Childhood-onset schizophrenia: Progressive brain changes during adolescence

Biological Psychiatry

Volumn 46, Issue 7, 1999, Pages 892-898

  Giedd, Jay N ^a   Jeffries, Neal O ^a   Blumenthal, Jonathan ^a   Castellanos, F X ^a   Vaituzis, Anna C ^a   Fernandez, Thomas ^a   Hamburger, Susan D ^a   Liu, Hong ^a   Nelson, Jean ^a   Bedwell, Jeff ^a   Tran, Lan ^a   Lenane, Marge ^a   Nicolson, Rob ^a   Rapoport, Judith L ^a  

^a Child Psychiat Br Natl I   (United States)

Author keywords

Adolescence; Brain; Child; Longitudinal; MRI; Schizophrenia

Indexed keywords

ADOLESCENCE; ADULT; AMYGDALOID NUCLEUS; ARTICLE; BRAIN DEVELOPMENT; BRAIN MALFORMATION; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SCHIZOPHRENIA;

ADOLESCENT; ADULT; AMYGDALA; BRAIN; CEREBRAL CORTEX; CEREBRAL VENTRICLES; CHILD; CROSS-SECTIONAL STUDIES; DELIRIUM, DEMENTIA, AMNESTIC, COGNITIVE DISORDERS; DISEASE PROGRESSION; FEMALE; HIPPOCAMPUS; HUMANS; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; SCHIZOPHRENIA, CHILDHOOD;

EID: 0032845546     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(99)00072-4     Document Type: Article

References (45)

