New insights into the molecular basis of glucocorticoid action

Immunology and Allergy Clinics of North America

Volumn 19, Issue 4, 1999, Pages 653-670

  Bloom, J W ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; CHAPERONE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR AP 1;

AMINO ACID SEQUENCE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; CHROMATIN; DRUG MECHANISM; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE LOCATION; GENE STRUCTURE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN STRUCTURE; RECEPTOR GENE; TRANSCRIPTION REGULATION;

EID: 0032711769     PISSN: 08898561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8561(05)70115-6     Document Type: Article

References (95)

1. L. Alland R. Muhle Hou H. Jr Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression [see comments] Nature 387 1997 49 55
2. V. Allfrey R.M. Faulkner A.E. Mirsky Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis Proc Natl Acad Sci U S A 51 1964 786 794
3. J. Atsuta J. Plitt B.S. Bochner Inhibition of VCAM-1 expression in human bronchial epithelial cells by glucocorticoids Am J Respir Cell Mol Biol 20 1999 643 650
4. N. Auphan J.A. DiDonato C. Rosette Immunosuppression by glucocorticoids: Inhibition of NF-kappa B activity through induction of I kappa B synthesis [see comments] Science 270 1995 286 90
5. P.A. Baeuerle D. Baltimore NF-kappa B: Ten years after Cell 87 1996 13 20
6. Baldwin A.S. Jr The NF-kappa B and I kappa B proteins: New discoveries and insights Annu Rev Immunol 14 1996 649 683
7. C.M. Bamberger A.M. Bamberger de Castro M. Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans J Clin Invest 95 1995 2435 2441
8. P.J. Barnes Anti-inflammatory actions of glucocorticoids: Molecular mechanisms [editorial] Clin Sci (Colch) 94 1998 572 557
9. P.J. Barnes NO or no NO in asthma? Thorax 51 1996 218 220
10. P.J. Barnes I. Adcock Anti-inflammatory actions of steroids: Molecular mechanisms [see comments] Trends Pharmacol Sci 14 1993 436 441
11. P.J. Barnes M. Karin Nuclear factor-kappa B: A pivotal transcription factor in chronic inflammatory diseases N Engl J Med 336 1997 1066 1071
12. P.J. Barnes S. Pedersen W.W. Busse Efficacy and safety of inhaled corticosteroids. New developments Am J Respir Crit Care Med 157 1998 S1 S53
13. M. Beato P. Herrlich G. Schutz Steroid hormone receptors: Many actors in search of a plot Cell 83 1995 851 857
14. M. Bickel Y. Iwai D.H. Pluznik Binding of sequence-specific proteins to the adenosine- plus uridine-rich sequences of the murine granulocyte/macrophage colony-stimulating factor mRNA Proc Natl Acad Sci U S A 89 1992 10001 10005
15. J.W. Bloom Molecular pharmacology of glucocorticoids Clinical Asthma Reviews 1 1997 99 107
16. J.W. Bloom R.L. Miesfeld Molecular mechanisms of glucocorticoid action Szefler S.J. Leung D.Y.M. Severe Asthma: Pathogenesis and Clinical Management 1996 Marcel Dekker New York 255 284
17. E. Caldenhoven J. Liden S. Wissink Negative cross-talk between RelA and the glucocorticoid receptor: A possible mechanism for the antiinflammatory action of glucocorticoids Mol Endocrinol 9 1995 401 412
18. V. Cavailles S. Dauvois F. L'Horset Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor EMBO J 14 1995 3741 3751
19. D. Chakravarti V.J. LaMorte M.C. Nelson Role of CBP/P300 in nuclear receptor signalling [see comments] Nature 383 1996 99 103
20. S. Collins M.G. Caron R.J. Lefkowitz Beta-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids J Biol Chem 263 1988 9067 1970
21. K. Dahlman-Wright T. Almlof I.J. McEwan Delineation of a small region within the major transactivation domain of the human glucocorticoid receptor that mediates transactivation of gene expression Proc Natl Acad Sci U S A 91 1994 1619 1623
