Common pattern of cortical pathology in childhood-onset and adult-onset schizophrenia as identified by proton magnetic resonance spectroscopic imaging

American Journal of Psychiatry

Volumn 155, Issue 10, 1998, Pages 1376-1383

  Bertolino, Alessandro ^b   Kumra, Sanjiv ^b   Callicott, Joseph H ^b   Mattay, Venkata S ^b   Lestz, Rachel M ^b   Jacobsen, Leslie ^b   Barnett, Ian S ^b   Duyn, Jeff H ^b   Frank, Joseph A ^b   Rapoport, Judith L ^b   Weinberger, Daniel R ^a  

^a St Elizabeths Hospital   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE; CREATINE; CREATINE PHOSPHATE; N ACETYLASPARTIC ACID;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; MORPHOMETRICS; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA; SPECTROSCOPY;

EID: 18744428638     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.155.10.1376     Document Type: Article

References (65)

1. Green WH, Padron-Gayol M, Hardesty AS, Bassiri M: Schizophrenia with childhood onset: a phenomenological study of 38 cases. J Am Acad Child Adolesc Psychiatry 1992; 31:976-986
2. Werry JS: Child and adolescent (early onset) schizophrenia: a review in light of DSM-III-R. J Autism Dev Disorder 1992; 22: 601-624
3. Zahn TP, Jacobsen LK, Gordon CT, McKenna K, Frazier JA, Rapoport JL: Autonomic nervous system markers of psychopathology in childhood onset schizophrenia. Arch Gen Psychiatry 1997; 54:904-912
4. Jacobsen LK, Hong WL, Hommer DW, Hamburger SD, Castellanos FX, Frazier JA, Giedd JN, Gordon CT, Karp BI, McKenna K, Rapoport JL: Smooth pursuit eye movements in childhood-onset schizophrenia: comparison with attention-deficit hyperactivity disorder and normal controls. Biol Psychiatry 1996; 40:1144-1154
5. Asarnow RF, Sherman T, Strandburg R: The search for the psychobiological substrate of childhood onset schizophrenia. J Am Acad Child Psychiatry 1986; 25:604-614
6. Goldberg TE, Gold JM: Neurocognitive deficits in schizophrenia, in Schizophrenia. Edited by Hirsch SR, Weinberger DR. Oxford, England, Blackwell Science, 1995, pp 142-162
7. Frazier JA, Giedd JN, Hamburger SD, Albus KE, Kaysen D, Vaituzis AC, Rajapakse JC, Lenane MC, McKenna K, Jacobsen LK, Gordon CT, Breier A, Rapoport JL: Brain anatomic magnetic resonance imaging in childhood-onset schizophrenia. Arch Gen Psychiatry 1996; 53:617-624
8. Rapoport JL, Giedd J, Kumra S, Jacobsen L, Smith A, Lee P, Nelson J, Hamburger S: Childhood-onset schizophrenia: progressive ventricular change during adolescence. Arch Gen Psychiatry 1997; 54:897-903
9. Urenjak J, Williams SR, Gadian DG, Noble M: Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosci 1993; 13:981-989
10. Toft PB, Leth H, Lou HC, Pryds O, Henriksen O: Metabolite concentrations in the developing brain estimated with proton MR spectroscopy. J Magn Reson Imaging 1994; 4:674-680
11. Arnold DL, Matthews PM, Francis G, Antel J: Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: assessment of the load of disease. Magn Reson Med 1990; 14:154-159
12. De Stefano N, Matthews PM, Arnold DL: Reversible decreases in N-acetylaspartate after acute brain injury. Magn Reson Med 1995; 34:721-727
13. Hugg JW, Kuzniecky RI, Gilliam FG, Morawetz RB, Fraught RE, Hetherington HP: Normalization of contralateral metabolic function following temporal lobectomy demonstrated by 1H magnetic resonance spectroscopic imaging. Ann Neurol 1996; 40:236-239
