Inhibition of VCAM-1 expression in human bronchial epithelial cells by glucocorticoids

American Journal of Respiratory Cell and Molecular Biology

Volumn 20, Issue 4, 1999, Pages 643-650

  Atsuta, Jun ^a   Plitt, Jim ^a   Bochner, Bruce S ^a   Schleimer, Robert P ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANE DERIVATIVE; ANTIINFLAMMATORY AGENT; BECLOMETASONE; FLUTICASONE; GLUCOCORTICOID; HYDROCORTISONE; MESSENGER RNA; MOMETASONE FUROATE; PREGNANE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; BRONCHUS; CELL LINE; CYTOLOGY; DRUG EFFECT; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; IMMUNOLOGY; KINETICS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANDROSTADIENES; ANTI-INFLAMMATORY AGENTS; BECLOMETHASONE; BRONCHI; CELL LINE; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HUMANS; HYDROCORTISONE; KINETICS; PREGNADIENEDIOLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0033111565     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.20.4.3265     Document Type: Article

References (36)

1. Proud, D. 1993. The epithelial cell as a target and effector cell in airway inflammation. In Asthma: Physiology. Immunopharmacology, and Treatment. S. T. Holgate, K. F. Austen, L. M. Lichtenstein, and A. B. Kay, editors. Academic Press, San Diego, CA. 199-209.
2. Barnes, P. J. 1994. Airway epithelial receptors. Eur. Respir. Rev. 4:371-379.
3. Schwiebert, L. M., C. Stellato, and R. P. Schleimer. 1996. The epithelium as a target of glucocorticoid action in the treatment of asthma. Am. J. Respir. Crit. Care Med. 154:S16-S20.
4. Churchill, L., B. Friedman, R. P. Schleimer, and D. Proud. 1992. Production of granulocyte-macrophage colony-stimulating factor by cultured human tracheal epithelial cells. Immunology 75:189-195.
5. Stellato, C., L. A. Beck, G. A. Gorgone, D. Proud, T. J. Schall, S. J. Ono, L. M. Lichtenstein, and R. P. Schleimer. 1995. Expression of the chemokine RANTES by a human bronchial epithelial cell line. J. Immunol. 155: 410-418.
6. Stellato, C., P. Collins, P. D. Ponath, D. Soler, W. Newman, G. L. Rosa, H. Li, J. White, L. M. Schweibert, C. Bickel, M. Liu, B. Bochner, T. Williams, and R. P. Schleimer. 1997. Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines. J. Clin. Invest. 99:926-936.
7. Schleimer, R. P., L. A. Beck, L. A. Schwiebert, C. Stellato, K. Davenpeck, and B. S. Bochner. 1997. Inhibition of inflammatory cell recruitment by glucocorticoids. Cytokine as primary targets. In Inhaled Glucocorticoids in Asthma: Mechanisms and Clinical Actions. R. P. Schleimer, W. W. Busse, and P. M. O'Byrne, editors. Marcel Dekker, Inc., New York. 203-238.
8. Levine, S. J., P. Larivee, C. Logun, C. W. Angus, and J. H. Shelhamer. 1993. Corticosteroids differentially regulate secretion of IL-6, IL-8, and G-CSF by a human bronchial epithelial cell line. Am. J Physiol. 265:L360-L368.
9. Kwon, O. J., B. T. Au, P. D. Collins, J. N. Baraniuk, I. M. Adcock, K. F. Chung, and P. J. Barnes. 1994. Inhibition of interleukin-8 expression by dexamethasone in human cultured airway epithelial cells. Immunology 81:389-394.
10. Atsuta, J., S. A. Sterbinsky, L. A. Schweibert, B. S. Bochner, and R. P. Schleimer. 1997. Phenotyping and cytokine regulation of the human bronchial epithelial cell line BEAS-2B: demonstration of inducible expression of the adhesion molecules VCAM-1 and ICAM-1. Am. J. Respir. Cell Mol. Biol. 17:571-582.
11. Reddel, R. R., Y. Ke, B. I. Gerwin, M. G. McMenamin, J. F. Lechner, R. T. Su, D. E. Brash, J.-B. Park, J. S. Rhim, and C. C. Harris. 1988. Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes. Cancer Res. 48:1904-1909.
12. Churchill, L., F. H. Chilton, J. H. Resau, R. Bascom, W. C. Fasoli, and D. Proud. 1989. Cyclooxygenase metabolism of endogenous arachidonic acid by cultured human tracheal epithelial cells. Am. Rev. Respir. Dis. 140:449-459.
13. Bochner, B. S., A. A. McKelvey, R. P. Schleimer, J. E. K. Hildreth, and D. W. MacGlashan, Jr. 1989. Flow cytometric methods for the analysis of human basophil surface antigens and viability. J. Immunol. Methods 125: 265-271.
14. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
15. Bickel, C. A., C. Stellato, and R. P. Schleimer. 1997. Comparison of the effect of inhaled glucocorticoids on human basophil histamine release and eosinophil viability. J. Allergy Clin. Immunol. 99:S401. (Abstr.)
