메뉴 건너뛰기




Volumn 155, Issue 6, 1999, Pages 1781-1785

Tau pathology generated by overexpression of tau

Author keywords

[No Author keywords available]

Indexed keywords

TAU PROTEIN;

EID: 0032805652     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65494-6     Document Type: Note
Times cited : (16)

References (75)
  • 2
    • 0024498630 scopus 로고
    • Structure of the bovine tau gene: alternatively spliced transcripts generate a protein family
    • A Himmler Structure of the bovine tau gene: alternatively spliced transcripts generate a protein family Mol Cell Biol 4 1989 1389 1396
    • (1989) Mol Cell Biol , vol.4 , pp. 1389-1396
    • Himmler, A1
  • 3
    • 0024387161 scopus 로고
    • Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain
    • M Goedert MG Spillantini MC Potier J Ulrich RA Crowther Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain EMBO J 2 1989 393 399
    • (1989) EMBO J , vol.2 , pp. 393-399
    • Goedert, M1    Spillantini, MG2    Potier, MC3    Ulrich, J4    Crowther, RA5
  • 5
    • 0033591225 scopus 로고    scopus 로고
    • 5′ splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10
    • M Hutton 5′ splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10 J Biol Chem 274 1999 15134 15143
    • (1999) J Biol Chem , vol.274 , pp. 15134-15143
    • Hutton, M1
  • 8
    • 0033525221 scopus 로고    scopus 로고
    • Altered conformation of recombinant frontotemporal dementia-17 mutant tau proteins
    • GA Jicha JM Rockwood B Berenfeld M Hutton P Davies Altered conformation of recombinant frontotemporal dementia-17 mutant tau proteins Neurosci Lett 260 1999 153 156
    • (1999) Neurosci Lett , vol.260 , pp. 153-156
    • Jicha, GA1    Rockwood, JM2    Berenfeld, B3    Hutton, M4    Davies, P5
  • 10
    • 0032561415 scopus 로고    scopus 로고
    • Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly
    • M Hasegawa MJ Smith M Goedert Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly FEBS Lett 437 1998 207 210
    • (1998) FEBS Lett , vol.437 , pp. 207-210
    • Hasegawa, M1    Smith, MJ2    Goedert, M3
  • 11
    • 0030713963 scopus 로고    scopus 로고
    • Genetics of aging
    • C Finch RE Tanzi Genetics of aging Science 278 1997 407 411
    • (1997) Science , vol.278 , pp. 407-411
    • Finch, C1    Tanzi, RE2
  • 15
    • 0022595501 scopus 로고
    • Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques
    • H Braak E Braak I Grundke-Iqbal K Iqbal Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques Neurosci Lett 65 1986 351 355
    • (1986) Neurosci Lett , vol.65 , pp. 351-355
    • Braak, H1    Braak, E2    Grundke-Iqbal, I3    Iqbal, K4
  • 16
    • 0033142961 scopus 로고    scopus 로고
    • Tau protein pathology in Alzheimer's disease and related disorders
    • M Tolnay A Probst Tau protein pathology in Alzheimer's disease and related disorders Neuropathol Appl Neurobiol 25 1999 171 187
    • (1999) Neuropathol Appl Neurobiol , vol.25 , pp. 171-187
    • Tolnay, M1    Probst, A2
  • 17
    • 0014851803 scopus 로고
    • Observations on the brains of demented old people
    • BE Tomlinson G Blessed M Roth Observations on the brains of demented old people J Neurol Sci 11 1970 205 242
    • (1970) J Neurol Sci , vol.11 , pp. 205-242
    • Tomlinson, BE1    Blessed, G2    Roth, M3
  • 18
    • 0023200370 scopus 로고
    • Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis
    • I Alafuzoff K Iqbal H Friden R Adolfsson B Winblad Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis Acta Neuropathol (Berl) 74 1987 209 225
    • (1987) Acta Neuropathol (Berl) , vol.74 , pp. 209-225
