Assembly of productive T cell receptor δ variable region genes exhibits allelic inclusion

Journal of Experimental Medicine

Volumn 188, Issue 8, 1998, Pages 1465-1471

  Sleckman, Barry P ^a,c   Khor, Bernard ^a   Monroe, Robert ^a   Alt, Frederick W ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

T cells; Allelic exclusion; T cell receptor ; T cell receptor rearrangement; T cells

Indexed keywords

DNA; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; T LYMPHOCYTE RECEPTOR;

ALLELE; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DNA SEQUENCE; FLOW CYTOMETRY; GENE REARRANGEMENT; HYBRIDOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE;

ALLELES; ANIMALS; GENE REARRANGEMENT, DELTA-CHAIN T-CELL ANTIGEN RECEPTOR; HYBRIDOMAS; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES;

EID: 0032547846     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.8.1465     Document Type: Article

References (46)

1. Sleckman, B.P., J.R. Gorman, and F.W. Alt. 1996. Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements. Annu. Rev. Immunol. 14:459-481.
2. Okada, A., and F.W. Alt. 1994. Mechanisms that control antigen receptor variable region gene assembly. Sem. Immunol. 6:185-196.
3. Malissen, M., J. Trucy, E. Jouvin-Marche, P.-A. Cazenave, R. Scollay, and B. Malissen. 1992. Regulation of TCR α and β gene allelic exclusion during T cell development. Immunol. Today. 13:315-322.
4. Alt, F.W., V. Enea, A.L. Bothwell, and D. Baltimore. 1980. Activity of multiple light chain genes in murine multiple myeloma cells producing a single, functional light chain. Cell. 21:1-12.
5. Casanova, J.-L., P. Romero, C. Widmann, P. Kourilsky, and J.L. Maryanski. 1991. T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for Plasmodium berghei nonapeptide: Implications for T cell allelic exclusion and antigen-specific repertoire. J. Exp. Med. 174:1371-1383.
6. Padovan, E., G. Casorati, P. Dellabona, S, Meyer, M. Brockhaus, and A. Eanzavecchia. 1993. Expression of two T cell receptor α chains: dual receptor T cells. Science. 262:422-424.
7. Davodeau, F., M.-A. Peyrat, I. Houde, M.-M. Hallet, G. De Libero, H. Vie, and M. Bonneville. 1993. Surface expression of two distinct functional antigen receptors on human γδ T cells. Science. 260:1800-1802.
8. Coleclough, C., R.P. Perry, K. Karjalainen, and M. Weigert. 1981. Aberrant rearrangements contribute significantly to allelic exclusion of immunoglobulin gene expression. Nature. 290:372-378.
9. Lansford, R., A. Okada, J. Chen, E.M. Oltz, T.K. Blackwell, F.W. Alt, and G. Rathbun. Mechanism and control of immunoglobulin gene rearrangement. In Molecular Immunology-Frontiers in Molecular Biology. 2nd edition. D.B. Hames, and D.M. Glover, editors. IRL Press, New York. 1-100.
10. ten Boekel, E., F. Melchers, and A. Rolink. 1995. The status of Ig rearrangements in single cells from different stages of B cell development. Int. Immunol. 7:1013-1019.
11. Wabl, M., and C. Steinberg. 1982. A theory of allelic exclusion for the immunoglobulin genes. Proc. Natl. Acad. Sci. USA. 79:6976-6978.
12. Sonoda, E., Y. Pewzner-Jung, S. Schwers, S. Taki, S. Jung, D. Eilat, and K. Rajewsky. 1997. B cell development under the condition of allelic inclusion. Immunity. 6:225-234.
13. Alt, F.A., N. Rosenberg, S. Lewis, E. Thomas, and D. Baltimore. 1981. Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not light chain genes. Cell. 27:381-390.
14. Alt, F.W., G.D. Yancopoulos, T.K. Blackwell, C. Wood, E. Thomas, M. Boss, R. Coffman, N. Rosenberg, S. Tonegawa, and D. Baltimore. 1984. Ordered rearrangement of immunoglobulin heavy chain variable region genes. EMBO (Eur. Mol. Biol. Organ.) 3:1209-1219.
15. Rusconi, S., and G. Kohler. 1985. Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line. Nature. 314:330-334.
16. Weaver, D., F. Costantini, T. Imanishi-Kari, and D. Baltimore. 1985. A transgenic immunoglobulin mu gene prevents rearrangement of endogenous genes. Cell. 42:117-127.
17. Nussenzweig, M.C., A.C. Shaw, E. Sinn, D.B. Danner, K.L. Holmes, H.C. Morse III, and P. Leder. 1987. Allelic exclusion in mice that express the membrane form of immunoglobulin μ. Science. 236:816-819.
18. Storb, U., C. Pinkert, B. Arp, P. Engler, K. Gollahon, J. Manz, W. Brady, and R. Brinster. 1986. Transgenic mice with μ and κ encoding anti-phosphorylcholine antibodies. J. Exp. Med. 164:627-638.
19. Uematsu, Y., S. Ryser, Z. Dembic, P. Borgulya, P. Krimpenfort, A. Berns, H. von Boehmer, and M. Steinmetz. 1988. In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes. Cell. 52:831-841.
20. Loffert, D., A. Ehlich, W. Muller, and K. Rajewsky. 1996. Surrogate light chain expression is required to establish heavy chain allelic exclusion during B cell development. Immunity. 4:133-144.
