Molecular genetic studies of schizophrenia

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 61, Issue , 1996, Pages 815-822

  Mcguffin, P ^a   Owen, M J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; CHROMOSOME 13Q; CHROMOSOME 22; CHROMOSOME 6P; CHROMOSOME 8P; CONFERENCE PAPER; GENE MUTATION; GENETIC LINKAGE; GENETIC RISK; GENETIC SUSCEPTIBILITY; HUMAN; MONOZYGOTIC TWINS; PRIORITY JOURNAL; SCHIZOPHRENIA; ANTICIPATION; ARTICLE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETICS; MOLECULAR BIOLOGY; MOLECULAR CLONING; MOLECULAR DYNAMICS; NEUROTRANSMISSION;

EID: 0030437448     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.1996.061.01.080     Document Type: Conference Paper

References (63)

1. American Psychiatric Association. 1980. Diagnostic and statistical manual (DSM-III), 3rd edition. American Psychiatric Association, Washington, D.C.
2. American Psychiatrie Association. 1987. Diagnostic and statistical manual (DSM-IIIR), 3rd edition. American Psychiatric Association, Washington, D.C.
3. Antonarakis, S.E., J. Blouin, A.E. Pulver, P. Wolyniec, V.K. Lasseter, G. Nestadt, L. Kasch, R. Babb, H.H. Kazazian, B. Dombroski, M. Kimberland, J. Ott, D. Housman, M. Karayiorgou, and C.J. Maclean. 1995. Schizophrenia susceptibility and chromosome 6p24. Nat. Genet. 11: 235.
4. Arranz, M.J., D. Collier, M. Sodhi, D. Ball, G. Roberts, J. Price, P. Sham, and R. Kerwin. 1995. Association between clozapine response and allelic variation in the 5HT2A receptor gene. Lancet 346: 281.
5. Asherson, P., C. Waash, J. Williams, M. Sargeant, C. Taylor, A. Clements, M. Gill, M. Owen, and P. McGuffin. 1994. Imprinting and anticipation. Are they relevant to genetic studies of schizophrenia? Br. J. Psychiatry 164: 619.
6. Asherson, P., R. Mant, P. Holmans, J. Williams, A. Cardno, K. Murphy, L. Jones, D. Collier, P. McGuffin, and M.J. Owen. 1996. Linkage, association and mutational analysis of the dopamine D3 receptor gene in schizophrenia. Mol. Psychiatry 1: 125.
7. Bassett, A.S. and G.H. Honer. 1994. Evidence for anticipation in schizophrenia. Am. J. Genet. 54: 864.
8. Brook, J.D., M.E. McCurrach, H.G. Harley, A.J. Buckler, D. Church, H. Aburatani, K. Hunter, V.P. Stanton, J.P. Thirion, T. Hudson, R. Sohn, B. Zemelman, R.G. Snell, S.A. Rundle, S. Crow, J. Davies, P. Shelbourne, J. Buxton, C. Jones, V. Juvonen, K. Johnson, P.S. Harper, D.J. Shaw, and D.E. Housman. 1992. Molecular basis of myotonic dystrophy: Expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member. Cell 68: 799.
9. Buckland, P.R., M.C. O'Donovan, and P. McGuffin. 1992. Changes in dopamine D1, D2 and D3 receptor mRNA levels in rat brain following antipsychotic treatment. Psychopharmacology 106: 479.
10. _. 1993. Clozapine and sulpiride upregulate dopamine D3 receptor mRNA levels. Neuropharmacology 32: 901.
11. Coon, H., S.H. Jensen, J. Holik, M. Hoff, M. Myles-Worsley, F. Reimherr, P. Wender, W Merilyne, R. Freedaman, M. Leppert, and W. Byerley. 1994. Genomic scan for genes predisposing to schizophrenia. Am. J. Med. Genet. 54: 59.
12. Crocq, M.A., R. Mant, P Asherson, J. Williams, Y. Hode, A. Mayerova, D. Collier, L. Lannfelt, P. Sokoloff, J.-C. Schwartz, M. Gill, J.-P. Macher, P. McGuffin, and M.J. Owen. 1992. Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. J. Med. Genet. 29: 858.
13. Daniels, J.K., N.M. Williams, R. Plomin, P. McGuffin, and M.J. Owen. 1995. Selective DNA pooling using automated technology: A rapid technique for allelic association studies in quantitative trasts and complex diseases. Psychiatr. Genet. 153: 268.
14. Davies, J.L., Y. Kawaguchi, S T. Bennett, J.B. Copeman, H.J. Cordell, L.E. Pritchard, P.W. Reed, S.C.L. Gough, S.C. Jenkins, S.M. Palmer, K.M., Balfour, B.R. Rowe, M. Farrall, A.H. Barnett, S.C. Bain, and J.A. Todd. 1994. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 371: 132.