14. Cheng LL, Ma MJ, Becerra L, Ptak T, Tracey I, Lackner A, Gonzalez RG: Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy. Proc Natl Acad Sci USA 1997; 94:6408-6413
15. Miller BL: A review of chemical issues in 1H NMR spectroscopy: N-acetyl-L-aspartate, creatine and choline. NMR Biomed 1991; 4:47-52
16. Barker PB, Breiter SN, Soher BJ, Chatham JC, Forder JR, Samphilipo MA, Magee CA, Anderson JH: Quantitative proton spectroscopy of canine brain: in vivo and in vitro correlations. Magn Reson Med 1994; 32:157-163
17. Yurgelun-Todd DA, Renshaw PF, Gruber SA, Waternaux CM, Cohen BM: Proton magnetic resonance spectroscopy of the temporal lobes in schizophrenics and normal controls. Schizophr Res 1996; 19:55-59
18. Renshaw PF, Yurgelun-Todd DA, Tohen M, Gruber S, Cohen BM: Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis. Am J Psychiatry 1995; 152:444-446
19. Nasrallah HA, Skinner TE, Schmalbrock P, Robitaille PM: Proton magnetic resonance spectroscopy of the hippocampal formation in schizophrenia: a pilot study. Br J Psychiatry 1994; 165:481-485
20. Maier M, Ron MA, Barker GJ, Tofts PS: Proton magnetic resonance spectroscopy: an in vivo method of estimating hippocampal neuronal depletion in schizophrenia. Psychol Med 1995; 25:1201-1209
21. Buckley PF, Moore C, Long H, Larkin C, Thompson P, Mulvany F, Redmond O, Stack JP, Ennis JT, Waddington JL: 1H Magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: clinical neurodevelopmental and cognitive correlates. Biol Psychiatry 1994; 36:792-800
22. Fukuzako H, Takeuchi K, Hokazono Y, Fukuzako T, Yamada K, Hashiguchi T, Obo Y, Ueyama K, Takigawa M, Fujimoto T: Proton magnetic resonance spectroscopy of the left medial temporal and frontal lobes in chronic schizophrenia: preliminary report. Psychiatry Res 1995; 61:193-200
23. Stanley JA, Williamson PC, Drost DJ, Rylett RJ, Carr TJ, Malla A, Thompson RT: An in vivo proton magnetic resonance spectroscopy study of schizophrenia patients. Schizophr Bull 1996; 22:597-609
24. Bartha R, Williamson PC, Drost DJ, Malla A, Carr TJ, Cortese L, Canaran G, Rylett RJ, Neufeld RWJ: Measurement of glutamate and glutamine in the medial prefrontal cortex of never treated schizophrenic patients and healthy controls by proton magnetic resonance spectroscopy. Arch Gen Psychiatry 1997;54:959-965
25. Duyn JH, Gillen J, Sobering G, van Zijl PC, Moonen CTW: Multisection proton MR spectroscopic imaging of the brain. Radiology 1993; 188:277-282
26. Bertolino A, Nawroz S, Mattay VS, Barnett AS, Duyn JH, Moonen CTW, Frank JA, Tedeschi G, Weinberger DR: Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging. Am J Psychiatry 1996; 153:1554-1563
27. Bertolino A, Callicott JH, Nawroz S, Mattay VS, Duyn JH, Tedeschi G, Frank JA, Weinberger DR: Reproducibility of proton magnetic resonance spectroscopic imaging in patients with schizophrenia. Neuropsychopharmacology 1998; 18:11-19
28. Bertolino A, Callicott JH, Elman I, Mattay VS, Tedeschi G, Frank JA, Breier A, Weinberger DR: Regionally specific neuronal pathology in untreated patients with schizophrenia: a proton magnetic resonance spectroscopic imaging study. Biol Psychiatry 1998; 43:641-648
