Mechanisms of Disease: Nitric oxide as a mediator of hemodynamic abnormalities and sodium and water retention in cirrhosis

New England Journal of Medicine

Volumn 339, Issue 8, 1998, Pages 533-541

  Martin, Pierre Yves ^a   Ginès, Pere ^b   Schrier, Robert W ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SODIUM;

ASCITES; ELECTROLYTE DISTURBANCE; ENZYME INHIBITION; HEMODYNAMICS; HUMAN; LIVER CIRRHOSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SODIUM RETENTION; WATER RETENTION; ANIMAL; DRUG ANTAGONISM; EXPERIMENTAL LIVER CIRRHOSIS; EXTRACELLULAR SPACE; HOMEOSTASIS; KIDNEY DISEASE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PORTAL HYPERTENSION; SPLANCHNIC BLOOD FLOW;

ANIMALS; ASCITES; EXTRACELLULAR SPACE; HEMODYNAMIC PROCESSES; HOMEOSTASIS; HUMANS; HYPERTENSION, PORTAL; KIDNEY DISEASES; LIVER CIRRHOSIS; LIVER CIRRHOSIS, EXPERIMENTAL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SODIUM; SPLANCHNIC CIRCULATION;

EID: 0032551891     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199808203390807     Document Type: Review

References (73)

