Clinical and neurobiological correlates of cytogenetic abnormalities in childhood-onset schizophrenia

American Journal of Psychiatry

Volumn 156, Issue 10, 1999, Pages 1575-1579

  Nicolson, Rob ^a,b   Giedd, Jay N ^a   Lenane, Marge ^a   Hamburger, Susan ^a   Singaracharlu, Sujatha ^a   Bedwell, Jeffrey ^a   Fernandez, Tom ^a   Thaker, Gunvant K ^a   Malaspina, Dolores ^a   Rapoport, Judith L ^a  

^a YALE UNIVERSITY   (United States)

^b MSC 1600 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHILD; CHROMOSOME ABERRATION; CLINICAL ARTICLE; CYTOGENETICS; FEMALE; HUMAN; HUMAN CELL; INTELLIGENCE QUOTIENT; MALE; MENTAL DISEASE; ONSET AGE; PRIORITY JOURNAL; PSYCHOSIS; SCHIZOPHRENIA;

EID: 0032859010     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.156.10.1575     Document Type: Article

References (43)

1. Kendler KS, Diehl SR: The genetics of schizophrenia: a current, genetic-epidemiologic perspective. Schizophr Bull 1993; 19:261-285
2. Tsuang MT, Faraone SV: The case for heterogeneity in the etiology of schizophrenia. Schizophr Res 1995; 17:161-175
3. Karayiorgou M, Gogos JA: A turning point in schizophrenia genetics. Neuron 1997; 19:967-979
4. DeLisi LE, Friedrich U, Wahlstrom J, Boccio-Smith A, Forsman A, Eklund K, Crow TJ: Schizophrenia and sex chromosome anomalies. Schizophr Bull 1994; 20:495-505
5. Bassett AS: Chromosomal aberrations and schizophrenia: autosomes. Br J Psychiatry 1992; 161:323-334
6. Karayiorgou M, Morris MA, Morrow B, Shprintzen RJ, Goldberg R, Borrow J, Gos A, Nestadt G, Wolyniec PS, Lasseter VK, Eisen H, Childs B, Kazazian HH, Kucherlapati R, Antonarakis SE, Pulver AE, Housman DE: Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11. Proc Natl Acad Sci USA 1995; 92:7612-7616
7. Burn J, Goodship J: Congenital heart disease, in Emery and Rimoin's Principles and Practice of Medical Genetics, 3rd ed. Edited by Rimoin DL, Connor JM, Pyeritz RE. New York, Churchill Livingstone, 1996, pp 767-828
8. Papolos DF, Faedda GL, Veit S, Goldberg R, Morrow B, Kucherlapati R, Shprintzen RJ: Bipolar spectrum disorders in patients diagnosed with velo-cardio-facial syndrome: does a hemizygous deletion of chromosome 22q11 result in bipolar affective disorder? Am J Psychiatry 1996; 153:1541-1547
9. Childs B, Scriver CR: Age at onset and causes of disease. Perspect Biol Med 1986; 29:437-460
10. Jacobsen LK, Rapoport JL: Research update: childhood-on-set schizophrenia: implications of clinical and neurobiological research. J Child Psychol Psychiatry 1998; 39:101-113
11. Gordon CT, Frazier JA, McKenna K, Giedd J, Zametkin A, Zahn T, Hommer D, Hong W, Kaysen D, Albus KE, Rapoport JL: Childhood-onset schizophrenia: an NIMH study in progress. Schizophr Bull 1994; 20:697-712
12. McKenna K, Gordon CT, Lenane M, Kaysen D, Fahey K, Rapoport JL: Looking for childhood-onset schizophrenia: the first 71 cases screened. J Am Acad Child Adolesc Psychiatry 1994; 33:636-644
13. Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N: Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 1997; 36:980-988
14. Yan W, Jacobsen LK, Krasnewich DM, Guan XY, Lenane MC, Paul SP, Dalwadi HN, Zhang H, Long RT, Kumra S, Martin BM, Scambler PJ, Trent JM, Sidransky E, Ginns EI, Rapoport JL: Chromosome 22q11.2 interstitial deletions among childhood-onset schizophrenics and "multidimensionally impaired." Am J Med Genet 1998; 81:41-43
15. Guy W (ed): ECDEU Assessment Manual for Psychopharmacology: Publication ADM 76-338. Washington, DC, US Department of Health, Education, and Welfare, 1976, pp 157-169
16. Andreasen NC: Scale for the Assessment of Positive Symptoms (SAPS). Iowa City, University of Iowa, 1984
17. Andreasen NC: Scale for the Assessment of Negative Symptoms (SANS). Iowa City, University of Iowa, 1983
18. Wechsler D: The Wechsler Intelligence Scale for Children, 3rd ed. Cleveland, Psychological Corp, 1991
19. Jacobsen LK, Hong WL, Hommer DW, Hamburger SD, Castellanos FX, Frazier JA, Giedd JN, Gordon CT, Karp BI, McKenna K, Rapoport JL: Smooth pursuit eye movements in childhood-onset schizophrenia: comparison with attention-deficit hyperactivity disorder and normal controls. Biol Psychiatry 1996; 40:1144-1154