15. Erdmann, J., D. Shimron-Abarbanell, and M. Rietschel. 1996. Systematic screening for mutations in the human serotonin-2A (5HT2A) receptor gene: Identification of two naturally occurring receptor variants and association analysis in schizophrenia. Hum. Gen. 97: 614.
16. Falconer, D.S. 1965. The inheritance of liability to certain diseases, estimated from the incidence among relatives. Ann. Hum. Genet. 29: 51.
17. Farmer, A.E., P. McGuffin, and I.I. Gottesman. 1987. Twin concordance and DSM III schizophrenia: Scrutinizing the validity of the definition. Arch. Gen. Psychiatry 44: 634.
18. Goate, A., M. Chartier-Harlin, M. Mullan, J. Brown, T. Crawford, L. Fidani, L. Giuffra, A. Haynes, N. Irving, L. James, R. Mant, P. Newton, K. Rooke, P. Roques, C. Talbot, M. Pericak-Vance, A. Roses, R. Williamson, M. Rossor, M. Owen, and J. Hardy. 1991. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349: 704.
19. Gottesman, I.I. 1991. Schizophrenia genesis. W.H. Freeman, New York.
20. Gottesman, I.I. and J. Shields. 1967. A polygenic theory of schizophrenia. Proc. Natl. Acad. Sci. 1: 199.
21. Gurling, H., G. Kalsi, A.H. Chen, M. Green, R. Butler, T. Read, P. Murphy, D. Curtis, T. Sharma, H. Petursson, and J. Brynjolfsson. 1995. Schizophrenia susceptibility and chromosome 6p24-22. Nat. Genet. 11: 234.
22. Huntington's Disease Collaborative Research Group 1993. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72: 971.
23. Inayama, Y., H. Yoneda, T. Ishida, Y. Nonomura, Y. Kono, J. Koh, K. Kuroda, H. Higashi, H. Asaba, and T. Sakai. 1994. An association between schizophrenia and a serotonin receptor DNA marker (5HTR2). Neuropsychopharmacology 10: 56.
24. Jonsson, E., L. Lannfelt, P. Sokoloff, J.C. Schwartz, and G. Sedrall. 1993. Lack of association between schizophrenia and alleles of the D3 receptor gene. Acta. Psychiatr. Scand. 87: 345.
25. Kehoe, P., J. Williams, S. Lovestone, G. Wilcock, M.J. Owen, and the U.K. Alzheimer's Disease Collaborative Group. 1996. Presenilin 1 polymorphism and Alzheimer's disease. Lancet 347: 1185.
26. Lannfelt, L., P. Sokoloff, M. Martres, C. Pilon, B. Giros, E. Jonsson, G. Sedvall, J.C. Schwartz, and R. Berger. 1992. Amino-acid substitution in the dopamine D3 receptor as a useful polymorphism for investigating psychiatric disorders. Psychiatr. Genet. 2: 249.
27. Liddell, M.B., A.J. Bayer, and M.J. Owen. 1995. No evidence that common allelic variation in the amyloid precursor protein (APP) gene confers susceptibility to Alzheimer's disease. Hum. Mol. Genet. 4: 853.(Abstr.)
28. Lin, M., D. Curtis, N. Williams, M. Arranz, S. Nanko, D. Collier, P. McGuffin, R. Murray, M. Owen, M. Gill, and J. Powell. 1995. Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32. Psychiatr. Genet. 5: 11.
29. Lindblad, K., P. Nylander, A. De Bruyn, D. Sourey, C. Zander, C. Engstrom, G. Holmgren, T. Hudson, J. Chotai, J. Mendlewicz, C. Van Broeckhoven, M. Schalling, and R. Adolfsson. 1995. Detection of expanded CAG repeats in bipolar affective disorder using the repeat expansion detection (RED) method. Neurobiol Dis. 2: 55.
30. Mant, R., J. Williams, P. Asherson, E. Parfitt, P. McGuffin, and M.J. Owen. 1994. Relationship between homozygosity at the dopamine D3 receptor gene and schizophrenia. Am. J. Med. Genet. 54: 21.
31. McGue, M., I.I. Gottesman, and D.C. Rao. 1985. Resolving genetic models for the transmission of schizophrenia. Genet. Epidemiol. 2: 99.
32. McGuffin, P. and E. Sturt. 1986. Genetic markers in schizophrenia. Hum. Hered. 16: 461.
33. McGuffin, P., M.J. Owen, and A,E. Farmer. 1995. Genetic basis of schizophrenia. Lancet 346: 678.
34. McGuffin, P., M.J. Owen, M.C. O'Donovan, A. Thapar, and I.I. Gottesman. 1994. Seminars in psychiatric genetics. Gaskell, London.
