Progressive reduction of temporal lobe structures in childhood-onset schizophrenia

American Journal of Psychiatry

Volumn 155, Issue 5, 1998, Pages 678-685

  Jacobsen, Leslie K ^a,b   Giedd, Jay N ^a   Castellanos, F Xavier ^a   Vaituzis, A Catherine ^a   Hamburger, Susan D ^a   Kumra, Sanjiv ^a   Lenane, Marge C ^a   Rapoport, Judith L ^a  

^a Child Psychiatry Branch

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ARTICLE; BRAIN ATROPHY; BRAIN SIZE; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; ONSET AGE; PRIORITY JOURNAL; SCHIZOPHRENIA; TEMPORAL LOBE;

EID: 0031978814     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.155.5.678     Document Type: Article

References (56)

1. Alaghband-Rad J, McKenna K, Gordon CT, Albus KE, Hamburger SD, Rumsey JM, Frazier JA, Lenane MC, Rapoport JL: Childhood-onset schizophrenia: the severity of premorbid course. J Am Acad Child Adolesc Psychiatry 1995; 34:1273-1283
2. Jacobsen LK, Rapoport JL: Childhood onset schizophrenia: implications of clinical and neurobiological research. J Child Psychol Psychiatry (in press)
3. Jacobsen LK, Hong WL, Hommer DW, Castellanos FX, Frazier JA, Giedd JN, Gordon CT, Karp BI, McKenna K, Rapoport JL: Smooth pursuit eye movements in childhood-onset schizophrenia: comparison with ADHD and normal controls. Biol Psychiatry 1996; 40:1144-1154
4. Zahn TP, Jacobsen LK, Gordon CT, McKenna K, Frazier JA, Rapoport JL: Autonomic nervous system markers of psychopathology in childhood onset schizophrenia. Arch Gen Psychiatry 1997; 54:904-912
5. Frazier JA, Giedd JN, Hamburger SD, Albus KE, Kaysen D, King AC, Rajapakse JC, Lenane MC, McKenna K, Jacobsen LK, Gordon CT, Breier A, Rapoport JL: Brain anatomic magnetic resonance imaging in childhood onset schizophrenia. Arch Gen Psychiatry 1996; 53:617-624
6. Weinberger DR: Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 1987; 44:660-669
7. Murray RM, Lewis SW: Is schizophrenia a neurodevelopmental disorder? Br Med J 1987; 295:681-682
8. Rapoport JL, Giedd J, Kumra S, Jacobsen LK, Smith A, Lee P, Nelson J, Hamburger S: Childhood onset schizophrenia: progressive ventricular change during adolescence. Arch Gen Psychiatry 1997; 54:897-903
9. DeLisi LE, Tew W, Xie S, Hoff AL, Sakuma M, Kushner M, Lee G, Shedlack K, Smith AM, Grimson R: A prospective follow-up study of brain morphology and cognition in 1st episode schizophrenic patients: preliminary findings. Biol Psychiatry 1995; 38:349-360
10. Mathalon DH, Sullivan EV, Lim KO, Pfefferbaum A: Longitudinal analysis of MRI brain volumes in schizophrenia (abstract). Schizophr Res 1997; 24:152
11. Kemali D, Maj M, Galderisi S, Milici N, Salvati A: Ventricle-to-brain ratio in schizophrenia: a controlled follow-up study. Biol Psychiatry 1989; 26:753-756
12. Woods BT, Yurgelun-Todd D, Benes FM, Frankenburg FR, Pope HG, McSparren J: Progressive ventricular enlargement in schizophrenia: comparison to bipolar affective disorder and correlation with clinical course. Biol Psychiatry 1990; 27:341-352
13. DeLisi LE, Sakuma M, Tew W, Kushner M, Hoff AL, Grimson R: Schizophrenia as a chronic active brain process: a study of progressive brain structural change subsequent to the onset of schizophrenia. Psychiatry Res Neuroimaging 1997; 74:129-140
14. Degreef G, Ashtari M, Wu H, Borenstein M, Geisler S, Lieberman J: Follow up MRI study in first episode schizophrenia. Schizophr Res 1991; 5:183-210
15. Jaskiw GE, Juliano DM, Goldberg TE, Hertzman M, Urow-Hamell E, Weinberger DR: Cerebral ventricular enlargement in schizophreniform disorder does not progress: a seven year follow-up study. Schizophr Res 1994; 14:23-28
16. Illowsky BP, Juliano DM, Bigelow LB, Weinberger DR: Stability of CT scan findings in schizophrenia: results of an 8 year follow-up study. J Neurol Neurosurg Psychiatry 1988; 51:209-213
