Use of the multiple copy simultaneous search (MCSS) method to design a new class of picornavirus capsid binding drugs

Proteins: Structure, Function and Genetics

Volumn 29, Issue 1, 1997, Pages 32-58

  Joseph McCarthy, Diane ^a,b   Hogle, James M ^a   Karplus, Martin ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

Computer aided ligand design; Multiple copy simultaneous search; Poliovirus; Rhinovirus; Structure based drug design

Indexed keywords

ANTIVIRUS AGENT; DISOXARIL; PIRODAVIR; R 78206; R 80633; SPHINGOSINE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG BINDING; DRUG DESIGN; NONHUMAN; PICORNAVIRUS; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; RHINOVIRUS; VIRUS CAPSID;

ALGORITHMS; ANTIVIRAL AGENTS; CAPSID; CLUSTER ANALYSIS; COMPUTER SIMULATION; DRUG DESIGN; LIGANDS; MODELS, MOLECULAR; PICORNAVIRIDAE; POLIOVIRUS; PROTEIN BINDING; RHINOVIRUS;

MIRIDAE; PICORNAVIRIDAE; POLIOVIRUS; RHINOVIRUS;

EID: 0030963674     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(199709)29:1<32::AID-PROT3>3.0.CO;2-H     Document Type: Article

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