Childhood-onset schizophrenia: Rare but worth studying

Biological Psychiatry

Volumn 46, Issue 10, 1999, Pages 1418-1428

  Nicolson, Rob ^a   Rapoport, Judith L ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Family studies; Genetics; Schizophrenia

Indexed keywords

AUTONOMIC DYSFUNCTION; CENTRAL NERVOUS SYSTEM; CHILDHOOD DISEASE; CONTROLLED STUDY; CYTOGENETICS; DEVELOPMENTAL DISORDER; FAMILIAL DISEASE; GENETIC DISORDER; HUMAN; NERVOUS SYSTEM DEVELOPMENT; NEUROPSYCHOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POSITRON EMISSION TOMOGRAPHY; PREGNANCY COMPLICATION; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA;

AGE FACTORS; BRAIN; CHILD; CHILD, PRESCHOOL; HUMANS; MAGNETIC RESONANCE IMAGING; RISK FACTORS; SACCADES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 0032730290     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(99)00231-0     Document Type: Review

References (97)

1. Alaghband-Rad J., McKenna K., Gordon C.T., Albus K.E., Hamburger S.D., Rumsey J.M., et al. Childhood-onset schizophrenia The severity of premorbid course . J Am Acad Child Adolesc Psychiatry. 34:1995;1273-1283.
2. Diagnostic and Statistical Manual of Mental Disorders. 2nd Edition. 1968;American Psychiatric Association, Washington, DC.
3. Asarnow J.R., Ben-Meir S. Children with schizophrenia spectrum and depressive disorders A comparative study of premorbid adjustment, onset pattern and severity of impairment . J Child Psychol Psychiatry. 29:1988;477-488.
4. Asarnow J.R., Tompson M.C., Goldstein M.J. Childhood-onset schizophrenia A followup study . Schizophr Bull. 20:1994;599-617.
5. Asarnow R.F. What are the boundaries of the schizophrenia phenotype? [Abstract]. Biol Psychiatry. 45:1999;12S.
6. Asarnow R.F., Asamen J., Granholm E., Sherman T., Watkins J.M., Williams M.E. Cognitive/neuropsychological studies of children with a schizophrenic disorder. Schizophr Bull. 20:1994;647-669.
7. Bassett A.S. Chromosomal aberrations and schizophrenia. Autosomes. Br J Psychiatry. 161:1992;323-334.
8. Bearden C.E., Cannon T.D., Hollister J.M., Gasperoni T.L., Hadley T. A prospective cohort study of childhood behavioral deviance and language abnormalities as predictors of adult schizophrenia [Abstract]. Schizophr Res. 36:1999;37.
9. Bedwell JS, Keller B, Smith AK, Hamburger S, Kumra S, Rapoport JL (in press): Childhood-onset schizophrenia: Why does post-psychotic full-scale IQ decline. Am J Psychiatry.
10. Bertolino A., Kumra S., Callicott J.H., Mattay V.S., Lestz R.M., Jacobsen L., et al. Common pattern of cortical pathology in childhood-onset and adult-onset schizophrenia as identified by proton magnetic resonance spectroscopic imaging. Am J Psychiatry. 155:1998;1376-1383.
11. Bleuler (1911/1950): Dementia Praecox or the Group of Schizophrenias. Zinkin J, translator. New York: International Universities Press.
12. Buka S.L., Tsuang M.T., Lipsitt L.P. Pregnancy/delivery complications and psychiatric diagnosis. A prospective study. Arch Gen Psychiatry. 50:1993;151-156.
13. Chakos M.H., Lieberman J.A., Alvir J., Bilder R., Ashtari M. Caudate nuclei volumes in schizophrenic patients treated with typical antipsychotics or clozapine. Lancet. 345:1995;456-457.
14. Childs B., Scriver C.R. Age at onset and causes of disease. Perspect Biol Med. 29:1986;437-460.
15. Corder E.H., Saunders A.M., Risch N.J., Strittmatter W.J., Schmechel D.E., Gaskell P.C. Jr, et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet. 7:1994;180-184.
16. DeLisi L.E., Friedrich U., Wahlstrom J., Boccio-Smith A., Forsman A., Eklund K., et al. Schizophrenia and sex chromosome anomalies. Schizophr Bull. 20:1994;495-505.
17. DeSanctis S (1906): On some varieties of dementia praecox. In: Szurek SA, Berlin IN, editors (1973): Clinical Studies in Childhood Psychosis: 25 years in Collaborative Treatment and Research. New York: Bruner/Mazel, 31-47.