17. Nasrallah HA, Olson SC, McCalley-Whitters M, Chapman S, Jacoby CG: Cerebral ventricular enlargement in schizophrenia: a preliminary follow-up study. Arch Gen Psychiatry 1986; 43:157-159
18. Vita A, Sacchetti E, Valvassori G, Cazzullo CL: Brain morphology in schizophrenia: a 2- to 5-year CT scan follow-up study. Acta Psychiatr Scand 1988; 78:618-621
19. Hoffman WF, Ballard L, Turner EH, Casey DE: Three-year follow-up of older schizophrenics: extrapyramidal syndromes, psychiatric symptoms, and ventricular brain ratio. Biol Psychiatry 1991; 30:913-926
20. Sponheim SR, Iacono WG, Beiser M: Stability of ventricular size after the onset of psychosis in schizophrenia. Psychiatry Res Neuroimaging 1991; 40:21-29
21. Mayhew TM, Gundersen HJG: "If you assume, you can make an ass out of u and me": a decade of the disector for stereological counting of particles in 3D space. J Anat 1996; 188:1-15
22. Altshuler LL, Casanova MF, Goldberg TE, Kleinman JE: The hippocampus and parahippocampus in schizophrenic, suicide, and control brains. Arch Gen Psychiatry 1990; 47:1029-1034
23. Suddath RL, Christison GW, Torrey EF, Casanova MF, Weinberger DR: Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. N Engl J Med 1990; 322:789-794
24. Shenton ME, Kikinis R, Jolesz FA, Pollak SD, LeMay M, Wible CG, Hokama H, Martin J, Metcalf D, Coleman M, McCarley RW: Abnormalities of the left temporal lobe and thought disorder in schizophrenia. N Engl J Med 1992; 327:604-612
25. Barta PE, Pearlson GD, Powers RE, Richards SS, Tune LE: Auditory hallucinations and smaller superior temporal gyms volume in schizophrenia. Am J Psychiatry 1990; 147:1457-1462
26. Stefanis N, Yakeley J, Frangou S, Sharma T, O'Connell P, Morgan K, Murray R: Pregnancy and birth complications (PBC)-associated hippocampal volume reduction in sporadic schizophrenia (abstract). Schizophr Res 1997; 24:157
27. Flaum M, Swayze VW II, O'Leary DS, Yuh WTC, Ehrhardt JC, Arndt SV, Andreasen NC: Effects of diagnosis, laterally, and gender on brain morphology in schizophrenia. Am J Psychiatry 1995; 152:704-714
28. Heckers S, Heinsen H, Heinsen YC, Beckmann H: Limbic structures and lateral ventricle in schizophrenia: a quantitative postmortem study. Arch Gen Psychiatry 1990; 47:1016-1022
29. Zipursky RB, Marsh L, Lim KO, DeMent S, Shear PK, Sullivan EV, Murphy GM, Csernansky JG, Pfefferbaum A: Volumetric MRI assessment of temporal lobe structures in schizophrenia. Biol Psychiatry 1994; 35:501-516
30. DeLisi LE, Hoff AL, Schwartz JE, Shields GW, Halthore SN, Gupta SM, Henn FA, Anand AK: Brain morphology in first-episode schizophrenic-like psychotic patients: a quantitative magnetic resonance imaging study. Biol Psychiatry 1991; 29:159-175
31. DeLisi LE, Stritzke P, Riordan H, Holan V, Boccio A, Kushner M, McClelland J, Van Eyl O, Anand A: The timing of brain morphological changes in schizophrenia and their relationship to clinical outcome. Biol Psychiatry 1992; 31:241-254
32. Johnstone EC, Owens DGC, Crow TJ, Frith CD, Alexandropolis K, Bydder G, Colter N: Temporal lobe structure as determined by nuclear magnetic resonance in schizophrenia and bipolar affective disorder. J Neurol Neurosurg Psychiatry 1989; 52:736-741
33. Breier A, Buchanan RW, Elkashef A, Munson RC, Kirkpatrick B, Gellad F: Brain morphology and schizophrenia: a magnetic resonance imaging study of limbic, prefrontal cortex, and caudate structures. Arch Gen Psychiatry 1992; 49:921-926
34. Bogerts B, Ashtari M, Degreef G, Alvir JMJ, Bilder RM, Lieberman JA: Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia. Psychiatry Res 1990; 35:1-13
35. Jacobsen LK, Giedd JN, Vaituzis AC, Hamburger SD, Rajapakse JC, Frazier JA, Kaysen D, Lenane MC, McKenna K, Gordon CT, Rapoport JL: Temporal lobe morphology in childhood-onset schizophrenia. Am J Psychiatry 1996; 153:355-361; correction, 1996; 153:851