    • Alafuzoff, I1    Iqbal, K2    Friden, H3    Adolfsson, R4    Winblad, B5
  • 19
    • 0026740795 scopus 로고
    • Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
    • PA Arigada JH Growdon ET Hedley-White BT Hyman Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease Neurology 42 1992 631 639
    • (1992) Neurology , vol.42 , pp. 631-639
    • Arigada, PA1    Growdon, JH2    Hedley-White, ET3    Hyman, BT4
  • 22
    • 0021847557 scopus 로고
    • Some morphometric observations on the cerebral cortex and hippocampus in presenile Alzheimer's disease, senile dementia of Alzheimer type and Down's syndrome in middle age
    • DMA Mann PO Yates B Marcynuik Some morphometric observations on the cerebral cortex and hippocampus in presenile Alzheimer's disease, senile dementia of Alzheimer type and Down's syndrome in middle age J Neurol Sci 69 1985 139 159
    • (1985) J Neurol Sci , vol.69 , pp. 139-159
    • Mann, DMA1    Yates, PO2    Marcynuik, B3
  • 23
    • 0023009658 scopus 로고
    • Microtubule-associated protein tau: a component of Alzheimer paired helical filaments
    • I Grundke-Iqbal K Iqbal M Quinlan Y-C Tung MS Zaidi HM Wisniewski Microtubule-associated protein tau: a component of Alzheimer paired helical filaments J Biol Chem 261 1986 6084 6089
    • (1986) J Biol Chem , vol.261 , pp. 6084-6089
    • Grundke-Iqbal, I1    Iqbal, K2    Quinlan, M3    Tung, Y-C4    Zaidi, MS5    Wisniewski, HM6
  • 24
    • 0022744803 scopus 로고
    • Abnormal phosphorylation of the microtubule associated protein τ (tau) in Alzheimer cytoskeletal pathology
    • I Grundke-Iqbal K Iqbal Y-C Tung M Quinlan HM Wisniewski LI Binder Abnormal phosphorylation of the microtubule associated protein τ (tau) in Alzheimer cytoskeletal pathology Proc Natl Acad Sci USA 83 1986 4913 4917
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 4913-4917
    • Grundke-Iqbal, I1    Iqbal, K2    Tung, Y-C3    Quinlan, M4    Wisniewski, HM5    Binder, LI6
  • 25
    • 0029008731 scopus 로고
    • Alzheimer abnormally phosphorylated tau is more hyperphosphorylated than the fetal tau and causes the disruption of microtubules
    • K Iqbal I Grundke-Iqbal Alzheimer abnormally phosphorylated tau is more hyperphosphorylated than the fetal tau and causes the disruption of microtubules Neurobiol Aging 16 1995 375 379
    • (1995) Neurobiol Aging , vol.16 , pp. 375-379
    • Iqbal, K1    Grundke-Iqbal, I2
  • 26
    • 0024512038 scopus 로고
    • Abnormal tau species are produced during Alzheimer's disease neurodegenerating process
    • S Flament A Delacourte Abnormal tau species are produced during Alzheimer's disease neurodegenerating process FEBS Lett 247 1989 213 216
    • (1989) FEBS Lett , vol.247 , pp. 213-216
    • Flament, S1    Delacourte, A2
  • 28
    • 0025904444 scopus 로고
    • A68: a major subunit of paired helical filaments and derivatized forms of normal tau
    • VM-Y Lee BJ Balin L Otvos Jr JQ Trojanowski A68: a major subunit of paired helical filaments and derivatized forms of normal tau Science 251 1991 675 678
    • (1991) Science , vol.251 , pp. 675-678
    • Lee, VM-Y1    Balin, BJ2    Otvos, L3    Trojanowski, JQ4
  • 30
    • 0005026184 scopus 로고
    • Disturbances of axoplasmic transport in Alzheimer's disease
    • P Dustin J Flament-Durand Disturbances of axoplasmic transport in Alzheimer's disease DG Weiss A Gorio Axoplasmic transport and pathology 1982 Springer-Verlag Berlin, Heidelberg 131 136
    • (1982) , pp. 131-136
    • Dustin, P1    Flament-Durand, J2
  • 31