1. Schrier RW, Arroyo V, Bernardi M, Epstein M, Henriksen JH, Rodes J. Peripheral arterial vasodilation hypothesis: a proposal for the initiation of renal sodium and water retention in cirrhosis. Hepatology 1988;8:1151-7.
2. Palmer RMJ, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988;333:664-6.
3. Vallance P, Moncada S. Hyperdynamic circulation in cirrhosis: a role for nitric oxide? Lancet 1991;337:776-8.
4. Ginès P, Schrier RW. Hepatorenal syndrome and renal dysfunction associated with liver disease. In: Schrier RW, Gottschalk CW, eds. Diseases of the kidney. 6th ed. Vol. 3. Boston: Little, Brown, 1997:2099-127.
5. Ginès P, Fernández-Esparrach G, Arroyo V, Rodés J. Pathogenesis of ascites in cirrhosis. Semin Liver Dis 1997;17:175-89.
6. Ginès P, Martin PY, Niederberger M. Prognostic significance of renal dysfunction in cirrhosis. Kidney Int Suppl 1997;61:S77-S82.
7. Bosch J, Ginés P, Arroyo V, Navasa M, Rodés J. Hepatic and systemic hemodynamics and the neurohumoral systems in cirrhosis. In: Epstein M, ed. The kidney in liver disease. 3rd ed. Baltimore: Williams & Wilkins, 1988:286-308.
8. Bernardi M, Trevisani F. Systemic and regional hemodynamics in preascitic cirrhosis. J Hepatol 1997;27:588-91.
9. Bernardi M, Di Marco C, Trevisani F, et al. The hemodynamic status of preascitic cirrhosis: an evaluation under steady-state conditions and after postural change. Hepatology 1992;16:341-6.
10. La Villa G, Salmerón JM, Arroyo V, et al. Mineralocorticoid escape in patients with compensated cirrhosis and portal hypertension. Gastroenterology 1992;102:2114-9.
11. Iwao T, Toyonaga A, Sato M, et al. Effect of posture-induced blood volume expansion on systemic and regional hemodynamics in patients with cirrhosis. J Hepatol 1997;27:484-91.
12. Wood LJ, Massie D, McLean AJ, Dudley FJ. Renal sodium retention in cirrhosis: tubular site and relation to hepatic dysfunction. Hepatology 1988;8:831-6.
13. Bernardi M, Di Marco C, Trevisani F, et al. Renal sodium retention during upright posture in preascitic cirrhosis. Gastroenterology 1993;105: 188-93.
14. Groszmann RJ. Hyperdynamic circulation of liver disease 40 years later: pathophysiology and clinical consequences. Hepatology 1994;20:1359-63.
15. Møller S, Christensen E, Henriksen JH. Continuous blood pressure monitoring in cirrhosis: relations to splanchnic and systemic haemodynamics. J Hepatol 1997;27:284-94.
16. Bichet DG, Van Putten VJ, Schrier RW. Potential role of increased sympathetic activity in impaired sodium and water excretion in cirrhosis. N Engl J Med 1982;307:1552-7.
17. Bernardi M, Fornalé L, Di Marco C, et al. Hyperdynamic circulation of advanced cirrhosis: a re-appraisal based on posture-induced changes in hemodynamics. J Hepatol 1995;22:309-18.
18. Richer D, Szatalowicz V, Chaimovitz C, Schrier RW. Role of vasopressin in abnormal water excretion in cirrhotic patients. Ann Intern Med 1982;96:413-7.
19. Schroeder ET, Anderson GH, Goldman SH, Streeten DH. Effect of blockade of angiotensin II on blood pressure, renin and aldosterone in cirrhosis. Kidney Im 1976;9:511-9.
20. Clària I, Jiménez W, Arroyo V, et al. Effect of V1-vasopressin receptor blockade on arterial pressure in conscious rats with cirrhosis and ascites. Gastroenterology 1991;100:494-501.
21. Esler M, Dudley F, Jennings G, et al. Increased sympathetic nervous activity and the effects of its inhibition with clonidine in alcoholic cirrhosis. Ann Intern Med 1992;116:446-55.
22. Ginès P, Jiméncz W, Arroyo V, et al. Atrial natriuretic factor in cirrhosis with ascites: plasma levels, cardiac release and splanchnic extraction. Hepatology 1988;8:636-42.
23. Poulos JE, Gower WR, Fontanet HL, Kalmus GW, Vesely DL. Cirrhosis with ascites: increased atrial natriurctic peptide messenger RNA expression in rat ventricle. Gastroenterology 1995;108:1496-503.
24. Vorobioff J, Bredfeldt JE, Groszmann RJ. Increased blood flow through the portal system in cirrhotic rats. Gastroenterology 1984;87:1120-6.
25. Sato S, Ohnishi K, Sugita S, Okuda K. Splenic artery and superior mesenteric artery blood flow: nonsurgical Doppler US measurement in healthy subjects and patients with chronic liver disease. Radiology 1987; 164:347-52.