36. Bogerts B, Lieberman JA, Ashtari M, Bilder RM, Degreef G, Lerner G, Johns C, Masiar S: Hippocampus-amygdala volumes and psychopathology in chronic schizophrenia. Biol Psychiatry 1993; 33:236-246
37. Flaum M, O'Leary DS, Swayze VW II, Miller DD, Arndt S, Andreasen NC: Symptom dimensions and brain morphology in schizophrenia and related psychotic disorders. J Psychiatr Res 1995; 29:261-276
38. Menon RR, Barta PE, Aylward EH, Richards SS, Vaughn DD, Tien AY, Harris GJ, Pearlson GD: Posterior superior temporal gyrus in schizophrenia: grey matter changes and clinical correlates. Schizophr Res 1995; 16:127-135
39. Andreasen NC: Scale for the Assessment of Positive Symptoms (SAPS). Iowa City, University of Iowa, 1984
40. Andreasen NC: Scale for the Assessment of Negative Symptoms (SANS). Iowa City, University of Iowa, 1983
41. Kumra S, Frazier JA, Jacobsen LK, McKenna K, Gordon CT, Hamburger SD, Smith AK, Albus KE, Alaghband-Rad J, Lenane MC, Rapoport JL: Childhood-onset schizophrenia: a double-blind clozapine-haloperidol comparison. Arch Gen Psychiatry 1996; 53:1090-1097
42. Giedd JN, Snell JW, Lange N, Rajapakse JC, Casey BJ, Koruch PL, Vaituzis AC, Vauss YC, Hamburger SD, Kaysen D, Rapoport JL: Quantitative magnetic resonance imaging of human brain development: ages 4-18. Cereb Cortex 1996; 6:551-560
43. Snell JW, Merickel MB, Ortega JM, Goble JC, Brookeman JR, Kassell NF: Boundary estimation of complex objects using hierarchical active surface templates. Pattern Recognition 1995; 28:1599-1609
44. Rasband W: Image 1.6. Bethesda, Md, National Institutes of Health, 1993 (public domain)
45. Bilder RM, Wu H, Bogerts B, Degreef G, Ashtari M, Alvir JMJ, Snyder PJ, Lieberman JA: Absence of regional hemispheric volume asymmetries in first-episode schizophrenia. Am J Psychiatry 1994; 151:1437-1447
46. SAS Language and Procedures: Usage, version 6.07. Cary, NC, SAS Institute, 1989
47. BMDP Statistical Software I: BMDP. Berkeley, University of California Press, 1990
48. Chakos MH, Lieberman JA, Alvir J, Bilder R, Ashtari M: Caudate nuclei volumes in schizophrenic patients treated with typical antipsychotics or clozapine. Lancet 1995; 345:456-457
49. Frazier JA, Giedd JN, Kaysen D, Albus K, Hamburger S, Alaghband-Rad J, Lenane MC, McKenna K, Breier A, Rapoport JL: Childhood-onset schizophrenia: brain MRI rescan after 2 years of clozapine maintenance treatment. Am J Psychiatry 1996; 153:564-566
50. DeLisi LE: Is schizophrenia a lifetime disorder of brain plasticity, growth and aging? Schizophr Res 1997; 23:119-129
51. Keshavan MS: Neurodevelopment and schizophrenia: quo vadis? in Neurodevelopment and Adult Psychopathology. Edited by Keshavan MS, Murray RM. Cambridge, England, Cambridge University Press (in press)
52. Woods BT, Yurgelun-Todd D, Goldstein JM, Seidman LJ, Tsuang MT: MRI brain abnormalities in chronic schizophrenia: one process or more? Biol Psychiatry 1996; 40:585-596
53. Feinberg I: Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence? J Psychiatr Res 1982; 17:319-334
54. Giedd JN, Castellanos FX, Rajapakse JC, Jacobsen LK, Frazier JA, Hamburger SD, Rapoport JL: Quantitative analysis of gray matter volumes in childhood-onset schizophrenia and attention deficit/hyperactivity disorder. Abstracts of the Society for Neuroscience 1996; 22:1166
55. Aylward E, Walker E, Bettes B: Intelligence in schizophrenia: meta-analysis of the research. Schizophr Bull 1984; 10:430-459
56. Giedd JN, Vaituzis AC, Lange N, Rajapakse JC, Kaysen D, Vauss YC, Hamburger SD, Rapoport JL: Quantitative MRI of the temporal lobe, amygdala, and hippocampus in normal human development: ages 4-18. J Comp Neurol 1996; 366:223-230