29. Deicken RF, Zhou L, Corwin F, Vinogradov S, Weiner MW: Decreased left frontal lobe N-acetylaspartate in schizophrenia. Am J Psychiatry 1997; 154:688-690
30. Bertolino A, Saunders RC, Mattay VS, Bachevalier J, Frank JA, Weinberger DR: Proton magnetic resonance spectroscopic imaging in monkeys with mesial temporo-limbic lesions. Cereb Cortex 1997; 7:740-748
31. Orvaschel H, Tabrizi MA, Chambers W: Schedule for Affective Disorders and Schizophrenia for School-Age Children - Epidemiologic Version, 3rd ed. New York, New York State Psychiatric Institute and Yale University School of Medicine, 1980
32. Reich W, Welner Z: Diagnostic Interview for Children and Adolescents-RC (DSM-III-R Version). St Louis, Washington University, 1988
33. Hollingshead A, Frederick RC: Social stratification and psychiatric disorders. Am Sociological Rev 1958; 18:163-169
34. Talaraich J, Tournoux P: A Co-Planar Sterotaxic Atlas of a Human Brain. Stuttgart, Germany, Theime, 1988
35. Duvernoy HM, Cabnis EA: The Human Brain: Surface, Three-Dimensional Sectional Anatomy, and MRI. New York, Springer-Verlag, 1991
36. Andreasen NC: Scale for the Assessment of Positive Symptoms (SAPS). Iowa City, University of Iowa, 1983
37. Andreasen NC: Scale for the Assessment of Negative Symptoms (SANS). Iowa City, University of Iowa, 1983
38. Overall JE, Gorham DR: The Brief Psychiatric Rating Scale. Psychol Rep 1962; 10:799-812
39. Weinberger DR: Anteromedial temporal-prefrontal connectivity: a functional neuroanatomical system implicated in schizophrenia, in Psychopathology and the Brain. Edited by Carroll BJ, Barrett JE. New York, Raven Press, 1991, pp 25-43
40. Falkai P, Bogerts B: Cell loss in the hippocampus of schizophrenics. Eur Arch Psychiatry Neurol Sci 1986; 236:154-161
41. Jakob H, Beckman H: Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J Neural Transm 1989; 65:303-326
42. Jeste DV, Lohr JB: Hippocampal pathologic findings in schizophrenia: a morphometric study. Arch Gen Psychiatry 1989; 46:1019-1024
43. Arnold SE, Hyman BT, Van Hoesen GW, Damasio AR: Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia. Arch Gen Psychiatry 1991; 48:625-632
44. Selemon LD, Rajkowska G, Goldman-Rakic PS: Abnormally high neuronal density in the schizophrenic cortex: a morphometric analysis of prefrontal area 9 and occipital area 17. Arch Gen Psychiatry 1995; 52:805-818
45. Suddath RL, Christison GW, Torrey EF, Casanova MF, Weinberger DR: Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. N Engl J Med 1990; 322:789-794
46. Breier A, Buchanan RW, Elkashef A, Munson RC, Kirkpatrick B, Cellad F: Brain morphology and schizophrenia: a magnetic resonance imaging study of limbic prefrontal cortex and caudate structures. Arch Gen Psychiatry 1992; 49:921-926
47. Bogerts B, Lieberman JA, Ashtari M, Bilder RM, Degreef G, Lerner G, Johns C, Masiar S: Hippocampus-amygdala volumes and psychopathology in chronic schizophrenia. Biol Psychiatry 1993; 33:236-246
48. Marsh L, Suddath R, Higgins N, Weinberger DR: Medial temporal lobe structures in schizophrenia: relationship of size to duration of illness. Schizophr Res 1994; 11:225-238