    • 0017173036 scopus 로고
    • Progressive dendritic changes in the aging human limbic system
    • ME Scheibel RD Lindsay U Tomiyasu AB Scheibel Progressive dendritic changes in the aging human limbic system Exp Neurol 53 1976 420 430
    • (1976) Exp Neurol , vol.53 , pp. 420-430
    • Scheibel, ME1    Lindsay, RD2    Tomiyasu, U3    Scheibel, AB4
  • 32
    • 0033028074 scopus 로고    scopus 로고
    • Neurons may live for decades with neurofibrillary tangles
    • R Morsch W Simon PD Coleman Neurons may live for decades with neurofibrillary tangles J Neuropathol Exp Neurol 58 1999 188 197
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 188-197
    • Morsch, R1    Simon, W2    Coleman, PD3
  • 35
    • 0028065142 scopus 로고
    • Analysis of microtubule-associated protein tau glycation in paired helical filaments
    • MD Ledesma P Bonay C Colaço J Avila Analysis of microtubule-associated protein tau glycation in paired helical filaments J Biol Chem 269 1994 21614 21619
    • (1994) J Biol Chem , vol.269 , pp. 21614-21619
    • Ledesma, MD1    Bonay, P2    Colaço, C3    Avila, J4
  • 37
    • 0029995590 scopus 로고    scopus 로고
    • Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1
    • JZ Wang I Grundke-Iqbal K Iqbal Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1 Mol Brain Res 38 1996 200 208
    • (1996) Mol Brain Res , vol.38 , pp. 200-208
    • Wang, JZ1    Grundke-Iqbal, I2    Iqbal, K3
  • 38
    • 0026030994 scopus 로고
    • Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease
    • C Bancher I Grundke-Iqbal K Iqbal VA Fried HT Smith HM Wisniewski Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease Brain Res 539 1991 11 18
    • (1991) Brain Res , vol.539 , pp. 11-18
    • Bancher, C1    Grundke-Iqbal, I2    Iqbal, K3    Fried, VA4    Smith, HT5    Wisniewski, HM6
  • 39
    • 0027361281 scopus 로고
    • Microtubule associated protein tau: abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease
    • E Köpke Y-C Tung S Shaikh C Alonso A del K Iqbal I Grundke-Iqbal Microtubule associated protein tau: abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease J Biol Chem 268 1993 24374 24384
    • (1993) J Biol Chem , vol.268 , pp. 24374-24384
    • Köpke, E1    Tung, Y-C2    Shaikh, S3    Alonso A del, C4    Iqbal, K5    Grundke-Iqbal, I6
  • 40
    • 0028227962 scopus 로고
    • Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease
    • C Alonso A del T Zaidi I Grundke-Iqbal K Iqbal Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease Proc Natl Acad Sci USA 91 1994 5562 5566
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5562-5566
    • Alonso A del, C1    Zaidi, T2    Grundke-Iqbal, I3    Iqbal, K4
  • 41
    • 0029999787 scopus 로고    scopus 로고
    • Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
    • C Alonso A del I Grundke-Iqbal K Iqbal Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules Nat Med 2 1996 783 787
    • (1996) Nat Med , vol.2 , pp. 783-787
    • Alonso A del, C1    Grundke-Iqbal, I2    Iqbal, K3
  • 42
    • 0031012497 scopus 로고    scopus 로고
    • Abnormal phosphorylation of tau, and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of MAP1 and MAP2 and the disassembly of microtubules by the abnormal tau
    • C Alonso A del I Grundke-Iqbal HS Barra K Iqbal Abnormal phosphorylation of tau, and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of MAP1 and MAP2 and the disassembly of microtubules by the abnormal tau Proc Natl Acad Sci USA 94 1997 298 303
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 298-303