22. de Castro M. S. Elliot T. Kino The non-ligand binding beta-isoform of the human glucocorticoid receptor (hGR beta): Tissue levels, mechanism of action, and potential physiologic role Mol Med 2 1996 597 607
23. J. Drouin Y.L. Sun M. Chamberland Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene EMBO J 12 1993 145 156
24. O. Eickelberg M. Roth R. Lorx Ligand-independent activation of the glucocorticoid receptor by beta2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells J Biol Chem 274 1999 1005 1010
25. I.J. Encio S.D. Detera-Wadleigh The genomic structure of the human glucocorticoid receptor J Biol Chem 266 1991 7182 7188
26. M.L. Espinas J. Roux R. Pictet Glucocorticoids and protein kinase A coordinately modulate transcription factor recruitment at a glucocorticoid-responsive unit Mol Cell Biol 15 1995 5346 5354
27. R.J. Flower Lipocortin and the mechanism of action of the glucocorticoids Br J Pharmacol 94 1988 987 1015
28. U. Francke B.E. Foellmer The glucocorticoid receptor gene is in 5q31-q32 Genomics 4 1989 610 612
29. L.P. Freedman Anatomy of the steroid receptor zinc finger region Endocr Rev 13 1992 129 145
30. P.J. Godowski D. Picard K.R. Yamamoto Signal transduction and transcriptional regulation by glucocorticoid receptor-LexA fusion proteins Science 241 1988 812 816
31. P.S. Goldman V.K. Tran R.H. Goodman The multifunctional role of the co-activator CBP in transcriptional regulation Recent Prog Horm Res 52 1997 103 19
32. A.P. Greening P.W. Ind M. Northfield Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Allen & Hanburys Limited UK Study Group [see comments] Lancet 344 1994 219 224
33. B. Hanstein R. Eckner J. DiRenzo p300 is a component of an estrogen receptor coactivator complex Proc Natl Acad Sci U S A 93 1996 11540 11545
34. C.A. Hassig S.L. Schreiber Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs Curr Opin Chem Biol 1 1997 300 308
35. S. Heck M. Kullmann A. Gast A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1 EMBO J 13 1994 4087 4095
36. D.M. Heery E. Kalkhoven S. Hoare A signature motif in transcriptional co-activators mediates binding to nuclear receptors [see comments] Nature 387 1997 733 736
37. T. Heinzel R.M. Lavinsky T.M. Mullen A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression [see comments] Nature 387 1997 43 48
38. R.C. Hennekam M. Tilanus B.C. Hamel Deletion at chromosome 16p13.3 as a cause of Rubinstein-Taybi syndrome: Clinical aspects Am J Hum Genet 52 1993 255 262
39. S.M. Hollenberg R.M. Evans Multiple and cooperative trans-activation domains of the human glucocorticoid receptor Cell 55 1988 899 906
40. N.A. Huizenga J.W. Koper De Lange P. A polymorphism in the glucocorticoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo J Clin Endocrinol Metab 83 1998 144 151
41. R. Janknecht T. Hunter Transcription. A growing coactivator network [news; comment] Nature 383 1996 22 23
42. G. Jenster Coactivators and corepressors as mediators of nuclear receptor function: An update Mol Cell Endocrinol 143 1998 1 7
43. Y. Kamei L. Xu T. Heinzel A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors Cell 85 1996 403 414
44. C.D. Laherty W.M. Yang J.M. Sun Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression Cell 89 1997 349 356
45. Le Douarin B. A.L. Nielsen J.M. Garnier A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors EMBO J 15 1996 6701 6715
46. D.Y. Leung S.J. Szefler New insights into steroid resistant asthma Pediatr Allergy Immunol 9 1998 3 12
47. D.Y.M. Leung Q. Hamid A. Vottero Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta J Exp Med 186 1997 1567 1574