49. Zipursky RB, Marsh L, Lim KO, DeMent S, Shear PK, Sullivan EV, Murphy GM, Csernansky JG, Pfefferbaum A: Volumetric MRI assessment of temporal lobe structures in schizophrenia. Biol Psychiatry 1994; 35:501-516
50. Andreasen NC, Flashman L, Flaum M, Arndt S, Swayze V, O'Leary DS, Ehrhardt JC, Yuh WT: Regional brain abnormalities in schizophrenia measured with magnetic resonance imaging. JAMA 1994; 272:1763-1769
51. Kelsoe JR, Cadet JL, Pickar D, Weinberger DR: Quantitative neuroanatomy in schizophrenia. Arch Gen Psychiatry 1988; 45:533-541
52. Weinberger DR, Berman KF: Prefrontal function in schizophrenia: confounds and controversies. Philos Trans R Soc Lond B Biol Sci 1996; 351:1495-1503
53. Tsai G, Passani LA, Slusher BS, Carter R, Baer L, Kleinman JE, Coyle JT: Abnormal excitatory neurotransmitter metabolism in schizophrenic brains. Arch Gen Psychiatry 1995; 52: 829-836
54. Jacobsen LK, Hamburger SD, Van Horn JD, Vaituzis AC, McKenna K, Frazier JA, Gordon CT, Lenane MC, Rapoport JL, Zametkin AJ: Cerebral glucose metabolism in childhood onset schizophrenia. Psychiatry Res 1997; 75:131-144
55. Thomas AM, Ke Y, Caplan R, Levitt J, Azarnow R, Curran J, McCracken J: Frontal lobe 1H-MR spectroscopy of children with schizophrenia. International Society of Magnetic Resonance in Medicine Abstracts 1996; 3:1000
56. 1 selective cholinergic agonist. Am J Psychiatry 1997; 154:1459-1461
57. Stoll A, Renshaw PF, De Micheli E, Wurtmann R, Pillay SS, Cohen B: Choline ingestion increases the resonance of choline-containing compounds in human brain: an in vivo proton magnetic resonance study. Biol Psychiatry 1995; 37:170-174
58. Gadian DG, Connelly A, Duncan JS, Cross JH, Kirkham FJ, Johnson CL, Vargha-Khadem F, Neville BGR, Jackson GD: 1H Magnetic resonance spectroscopy in the investigation of intractable epilepsy. Acta Neurol Scand Suppl 1994; 152:116-121
59. Hetherington H, Kuzniecky R, Pan J, Mason G, Morawetz R, Harris C, Faught E, Vaughan T, Pohost G: Proton nuclear magnetic resonance spectroscopic imaging of human temporal lobe epilepsy at 4.1 T. Ann Neurol 1995; 38:396-404
60. Brenner RE, Munro PM, Williams SC, Bell JD, Barker GJ, Hawkins CP, Landon DN, McDonald WI: The proton NMR spectrum in acute EAE: the significance of the change in the Cho:Cr ratio. Magn Reson Med 1993; 29:737-745
61. De Stefano N, Matthews P, Antel JP, Preul M, Francis G, Arnold DL: Chemical pathology of acute demyelinating lesions and its correlations with disability. Ann Neurol 1995; 38:901-909
62. Vion-Dury J, Salvan AM, Confort-Gouny S, Dhiver C, Cozzone P: Reversal of brain metabolic alterations with zidovudine detected by proton localised magnetic resonance spectroscopy. Lancet 1995; 345:60-61
63. Rango M, Spagnoli D, Tomei G, Bamonti F, Scarlato G, Zetta L: Central nervous system transsynaptic effects of acute axonal injury: a 1H magnetic resonance spectroscopy study. Magn Reson Med 1995; 33:595-600
64. Falconer JC, Liu SJ, Abbe RA, Narayana PA: Time dependence of N-acetyl-aspartate, lactate, and pyruvate concentrations following spinal cord injury. J Neurochem 1996; 66:717-722
65. Okumura N, Otsuki S, Nasu H: The influence of insulin hypoglycaemic coma, repeated electroshocks, and chlorpromazine or beta-phenylisopropylmethylamine administration on the free amino acids in the brain. J Biochem 1959; 46:247-252