35. McGuffin, P., M. Sargeant, G. Hett, S. Tidmarsh, S. Whatley, and R.M. Marchbanks. 1990. Exclusion of a schizophrenia susceptibility gene from the chromosome 5q11-q13 region. New data and a reanalysis of previous reports. Am. J. Hum. Genet. 47: 524.
36. McPherson, K., C.M. Steel, and J.M. Dixon. 1994. Breast cancer - Epidemiology, risk factors and genetics. Br. Med. J. 309: 1003.
37. Moises, H.W., L. Yang, T. Li, B. Havsteen, R. Timmers, M.D. Baur, X. Liu, and I.I. Gottesman. 1995a. Potential linkage disequilibrium between schizophrenia and locus D22S278 on the long arm of chromosome 22. Am. J. Med. Genet. 60: 465.
38. Moises, H.W., L. Yang, H. Kristbjarnarson, C. Wiese, W. Byerley, G. Macciardi, V. Arolt, D. Blackwood, X. Liu, B. Sjogren, H.N. Aschauer, H. Hwu, K. Jang, W.J. Livesley, J.L. Kennedy, T. Zoega, O. Ivarsson, M. Bui, M. Yu, B. Havsteen, D. Commenges, J. Weissenbach, E. Schwinger, I.I. Gottesman, A.J. Pakstis, L. Wetterburg, K.K. Kidd, and T. Helgason. 1995b. An international two-stage genome-wide search for schizophrenia susceptibility genes. Nat. Genet. 11: 321.
39. Morris, A.G., E. Gaitonde, P.J. McKenna, J.D. Mollon, and D.M. Hunt. 1995. CAG repeat expansions and schizophrenia: Association with disease in females and with early age-at-onset. Hum. Mol. Genet. 4: 1957.
40. Mott, F.W. 1910. Hereditary aspect of nervous and mental diseases. Br. Med. J. 2: 1013.
41. Mowry, B.J., D.J. Mancarrow, D.P. Lennon, L.A. Sandkuijl, R.R. Crowe, J.M. Silverman, R.C. Mohs, L.J. Siever, J. Endicott, L. Sharpe, M.K. Walters, N.K. Hayward, and D.F. Levinson. 1995. Schizophrenia susceptibility and chromosome 6p24-22. Nat. Genet 11: 233.
42. Neale, M.C. and L.R. Cardon. 1990. Methodology for genetic studies of twins and families. Kluwer Academic, Dordrecht, The Netherlands.
43. Nimgaonkar, V.L., X.R. Zhang, J.G. Caldwell, R. Ganguli, and A. Chakravarti. 1993. Association study of schizophrenia with dopamine D3 receptor gene polymorphisms: Probable effects of family history of schizophrenia? Am. J. Med. Genet. 48: 214.
44. O'Donovan, M.C., C. Guy, N. Craddock, K.C. Murphy, A.G. Cardno, L.A. Jones, M.J. Owen, and P. McGuffin. 1995. Expanded CAG repeats in schizophrenia and bipolar disorder. Nat. Genet. 10: 380.
45. O'Donovan, M.C., C. Guy, N. Craddock, T. Bowen, P. McKeon, A. Macedo, W. Maier, D. Wildenauer, H.N. Aschauer, S. Sorbi, E. Feldman, L. Mynett-Johnson, E. Claffey, B. Nacimas, J. Valente, A. Dourado, E. Grassi, E. Lenzinger, A.M. Heiden, S. Moorhead, D. Harrison, J. Williams, P. McGuffin, and M.J. Owen. 1996. Confirmation of association between expanded CAG/CTG repeats and both schizophrenia and bipolar disorder. Psychiatr. Med. (in press).
46. Onstad, S., I. Skre, S. Torgersen, and E. Kringlen. 1991. Twin concordance for DSM-111-R schizophrenia. Acta Psychiatr. Scand. 83: 395.
47. Penrose, L.S. 1948. The problem of anticipation in pedigrees of dystrophia myotonica. Ann. Eugenics 14: 125.
48. Pulver, A.E., V.K. Lasseter, L. Kasch, P. Wolyniec, G. Nestadt, J.-L. Blouin, M. Kimberland, R. Babb, S. Vourlis, H. Chen, M. Lalioti, M.A. Morris, M. Karayiorgou, J. Ott, D. Meyers, S.E. Antonarakis, D. Housman, and H.H. Kazazian. 1995. Schizophrenia: A genome scan targets chromosome 3p and 8p as potential sites of susceptibility genes. Am. J. Med. Genet. 60: 252.