48. T.D. LeVan F.D. Behr K.K. Adkins Glucocorticoid receptor signaling in a bronchial epithelial cell line Am J Physiol 272 1997 L838 843
49. D.J. Mangelsdorf C. Thummel M. Beato The nuclear receptor superfamily: The second decade Cell 83 1995 835 839
50. R.L. Miesfeld J.W. Bloom Glucocorticoid receptor structure and function Schleimer R.P. Busse W.W. O'Byrne P.M. Inhaled Glucocorticoids in Asthma 1996 Marcel Dekker New York 3 27
51. J.N. Miner K.R. Yamamoto The basic region of AP-1 specifies glucocorticoid receptor activity at a composite response element Genes Dev 6 1992 2491 2501
52. J.A. Mitchell M.G. Belvisi P. Akarasereenont Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: Regulation by dexamethasone Br J Pharmacol 113 1994 1008 1014
53. M. Montminy Transcriptional activation. Something new to hang your HAT on [news; comment] Nature 387 1997 654 655
54. N. Mukaida M. Morita Y. Ishikawa Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression J Biol Chem 269 1994 13289 13295
55. L. Nagy H.Y. Kao D. Chakravarti Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase Cell 89 1997 373 380
56. R. Newton J. Seybold L.M. Kuitert Repression of cyclooxygenase-2 and prostaglandin E2 release by dexamethasone occurs by transcriptional and post-transcriptional mechanisms involving loss of polyadenylated mRNA J Biol Chem 273 1998 32312 32321
57. Y. Nobukuni C.L. Smith G.L. Hager Characterization of the human glucocorticoid receptor promoter Biochemistry 34 1995 8207 8214
58. R.H. Oakley M. Sar J.A. Cidlowski The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function J Biol Chem 271 1996 9550 9559
59. R.H. Oakley J.C. Webster M. Sar Expression and subcellular distribution of the beta-isoform of the human glucocorticoid receptor Endocrinology 138 1997 5028 5038
60. S. Okret Y. Dong M. Bronnegard Regulation of glucocorticoid receptor expression Biochimie 73 1991 51 59
61. M.J. Pazin J.T. Kadonaga What's up and down with histone deacetylation and transcription? Cell 89 1997 325 328
62. M.C. Pepin F. Pothier N. Barden Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene Nature 355 1992 725 728
63. F. Petrij R.H. Giles H.G. Dauwerse Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP [see comments] Nature 376 1995 348 351
64. A. Ray K.E. Prefontaine Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor Proc Natl Acad Sci U S A 91 1994 752 756
65. F. Re M. Muzio De Rossi M. The type II “receptor” as a decoy target for interleukin 1 in polymorphonuclear leukocytes: Characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor J Exp Med 179 1994 739 743
66. A. Ristimaki K. Narko T. Hla Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: Evidence for post-transcriptional regulation Biochem J 318 1996 325 331
67. D.D. Sakai S. Helms J. Carlstedt-Duke Hormone-mediated repression: A negative glucocorticoid response element from the bovine prolactin gene Genes Dev 2 1988 1144 1154
68. R.I. Scheinman P.C. Cogswell A.K. Lofquist Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids [see comments] Science 270 1995 283 286
69. R.I. Scheinman A. Gualberto C.M. Jewell Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors Mol Cell Biol 15 1995 943 953
70. R. Schule P. Rangarajan S. Kliewer Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor Cell 62 1990 1217 1217
71. K.A. Sheppard K.M. Phelps A.J. Williams Nuclear integration of glucocorticoid receptor and nuclear factor-kappa B signaling by CREB-binding protein and steroid receptor coactivator-1 J Biol Chem 273 1998 29291 29294
72. H. Shibata T.E. Spencer S.A. Onate Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action Recent Prog Horm Res 52 1997 141 64