18. Done D.J., Johnstone E.C., Frith C.D., Golding J., Shepherd P.M., Crow T.J. Complications of pregnancy and delivery in relation to psychosis in adult life Data from the British perinatal mortality survey sample . BMJ. 302:1991;1576-1580.
19. Done D.J., Crowe T.J., Johnstone E.C., Sacker A. Childhood antecedents of schizophrenia and affective illness Social adjustment at ages 7 and 11 . BMJ. 309:1994;699-703.
20. Eagles J.M., Gibson I., Bremner M.H., Clunie F., Ebmeier K.P., Smith N.C. Obstetric complications in DSM-III schizophrenics and their siblings. Lancet. 335:1990;1139-1141.
21. Fernandez T., Yan W.L., Hamburger S., Rapoport J.L., Saunders A.M., Schapiro M., et al. Apolipoprotein E alleles in childhood-onset schizophrenia. Am J Med Genet. 88:1999;211-213.
22. FitzGerald M.G., MacDonald D.J., Krainer M., Hoover O. I, 'Neil E., Unsal H., et al. Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer. N Engl J Med. 334:1996;143-149.
23. Frangou S. The Maudsley early onset schizophrenia study Abnormal genes, abnormal brains, abnormal families [Abstract] . Biol Psychiatry. 45:1999;12S.
24. Frazier J.A., Giedd J.N., Hamburger S.D., Albus K.E., Kaysen D., Vaituzis A.C., et al. Brain anatomic magnetic resonance imaging in childhood-onset schizophrenia. Arch Gen Psychiatry. 53:1996;617-624.
25. Frazier J.A., Giedd J.N., Kaysen D., Albus K., Hamburger S., Alaghband-Rad J., Lenane M.C., McKenna K., Breier A., Rapoport J.L. Childhood-onset schizophrenia Brain MRI rescan after 2 years of clozapine maintenance treatment . Am J Psychiatry. 153:1996;564-566.
26. Frazier J.A., Alaghband-Rad J., Jacobsen L., Lenane M.C., Hamburger S., Albus K., et al. Pubertal development and onset of psychosis in childhood onset schizophrenia. Psychiatry Res. 70:1997;1-7.
27. Geddes J.R., Lawrie S.M. Obstetric complications and schizophrenia a meta-analysis . Br J Psychiatry. 167:1995;786-793.
28. Giedd JN, Jeffries NO, Blumenthal J, Castellanos FX, Vaituzis AC, Fernandez T, et al (in press): Childhood-onset schizophrenia: Progressive brain changes during adolescence. Biol Psychiatry 46:892-898.
29. Ginns E.I., St Jean P., Philibert R.A., Galdzicka M., Damschroder-Williams P., Thiel B., et al. A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish. Proc Natl Acad Sci U S A. 95:1998;15531-15536.
30. Goldberg T.E., Gold J.M. Neurocognitive functioning in patients with schizophrenia An overview . Bloom F.E., Kupfer D.J. Psychopharmacology The Fourth Generation of Progress . 1995;1245-1257 Raven Press, New York.
31. Gordon C.T., Frazier J.A., McKenna K., Giedd J., Zametkin A., Zahn T., et al. Childhood-onset schizophrenia An NIMH study in progress . Schizophr Bull. 20:1994;697-712.
32. Green W.H., Padron-Gayol M., Hardesty A.S., Bassiri M. Schizophrenia with childhood onset A phenomenological study of 38 cases . J Am Acad Child Adolesc Psychiatry. 31:1992;968-976.
33. Gunther-Genta F., Bovet P., Hohlfeld P. Obstetric complications and schizophrenia. A case-control study. Br J Psychiatry. 164:1994;165-170.
34. Gupta S., Rajaprabhakaran R., Arndt S., Flaum M., Andreasen N.C. Premorbid adjustment as a predictor of phenomenological and neurobiological indices in schizophrenia. Schizophr Res. 16:1995;189-197.
35. Hafner H., Maurer K., Loffler W., Riecher-Rossler A. The influence of age and sex on the onset and early course of schizophrenia. Br J Psychiatry. 162:1993;80-86.
36. Hollis C. Child and adolescent (juvenile onset) schizophrenia A case-control study of premorbid developmental impairments . Br J Psychiatry. 166:1995;489-495.
37. Jacobsen L.K., Giedd J.N., Vaituzis A.C., Hamburger S.D., Rajapakse J.C., Frazier J.A., et al. Temporal lobe morphology in childhood-onset schizophrenia. Am J Psychiatry. 153:1996;355-361.