49. Pulver, E.A., M. Karayiorgou, P. Wolyniec, V.K. Lasseter, L. Kasch, G. Nestadt, S. Antonarakis, D. Housman, H.H. Kazazian, D. Meyers, J. Ott, M. Lamacz, K. Liang, J. Hanfelt, G. Ullrich, N. DeMarchi, E. Ramu, P.R. McHugh, L. Adler, M. Thomas, W.T. Carpenter, T. Manschreck, C.T. Gordon, M. Kimberland, R. Babb, J. Puck, and B. Childs. 1994a. Sequential strategy to identify a susceptibility gene for schizophrenia: Report of potential linkage on chromosome 22q12-q13.1 (part 1). Am. J. Med. Genet. 54: 36.
50. Pulver, A.E., M. Karayiorgou, V.K. Lasseter, P. Wolyniec, L. Kasch, S. Antonarakis, D. Housman, H.H. Kazazian, D. Meyers, G. Nestadt, J. Ott, K. Liang, M. Lamacz, M. Thomas, B. Childs, S.R. Diehl, S. Wang, B. Murphy, C. Sun, F.A. O'Neill, L. Nie, P. Sham, J. Burke, B.W. Dike, F. Duke, B.R. Kipps, J. Bray, W Hunt, R. Shinkwin, M.N. Nuallain, Y. Su, C.J. Maclean, D. Walsh, K.S. Kendler, M. Gill, H. Vallada, R. Mant, P. Asherson, D. Collier, E. Parfitt, E. Roberts, S. Nanko, C. Walsh, J. Daniels, R. Murray, P. McGuffin, M. Owen, C. Laurent, J. Dumas, T. D'Amato, M. Jay, M. Martinez, D. Campion, and J. Mallet. 1994b. Sequential strategy to identify a susceptibility gene for schizophrenia: Report of a potential linkage on chromosome 22q12-q13.1 (part 2). Am. J. Med. Genet. 54: 44.
51. Risch, N. 1990. Linkage strategies for genetically complex traits. III. The effect of marker polymorphism analysis on affected relative pairs. Am. J. Hum. Genet. 46: 242.
52. Sandbrink, R., T. Hartmann, C.L. Masters, and K. Beyreuther. 1996. Genes contributing to Alzheimer's disease. Mol. Psychiatry 1: 27.
53. Schizophrenia Collaborative Linkage Group. 1996. A combined analysis of D22S278 marker alleles in affected sibpairs: Support for a susceptibility locus for schizophrenia at chromosome 22q12. Am. J. Med. Genet. 67: 40.
54. Schwab, S.G., M. Albus, J. Hallnayer, S. Honig, M. Borrmann, D. Lichtermann, R.P. Ebstein, M. Ackenheil, B. Lerer, N. Risch, W. Maier, and D.R. Wildenauer. 1995. Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis. Nat. Genet. 11: 325.
55. Sherrington, R., J. Brynjolfsson, H. Petursson, M. Potter, K. Dudleston, B. Barraclough, J. Wasmuth, M. Dobbs, and H. Gurling. 1988. Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature 336: 164.
56. Sobell, J.L., L.L. Heston, and S.S. Sommer. 1992. Delineation of genetic predisposition to multifactorial disease: A general approach on the threshold of feasibility. Genomics 12: 1.
57. Sokoloff, P., L. Lannfeldt, M.P. Martres, B. Giros, M.L. Bouthenet, and J.C. Schwartz. 1992. The D3 dopamine receptor gene as a candidate gene for genetic linkage studies. In Genetic research in psychiatry (ed. J. Mendlewicz and H. Hippus), p. 135. Springer-Verlag, Berlin.
58. Spielman, R.S., R.E. McGinnis, and W.J. Ewenst. 1993. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52: 506.
59. Straub, R.E., C.J. Maclean, F.A. O'Neill, J. Burke, B. Muphy, F. Duke, R. Shinkwin, B.T. Webb, J. Zhang, D. Walsh, and K.S. Kendler. 1995. A potential vulnerability locus for schizophrenia on chromosome 6p24-22: Evidence for genetic heterogeneity. Nat. Genet. 11: 287.
60. Vallada, H., D. Curtis, P.C. Sham, R.M. Murray, P. McGuffin, S. Nanko, M. Gill, M. Owen, and D.A. Collier. 1995. Chromosome 22 markers demonstrate transmission disequilibrium with schizophrenia. Psychiatr. Genet. 5: 127.
61. Williams, J., G. Spurlock, P. McGuffin, J. Mallet, M.M. Nothen, M. Gill, H.N. Aschauer, P. Nylander, F. Macciardi, and M.J. Owen. 1996. Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. Lancet 347: 1294.
62. Williams, N.M., L.A. Jones, K.C. Murphy, A.C. Cardno, P. Asherson, J. Williams, P. McGuffin, and M.J. Owen. 1996. No evidence for allelic association between schizophrenia and markers D22S278 and D22S283. Am. J. Med. Genet. (in press).
63. Wragg, M., M. Hutton, C. Talbot, and the Alzheimer's Disease Collaborative Group. 1996. Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Lancet 347: 509.