20. Thaker G, Kirkpatrick B, Buchanan RW, Ellsberry R, Lahti A, Tamminga C: Oculomotor abnormalities and their clinical correlates in schizophrenia. Psychopharmacol Bull 1989; 25: 491-497
21. Lawrie SM, Abukmeil SS: Brain abnormality in schizophrenia: a systematic and quantitative review of volumetric magnetic resonance imaging studies. Br J Psychiatry 1998; 172:110-120
22. Frazier JA, Giedd JN, Hamburger SD, Albus KE, Kaysen D, Vaituzis AC, Rajapakse JC, Lenane MC, McKenna K, Jacobsen LK, Gordon CT, Breier A, Rapoport JL: Brain anatomic magnetic resonance imaging in childhood-onset schizophrenia. Arch Gen Psychiatry 1996; 53:617-624
23. Lewis SW, Owen MJ, Murray RM: Obstetric complications and schizophrenia: methodology and mechanisms, in Schizophrenia: Scientific Progress. Edited by Schulz SC, Tamminga CA. New York, Oxford University Press, 1989, pp 56-68
24. Hollis C: Child and adolescent (juvenile onset) schizophrenia: a case control study of premorbid developmental impairments. Br J Psychiatry 1995; 166:489-495
25. Fyer AJ, Mannuzza SM, Klein DF, Endicott J: Schedule for Affective Disorders and Schizophrenia - Lifetime Version Modified for the Study of Anxiety Disorders (SADS-LA). New York, New York State Psychiatric Institute, 1985
26. Pfohl B, Blum N, Zimmerman M: Structured Interview for DSM-IV Personality: SIDP-IV. Iowa City, University of Iowa, Department of Psychiatry, 1995
27. Reich W, Leacock N, Shanfeld K: Diagnostic Interview for Children and Adolescents (DICA-R). St Louis, Washington University, 1995
28. Kumra S, Wiggs E, Krasnewich D, Meck J, Smith AC, Bedwell J, Fernandez T, Jacobsen LK, Lenane M, Rapoport JL: Brief report: association of sex chromosome anomalies with childhood-onset psychotic disorders. J Am Acad Child Adolesc Psychiatry 1998; 37:292-296
29. Gordon CT, Krasnewich D, White B, Lenane M, Rapoport JL: Brief report: translocation involving chromosomes 1 and 7 in a boy with childhood-onset schizophrenia. J Autism Dev Disord 1994; 24:537-545
30. Nicolson R, Rapoport JL: Childhood-onset schizophrenia: what can it teach us? in Childhood Onset of "Adult" Psychopathology: Clinical and Research Advances. Edited by Rapoport JL. Washington, DC, American Psychiatric Press (in press)
31. Kendler KS: The impact of diagnostic hierarchies on prevalence estimates for psychiatric disorders. Compr Psychiatry 1988; 29:218-227
32. Nielsen J, Wohlert M: Chromosome abnormalities found among 34,910 newborn children: results from a 13-year incidence study in Arhus, Denmark. Hum Genet 1991; 87:81-83
33. Bassett AS, Chow E, Scutt L, Hodgkinson K, Weksberg R: Psychiatric phenotype of a genetic subtype of schizophrenia (abstract). Schizophr Res 1999; 36:87
34. Weis S, Weber G, Neuhold A, Rett A: Down syndrome: MR quantification of brain structures and comparison with normal control subjects. AJNR Am J Neuroradiol 1991; 12:1207-1211
35. Murphy DG, DeCarli C, Daly E, Haxby JV, Allen G, White BJ, McIntosh AR, Powell CM, Horwitz B, Rapoport SI: X-chromosome effects on female brain: a magnetic resonance imaging study of Turner's syndrome. Lancet 1993; 342:1197-1200
36. Jernigan TL, Bellugi U, Sowell E, Doherty S, Hesselink JR: Cerebral morphologic distinctions between Williams and Down syndromes. Arch Neurol 1993; 50:186-191
37. Bingham PM, Zimmerman RA, McDonald-McGinn D, Driscoll D, Emanuel BS, Zackai E: Enlarged sylvian fissures in infants with interstitial deletion of chromosome 22q11. Am J Med Genet 1997; 74:538-543
38. Murray RM, Lewis SW: Is schizophrenia a neurodevelopmental disorder? BMJ 1987; 295:681-682
39. Weinberger DR: Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 1987; 44:660-669
40. Risch N: Linkage strategies for genetically complex traits, I: multilocus models. Am J Hum Genet 1990; 46:222-228
41. Jones P, Murray RM: The genetics of schizophrenia is the genetics of neurodevelopment. Br J Psychiatry 1991; 158:615-623
42. Beitchman JH: Childhood schizophrenia: a review and comparison with adult-onset schizophrenia. Psychiatr Clin North Am 1985; 8:793-814
43. Gustavson KH, Holmgren G, Blomquist HK: Chromosomal aberrations in mildly mentally retarded children in a northern Swedish county. Ups J Med Sci Suppl 1987; 44:165-168