38. Jacobsen L.K., Hong W.L., Hommer D.W., Hamburger S.D., Castellanos F.X., Frazier J.A., et al. Smooth pursuit eye movements in childhood-onset schizophrenia Comparison with attention-deficit hyperactivity disorder and normal controls . Biol Psychiatry. 40:1996;1144-1154.
39. Jacobsen L.K., Giedd J.N., Berquin P.C., Krain A.L., Hamburger S.D., Kumra S., et al. Quantitative morphology of the cerebellum and fourth ventricle in childhood-onset schizophrenia. Am J Psychiatry. 154:1997;1663-1669.
40. Jacobsen L.K., Giedd J.N., Rajapakse J.C., Hamburger S.D., Vaituzis A.C., Frazier J.A., et al. Quantitative magnetic resonance imaging of the corpus callosum in childhood onset schizophrenia. Psychiatry Res. 68:1997;77-86.
41. Jacobsen L.K., Giedd J.N., Tanrikut C., Brady D.R., Donohue B.C., Hamburger S.D., et al. Three-dimensional cortical morphometry of the planum temporale in childhood-onset schizophrenia. Am J Psychiatry. 154:1997;685-687.
42. Jacobsen L.K., Hamburger S.D., Van Horn J.D., Vaituzis A.C., McKenna K., Frazier J.A., et al. Cerebral glucose metabolism in childhood onset schizophrenia. Psychiatry Res. 75:1997;131-144.
43. Jacobsen L.K., Giedd J.N., Castellanos F.S., Vaituzis A.C., Hamburger S.D., Kumra S., Lenane M.C., Rapoport J.L. Progressive reduction of temporal lobe structures in childhood-onset schizophrenia. Am J Psychiatry. 155:1998;678-685.
44. Jacobsen L.K., Mittleman B.B., Kumra S., Lenane M.C., Barracchini K.C., Adams S., et al. HLA antigens in childhood-onset schizophrenia. Psychiatry Res. 78:1998;123-132.
45. Jacobsen L.K., Rapoport J.L. Childhood-onset schizophrenia implications of clinical and neurobiological research . J Child Psychol Psychiat. 38:1998;697-712.
46. Jones P., Rodgers B., Murray R., Marmot M. Child development risk factors for schizophrenia in the British 1946 birth cohort. Lancet. 344:1994;1398-1402.
47. Jones P.B., Rantakallio P., Hartikainen A.L., Isohanni M., Sipila P. Schizophrenia as a long-term outcome of pregnancy, delivery, and perinatal complications A 28-year follow-up of the 1966 north Finland general population birth cohort . Am J Psychiatry. 155:1998;355-364.
48. Kallmann F.J., Roth B. Genetic aspects of preadolescent schizophrenia. Am J Psychiatry. 112:1956;599-606.
49. Karayiorgou M., Gogos J.A. A turning point in schizophrenia genetics. Neuron. 19:1997;967-979.
50. Kegeles L.S., Humaran T.J., Mann J.J. In vivo neurochemistry of the brain in schizophrenia as revealed by magnetic resonance spectroscopy. Biol Psychiatry. 44:1998;382-398.
51. Kendler K.S., Tsuang M.T., Hays P. Age at onset in schizophrenia. A familial perspective. Arch Gen Psychiatry. 44:1987;881-890.
52. Kendler K.S. The impact of diagnostic hierarchies on prevalence estimates for psychiatric disorders. Compr Psychiatry. 29:1988;218-227.
53. Kendler K.S., Diehl S.R. The genetics of schizophrenia A current, genetic-epidemiologic perspective . Schizophr Bull. 19:1993;261-285.
54. Kendler K.S., McGuire M., Gruenberg A.M., Spellman M., OHare A., Walsh D. The Roscommon Family Study. II. The risk of nonschizophrenic nonaffective psychoses in relatives. Arch Gen Psychiatry. 50:1993;645-652.
55. Kendler K.S., McGuire M., Gruenberg A.M., O'Hare A., Spellman M., Walsh D. The Roscommon Family Study. I. Methods, diagnosis of probands, and risk of schizophrenia in relatives. Arch Gen Psychiatry. 50:1993;527-540.
56. Kendler K.S., McGuire M., Gruenberg A.M., O'Hare A., Spellman M., Walsh D. The Roscommon Family Study. III. Schizophrenia-related personality disorders in relatives. Arch Gen Psychiatry. 50:1993;781-788.
