Dexamethasone regulation of lung epithelial cell and fibroblast interleukin-11 production

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 276, Issue 1 20-1, 1999, Pages

  Wang, Jingming ^a   Zhu, Zhou ^a   Nolfo, Robert ^a   Elias, Jack A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Corticosteroid; Fibroblast; Messenger ribonucleic acid degradation; Respiratory syncytial virus; Rhinovirus; RU 486; Transforming growth factor

Indexed keywords

CORTICOSTEROID; DACTINOMYCIN; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR ANTAGONIST; INTERLEUKIN 11; LUCIFERASE; MESSENGER RNA; MIFEPRISTONE; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROBLAST; PRIORITY JOURNAL; PROMOTER REGION; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RHINOVIRUS; TRANSCRIPTION REGULATION;

EID: 0032891082     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1999.276.1.l175     Document Type: Article

References (48)

1. Alberta, J. A., K. Rundell, and C. D. Stiles. Identification of an activity that interacts with the 3′-untranslated region of c-Myc mRNA and the role of its target sequence in mediating rapid mRNA degradation. J. Biol. Chem. 269: 4532-4538, 1994.
2. Auphan, N., J. A. DiDonato, C. Rosette, A. Helmberg, and M. Karin. Immunosuppression by glucocorticoids: inhibition of NFκB activity through induction of IκB synthesis. Science 270: 286-290, 1995.
3. Baumann, H., O. Victoria, J. Gauldie, and G. P. Jahreis. Distinct sets of acute phase plasma proteins are stimulated by separate human hepatocyte-stimulating factors and monokines in rat hepatoma cells. J. Biol. Chem. 262: 9756-9768, 1987.
4. Bitko, V., A. Velazquez, L. Yang, Y.-C. Yang, and S. Barik. Transcriptional induction of multiple cytokines by human respiratory syncytial virus requires activation of NF-kappa β and is inhibited by sodium salicylate and aspirin. Virology 232: 369-378, 1997.
5. Brattsand, R., and M. Linden. Cytokine modulation by glucocorticoids: mechanisms and actions in cellular studies. Aliment. Pharmacol. Ther. 10: 81-90, 1996.
6. Drouin, J., M. A. Trifiro, R. K. Plante, M. Nemer, P. Eriksson, and O. Wrange. Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription. Mol. Cell. Biol. 9: 5305-5314, 1989.
7. Du, X. X., and D. A. Williams. Interleukin-11: a multifunctional growth factor derived from the hematopoietic microenvironment. Blood 83: 2023-2030, 1994.
8. Ehrenman, K., L. Long, B. J. Wagner, and G. Brewer. Characterization of cDNAs encoding the murine A + U-rich RNA-binding protein AUF1. Gene 149: 315-319, 1994.
9. Einarsson, O., G. P. Geba, Z. Zhu, M. Landry and J. A. Elias. Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness. J. Clin. Invest. 97: 915-924, 1996.
10. Elias, J. A., and V. Lentz. Interleukin-1 and tumor necrosis factor synergistically stimulate fibroblast interleukin-6 production and stabilize interleukin-6 messenger RNA. J. Immunol. 145: 161-166, 1990.
11. Elias, J. A., Y. Wu, T. Zheng, and R. Panettieri, Jr. Cytokine-and virus-stimulated airway smooth muscle cells produce IL-11 and other IL-6-type cytokines. Am. J. Physiol. 273 (Lung Cell. Mol. Physiol. 17): L648-L655, 1997.
12. Elias, J. A., T. Zheng, O. Einarsson, M. Landry, T. K. Trow, N. Rebert, and J. Panuska. Epithelial interleukin-11: regulation by cytokines, respiratory syncytial virus and retinoic acid. J. Biol. Chem. 169: 22261-22268, 1994.
13. Elias, J. A., T. Zheng, N. L. Whiting, A. Marcovici, and T. K. Trow. Cytokine-cytokine synergy and protein kinase C in the regulation of lung fibroblast leukemia inhibitory factor. Am. J. Physiol. 266 (Lung Cell. Mol. Physiol. 10): L426-L435, 1994.