16. Johnson, M. 1996. Pharmacodynamics and pharmacokinetics of inhaled glucocorticoids. J. Allergy Clin. Immunol. 97:169-176.
17. Kaiser, J., C. A. Bickel, B. S. Bochner, and R. P. Schleimer. 1993. The effect of the potent glucocorticoid budesonide on adhesion of eosinophils to human vascular endothelial cells and on endothelial expression of adhesion molecules. J. Pharmacol. Exp. Ther. 267:245-249.
18. Bochner, B. S., D. A. Klunk, S. A. Sterbinsky, R. L. Coffman, and R. P. Schleimer. 1995. IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells. J. Immunol. 154:799-803.
19. Johnson, M. 1995. The anti-inflammatory profile of fluticasone propionate. Allergy 50:11-14.
20. Tessier, P., P. Cattaruzzi, and S. R. McColl. 1996. Inhibition of lymphocyte adhesion to cytokine-activated synovial fibroblasts by glucocorticoids involves the attenuation of vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 gene expression. Arthritis Rheum. 39:226-234.
21. Wuthrich, R. P., and P. Sekar. 1993. Effect of dexamethasone, 6-mercaptopurine, and cyclosporine A on intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression. Biochem. Pharmacol. 46: 1349-1353.
22. Yasuda, M., F. Kokubu, H. Izumi, S. Matsukura, H. Tokunaga, T. Yamamoto, Y. Kuroiwa, and M. Adachi. 1995. Effect of dexamethasone on intercellular adhesion molecule-1 expression on cultured bronchial epithelial cells stimulated by inflammatory cytokines. Jpn. J. Allergol. 44:100-103.
23. Burke-Gaffney, A., and P. G. Hellewell. 1996. Regulation of ICAM-1 by dexamethasone in a human vascular endothelial cell line EAhy926. Am. J. Physiol. 270:C552-C561.
24. Forsyth, K. D., and V. Talbot. 1992. Role of glucocorticoids in neutrophil and endothelial adhesion molecule expression and function. Mediat. Inflamm. 1:101-106.
25. van de Stolpe, A., E. Caldenhoven, J. A. M. Raaijmakers, P. T. van der Saag, and L. Koenderman. 1993. Glucocorticoid-mediated repression of intercellular adhesion molecule-1 expression in human monocytic and bronchial epithelial cell lines. Am. J. Respir. Cell Mol. Biol. 8:340-347.
26. Rothlein, R., M. Czajkowski, M. M. O'Neill, S. D. Marlin, E. Mainolfi, and V. J. Merluzzi. 1988. Induction of intercellular adhesion molecule 1 on primary and continuous cell lines by pro-inflammatory cytokines. J. Immunol. 141:1665-1669.
27. Reinhart, D., B. Becker, M. Nagel-Hiemke, R. Schiffer, and T. Zehmisch. 1983. Influence of beta-receptor-agonist and glucocorticoids on alpha- and beta-adrenoreceptors of isolated blood cells from asthmatic children. Pediatr. Pharmacol. 3:293-302.
28. Mak, J. C. W., I. Adcock, and P. J. Barnes. 1992. Dexamethasone increases β2-receptor gene expression in human lung. Am. Rev. Respir. Dis. 145: 834A. (Abstr.)
29. Zanker, B., G. Walz, K. J. Wieder, and T. B. Strom. 1990. Evidence that glucocorticosteroids block expression of the human interleukin-6 gene by accessing cells. Transplantation 49:183-185.
30. Collins, T., M. A. Read, A. S. Neish, M. Z. Whitley, D. Thanos, and T. Maniatis. 1995. Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers. FASEB J. 9:899-909.
31. Karin, M., and F. Saatcioglu. 1997. Negative transcriptional regulation by the glucocorticoid receptor is responsible for the anti-inflammatory activity of glucocorticoids. In Inhaled Glucocorticoids in Asthma: Mechanisms and Clinical Actions. R. P. Schleimer, W. W. Busse, and P. M. O'Bryne, editors. Marcel Dekker, Inc., New York. 29-52.
32. Peppel, K., J. M. Vinci, and C. Baglioni. 1991. The AU-rich sequences in the 3' untranslated region mediate the increased turnover of interferon mRNA induced by glucocorticoids. J. Exp. Med. 173:349-355.
33. Malter, J. S. 1989. Identification of an AUUUA-specific messenger RNA-binding protein. Science 246:664-666.
34. Shaw, G., and R. Kamen. 1986. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46:659-667.
35. Nagata, M., J. B. Sedgwick, M. E. Bates, H. Kita, and W. W. Busse. 1995. Eosinophil adhesion to vascular cell adhesion molecule-1 activates superoxide anion generation. J. Immunol. 155:2194-2202.
36. Walsh, G. M., and A. J. Wardlaw. 1997. Eosinophil interaction with extracellular matrix proteins. In Adhesion Molecules in Allergic Disease. B. S. Bochner, editor. Marcel Dekker, Inc. New York. 187-199.