Bridging the gap: From ion channels to networks and behaviour

Current Opinion in Neurobiology

Volumn 9, Issue 6, 1999, Pages 663-669

  Grillner, Sten ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ION CHANNEL;

CENTRAL NERVOUS SYSTEM; LOCOMOTION; NERVE CELL NETWORK; NEUROBIOLOGY; NEUROSCIENCE; NONHUMAN; PRIORITY JOURNAL; REVIEW; VERTEBRATE;

EID: 0032787653     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(99)00036-7     Document Type: Review

References (73)

1. Markram H., Wang Y., Tsodyks M. Differential signaling via the same axon of neocortical pyramidal neurons. Proc Natl Acad Sci USA. 95:1998;5323-5328. Reports that during repetitive activation of an individual nerve cell, the synaptic effects exerted in its target cells may differ. The authors made multiple intracellular recordings in neocortical pyramidal neurons and found activity-dependent facilitation of synaptic transmission at one synapse, but depression at a different synapse. Thus, it appears that the property of a given synaptic terminal depends on the type of target cell innervated.
2. Markram H., Gupta A., Uziel A., Wang Y., Tsodyks M. Information processing with frequency-dependent synaptic connections. Neurobiol Learn Mem. 70:1998;101-112.
3. Calabrese R.L. Cellular, synaptic, network, and modulatory mechanisms involved in rhythm generation. Curr Opin Neurobiol. 8:1998;710-717.
4. Marder E., Calabrese R.L. Principles of rhythmic motor pattern generation. Physiol Rev. 76:1996;687-717.
5. Marder E. From biophysics to models of network function. Annu Rev Neurosci. 21:1998;25-45.
6. Buschges A., El Manira A. Sensory pathways and their modulation in the control of locomotion. Curr Opin Neurobiol. 8:1998;733-739.
7. Kristan W.B. Jr., Shaw B.K. Population coding and behavioral choice. Curr Opin Neurobiol. 7:1997;826-831.
8. Wessel R., Kristan W.B. Jr., Kleinfeld D. Supralinear summation of synaptic inputs by an invertebrate neuron: dendritic gain is mediated by an 'inward rectifier' K(+) current. J Neurosci. 19:1999;5875-5888.
9. Chain D.G., Casadio A., Schacher S., Hegde A.N., Valbrun M., Yamamoto N., Goldberg A.L., Bartsch D., Kandel E.R., Schwartz J.H. Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia. Neuron. 22:1999;147-156.
10. Ramirez J.M., Schwarzacher S.W., Pierrefiche O., Olivera B.M., Richter D.W. Selective lesioning of the cat pre-Botzinger complex in vivo eliminates breathing but not gasping. J Physiol (Lond). 507:1998;895-907.
11. Elsen F.P., Ramirez J.M. Calcium currents of rhythmic neurons recorded in the isolated respiratory network of neonatal mice. J Neurosci. 18:1998;10652-10662.
12. B-mediated inhibition changes in respiratory rhythm-generating network markedly during early postnatal stage. Soc Neurosci Abstr. 25:1999;694.
13. 2+ channels changes as does their modulation via GABAergic mechanisms.
14. B-mediated modulation in a developing respiratory rhythm-generating network of the neonatal mouse. Eur J Neurosci. 1999;. in press.
15. Atsuta Y., Garcia-Rill E., Skinner R.D. Electrically induced locomotion in the in vitro brainstem spinal cord preparation. Brain Res. 470:1988;309-312.
16. Cazalets J.R., Sqalli-Houssaini Y., Clarac F. Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat. J Physiol (Lond). 455:1992;187-204.
17. Kiehn O., Kjaerulff O. Distribution of central pattern generators for rhythmic motor outputs in the spinal cord of limbed vertebrates. Ann NY Acad Sci. 860:1998;110-129. This is a review of the neonatal rat spinal cord preparation. The evidence for the longitudinal distribution of the hind limb pattern generator network in the lumbo-sacral spinal cord is reviewed, as well as the interneuronal groups that are active during locomotor activity.