    • Alonso A del, C1    Grundke-Iqbal, I2    Barra, HS3    Iqbal, K4
  • 43
    • 0028361538 scopus 로고
    • Alzheimer paired helical filaments: restoration of the biological activity by dephosphorylation
    • K Iqbal T Zaidi C Bancher I Grundke-Iqbal Alzheimer paired helical filaments: restoration of the biological activity by dephosphorylation FEBS Lett 349 1994 104 108
    • (1994) FEBS Lett , vol.349 , pp. 104-108
    • Iqbal, K1    Zaidi, T2    Bancher, C3    Grundke-Iqbal, I4
  • 44
    • 0028902487 scopus 로고
    • Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B
    • JZ Wang C-X Gong T Zaidi I Grundke-Iqbal K Iqbal Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B J Biol Chem 270 1995 4854 4860
    • (1995) J Biol Chem , vol.270 , pp. 4854-4860
    • Wang, JZ1    Gong, C-X2    Zaidi, T3    Grundke-Iqbal, I4    Iqbal, K5
  • 45
    • 0029815467 scopus 로고    scopus 로고
    • Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer's disease
    • JZ Wang I Grundke-Iqbal K Iqbal Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer's disease Nat Med 2 1996 871 875
    • (1996) Nat Med , vol.2 , pp. 871-875
    • Wang, JZ1    Grundke-Iqbal, I2    Iqbal, K3
  • 47
  • 48
    • 0025325524 scopus 로고
    • Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease
    • M Hasegawa T Arai Y Ihara Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease Neuron 4 1990 909 918
    • (1990) Neuron , vol.4 , pp. 909-918
    • Hasegawa, M1    Arai, T2    Ihara, Y3
  • 49
    • 0028003725 scopus 로고
    • Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients
    • L Ulloa EM de Garcini P Gòmez-Ramos MA Moràn J Avila Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients Mol Brain Res 26 1994 113 122
    • (1994) Mol Brain Res , vol.26 , pp. 113-122
    • Ulloa, L1    de Garcini, EM2    Gòmez-Ramos, P3    Moràn, MA4    Avila, J5
  • 50
    • 0027214404 scopus 로고
    • Phosphoprotein phosphatase activities in Alzheimer disease
    • C-X Gong TJ Singh I Grundke-Iqbal K Iqbal Phosphoprotein phosphatase activities in Alzheimer disease J Neurochem 61 1993 921 927
    • (1993) J Neurochem , vol.61 , pp. 921-927
    • Gong, C-X1    Singh, TJ2    Grundke-Iqbal, I3    Iqbal, K4
  • 51
    • 0029113874 scopus 로고
    • Phosphatase activity toward abnormally phosphorylated τ: decrease in Alzheimer disease brain
    • C-X Gong S Shaikh J-Z Wang T Zaidi I Grundke-Iqbal K Iqbal Phosphatase activity toward abnormally phosphorylated τ: decrease in Alzheimer disease brain J Neurochem 65 1995 732 738
    • (1995) J Neurochem , vol.65 , pp. 732-738
    • Gong, C-X1    Shaikh, S2    Wang, J-Z3    Zaidi, T4    Grundke-Iqbal, I5    Iqbal, K6
  • 52
    • 0028044722 scopus 로고
    • Alzheimer disease abnormally phosphorylated tau is dephosphorylated by protein phosphatase 2B (calcineurin)
    • C-X Gong TJ Singh I Grundke-Iqbal K Iqbal Alzheimer disease abnormally phosphorylated tau is dephosphorylated by protein phosphatase 2B (calcineurin) J Neurochem 62 1994 803 806
    • (1994) J Neurochem , vol.62 , pp. 803-806
    • Gong, C-X1    Singh, TJ2    Grundke-Iqbal, I3    Iqbal, K4
  • 53
    • 0028350740 scopus 로고
    • Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease
    • C-X Gong I Grundke-Iqbal Z Damuni K Iqbal Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease FEBS Lett 341 1994 94 98
    • (1994) FEBS Lett , vol.341 , pp. 94-98
    • Gong, C-X1    Grundke-Iqbal, I2    Damuni, Z3    Iqbal, K4
  • 54
    • 0028064431 scopus 로고
    • Dephosphorylation of Alzheimer disease abnormally phosphorylated tau by protein phosphatase-2A