14. Elias, J. A., T. Zheng, N. L. Whiting, T. K. Trow, W. W. Merrill, R. Zitnik, P. Ray, and E. M. Alderman. Interleukin-1 and transforming growth factor β regulation of fibroblast-derived interleukin-11. J. Immunol. 152: 2421-2429, 1994.
15. Eustice, D. C., P. A. Feldman, A. M. Colberg-Poley, R. M. Buchery, and R. H. Neubauer. A sensitive method for the detection of beta-galactosidase in transfected mammalian cells. Biotechniques 11: 739-740, 1991.
16. Fenton, M. J., J. A. Buras, and R. P. Donnelly. IL-4 reciprocally regulates IL-1 and IL-1 receptor antagonist expression in human monocytes. J. Immunol. 149: 1283-1288, 1992.
17. Girasole, G., G. Passeri, R. L. Jilka, and S. C. Manolagas. Interleukin-11: a new cytokine critical for osteoclast development. J. Clin. Invest. 93: 1516-1524, 1994.
18. Ip, N. Y., S. H. Nye, T. G. Boulton, S. Davis, T. Taga, Y. Li, S. J. Birren, K. Yasukawa, T. Kishimoto, D. J. Anderson, N. Stahl, and G. D. Yancopoulos. CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell 69: 1121-1132, 1992.
19. Jonat, C., H. Rahmsdorf, K.-K. Park, A. C. Cato, S. Gebel, H. Ponta, and P. Herrlich. Antitumor promotion and antiinflammation: down-modulation of AP-1 (fos/jun) activity by glucocorticoid hormone. Cell 62: 1189-1204, 1990.
20. Keith, J., C. James, L. Albert, S. T. Sonis, C. J. Pfeiffer, and R. G. Schaub. IL-11, a pleiotropic cytokine: exciting new effects of IL-11 on gastrointestinal mucosal biology. Stem Cells 12, Suppl. 1: 79-90, 1994.
21. Lagnado, C. A., C. Y. Brown, and G. J. Goodall. AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A) (U/A). Mol. Cell. Biol. 14: 7984-7995, 1994.
22. Leng, S. X., and J. A. Elias. Interleukin-11 inhibits macrophage interleukin-12 production. J. Immunol. 159: 2161-2168, 1997.
23. Levine, S. J., T. Benfield, and J. H. Shelhamer. Corticosteroids induce intracellular interleukin 1 receptor antagonist type 1 by a human airway epithelial cell line. Am. J. Respir. Cell Mol. Biol. 15: 245-251, 1996.
24. Maier, R., V. Ganu, and M. Lotz. Interleukin-11, an inducible cytokine in human articular chondrocytes and synoviocytes, stimulates the production of the tissue inhibitor of metalloproteinases. J. Biol. Chem. 268: 21527-21532, 1993.
25. Malter, J. S. Identification of an AUUUA-specific messenger RNA binding protein. Science 246: 664-666, 1989.
26. Mehler, M. F., R. Roxental, M. Dougherty, D. C. Spray, and J. A. Kessler. Cytokine regulation of neuronal differentiation of hippocampal progenitor cells. Nature 362: 62-65, 1993.
27. Paul, S. R., F. Bennett, J. A. Calvetti, K. Kelleher, C. R. Wood, R. M. J. Oharra, A. C. Leary, B. Sibley, S. C. Clark, D. A. Williams, and Y.-C. Yang. Molecular cloning of a cDNA encoding interleukin-11, a stromal cell derived lymphopoietic and hematopoietic cytokine. Proc. Natl. Acad. Sci. USA 87: 7512-7516, 1990.
28. Peppel, K., J. Vinci, and C. J. Baglioni. The AU-rich sequences in the 3′ untranslated region mediate the increased turnover of interferon mRNA induced by glucocorticoids. J. Exp. Med. 173: 349-355, 1991.
29. Ray, A., S. LaForge, and P. B. Sehgal. On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: enhancer, TATA box, and RNA start site (Inr motif) occlusion. Mol. Cell. Biol. 10: 5736-5746, 1990.
30. Ray, A., and K. E. Prefontaine. Physical association and functional antagonism between the -65 subunit of transcription factor NFκB and the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 91: 752-756, 1994.
31. Ray, P., W. Tang, P. Wang, R. Homer, C. I. Kuhn, R. A. Flavell, and J. A. Elias. Regulated overexpression of interleukin-11 in the lung: use to dissociate development-dependent and -independent phenotypes. J. Clin. Invest. 100: 2501-2511, 1997.