18. Eide A.L., Glover J., Kjaerulff O., Kiehn O. Characterization of commissural interneurons in the lumbar region of the neonatal rat spinal cord. J Comp Neurol. 403:1999;332-345.
19. Kjaerulff O., Kiehn O. Crossed rhythmic synaptic input to motoneurons during selective activation of the contralateral spinal locomotor network. J Neurosci. 17:1997;9433-9447.
20. Kjaerulff O. Distribution of networks generating and coordinating locomotor activity in the neonatal rat spinal cord in vitro: a lesion study. J Neurosci. 16:1996;5777-5794.
21. Clarac F., Vinay L., Cazalets J.-R., Fady J.-C., Jamon M. Role of gravity in the development of posture and locomotion in the neonatal rat. Brain Res Rev. 28:1998;35-43. An excellent review of the development of the brainstem-spinal-cord control mechanisms, including descending pathways, underlying the development of posture and locomotion in the rat.
22. Fady J.C., Jamon M., Clarac F. Early olfactory-induced rhythmic limb activity in the newborn rat. Brain Res Dev Brain Res. 108:1998;111-123.
23. Jamon M., Clarac F. Early walking in the neonatal rat: a kinematic study. Behav Neurosci. 112:1998;1218-1228.
24. Brocard F., Vinay L., Clarac F. Gradual development of the ventral funiculus input to lumbar motoneurons in the neonatal rat. Neuroscience. 90:1999;1543-1554.
25. Iizuka M., Nishimaru H., Kudo N. Development of the spatial pattern of 5-HT-induced locomotor rhythm in the lumbar spinal cord of rat fetuses in vitro. Neurosci Res. 31:1998;107-111.
26. ••].
27. ••] demonstrate how the motor pattern underlying locomotion develops in the embryo. Cervical circuits develop before the lumbar circuits, and the co-ordination within one limb girdle goes from synchronous bilateral activity in all limb muscles to a final alternating flexor-extensor activity in the single limb.
28. Sillar K.T., Reith C.A., McDearmid J.R. Development and aminergic neuromodulation of a spinal locomotor network controlling swimming in Xenopus larvae. Ann NY Acad Sci. 860:1998;318-332.
29. Dale N., Kuenzi F. Ionic currents, transmitters and models of motor pattern generators. Curr Opin Neurobiol. 7:1997;790-796.
30. 2+ channels. J Neurosci. 19:1999;890-899.
31. Dale N. Delayed production of adenosine underlies temporal modulation of swimming in frog embryo. J Physiol (Lond). 511:1998;265-272. It is shown that adenosine accumulates during each locomotor episode in the frog embryo. Adenosine has a depressing effect on the locomotor network and contributes to the termination of its activity.
32. Roberts A., Walford A., Soffe S.R., Yoshida M. Motoneurons of the axial swimming muscles in hatchling Xenopus tadpoles: features, distribution, and central synapses. J Comp Neurol. 411:1999;472-486.
33. Fetcho J.R., Liu K.S. Zebrafish as a model system for studying neuronal circuits and behavior. Ann NY Acad Sci. 860:1998;333-345.
34. Liu K.S., Fetcho R. Laser ablations reveal functional relationships of segmental hindbrain neurons in zebrafish. Neuron. 23:1999;325-335. The escape behaviour in the larval zebra fish is analysed by selective inactivation of individual brainstem neurones through laser ablation. It is shown that individual neurones contribute specifically to different aspects of the escape response.
35. O'Malley D.M., Kao Y.-H., Fetcho J.R. Imaging the functional organization of zebrafish hindbrain segments during escape behaviors. Neuron. 17:1996;1145-1155.
36. Fetcho J.R., O'Malley D.M. Imaging neuronal networks in behaving animals. Curr Opin Neurobiol. 7:1997;832-838.
37. Granato M., van Eeden F.J., Schach U., Trowe T., Brand M., Furutani-Seiki M., Haffter P., Hammerschmidt M., Heisenberg C.P., Jiang Y.J. Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development. 123:1996;399-413.
