Comparison of Methods for Analysis of Clinical [1C]Raclopride Studies

Journal of Cerebral Blood Flow and Metabolism

Volumn 16, Issue 1, 1996, Pages 42-52

  Lammertsma, A A ^a   Bench, C J ^a   Hume, S P ^a   Osman, S ^a   Gunn, K ^b   Brooks, D J ^a   Frackowiak, R S J ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Dopamine D2 receptors; Positron emission tomography; Tracer kinetic modelling; 11C raclopride

Indexed keywords

CARBON 11; RACLOPRIDE;

ADULT; ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; CEREBELLUM; COMPARTMENT MODEL; CORPUS STRIATUM; DIAGNOSTIC ACCURACY; DRUG BRAIN LEVEL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REFERENCE VALUE;

ADULT; ANTIPSYCHOTIC AGENTS; BODY FLUID COMPARTMENTS; BRAIN; CARBON RADIOISOTOPES; CEREBELLUM; CORPUS STRIATUM; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; MODELS, BIOLOGICAL; NONLINEAR DYNAMICS; PIPERAZINES; RACLOPRIDE; RECEPTORS, DOPAMINE D2; REFERENCE VALUES; REGRESSION ANALYSIS; SALICYLAMIDES; THIAZOLES; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0030060961     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199601000-00005     Document Type: Article

References (39)

1. Akaike H (1974) A new look at the statistical model identification. IEEE Trans Automat Contr 19:716-723
2. 11C-raclopride. Arch Neurol 50:474-480
3. 1C-raclopride. Psychopharmacology 112:308-314
4. Blomqvist G (1984) On the construction of functional maps in positron emission tomography. J Cereb Blood Flow Metab 4:629-632
5. Brooks DJ, Ibanez V, Playford ED, Sawle GV, Leigh PN, Kocen RS, Harding AE, Marsden CD (1991) Presynaptic and postsynaptic striatal dopaminergic function in neuroacanthocytosis: A positron emission tomographic study. Ann Neurol 30:166-171
6. 11C-raclopride and positron emission tomography. Ann Neurol 31:184-192
7. 2 sites. Neuroscience 28:275-290
8. 18F]cyclofoxy and positron emission tomography. J Cereb Blood Flow Metab 13:24-42
9. Cunningham VJ (1985) Non-linear regression techniques in data analysis. Med Inform 10:137-142
10. Cunningham VJ, Hume SP, Price GR, Ahier RG, Cremer JE, Jones AKP (1991) Compartmental analysis of diprenorphine binding to opiate receptors in the rat in vivo and its comparison with equilibrium data in vitro. J Cereb Blood Flow Metab 11:1-9
11. Farde L, Ehrin E, Eriksson L, Greitz T, Hall H, Hedström CG, Litton JE, Sedvall G (1985) Substituted benzamides as ligands for visualization of dopamine receptor binding in the human brain by positron emission tomography. Proc Natl Acad Sci USA 82:3863-3867
12. 2 dopamine receptor binding in the living human brain by PET. Science 231:258-261
13. 2 receptor increase in PET study of schizophrenia. Arch Gen Psychiatry 44:671-672
14. 2-dopamine receptors by PET. Psychopharmacology 94:471-478
15. Farde L, Wiesel FA, Halldin C, Sedvall G (19886) Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs. Arch Gen Psychiatry 45: 71-76
16. 11C]raclopride binding to D2-dopamine receptors studied by PET - A comparison to the equilibrium analysis. J Cereb Blood Flow Metab 9:696-708
17. 2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine: Relation to extrapyramidal side effects. Arch Gen Psychiatry 49:538-544
18. 3H]spiroperidol. Brain Res 136:578-584
19. 1C]citalopram as a radioligand for in vivo labelling of 5-hydroxytryptamine uptake sites. Nucl Med Biol 19:851-855
20. Hume SP, Myers R, Bloomfield PM, Opacka-Juffry J, Cremer JE, Ahier RG, Luthra SK, Brooks DJ, Lammertsma AA (1992b) Quantitation of carbon-11-labeled raclopride in rat striatum using positron emission tomography. Synapse 12: 47-54
21. 3H-raclopride: A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain. Biochem Pharmacol 34:2,251-2,259
22. 11C]deprenyl and dynamic positron emission tomography. J Cereb Blood Flow Metab 11:545-556
23. 11C]deprenyl: Inclusion of Compartmental analysis of plasma metabolites and a new model not requiring measurement of plasma metabolites. In: Quantification of Brain Function: Tracer Kinetics and Image Analysis in Brain PET(Uemura K, Lassen NA, Jones T, Kanno I, eds), Amsterdam, Excerpta Medica, pp 313-318
24. 2 receptor occupancy in hu man volunteers measured using positron emission tomography (PET). Eur J Clin Pharmacol 44:135-140
25. 11C-methyl]-( - )-cocaine PET studies in human subjects. J Cereb Blood Flow Metab 10:740-747
26. Luthra SK, Osman S, Turton DR, Vaja V, Dowsett K, Brady F (1993) An automated system based on solid phase extraction and HPLC for the routine determination in plasma of unchanged [11C]-L-deprenyl; [11C]diprenorphine; [11C]flumazenil; [11C]raclopride; and [11C]Scherring 23390. J Label Compd Radiopharm 32:518-520
27. Mintun MA, Raichle ME, Kilbourn MR, Wooten GF, Welch MJ (1984) A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol 15:217-227
28. 11C]raclopride binding in healthy young adults and schizophrenic patients - reliability and age effects. Hum Psychopharmacol 7:157-165
29. 11C]raclopride. J Cereb Blood Flow Metab 13:310-314
30. 2 receptor changes during the progression of early Parkinson's disease. Mov Disord 8:134-138
31. Robb RA, Hanson DP (1991) A software system for interactive and qualitative visualization of multidimensional biomedical images. Australas Phys Eng Sci Med 14:9-30
32. 3H-raclopride in the mouse brain in vivo. Naunyn Schmiedebergs Arch Pharmacol 340:6-12
33. Sawle GV, Colebatch JG, Shah A, Brooks DJ, Marsden CD, Frackowiak RSJ (1990) Striatal function in normal aging: Implications for Parkinson's disease. Ann Neurol 28:799-804
34. 2 receptor status. Brain 116:853-867
35. Schwarz G (1978) Estimating the dimension of a model. Ann Statist 6:461-464
36. 2 receptors in schizophrenia is underestimated by radioactive raclopride. Arch Gen Psychiatry 47:1170-1172
37. Spinks TJ, Jones T, Gilardi MC, Heather JD (1988) Physical performance of the latest generation of commercial positron scanner. IEEE Trans Nucl Sci 35:721-725
38. Swahn CG, Farde L, Halldin C, Sedvall G (1992) Ligand metabolites in plasma during PET-studies with the 11C-labelled dopamine antagonists, raclopride, SCH 23390 and N-methylspiroperidol. Hum Psychopharmacol 7:97-103
39. Volkow ND, Fowler JS, Wang GJ, Dewey SL, Schlyer D, MacGregor R, Logan J, Alexoff D, Shea C, Hitzemann R, Angrist B, Wolf AP (1993) Reproducibility of repeated measures of carbon-11-raclopride binding in the human brain. J Nucl Med 34:609-613