Angiotensin production by the heart: A quantitative study in pigs with the use of radiolabeled angiotensin infusions

Circulation

Volumn 98, Issue 1, 1998, Pages 73-81

  Van Kats, Jorge P ^a   Danser, A H Jan ^a   Van Meegen, Jan R ^a   Sassen, Loes M A ^a   Verdouw, Pieter D ^a   Schalekamp, Maarten A D H ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

ACE inhibitors; Angiotensin; Renin

Indexed keywords

1,10 PHENANTHROLINE; ANGIOTENSIN; ANGIOTENSIN I; ANGIOTENSIN I I 125; ANGIOTENSIN II I 125; ANGIOTENSIN II [5 ISOLEUCINE]; ANGIOTENSINOGEN; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EDETATE SODIUM; REMIKIREN; RENIN; RENIN INHIBITOR;

ANGIOTENSIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL BLOOD; ARTICLE; CIRCULATION; CONTROLLED STUDY; CORONARY ARTERY; FEMALE; HEART; INTRACARDIAC DRUG ADMINISTRATION; ISOTOPE LABELING; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SWINE; TISSUE LEVEL;

EID: 0032493428     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.98.1.73     Document Type: Article

References (36)

1. Linz W, Schaper J, Wiemer G, Albus U, Schölkens BA. Ramipril prevents left ventricular hypertrophy with myocardial fibrosis without blood pressure reduction: a one year study in rats. Br J Pharmacol. 1992; 107:970-975.
2. The SOLVD Investigators. Effects of the angiotensin-converting enzyme inhibitor enalapril on the long-term progression of left ventricular dilatation in patients with asymptomatic systolic dysfunction. Circulation. 1993;88:2277-2283.
3. Danser AHJ, van Kats JP, Admiraal PJJ, Derkx FHM, Lamers JMJ, Verdouw PD, Saxena PR, Schalekamp MADH. Cardiac renin and angiotensins: uptake from plasma versus in situ synthesis. Hypertension. 1994; 24:37-48.
4. Ekker M, Tronik D, Rougeon F. Extrarenal transcription of the renin genes in multiple tissues of mice and rats. Proc Natl Acad Sci U S A. 1989;86:5155-5158.
5. Iwai N, Inagami T. Quantitative analysis of renin gene expression in extrarenal tissues by polymerase chain reaction method. J Hypertens. 1992;10:717-724.
6. Lou YK, Robinson BG, Morris BJ. Renin messenger RNA, detected by polymerase chain reaction, can be switched on in rat atrium. J Hypertens. 1993;11:237-243.
7. Passier RCJJ, Smits JFM, Verluyten MJA, Daemen MJAP. Expression and localization of renin and angiotensinogen in rat heart after myocardial infarction. Am J Physiol. 1996;271:H1040-H1048.
8. Lindpaintner K, Lu W, Niedermajer N, Schieffer B, Just H, Ganten D, Drexler H. Selective activation of cardiac angiotensinogen gene expression in post-infarction ventricular remodeling of the rat. J Mol Cell Cardiol. 1993;25:133-143.
9. de Lannoy LM, Danser AHJ, van Kats JP. Schoemaker RG, Saxena PR, Schalekamp MADH. Renin-angiotensin system components in the interstitial fluid of the isolated perfused rat heart: local production of angiotensin I. Hypertension. 1997;29:1240-1251.
10. Schunkert H, Dzau VJ, Tang SS, Hirsch AT, Apstein CS, Lorell BH. Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy: effects on coronary resistance, contractility, and relaxation. J Clin Invest. 1990;86: 1913-1920.
11. Sun Y, Cleutjens JPM, Diaz-Arias AA, Weber KT. Cardiac angiotensinconverting enzyme and myocardial fibrosis in the rat. Cardiovasc Res. 1994;28:1423-1432.
12. Falkenhahn M, Franke F, Bohle RM, Zhu Y-C, Stauss HM, Bachmann S, Danilov S, linger T. Cellular distribution of angiotensin-converting enzyme after myocardial infarction. Hypertension. 1995;25:219-226.
13. Hokimoto S, Yasue H, Fujimoto K, Yamamoto H, Nakao K, Kaikita K, Sakata R, Miyamoto E. Expression of angiotensin-converting enzyme in remaining viable myocytes of human ventricles after myocardial infarction. Circulation. 1996;94:1513-1518.
14. Danser AHJ, Koning MMG, Admiraal PJJ, Derkx FHM, Verdouw PD, Schalekamp MADH. Metabolism of angiotensin I by different tissues in the intact animal. Am J Physiol. 1992;263:H418-H428.
15. van Kats JP, Sassen LMA, Danser AHJ, Polak MPJ, Soei LK, Derkx FHM, Schalekamp MADH, Verdouw PD. Assessment of the role of the renin-angiotensin system in cardiac contractility utilizing the renin inhibitor remikiren. Br J Pharmacol. 1996;117:891-901.