26. Maroto A, Ginès P, Arroyo V, et al. Brachial and femoral artery blood flow in cirrhosis: relationship to kidney dysfunction. Hepatology 1993;17: 788-93.
27. Fernández-Seara J, Prieto J, Quiroga J, et al. Systemic and regional hemodynamics in patients with liver cirrhosis and ascites with and without functional renal failure. Gastroenterology 1989;97:1304-12.
28. Wong F, Liu P, Tobe S, Morali G, Blendis L. Central blood volume in cirrhosis: measurement with radionuclide angiography. Hepatology 1994; 19:312-21.
29. Henriksen JH, Møller S. Hemodynamics, distribution of blood volume, and kinetics of vasoactive substances in cirrhosis. In: Epstein M, ed. The kidney in liver disease. 4th ed. Philadelphia: Hanley & Belfus, 1996: 241-58.
30. Colombato LA, Albillos A, Groszmann RJ. The role of central blood volume in the development of sodium retention in portal hypertensive rats. Gastroenterology 1996;110:193-8.
31. Shapiro MD, Nicholls KM, Groves BM, et al. Interrelationship between cardiac output and vascular resistance as determinants of effective arterial blood volume in cirrhotic patients. Kidney Int 1985;28:206-11.
32. Guevara M, Ginès P, Fernández-Esparrach G, et al. Reversibility of hepatorenal syndrome by prolonged administration of ornipressin and plasma volume expansion. Hepatology 1998;27:35-41.
33. Castro A, Jiménez W, Clària J, et al. Impaired responsiveness to angiotensin II in experimental cirrhosis: role of nitric oxide. Hepatology 1993; 367-72.
34. Weigert AL, Martin PY, Niederberger M, et al. Endothelium-dependent vascular hyporesponsiveness without detection of nitric oxide synthase induction in aortas of cirrhotic rats. Hepatology 1995;22:1856-62.
35. Sieber CC, Lopez-Talavera JC, Groszmann RJ. Role of nitric oxide in the in vitro splanchnic vascular hyporeactivity in ascitic cirrhotic rats. Gastroenterology 1993;104:1750-4.
36. Atucha NM, Shah V, Garcia-Cardeña G, Sessa WE, Groszmann RJ. Role of endothelium in the abnormal response of mesenteric vessels in rats with portal hypertension and liver cirrhosis. Gastroenterology 1996;111: 1627-32.
37. Clària J, Jiménez W, Ros J, et al. Increased nitric oxide-dependent vasorelaxation in aortic rings of cirrhotic rats with ascites. Hepatology 1994;20:1615-21.
38. Lee FY, Albillos A, Colombato LA, Groszmann RJ. The role of nitric oxide in the vascular hyporesponsiveness to methoxamine in portal hypertensive rats. Hepatology 1992;16:1043-8.
39. Hartleb M, Moreau R, Cailmail S, Gaudin C, Lebrec D. Vascular hyporesponsiveness to endothelin 1 in rats with cirrhosis. Gastroenterology 1994;107:1085-93.
40. Clària J, Jiménez W, Ros J, et al. Pathogenesis of arterial hypotension in cirrhotic rats with ascites: role of endogenous nitric oxide. Hepatology 1992;15:343-9.
41. Pizcueta P, Piqué JM, Fernández M, et al. Modulation of the hyperdynamic circulation of cirrhotic rats by nitric oxide inhibition. Gastroenterology 1992;103:1909-15.
42. Niederberger M, Ginès P, Tsai P, et al. Increased aortic cyclic guanosine monophosphate concentration in experimental cirrhosis in rats: evidence for a role of nitric oxide in the pathogenesis of arterial vasodilation in cirrhosis. Hepatology 1995;21:1625-31.
43. Ros I, Jiménez W, Lamas S, et al. Nitric oxide production in arterial vessels of cirrhotic rats. Hepatology 1995;21:554-60.
44. Cahill PA, Foster C, Redmond EM, Gingalewski C, Wu Y, Sitzmann JV. Enhanced nitric oxide synthase activity in portal hypertensive rabbits. Hepatology 1995;22:598-606.
45. Cahill PA, Redmond EM, Hodges R, Zhang S, Sitzmann JV. Increased endothelial nitric oxide synthase activity in the hyperemic vessels of portal hypertensive rats. J Hepatol 1996;25:370-8.
46. Niederberger M, Ginès P, Martin PY, et al. Comparison of vascular nitric oxide production and systemic hemodynamics in cirrhosis versus prehepatic portal hypertension in rats. Hepatology 1996;24:947-51.
47. Niederberger M, Martin PY, Ginès P, et al. Normalization of nitric oxide production corrects arterial vasodilation and hyperdynamic circulation in cirrhotic rats. Gastroenterology 1995;109:1624-30.