    • C-X Gong I Grundke-Iqbal K Iqbal Dephosphorylation of Alzheimer disease abnormally phosphorylated tau by protein phosphatase-2A Neurosci 61 1994 765 772
    • (1994) Neurosci , vol.61 , pp. 765-772
    • Gong, C-X1    Grundke-Iqbal, I2    Iqbal, K3
  • 55
    • 0026784416 scopus 로고
    • P42 map kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1: implications for Alzheimer's disease
    • M Goedert ES Cohen R Jakes P Cohen P42 map kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1: implications for Alzheimer's disease FEBS Lett 312 1992 95 99
    • (1992) FEBS Lett , vol.312 , pp. 95-99
    • Goedert, M1    Cohen, ES2    Jakes, R3    Cohen, P4
  • 56
    • 0027753055 scopus 로고
    • Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcineurin and phosphatase-2A
    • G Drewes E-M Mandelkow K Baumann J Goris W Merlevede E Mandelkow Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcineurin and phosphatase-2A FEBS Lett 336 1993 425 432
    • (1993) FEBS Lett , vol.336 , pp. 425-432
    • Drewes, G1    Mandelkow, E-M2    Baumann, K3    Goris, J4    Merlevede, W5    Mandelkow, E6
  • 57
    • 0028157916 scopus 로고
    • Increased production of paired helical filament epitopes in a cell culture system reduces the turnover of τ
    • I Vincent M Rosado E Kim P Davies Increased production of paired helical filament epitopes in a cell culture system reduces the turnover of τ J Neurochem 62 1994 715 723
    • (1994) J Neurochem , vol.62 , pp. 715-723
    • Vincent, I1    Rosado, M2    Kim, E3    Davies, P4
  • 58
    • 0032540459 scopus 로고    scopus 로고
    • The regulation of phosphorylation of τ in SY5Y neuroblastoma cells: the role of protein phosphatases
    • T Tanaka J Zhong K Iqbal E Trenkner I Grundke-Iqbal The regulation of phosphorylation of τ in SY5Y neuroblastoma cells: the role of protein phosphatases FEBS Lett 426 1998 248 254
    • (1998) FEBS Lett , vol.426 , pp. 248-254
    • Tanaka, T1    Zhong, J2    Iqbal, K3    Trenkner, E4    Grundke-Iqbal, I5
  • 59
    • 0026597063 scopus 로고
    • Alzheimer's disease: the amyloid cascade hypothesis
    • JA Hardy GA Higgins Alzheimer's disease: the amyloid cascade hypothesis Science 256 1992 184 185
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, JA1    Higgins, GA2
  • 60
    • 0029064572 scopus 로고
    • Early Alzheimer disease-like histopathology increased in frequency with age in mice transgenic for β-APP751
    • LS Higgins JM Rodems R Catalano D Quon B Cordell Early Alzheimer disease-like histopathology increased in frequency with age in mice transgenic for β-APP751 Proc Natl Acad Sci USA 92 1995 4402 4406
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4402-4406
    • Higgins, LS1    Rodems, JM2    Catalano, R3    Quon, D4    Cordell, B5
  • 64
    • 0031824782 scopus 로고    scopus 로고
    • Aging renders the brain vulnerable to amyloid-protein neurotoxicity
    • C Geula C-K Wu D Saroff A Lorenzo M Yuan BA Yankner Aging renders the brain vulnerable to amyloid-protein neurotoxicity Nat Med 4 1998 827 831
    • (1998) Nat Med , vol.4 , pp. 827-831
    • Geula, C1    Wu, C-K2    Saroff, D3    Lorenzo, A4    Yuan, M5    Yankner, BA6
  • 65
    • 0028965635 scopus 로고
    • Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform
    • J Götz A Probst MG Spillantini T Schäfer R Jakes K Bürki M Goedert Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform EMBO J 14 1995 1304 1313
    • (1995) EMBO J , vol.14 , pp. 1304-1313
    • Götz, J1    Probst, A2    Spillantini, MG3    Schäfer, T4    Jakes, R5    Bürki, K6    Goedert, M7
