Optimizing the binding of fullerene inhibitors of the HIV-1 protease through predicted increases in hydrophobic desolvation

Journal of Medicinal Chemistry

Volumn 41, Issue 13, 1998, Pages 2424-2429

  Friedman, S H ^a   Ganapathi, P S ^a   Rubin, Y ^a   Kenyon, G L ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 PROPANOL; 2 PYRROLIDONE DERIVATIVE; CYCLOHEXYLAMINE; CYCLOPROPANE DERIVATIVE; DIMETHYL SULFOXIDE; DIPHENYLAMINE DERIVATIVE; FULLERENE DERIVATIVE; PROTEINASE INHIBITOR; SUCCINIC ACID METHYL ESTER;

ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG DESIGN; ENZYME ACTIVE SITE; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROPHOBICITY; LIGAND BINDING; SOLVATION;

BINDING SITES; CARBON; DRUG DESIGN; HIV PROTEASE; HIV PROTEASE INHIBITORS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RECOMBINANT PROTEINS; STEREOISOMERISM;

EID: 0032543623     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970689r     Document Type: Article

References (19)