1. Alaghband-Rad J., Hamburger S.D., Giedd J.N., Frazier J.A., Rapoport J.L. Childhood-onset schizophrenia Biological markers in relation to clinical characteristics . Am J Psychiatry. 154:1997;64-68.
2. Andreasen N.C. The Scale for the Assessment of Negative Symptoms (SANS). 1983;University of Iowa, Iowa City, Iowa.
3. Andreasen N.C. The Scale for the Assessment of Positive Symptoms (SAPS). 1984;University of Iowa, Iowa City, Iowa.
4. Asarnow R.F., Asamen J., Granholm E., Sherman T., Watkins J.M., Williams M.E. Cognitive/neuropsychological studies of children with a schizophrenic disorder. Schizophr Bull. 20:1994;647-669.
5. Bergin P.S., Raymond A.A., Free S.L., Sisodiya S.M., Stevens J.M. Magnetic resonance volumetry. Neurology. 44:1994;1770-1771.
6. Bogerts B., Lieberman J.A., Ashtari M., Bilder R.M., Degreef G., Lerner G., et al. Hippocampus-amygdala volumes and psychopathology in chronic schizophrenia. Biol Psychiatry. 33:1993;236-246.
7. Bremner J.D., Randall P., Scott T.M., Bronen R.A., Seibyl J.P., Southwick S.M. MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. Am J Psychiatry. 152:1995;973-981.
8. Bremner J.D., Randall P., Vermetten E., Staib L., Bronen R.A., Mazure C., et al. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse - a preliminary report. Biol Psychiatry. 41:1997;23-32.
9. Chugani H.T., Hovda D.A., Villablanca J.R., Phelps M.E., Xu W.F. Metabolic maturation of the brain A study of local cerebral glucose utilization in the developing cat . J Cereb Blood Flow Metab. 11:1991;35-47.
10. Cook M.J., Fish D.R., Shorvon S.D., Straughan K., Stevens J.M. Hippocampal volumetric and morphometric studies in frontal and temporal lobe epilepsy. Brain. 115:1992;1001-1015.
11. Davis K.L., Buchsbaum M.S., Shihabuddin L., Spiegel-Cohen J., Metzger M., Frecska E., et al. Ventricular enlargement in poor-outcome schizophrenia. Biol Psychiatry. 43:1998;783-793.
12. Degreef G., Ashtari M., Bogerts B., Bilder R.M., Jody D.N., Alvir J.M., et al. Volumes of ventricular system subdivisions measured from magnetic resonance images in first-episode schizophrenic patients. Arch Gen Psychiatry. 49:1992;531-537.
13. DeLisi L.E., Sakuma M., Tew W., Kushner M., Hoff A.L., Grimson R. Schizophrenia as a chronic active brain process A study of progressive brain structural change subsequent to the onset of schizophrenia . Psychiatry Res. Neuroimaging. 74:1997;129-140.
14. DeLisi L.E., Stritzke P., Riordan H., Holan V., Boccio A., Kushner M., et al. The timing of brain morphological-changes in schizophrenia and their relationship to clinical outcome. Biol Psychiatry. 31:1992;241-254.
15. Diggle P.J., Liang K.Y., Zeger S.L. Analysis of Longitudinal Data. 1994;Oxford University Press, Oxford.
16. Dwork A.J. Postmortem studies of the hippocampal formation in schizophrenia. Schizophr Bull. 23:1997;385-402.
17. Frazier J.A., Giedd J.N., Hamburger S.D., Albus K.E., Kaysen D., Vaituzis A.C., et al. Brain anatomic magnetic resonance imaging in childhood onset schizophrenia. Arch Gen Psychiatry. 53:1996;617-624.
18. Giedd J.N., Castellanos F.X., Rajapakse J.C., Vaituzis A.C., Rapoport J.L. Sexual dimorphism of the developing human brain. Prog Neuropsychopharmacol Biol Psychiatry. 21:1997;1185-1201.
19. Giedd J.N., Kozuch P., Kaysen D., Vaituzis A.C., Hamburger S.D., Bartko J.J., et al. Reliability of cerebral measures in repeated examinations with magnetic resonance imaging. Psychiatry Res. 61:1995;113-119.
20. Giedd J.N., Snell J.W., Lange N., Rajapakse J.C., Kaysen D., Vaituzis A.C., et al. Quantitative magnetic resonance imaging of human brain development Ages 4-18 . Cereb Cortex. 6:1996;551-560.
21. Giedd J.N., Vaituzis A.C., Hamburger S.D., Lange N., Rajapakse J.C., Kaysen D., et al. Quantitative MRI of the temporal lobe, amygdala, and hippocampus in normal human development Ages 4-18 years . J Comp Neurol. 366:1996;223-230.
22. Gur R.C., Cowell P.E., Turetsky B.I., Gallacher F., Cannon T.D., Bilker W., et al. A follow up magnetic resonance imaging study of schizophrenia. Relationship of neuroanatomic changes to clinical and neurobehavioral measures. Arch Gen Psychiatry. 55:1998;145-152.
23. Heckers S., Heinsen H., Heinsen Y.C., Beckmann. Limbic structures and lateral ventricle in schizophrenia. Arch Gen Psychiatry. 47:1990;1016-1022.
24. Huttenlocher P.R. Synapse elimination and plasticity in developing human cerebral cortex. Am J Ment Defic. 88:1984;488-496.
25. Illowsky B.P., Juliano D.M., Bigelow L.B., Weinberger D.R. Stability of CT scan findings in schizophrenia Results of an 8 year follow-up study . J Neurol Neurosurg Psychiatry. 51:1988;209-213.
26. Jacobsen L.K., Giedd J.N., Castellanos F.X., Vaituzis A.C., Hamburger S.D., Kumra S., et al. Progressive reduction of temporal lobe structures in childhood-onset schizophrenia. Am J Psychiatry. 155:1998;678-685.
27. Jacobsen L.K., Rapoport J.L. Research update Childhood-onset schizophrenia: Implications of clinical and neurobiological research . J Child Psychol Psychiatry. 39:1998;101-113.
28. Keshavan M.S., Haas G.L., Kahn C.E., Aguilar E., Dick E.L., Schooler N.R., et al. Superior temporal gyrus and the course of early schizophrenia Progressive, static, or reversible? J Psychiatr Res. 32:1998;161-167.
29. Kumra S., Jacobsen L.K., Lenane M., Karp B.I., Frazier J.A., Smith A.K., et al. Childhood-onset schizophrenia An open-label study of olanzapine in adolescents . J Am Acad Child Adolesc Psychiatry. 37:1998;377-385.
30. Lawrie S.M., Abukmeil S.S. Brain abnormality in schizophrenia - A systematic and quantitative review of volumetric magnetic resonance imaging studies. Br J Psychiatry. 172:1998;110-120.
31. Lim K.O., Harris D., Beal M., Hoff A.L., Minn K., Csernansky J.G., et al. Gray matter deficits in young onset schizophrenia are independent of age of onset. Biol Psychiatry. 40:1996;4-13.
32. Marsh L., Suddath R.L., Higgins N., Weinberger D.R. Medial temporal lobe structures in schizophrenia Relationship of size to duration of illness . Schizophr Res. 11:1994;225-238.
33. McKenna K., Gordon C.T., Lenane M., Kaysen D., Fahey K., Rapoport J.L. Looking for childhood-onset schizophrenia The first 71 cases screened . J Am Acad Child Adol Psychiatry. 33:1994;636-644.
34. Nelson M.D., Saykin A.J., Flashman L.A., Riordan H.J. Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging - A meta-analytic study. Arch Gen Psychiatry. 55:1998;433-440.
35. Nolte J. Olfactory and limbic systems. Farrell R. The Human Brain. An Introduction to Its Functional Anatomy. 3rd ed. 1993;397-413 Mosby-Year Book, Inc, St. Louis.
36. Overall J.E., Gorham D.E. The brief psychiatric rating scale. Psychol Rep. 10:1961;799-812.
37. Rapoport J.L., Giedd J., Kumra S., Jacobsen L., Smith A., Lee P., et al. Childhood-onset schizophrenia - Progressive ventricular change during adolescence. Arch Gen Psychiatry. 54:1997;897-903.
38. Rasband W (1993): Image (1.6), Bethesda, MD: National Institues of Health (Public Domain).
39. Selemon L.D., Goldman-Rakic P. The reduced neuropil hypothesis A circuit based model of schizophrenia . Biol Psychiatry. 45:1999;17-25.
40. Sheline Y.I. Neuroanatomical changes associated with unipolar major depression. Neuroscientist. 4:1998;331-334.
41. Shenton M.E., Kikinis R., Jolesz F.A., Pollak S.D., LeMay M., Wible C.G., et al. Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. N Engl J Med. 327:1992;604-612.
42. Snell J.W., Merickel M.B., Ortega J.M., Goble J.C., Brookeman J.R., Kassell N.F. Model-based boundary estimation of complex objects using hierarchical active surface templates. Pattern Recognition. 28:1995;1599-1609.
43. Ware J.H., Dockery D.W., Louis T.A., Xu X.P., Ferris B.G., Speizer F.E. Longitudinal and cross-sectional estimates of pulmonary-function decline in never-smoking adults. Am J Epidemiol. 132:1990;685-700.
44. Watkins J.M., Asarnow R.F., Tanguay P.E. Symptom development in childhood onset schizophrenia. J Am Acad Child Adol Psychiatry. 6:1988;865-878.
45. Woods B.T. Is schizophrenia a progressive neurodevelopmental disorder? Toward a unitary pathogenetic mechanism. Am J Psychiatry. 155:1998;1661-1670.