48. Martin P-Y, Xu DL, Niederberger M, et al. Upregulation of the endothelial constitutive NOS: a major role in the increased NO production in cirrhotic rats. Am J Physiol 1996;270:F494-F499.
49. Morales-Ruiz M, Jiménez W, Pérez-Sala D, et al. Increased nitric oxide synthase expression in arterial vessels of cirrhotic rats with ascites. Hepatology 1996;24:1481-6.
50. MacGilchrist AJ, Sumner D, Reid JL. Impaired pressor reactivity in cirrhosis: evidence for a peripheral vascular detect. Hepatology 1991;13:689-94.
51. ω-nitro-L-arginine ameliorates portal-systemic shunting in portalhypertensive rats. Gastroenterology 1993;105:1464-70.
52. Mosca P, Lee FY, Kaumann AJ, Groszmann RJ. Pharmacology of portal-systemic collaterals in portal hypertensive rats: role of endothelium. Am J Physiol 1992;263:G544-G550.
53. Arnal JF, el Arnrani AI, Michel JB. Atrial natriuretic factor influences in vivo plasma, lung and aortic wall cGMP concentrations differently. Eur J Pharmacol 1993;237:265-73.
54. Martin PY, Ohara M, Ginès P, et al. Nitric oxide synthase (NOS) inhibition for one week improves renal sodium and water excretion in cirrhotic rats with ascites. J Clin Invest 1998;101:235-42.
55. Mittal MK, Gupta TK, Lee FY, Sieber CC, Groszmann RJ. Nitric oxide modulates hepatic vascular tone in normal rat liver. Am J Physiol 1994; 267:G416-G422.
56. Shah V, Haddad FG, Garcia-Cardena G, et al. Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids. J Clin Invest 1997;100:2923-30.
57. Rockey DC, Chung JJ. Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension. Gastroenterology 1998;114:344-51.
58. Pilette C, Moreau R, Sogni P, et al. Haemodynamic and hormonal responses to long-term inhibition of nitric oxide synthesis in rats with portal hypertension. Eur J Pharmacol 1996;312:63-8.
59. Kone BC, Baylis C. Biosynthesis and homeostatic roles of nitric oxide in the normal kidney. Am J Physiol 1997;272:F561-F578.
60. Raij L, Baylis C. Glomerular actions of nitric oxide. Kidney Int 1995; 48:20-32.
61. Na, and vasoactive hormones in healthy humans. Am J Physiol 1996;270:F845-F851.
62. Ros J, Clària J, Jimenez W, et al. Role of nitric oxide and prostacyclin in the control of renal perfusion in experimental cirrhosis. Hepatology 1995;22:915-20.
63. Garcia-Estañ J, Atucha NM, Sabio JM, Vargas F, Quesada T, Romero JC. Increased endothelium-dependent renal vasodilation in cirrhotic rats. Am J Physiol 1994;267:R549-R553.
64. Atucha NM, Garcia-Estañ J, Ramírez A, Pérez MC, Quesada T, Romero JC. Renal effects of nitric oxide synthesis inhibition in cirrhotic rats. Am J Physiol 1994;267:R1454-R1460.
65. Campillo B, Chabrier PE, Pelle G, et al. Inhibition of nitric oxide synthesis in the forearm arterial bed of patients with advanced cirrhosis. Hepatology 1995;22:1423-9.
66. Albillos A, Rossi I, Cacho G, et al. Enhanced endothelium-dependent vasodilation in patients with cirrhosis. Am J Physiol 1995;268:G459-G464.
67. Battista S, Bar F, Mengozzi G, Zanon E, Grosso M, Molino G. Hyperdynamic circulation in patients with cirrhosis: direct measurement of nitric oxide levels in hepatic and portal veins. J Hepatol 1997;26:75-80.
68. Guarner C, Soriano G, Tomas A, et al. Increased serum nitrite and nitrate levels in patients with cirrhosis: relationship to endotoxemia. Hepatology 1993;18:1139-43.
69. Matsumoto A, Ogura K, Hirata Y, et al. Increased nitric oxide in the exhaled air of patients with decompensated liver cirrhosis. Ann Intern Med 1995;123:110-3.
70. Sogni P, Gamier P, Gadano A, et al. Endogenous pulmonary nitric oxide production measured from exhaled air is increased in patients with severe cirrhosis. J Hepatol 1995;23:471-3.
71. Laffi G, Foschi M, Masini E, et al. Increased production of nitric oxide by neutrophils and monocytes from cirrhotic patients with ascites and hyperdynamic circulation. Hepatology 1995;22:1666-73.
72. Criado-Jiménez M, Rivas-Cabanero L, Martin-Oterino JA, López-Novoa JM, Sanchez-Rodriguez A. Nitric oxide production by mononuclear leukocytes in alcoholic cirrhosis. J Mol Med 1995;73:31-3.
73. Forrest EH, Jones AL, Dillon JF, Walker J, Hayes PC. The effect of nitric oxide synthase inhibition on portal pressure and azygos blood flow in patients with cirrhosis. J Hepatol 1995;23:254-8.