  • 66
    • 0345580607 scopus 로고    scopus 로고
    • Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease
    • J-P Brion G Tremp J-N Octave Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease Am J Pathol 154 1999 255 270
    • (1999) Am J Pathol , vol.154 , pp. 255-270
    • Brion, J-P1    Tremp, G2    Octave, J-N3
  • 68
    • 0026694783 scopus 로고
    • Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein
    • S Khatoon I Grundke-Iqbal K Iqbal Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein J Neurochem 59 1992 750 753
    • (1992) J Neurochem , vol.59 , pp. 750-753
    • Khatoon, S1    Grundke-Iqbal, I2    Iqbal, K3
  • 70
    • 0032530145 scopus 로고    scopus 로고
    • Phosphorylation of tau at both Thr-231 and Ser-262 is required for maximal inhibition of its binding to microtubules
    • A Sengupta J Kabat M Novak Q Wu I Grundke-Iqbal K Iqbal Phosphorylation of tau at both Thr-231 and Ser-262 is required for maximal inhibition of its binding to microtubules Arch Biochem Biophys 357 1998 299 309
    • (1998) Arch Biochem Biophys , vol.357 , pp. 299-309
    • Sengupta, A1    Kabat, J2    Novak, M3    Wu, Q4    Grundke-Iqbal, I5    Iqbal, K6
  • 71
    • 0030923223 scopus 로고    scopus 로고
    • Free fatty acids stimulate the polymerization of tau and amyloid β peptides: in vitro evidence for a common effector of pathogenesis in Alzheimer's disease
    • D Wilson LI Binder Free fatty acids stimulate the polymerization of tau and amyloid β peptides: in vitro evidence for a common effector of pathogenesis in Alzheimer's disease Am J Pathol 150 1997 2181 2195
    • (1997) Am J Pathol , vol.150 , pp. 2181-2195
    • Wilson, D1    Binder, LI2
  • 72
    • 0030590911 scopus 로고    scopus 로고
    • RNA stimulates aggregation of microtubule associated protein tau into Alzheimer-like paired helical filaments
    • T Kampers P Friedhoff J Biernat E-M Mandelkow E Mandelkow RNA stimulates aggregation of microtubule associated protein tau into Alzheimer-like paired helical filaments FEBS Lett 399 1996 344 349
    • (1996) FEBS Lett , vol.399 , pp. 344-349
    • Kampers, T1    Friedhoff, P2    Biernat, J3    Mandelkow, E-M4    Mandelkow, E5
  • 73
    • 0029796168 scopus 로고    scopus 로고
    • Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction
    • M Perez JM Valpuesta M Medina E Montejo de Garcini J Avila Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction J Neurochem 67 1996 1183 1190
    • (1996) J Neurochem , vol.67 , pp. 1183-1190
    • Perez, M1    Valpuesta, JM2    Medina, M3    Montejo de Garcini, E4    Avila, J5
  • 74
    • 0029907548 scopus 로고    scopus 로고
    • Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans
    • M Goedert R Jakes MG Spillantini M Hasegawa MJ Smith RA Crowther Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans Nature 383 1996 550 553
    • (1996) Nature , vol.383 , pp. 550-553
    • Goedert, M1    Jakes, R2    Spillantini, MG3    Hasegawa, M4    Smith, MJ5    Crowther, RA6
  • 75
    • 0032516493 scopus 로고    scopus 로고
    • Rapid assembly of Alzheimer-like paired helical filaments from mictotuble-associated protein tau monitored by fluorescence in solution
    • P Friedhoff A Schneider EM Mandelkow E Mandelkow Rapid assembly of Alzheimer-like paired helical filaments from mictotuble-associated protein tau monitored by fluorescence in solution Biochem 28 1998 10223 102230
    • (1998) Biochem , vol.28 , pp. 10223-102230
    • Friedhoff, P1    Schneider, A2    Mandelkow, EM3    Mandelkow, E4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.