16. 1) receptor mediated accumulation of angiotensin II in tissues and its intracellular half life in vivo. Hypertension. 1997;30:42-49.
17. Admiraal PJJ, Derkx FHM, Danser AHJ, Pieterman H, Schalekamp MADH. Metabolism and production of angiotensin I in different vascular beds in subjects with hypertension. Hypertension. 1990;15:44-55.
18. Semen GGN, Boddi M, Coppo M, Chechi T, Zarone N, Moira M, Pogessi L, Margheri M, Simonetti I. Evidence for the existence of a functional cardiac renin-angiotensin system in humans. Circulation. 1996;94:1866-1893.
19. Danser AHJ, Koning MMG, Admiraal PJJ, Sassen LMA, Derkx FHM, Verdouw PD, Schalekamp MADH. Production of angiotensins I and II at tissue sites in intact pigs. Am J Physiol. 1992;263:H429-H437.
20. Admiraal PJJ, Danser AHJ, Jong MS, Pieterman H, Derkx FHM, Schalekamp MADH. Regional angiotensin II production in essential hypertension and renal artery stenosis. Hypertension. 1993;21:173-184.
21. Loudon M, Bing RF, Thurston H, Swales JD. Arterial wall uptake of renal renin and blood pressure control. Hypertension. 1983;5:629-634.
22. Danser AHJ, van Kesteren CAM, Bax WA, Tavenier M, Derkx FHM, Saxena PR, Schalekamp MADH. Prorenin. renin, angiotensinogen, and angiotensin-converting enzyme in normal and failing human hearts: evidence for renin binding. Circulation. 1997;96:220-226.
23. Sealey JE, Catanzaro DF, Lavin TN. Gahnem F, Pittaresi T, Hu L-f, Laragh JH. Specific prorenin/renin binding (ProBP): identification and characterization of a novel membrane site. Am J Hypertens. 1996;9:491-502.
24. Campbell DJ, Valentijn AJ. Identification of vascular renin-binding proteins by chemical cross-linking: inhibition of renin-binding by renin inhibitors. J Hypertens. 1994;12:879-890.
25. Nguyen G, Delarue F, Berrou J, Rondeau E, Sraer J-D. Specific binding of renin to human mesangial cells in culture increases plasminogen activator-1 antigen. Kidney Int. 1996;50:1897-1903.
26. Campbell DJ, Kladis A, Duncan AM. Nephrectomy, converting enzyme inhibition, and angiotensin peptides. Hypertension. 1993;22:513-522.
27. Yamagishi H, Kim S, Nishikimi T, Takeuchi K, Takeda T. Contribution of cardiac renin-angiotensin system to ventricular remodeling in myocardial-infarcted rats. J Mol Cell Cordiol. 1993;25:1369-1380.
28. Campbell DJ, Kladis A, Duncan AM. Effects of converting enzyme inhibitors on angiotensin and bradykinin peptides. Hypertension. 1994;23:439-449.
29. Ruzicka M. Skarda V, Leenen FHH. Effects of ACE inhibitors on circulating versus cardiac angiotensin II in volume overload-induced cardiac hypertrophy in rats. Circulation. 1995;92:3568-3573.
30. Urata H, Healy B, Stewart RW, Bumpus FM. Husain A. Angiotensin II-forming pathways in normal and failing human hearts. Circ Res. 1990;66:883-890.
31. Zisman LS, Abraham WT, Meixel GE, Vamvakias BN, Quaife RA, Lowes BD, Roden RL, Peacock SJ, Groves BM, Raynolds MV, Bristow MR, Perryman MB. Angiotensin II formation in the intact human heart: predominance of the angiotensin-converting enzyme pathway. J Clin Invest. 1995;95:1490-1498.
32. Kokkonen JO, Saarinen J, Kovanen PT. Regulation of local angiotensin II formation in the human heart in the presence of interstitial fluid: inhibition of chymase by protease inhibitors of interstitial fluid and of angiotensin-converting enzyme by Ang-(1-9) formed by heart carboxypeptidase A-like activity. Circulation. 1997;95:1455-1463.
33. Campbell DJ, Kladis A, Valentijn AJ. Effects of losartan on angiotensin and bradykinin peptides and angiotensin-converting enzyme. J Cardiovasc Pharmacol. 1995;26:233-240.
34. Griendling KK, Delafontaine R, Rittenhouse SE, Gimbrone MA, Alexander WA. Correlation of receptor sequestration with sustained diacylglycerol accumulation in angiotensin-II stimulated cultured vascular smooth muscle cells. J Biol Chem. 1987;262:14555-14562.
35. Eggena P, Zhu JH, Sannaporn S, Giordani M, Clegg K, Andersen PC, Hyun P, Barrett JD. Hepatic angiotensin II nuclear receptors and transcription of growth-related factors. J Hypertens. 1996;14:961-968.
36. Haller H, Lindschau C, Erdmann B, Quass P, Luft FC. Effects of intracellular angiotensin II in vascular smooth muscle cells. Circ Res. 1996;79:765-772.