21. Kitamura, D., and K. Rajewsky. 1992. Targeted disruption of μ chain membrane exon causes loss of heavy-chain allelic exclusion. Nature. 356:154-156.
22. ten Boekel, E., F. Melchers, and A.G. Rolink. 1998. Precursor B cells showing H chain allelic inclusion display allelic exclusion at the level of pre-B cell receptor surface expression. Immunity. 8:199-208.
23. Aifantis, I., J. Buer, H. von Boehmer, and O. Azogui. 1997. Essential role of the pre-T cell receptor in allelic exclusion. Immunity. 7:601-608.
24. Chien, Y.-H., M. Iwashima, K.B. Kaplan, J.F. Elliot, and M.M. Davis. 1987. A new T-cell receptor gene located within the a locus and expressed early in T cell differentiation. Nature. 327:677-682.
25. Satyanarayana, K., S. Hata, P. Devlin, M.C. Roncarolo, J.E. De Vries, H. Spits, J.L. Strominger, and M.S. Krangel. 1988. Genomic organization of the human T-cell antigen-receptor α/δ locus. Proc. Natl. Acad. Sci. USA. 85:8166-8170.
26. Fehling, H.J., and H. von Boehmer. 1997. Early αβ T cell development in the thymus of normal and genetically altered mice. Curr. Opin. Immunol. 9:263-275.
27. Willerford, D.M., W. Swat, and F.W. Alt. 1996. Developmental regulation of V(D)J recombination and lymphocyte differentiation. Curr. Opin. Gen. Dev. 6:603-609.
28. Seboun, E., N. Joshi, and S. Hauser. 1992. Haplotypic origin of beta-chain genes expressed by human T-cell clones. Immunogenetics. 36:363-368.
29. Marolleau, J.-P., J.D. Fondell, M. Malissen, J. Trucy, E. Barbier, K.B. Marcu, P.-A. Cazenave, and D. Primi. 1988. The joining of germ-line Vα to Jα genes replaces the preexisting Vα-Jα complexes in a T cell receptor α,β positive T cell line. Cell. 55:291-300.
30. Borgulya, P., H. Kishi, Y. Uematsu, and H. von Boehmer. 1992. Exclusion and inclusion of α and β T cell receptor alleles. Cell. 69:529-537.
31. Kang, J., and D.H. Raulet. 1997. Events that regulate differentiation of αβ TCR+ and γδ TCR+ T cells from a common precursor. Semin. Immunol. 9:171-179.
32. Chien, Y.-H., M. Iwashima, D.A. Wettstein, K.B. Kaplan, J.F. Elliot, W. Born, and M.M. Davis. 1987. T-cell receptor δ gene rearrangements in early thymocytes. Nature. 330:722-727.
33. Migone, N., S. Padovan, C. Zappador, C. Glachino, M. Bottaro, G. Matullo, C. Carbonara, G. De Libero, and G. Casorati. 1995. Restriction of the T-cell receptor V delta gene repertoire is due to preferential rearrangement and is independent of antigen selection. Immunogenetics. 42:323.
34. Sleckman, B.P., C.G. Bardon, R. Ferrini, L. Davidson, and F.W. Alt. 1997. Function of the TCRα enhancer in αβ and γδ T cells. Immunity. 7:505-515.
35. White, J., M. Blackman, J. Bill, J. Kappler, P. Marrack, D. Gold, and W. Born. 1989. Two better cell lines for making hybridomas expressing specific T cell receptors. J. Immunol. 143:1822-1825.
36. Chen, J., R. Lansford, V. Stewart, F. Young, and F.W. Alt. 1993. RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development. Proc. Natl. Acad. Sci. USA. 90:4528-4532.
37. Laird, P.W., A. Zijderveld, K. Linders, M.A. Rudnicki, R. Jaenisch, and A. Berns. 1991. Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19:4293.
38. Yancopoulos, G.D., T.K. Blackwell, H. Suh, L. Hood, and F.W. Alt. 1986. Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell. 44:251-259.
39. Korman, A.J., J. Maruyama, and D. Raulet. 1989. Rearrangement by inversion of a T-cell receptor δ variable region gene located 3′ of the δ constant region gene. Proc. Natl. Acad. Sci. USA. 86:267-271.
40. Winoto, A., and D. Baltimore. 1989. Separate lineages of T cells expressing the αβ and γδ receptors. Nature. 338:430-432.
41. Livak, F., H.T. Petrie, I.N. Crispe, and D.G. Schatz. 1995. In-frame TCR δ gene rearrangements play a critical role in the αβ/γδ T cell lineage decision. Immunity. 2:617-627.
42. Elliott, J.F., E.P. Rock, P.A. Patten, M.M. Davis, and Y.-H. Chen. 1988. The adult T-cell receptor δ-chain is diverse and distinct from that of fetal thymocytes. Nature. 331:627-631.
43. Arden, B., S.P. Clark, D. Kabelitz, and T.W. Mak. 1995. Mouse T-cell receptor variable gene segment families. Immunogenetics. 42:501-530.
44. Sleckman, B.P., C.H. Bassing, C.G. Bardon, A. Okada, B. Khor, J.-C. Bories, R. Monroe, and F.W. Alt. 1998. Accessibility control of variable region gene assembly during T cell development. Immunol. Rev. In press.
45. Krangel, M.S., H. Yssel, C. Brocklehurst, and H. Spits. 1990. A distinct wave of human T cell receptor γ/δ lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production. J. Exp. Med. 172:847-859.
46. Livak, F., A. Wilson, H.R. MacDonald, and D. Schatz. 1997. αβ lineage-committed thymocytes can be rescued by the γ/δ T cell receptor (TCR) in the absence of TCR β chain. Eur. J. Immunol. 27:2948-2958.