 cells to low dose ionizing radiation. Radiat Res 1999; 151: 559-569.