38. Drapeau P., Ali D.W., Buss R.R., Saint-Amant L. In vivo recording from identifiable neurons of the locomotor network in the developing zebrafish. J Neurosci Methods. 88:1999;1-13.
39. Selverston A., Elson R., Rabinovich M., Huerta R., Abarbanel H. Basic principles for generating motor output in the stomatogastric ganglion. Ann NY Acad Sci. 860:1998;35-50.
40. Fenelon V.S., Casasnovas B., Simmers J., Meyrand P. Development of rhythmic pattern generators. Curr Opin Neurobiol. 8:1998;705-709.
41. Fenelon V.S., Casasnovas B., Faumont S., Meyrand P. Ontogenetic alteration in peptidergic expression within a stable neuronal population in lobster stomatogastric nervous system. J Comp Neurol. 399:1998;289-305.
42. Fenelon V.S., Kilman V., Meyrand P., Marder E. Sequential developmental acquisition of neuromodulatory inputs to a central pattern-generating network. J Comp Neurol. 408:1999;335-351.
43. Kilman V., Fenelon V.S., Richards K.S., Thirumalai V., Meyrand P., Marder E. Sequential developmental acquisition of cotransmitters in identified sensory neurons of the stomatogastric nervous system of the lobster, Homarus americanus and Homarus gammarus. J Comp Neurol. 408:1999;318-334.
44. Combes D., Meyrand P., Simmers J. Dynamic restructuring of a rhythmic motor program by a single mechanoreceptor neuron in lobster. J Neurosci. 19:1999;3620-3628.
45. Combes D., Meyrand P., Simmers J. Motor pattern specification by dual descending pathways to a lobster rhythm-generating network. J Neurosci. 19:1999;3610-3619.
46. Blitz D.M., Christie A.E., Coleman M.J., Norris B.J., Marder E., Nusbaum M.P. Different proctolin neurons elicit distinct motor patterns from a multifunctional neuronal network. J Neurosci. 19:1999;5449-5463. The stomatogastric network is subject to a rich variety of peptidergic control mechanisms. It is shown here that different modulatory neurons exert different specific effects on the network motor pattern. When a given modulator neuron is recruited, it will thus modify the motor pattern in a reproducible way.
47. Bartos M., Manor Y., Nadim F., Marder E., Nusbaum M.P. Coordination of fast and slow rhythmic neuronal circuits. J Neurosci. 19:1999;6650-6660.
48. Cheng J., Stein R.B., Jovanoviæ K., Yoshida K., Bennett D.J., Han Y. Identification, localization, and modulation of neural networks for walking in the mudpuppy (Necturus macalatus) spinal cord. J Neurosci. 18:1998;4295-4304.
49. Jovanoviæ K., Petrov T., Greer J.J., Stein R.B. Serotonergic modulation of the mudpuppy (Necturus maculatus) locomotor pattern in vitro. Exp Brain Res. 111:1996;57-67.
50. Wheatley M., Jovanoviæ K., Stein R.B., Lawson V. The activity of interneurons during locomotion in the in vitro necturus spinal cord. J Neurophysiol. 71:1994;2025-2032.
51. Wheatley M., Stein R.B. An in vitro preparation of the mudpuppy for simultaneous intracellular and electromyographic recording during locomotion. J Neurosci Methods. 42:1992;129-137.
52. Wheatley M., Edamura M., Stein R.B.A. comparison of intact and in-vitro locomotion in an adult amphibian. Exp Brain Res. 88:1992;609-614.
53. Jovanovic K., Petrov T., Stein R.B. Effects of inhibitory neurotransmitters on the mudpuppy (Necturus maculatus) locomotor pattern in vitro. Exp Brain Res. 1999;. in press.
54. Grillner S. Control of locomotion in bipeds, tetrapods and fish. Brooks V.B. Handbook of Physiology, section 1. The Nervous System II. Motor Contol. 1981;1179-1236 Waverly Press, Baltimore Maryland.
55. Buschges A. Inhibitory synaptic drive patterns motoneuronal activity in rhythmic preparations of isolated thoracic ganglia in the stick insect. Brain Res. 783:1998;262-271.
56. Grillner S., Matsushima T., Wadden T., Tegnér J., El Manira A., Wallén P. The neurophysiological bases of undulatory locomotion in vertebrates. Semin Neurosci. 5:1993;17-27.