32. Redlich, C. A., X. Gao, S. Rockwell, M. Kelley, and J. A. Elias. IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury. J. Immunol. 157: 1705-1710, 1996.
33. Rochester, C. L., S. J. Ackerman, T. Zheng, and J. A. Elias. Eosinophil-fibroblast interactions: granule major basic protein stimulation of fibroblast interleukin-6, interleukin-11 and leukemia inhibitory factor expression. J. Immunol. 156: 4449-4456, 1996.
34. Sakai, D. D., S. Helms, J. Carlstedt-Duke, J.-A. Gustafsson, F. M. Rottman, and K. R. Yamamoto. Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene. Genes Dev. 2: 1144-1154, 1988.
35. Scheinman, R. I., P. C. Cogswell, A. L. Lofquist, and A. S. Baldwin, Jr. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 270: 286-290, 1995.
36. Schreiber, E., P. Matthias, M. M. Muller, and W. Schaffner. Rapid detection of octamer binding proteins with "mini-extracts," prepared from a small number of cells (Abstract). Nucleic Acids Res. 17: 6419, 1980.
37. Shaw, G., and R. Kamen. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46: 659-667, 1986.
38. Stromstedt, P.-E., L. Poellinger, J.-A. Gustaffson, and J. Carlstedt-Duke. The glucocorticoid receptor binds to a sequence overlapping the TATA box of the human osteocalcin promoter: a potential mechanism for negative regulation. Mol. Cell. Biol. 11: 3379-3383, 1991.
39. Tang, W., G. P. Geba, T. Zheng, P. Ray, R. Homer, C. I. Kuhn, R. A. Favell, and J. A. Elias. Targeted expression of IL-11 in the murine airway causes airways obstruction, bronchial remodeling and lymphocytic inflammation. J. Clin. Invest. 98: 2845-2853, 1996.
40. Tang, W., L. Yang, Y.-C. Yang, S. X. Leng, and J. A. Elias. Transforming growth factor-β stimulates interleukin 11 transcription via complex activating protein-1-dependent pathways. J. Biol. Chem. 273: 5506-5513, 1998.
41. Tobler, A., R. Meier, M. Seitz, B. Dewald, and M. Baggliolini. Glucocorticoids downregulate gene expression of GM-CSF in human fibroblasts. Blood 79: 45-51, 1992.
42. Trepicchio, W. L., M. Bozza, G. Pedneault, and A. J. Dorner. Recombinant human IL-11 attenuates the inflammatory response through down-regulation of proinflammatory cytokine release and nitric oxide production. J. Immunol. 157: 3627-3634, 1996.
43. Yang, L., and Y.-C. Yang. Heparin inhibits the expression of interleukin-11 and granulocyte-macrophage colony-stimulating factor in primate bone marrow stromal fibroblasts through mRNA destabilization. Blood 86: 2526-2533, 1995.
44. Yin, T., P. Schendel, and Y.-C. Yang. Enhancement of in vitro and in vivo antigen-specific antibody responses by IL-11. J. Exp. Med. 175: 211-216, 1992.
45. Zheng, T., M. Nathanson, and J. A. Elias. Histamine augments cytokine-stimulated interleukin-11 production by human lung fibroblasts. J. Immunol. 153: 4742-4752, 1994.
46. Zhu, Z., W. Tang, A. Ray, Y. Wu, O. Einarsson, M. L. Landry, J. Gwaltney, Jr., and J. A. Elias. Rhinovirus stimulation of interleukin-6 in vivo and in vitro: evidence for NF-κB-dependent transcriptional activation. J. Clin. Invest. 97: 421-430, 1996.
47. Zitnik, R. J., N. L. Whiting, and J. A. Elias. Glucocorticoid inhibition of interleukin-1-induced interleukin-6 production by human lung fibroblasts: evidence for transcriptional and post-transcriptional regulatory mechanisms. Am. J. Respir. Cell Mol. Biol. 10: 643-650, 1994.
48. Zubiaga, A. M., J. G. Belasco, and M. E. Greenberg. The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. Mol. Cell. Biol. 15: 2219-2230, 1995.