57. Kendler K.S., Gruenberg A.M., Kinney D.K. Independent diagnoses of adoptees and relatives as defined by DSM-III in the provincial and national samples of the Danish Adoption Study of Schizophrenia. Arch Gen Psychiatry. 51:1994;456-468.
58. Kendler K.S., Karkowski-Shuman L., Walsh D. Age at onset in schizophrenia and risk of illness in relatives. Results from the Roscommon Family Study. Br J Psychiatry. 169:1996;213-218.
59. Kety S.S., Wender P.H., Jacobsen B., Ingraham L.J., Jansson L., Faber B., et al. Mental illness in the biological and adoptive relatives of schizophrenic adoptees. Replication of the Copenhagen Study in the rest of Denmark. Arch Gen Psychiatry. 51:1994;442-455.
60. Kolvin I. Studies in the childhood psychoses. I. Diagnostic criteria and classification. Br J Psychiatry. 118:1971;381-384.
61. Kolvin I., Garside R.F., Kidd J.S. Studies in the childhood psychoses. IV. Parental personality and attitude and childhood psychoses. Br J Psychiatry. 118:1971;403-406.
62. Kraepelin E (1899/1919): Dementia Praecox and Paraphrenia, 8th ed. Edinburgh BR, translator. S Livingstone.
63. Kumra S., Jacobsen L.K., Lenane M., Zahn T.P., Wiggs E., Alaghband-Rad J., et al. "Multidimensionally impaired disorder" Is it a variant of very early-onset schizophrenia? J Am Acad Child Adolesc Psychiatry. 37:1988;91-99.
64. Kumra S., Bedwell J., Hommer D., Rapoport J. Comparison of smooth pursuit eye movements in pediatric patients with childhood-onset schizophrenia and "multidimensionally impaired syndrome" [Abstract]. Biol Psychiatry. 43:1998;68S.
65. Kumra S, Wiggs E, Bedwell J, Smith AK, Arling E, Albus K, et al (in press): Neuropsychological deficits in pediatric patients with childhood-onset schizophrenia and psychotic disorder not otherwise specified. Schizophr Res.
66. Lenane M.C., Nicolson R., Bedwell J., Rapoport J.L. Schizophrenia spectrum disorders in the relatives of patients with childhood-onset schizophrenia [Abstract]. Schizophr Res. 36:1999;92.
67. Levy D.L., Holzman P.S., Matthysse S., Mendell N.R. Eye tracking dysfunction and schizophrenia a critical perspective . Schizophr Bull. 19:1993;461-536.
68. Lewis S.W., Owen M.J., Murray R.M. Obstetric complications and schizophrenia Methodology and mechanisms . Schulz S.C., Tamminga C.A. Schizophrenia Scientific Progress . 1989;56-68 Oxford University Press, New York.
69. McCarley R.W., Wible C.G., Frumin M., Hirayasu Y., Levitt J.J., Fischer I.A., et al. MRI anatomy of schizophrenia. Biol Psychiatry. 45:1999;1099-1119.
70. McKenna K., Gordon C.T., Rapoport J.L. Childhood-onset schizophrenia Timely neurobiological research . J Am Acad Child Adolesc Psychiatry. 33:1994;771-781.
71. Nicolson R, Singaracharlu S, Lenane MC, Rapoport JL (1998, December): Premorbid language and motor abnormalities in childhood-onset schizophrenia: Association with genetic risk factors. Presented at the American College of Neuropsychopharmacology Annual Meeting, Puerto Rico.
72. Nicolson R., Hommer D., Thaker G., Brown M., Bedwell M., Lenane M., et al. Smooth pursuit eye movements in the relatives of patients with childhood-onset schizophrenia [Abstract]. Schizophr Res. 36:1999;93.
73. Nicolson R, Malaspina D, Giedd JN, Hamburger S, Lenane M, Bedwell J, et al (1999): Obstetrical complications in childhood-onset schizophrenia. Am J Psychiatry.
74. Nicolson R, Giedd JN, Lenane M, Hamburger S, Singaracharlu S, Bedwell J, et al (1999): Clinical and neurobiological correlates of cytogenetic abnormalities in childhood-onset schizophrenia. Am J Psychiatry.
75. O'Callaghan E., Gibson T., Colohan H.A., Buckley P., Walshe D.G., Larkin C., et al. Risk of schizophrenia in adults born after obstetric complications and their association with early onset of illness A controlled study . BMJ. 305:1993;1256-1259.
76. Picchio G.R., Gulizia R.J., Mosier D.E. Chemokine receptor CCR5 genotype influences the kinetics of human immunodeficiency virus type 1 infection in human PBL-SCID mice. J Virol. 71:1997;7124-7127.