57. Grillner S., Parker D., El Manira A. Vertebrate locomotion - a lamprey perspective. Ann NY Acad Sci. 860:1998;1-18.
58. Grillner S., Ekeberg, El Manira A., Lansner A., Parker D., Tegner J., Wallen P. Intrinsic function of a neuronal network - a vertebrate central pattern generator. Brain Res Brain Res Rev. 26:1998;184-197.
59. Tegner J., Lansner A., Grillner S. Modulation of burst frequency by calcium-dependent potassium channels in the lamprey locomotor system: dependence of the activity level. J Comput Neurosci. 5:1998;121-140.
60. El Manira A., Bussieres N. Calcium channel subtypes in lamprey sensory and motor neurons. J Neurophysiol. 78:1997;1334-1340.
61. Ullström M., Kotaleski J.H., Tegner J., Aurell E., Grillner S., Lansner A. Activity-dependent modulation of adaptation produces a constant burst proportion in a model of the lamprey spinal locomotor generator. Biol Cybern. 79:1998;1-14.
62. Parker D., Grillner S. Activity-dependent metaplasticity of inhibitory and excitatory synaptic transmission in the lamprey spinal cord locomotor network. J Neurosci. 19:1999;1647-1656. A short lasting application of tachykinins (10 min) causes a long lasting potentiation (24 h) of locomotor network activity in the lamprey. Inhibitory and excitatory pre-motor interneurones exhibit activity-dependent facilitation or depression of synaptic transmission to motorneurones. Tachykinins and 5-HT both profoundly modify this activity dependence, thus exerting a metaplastic effect.
63. Parker D., Grillner S. Long-lasting substance-P-mediated modulation of NMDA and induced rhythmic activity in the lamprey locomotor network involves separate RNA and protein-synthesis-dependent stages. Eur J Neurosci. 11:1999;1515-1522.
64. Parker D., Zhang W., Grillner S. Substance P modulates NMDA and responses and causes long-term protein synthesis-dependent modulation of the lamprey locomotor network. J Neurosci. 18:1998;4800-4813.
65. Parker D., Svensson E., Grillner S., Substance P. modulates sensory action potentials in the lamprey via a protein kinase C-mediated reduction of a 4-aminopyridine-sensitive potassium conductance. Eur J Neurosci. 9:1997;2064-2076.
66. Sillar K.T., Kiehn O., Kudo N. Chemical modulation of vertebrate motor circuits. Stein P.S.G., Grillner S., Selverston A.I., Stuart D.G. Neurons, Networks, and Motor Behavior. 1997;183-193 MIT Press, Cambridge, Massachusetts.
67. El Manira A., Parker D., Krieger P., Wikström M., Grillner S. Presynaptic inhibition of sensory transmission from sensory, interneuronal and supraspinal neurons to spinal target cells in lamprey. Rudomin P., Romo R., Mendell L. Presynaptic Inhibition and Neural Control. 1998;329-348 Oxford University Press, Oxford.
68. El Manira A., Tegner J., Grillner S. Locomotor-related presynaptic modulation of primary afferents in the lamprey. Eur J Neurosci. 9:1997;696-705.
69. Krieger P., Grillner S., El Manira A. Endogenous activation of metabotropic glutamate receptors contributes to burst frequency regulation in the lamprey locomotor network. Eur J Neurosci. 10:1998;3333-3342.
70. Schotland J., Shupliakov O., Wikström M., Brodin L., Srinivasan M., You Z., Herrera-Marschitz M., Zhang W., Hökfelt T., Grillner S. Control of lamprey locomotor neurons by colocalized monoamine transmitters. Nature. 374:1995;266-268.
71. Bacskai B.J., Wallén P., Lev-Ram V., Grillner S., Tsien R.Y. Activity-related calcium dynamics in lamprey motoneurons as revealed by video-rate confocal microscopy. Neuron. 14:1995;19-28.
72. 2+ currents, postinhibitory rebound, and postspike afterhyperpolatisation in lamprey neurons. J Neurophysiol 1993. 70:2606-2619.
73. Barthe J.Y., Grillner S. Neurotensin-induced modulation of spinal neurons and fictive locomotion in lamprey. J Neurophysiol. 73:1995;1308-1312.