73. N. Shikama J. Lyon La Thangue N.B. The p300/CBP family: Integrating signals with transcription factors and chromatin Trends Cell Biol 7 1997 230 236
74. U. Siebenlist G. Franzoso K. Brown Structure, regulation and function of NF-kappa B Annu Rev Cell Biol 10 1994 405 455
75. E. Stocklin M. Wissler F. Gouilleux Functional interactions between Stat5 and the glucocorticoid receptor Nature 383 1996 726 728
76. E. Stoecklin M. Wissler R. Moriggl Specific DNA binding of Stat5, but not of glucocorticoid receptor, is required for their functional cooperation in the regulation of gene transcription Mol Cell Biol 17 1997 6708 6716
77. U. Strahle A. Schmidt G. Kelsey At least three promoters direct expression of the mouse glucocorticoid receptor gene Proc Natl Acad Sci U S A 89 1992 6731 6735
78. P.E. Stromstedt L. Poellinger J.A. Gustafsson The glucocorticoid receptor binds to a sequence overlapping the TATA box of the human osteocalcin promoter: A potential mechanism for negative regulation Mol Cell Biol 11 1991 3379 3383
79. K. Struhl Histone acetylation and transcriptional regulatory mechanisms Genes Dev 12 1998 599 606
80. K. Struhl Z. Moqtaderi The TAFs in the HAT [comment] Cell 94 1998 1 4
81. P.A. Tessier P. Cattaruzzi S.R. McColl Inhibition of lymphocyte adhesion to cytokine-activated synovial fibroblasts by glucocorticoids involves the attenuation of vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 gene expression Arthritis Rheum 39 1996 226 234
82. A. Theriault E. Boyd S.B. Harrap Regional chromosomal assignment of the human glucocorticoid receptor gene to 5q31 Hum Genet 83 1989 289 291
83. J. Torchia C. Glass M.G. Rosenfeld Co-activators and co-repressors in the integration of transcriptional responses Curr Opin Cell Biol 10 1998 373 383
84. J. Torchia D.W. Rose J. Inostroza The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function [see comments] Nature 387 1997 677 684
85. M.J. Tsai B.W. O'Malley Molecular mechanisms of action of steroid/thyroid receptor superfamily members Annu Rev Biochem 63 1994 451 486
86. van de Stolpe A. E. Caldenhoven J.A. Raaijmakers Glucocorticoid-mediated repression of intercellular adhesion molecule-1 expression in human monocytic and bronchial epithelial cell lines Am J Respir Cell Mol Biol 8 1993 340 347
87. B.M. Vayssiere S. Dupont A. Choquart Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo Mol Endocrinol 11 1997 1245 1255
88. R. Wadgaonkar K.M. Phelps Z. Haque CREB-binding protein is a nuclear integrator of nuclear factor-kappaB and p53 signaling J Biol Chem 274 1999 1879 1882
89. J. Wang Z. Zhu R. Nolfo Dexamethasone regulation of lung epithelial cell and fibroblast interleukin-11 production Am J Physiol 276 1999 L175 175
90. X.Q. Wei I.G. Charles A. Smith Altered immune responses in mice lacking inducible nitric oxide synthase Nature 375 1995 408 411
91. O. Wessely E.M. Deiner H. Beug The glucocorticoid receptor is a key regulator of the decision between self-renewal and differentiation in erythroid progenitors EMBO J 16 1997 267 280
92. A.P. Wolffe D. Pruss Targeting chromatin disruption: Transcription regulators that acetylate histones Cell 84 1996 817 819
93. A. Woolcock B. Lundback N. Ringdal Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids Am J Respir Crit Care Med 153 1996 1481 1488
94. H.F. Yang-Yen J.C. Chambard Y.L. Sun Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction Cell 62 1990 1205 1215
95. R.J. Zitnik N.L. Whiting J.A. Elias Glucocorticoid inhibition of interleukin-1-induced interleukin-6 production by human lung fibroblasts: Evidence for transcriptional and post-transcriptional regulatory mechanisms Am J Respir Cell Mol Biol 10 1994 643 650