Evidence for bilineal inheritance of physiological indicators of risk in childhood-onset schizophrenia

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 88, Issue 2, 1999, Pages 188-199

  Ross, Randal G ^a,b,e   Olincy, Ann ^a,b   Harris, Josette G ^a   Radant, Allen ^c   Hawkins, Marjorie ^d   Adler, Lawrence E ^a,b   Freedman, Robert ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c Puget Sound Health Care System   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

^e NONE   (United States)

Author keywords

Child; Evoked potential; Schizophrenia; Smooth pursuit

Indexed keywords

ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CONTROLLED STUDY; DISEASE SEVERITY; EVOKED AUDITORY RESPONSE; GENETIC SUSCEPTIBILITY; HUMAN; ONSET AGE; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT; SCHIZOPHRENIA; SMOOTH PURSUIT EYE MOVEMENT;

ADOLESCENT; AGE OF ONSET; ALLELES; CHILD; CHILD, PRESCHOOL; EVOKED POTENTIALS, AUDITORY; EYE MOVEMENTS; FATHERS; GENETICS, POPULATION; HUMANS; MOTHERS; RISK; SACCADES; SCHIZOPHRENIA, CHILDHOOD;

EID: 0033574644     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19990416)88:2<188::AID-AJMG17>3.0.CO;2-E     Document Type: Article

References (27)

1. Abel L, Ziegler A. 1988. Smooth pursuit eye movements in schizophrenics-What constitutes quantitative assessment? Biological Psychiatry 24:747-761.
2. Alaghband-Rad J, Hamburger SD, Giedd JN, Frazier JA, Rapoport JL. 1997. Childhood-onset schizophrenia: Biological markers in relation to clinical characteristics. Am J Psychiatr 154:64-68.
3. Alaghband-Rad J, McKenna K, Gordon CT, Albus KE, Hamburger SD, Rumsey JM, Frazier JA, Lenane MC, Rapoport JL. 1995. Childhoodonset schizophrenia: The severity of premorbid course. J Amer Acad Child Adolesc Psychiatr 34:1273-1283.
4. American Psychiatric Association. 1987. Diagnostic and statistical manual of mental disorders, 3rd ed. rev. Washington DC: American Psychiatric Association Press.
5. Arolt V, Lencer R, Nolte A, Muller-Myhsok B, Purmann S, Schurmann M, Leutelt J, Pinnow M, Schwinger E. 1996. Eye tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the disease. Am J Med Genet 67:564-579.
6. Beitchman JH. 1985. Childhood schizophrenia: A Review and comparison of adult-onset schizophrenia. Psychiatr Clinics N Am 8:793-814.
7. Davis CJ Jr, Mostofi FK, Sesterhenn IA. Renal Medullary Carcinoma. 1995. Am J Surg Pathol 19:1-11.
8. Diggs LW. 1984a. The sickle cell train in relation to the training and assignment of duties in the armed forces: II. Aseptic splenic necrosis. Aviat Space Environ Med 55:358-364.
9. Diggs LW. 1984b. The sickle cell trait in relation to the training and assignment of duties in the armed forces: III. Hyposthenuria, hematuria, sudden death, rhabdomyolysis, and acute tubular necrosis. Aviat Space Environ Med 55:271-276.
10. Endicott J, Andreasen N, Spitzer RL. 1978. Family History-Research Diagnostic Criteria. New York: Biometrics Research Division, New York State Psychiatric Institute.
11. Faraone SV, Kremen WS, Lyons MJ, Pepple JR, Siedman LJ, Tsuang MT. 1995. Diagnostic accuracy and linkage analysis: How useful are schizophrenia spectrum phenotypes. Am J Psychiatr 152:1286-1290.
12. Forget BG. 1985. Sickle cell anemia and associated homglobinopathies. In: Wyngaarden JB, Smith LH Jr., editors. Cecil textbook of medicine. Philadelphia: WB Saunders. p 927-932.
13. Freedman R, Adler LE, Bickford P, Byerley W, Coon H, Cullum CM, Griffith JM, Harris JG, Leonard S, Miller C, Myles-Worsley M, Nagamoto HT, Rose G, Waldo M. 1994. Schizophrenia and nicotinic receptors. Harvard Rev Psychiatr 2:179-192.
14. Freedman R, Adler LE, Myles-Worsley M, Nagamoto HT, Miller C, Kisley M, McRae K, Cawthra E, Waldo M. 1996. Inhibitory gating of an evoked response to repeated auditory stimuli in schizophrenic and normal subjects. Arch Gen Psychiatr 53:1114-1121.
15. Freedman R, Coon H, Myles-Worsley M, OrrUrteger A, OlincyA, Davis A, Polymeropoulos M, Holik J, Hopkins J, Hoff M, Rosenthal J, Waldo MC, Reimherr F, Wender P, Yaw J, Young DA, Breesc CR, Adams C, Patterson D, Adler LE, Kruglyak L, Leonard S, and Byerley W. 1997a. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci 94:587-592.
16. Freedman R, Ross RG, Adler LE. 1997b. Physiological indicators of the schizophrenia phenotype. In: Watson SJ, editor. Psychopharmacology: Fourth generation of progress.
17. Gottesman H, Bertelsen A. 1989. Confirming unexpressed genotypes for schizophrenia. Arch Gen Psychiatr 46:867-872.
18. Harris JG, Adler LE, Young DA, Cullum CM, Rilling LM, Cicerello A, Intemann PM, Freedman R. 1996. Neuropsychological dysfunction in parents of schizophrenics. Schiz Res 20:253-260.
19. Holzman PS, Kringlen E, Matthysse S, Flanagan SD, Lipton RB, Cramer G, Levin S, Lange K, Levy DL. 1988. A single dominant gene can account for eye tracking dysfunction and schizophrenia in offspring of discordant twins. Arch Gen Psychiatr 45:641-647.
20. Humphries JE, Wheby MS. 1992. Case report: Sickle cell trait and recurrent deep venous thrombosis. Am J Med Sci 303:112-114.
21. Jackson H, Bentley CR, Hingorani M, Atkinson P, Aclimandos WA, Thompson GM. 1995. Sickle retinopathy in patients with sickle trait. Eye 9:589-593.
22. Jacobsen LK. 1995. Physiologic markers of schizophrenia in children and adolescents. Am Acad Child Adol Psychiatr [abstracts] 11:81.
23. Jacobsen LK, Hong WL, Hommer DW, Hamburger SD, Castellanos FX, Frazier JA, Giedd JN, Gordon CT, Karp BI, McKenna K, Rapoport JL. 1996. Smooth pursuit eye movements in childhood onset schizophrenia: Comparison with attention-deficit hyperactivity disorder and normal controls. Biol Psychiatr 40:1144-1154.
24. Kark JA, Posey DM, Schumacher HR, Ruehle CJ. 1987. Sickle-cell trait as a risk factor for sudden death in physical training. New England J Med 317:781-787.
25. Kerle KK, Nishimura KD. 1996. Exertional collapse and sudden death associated with sickle cell trait. Am Family Physician 54:237-240.
26. Kozlova SI, Prytkow AN, Blinnikova OE, Sultanova FA, Bochkova DN. 1984. Presumed homozygous Ehlers-Danlos Syndrome Type I in a highly inbred kindred. Am J Med Genet 18:763-767.
27. Lane PA, Githens JH. 1985. Splenic syndrome at mountain altitudes in sickle cell trait. J Am Med Assoc 253:2251-2254.