77. Pulver A.E., Liang K.Y. Estimating effects of proband characteristics on familial risk II. The association between age at onset and familial risk in the Maryland schizophrenia sample . Genet Epidemiol. 8:1991;339-350.
78. Rapoport J.L., Giedd J., Kumra S., Jacobsen L., Smith A., Lee P., et al. Childhood-onset schizophrenia. Progressive ventricular change during adolescence. Arch Gen Psychiatry. 54:1997;897-903.
79. Rapoport J.L., Giedd J., Blumenthal J., Hamburger S., Jeffries N., Fernandez T., et al. Progressive cortical change during adolescence in childhood-onset schizophrenic subjects A longitudinal study . Arch Gen Psychiatry. 56:1999;649-654.
80. Rapoport JL (in press): Childhood Onset of "Adult Psychopathology": Clinical and Research Advances. Washington DC: American Psychiatric Press.
81. Risch N. Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet. 46:1990;222-228.
82. Ross R.G., Olincy A., Harris J.G., Radant A., Hawkins M., Adler L.E., et al. Evidence for bilineal inheritance of physiological indicators of risk in childhood-onset schizophrenia. Am J Med Genet. 88:1999;188-199.
83. Russel A.T. The clinical presentation of childhood-onset schizophrenia. Schizophr Bull. 20:1994;631-646.
84. Russell A.T., Bott L., Sammons C. The phenomenology of schizophrenia occurring in childhood. J Am Acad Child Adolesc Psychiatry. 28:1989;399-407.
85. Rutter M., Mawhood L. The long-term psychosocial sequelae of specific developmental disorders of speech and language. Rutter M., Cesar P. Biological Risk Factors for Psychosocial Disorders. 1991;233-259 Cambridge University Press, Cambridge.
86. St George-Hyslop P.H., Levesque G., Levesque L., Rommens J., Westaway D., Fraser P.E. Two homologous genes causing early-onset familial Alzheimer's disease. Cold Spring Harb Symp Quant Biol. 61:1996;559-564.
87. Sidransky E., Burgess C., Ikeuchi T., Lindblad K., Long R.T., Philibert R.A., et al. A triplet repeat on 17q accounts for most expansions detected by the repeat-expansion-detection technique. Am J Hum Genet. 62:1998;1548-1551.
88. Spencer E.K., Campbell M. Children with schizophrenia Diagnosis, phenomenology, and pharmacotherapy . Schizophr Bull. 20:1994;713-725.
89. Suvisaari J.M., Haukka J., Tanskanen A., Lonnqvist J.K. Age at onset and outcome in schizophrenia are related to the degree of familial loading. Br J Psychiatry. 173:1998;494-500.
90. Swanson C.L., Mozley L.M.H., Gur R.E. Positron emission tomography studies of cerebral metabolism and blood flow in schizophrenia. Krishnan K.R.R., Doraiswamy P.M. Brain Imaging in Clinical Psychiatry. 1997;401-424 Marcel Dekker, New York.
91. Thomas M.A., Ke Y., Levitt J., Caplan R., Curran J., Asarnow R., et al. Preliminary study of frontal lobe H-1 MR spectroscopy in childhood-onset schizophrenia. J Magn Reson Imaging. 8:1998;841-846.
92. Verdoux H., Geddes J.R., Takei N., Lawrie S.M., Bovet P., Eagles J.M., et al. Obstetric complications and age at onset in schizophrenia An international collaborative meta-analysis of individual patient data . Am J Psychiatry. 154:1997;1220-1227.
93. Watkins J.M., Asarnow R.F., Tanguay P.E. Symptom development in childhood-onset schizophrenia. J Child Psychol Psychiatry. 29:1988;865-878.
94. Weiss K.M. Genetic Variation and Human Disease Principles and Evolutionary Approaches . 1993;Cambridge University Press, New York.
95. Werry J.S. Childhood schizophrenia. Volkmar F.R. Psychoses and Pervasive Developmental Disorders in Childhood and Adolescence. 1996;1-48 American Psychiatric Press, Washington, DC.
96. Wicker L.S., Todd J.A., Prins J.B., Podolin P.L., Renjilian R.J., Peterson L.B. Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes. J Exp Med. 180:1994;1705-1713.
97. Zahn T.P., Jacobsen L.K., Gordon C.T., McKenna K., Frazier J.A., Rapoport J.L. Autonomic nervous system markers of psychopathology in childhood-onset schizophrenia. Arch Gen Psychiatry. 54:1997;904-912.