메뉴 건너뛰기




Volumn 43, Issue 5, 1999, Pages 1129-1136

Streptococcus pneumoniae DNA gyrase and topoisomerase IV: Overexpression, purification, and differential inhibition by fluoroquinolones

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; CLINAFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE IV; ISOMERASE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SPARFLOXACIN; UNCLASSIFIED DRUG;

EID: 0032946666     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.5.1129     Document Type: Article
Times cited : (112)

References (46)
  • 1
    • 0026712869 scopus 로고
    • The role of topoisomerase IV in partitioning DNA replicons and the structure of catenated intermediates in DNA replication
    • Adams, D. E., E. M. Shekhtman, E. L. Zechiedrich, M. B. Schmid, and N. R. Cozzarelli. 1992. The role of topoisomerase IV in partitioning DNA replicons and the structure of catenated intermediates in DNA replication. Cell 71:277-288.
    • (1992) Cell , vol.71 , pp. 277-288
    • Adams, D.E.1    Shekhtman, E.M.2    Zechiedrich, E.L.3    Schmid, M.B.4    Cozzarelli, N.R.5
  • 2
    • 0032463438 scopus 로고    scopus 로고
    • Molecular characterization of the gene encoding the DNA gyrase A subunit of Streptococcus pneumoniae
    • Balas, D., E. Fernández-Moreira, and A. G. De la Campa. 1998. Molecular characterization of the gene encoding the DNA gyrase A subunit of Streptococcus pneumoniae. J. Bacteriol 180:2854-2861.
    • (1998) J. Bacteriol , vol.180 , pp. 2854-2861
    • Balas, D.1    Fernández-Moreira, E.2    De La Campa, A.G.3
  • 3
    • 0029643776 scopus 로고
    • Community-acquired pneumonia
    • Bartlett, J. G., and L. M. Grundy. 1995. Community-acquired pneumonia. N. Engl. J. Med. 333:1618-1624.
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1618-1624
    • Bartlett, J.G.1    Grundy, L.M.2
  • 5
    • 0024383245 scopus 로고
    • Cloning and characterization of a DNA gyrase A gene from Escherichia coli that confers clinical resistance to 4-quinolones
    • Cullen, M. E., A. W. Wyke, R. Kuroda, and L. M. Fisher. 1989. Cloning and characterization of a DNA gyrase A gene from Escherichia coli that confers clinical resistance to 4-quinolones. Antimicrob. Agents Chemother. 33:886-894.
    • (1989) Antimicrob. Agents Chemother. , vol.33 , pp. 886-894
    • Cullen, M.E.1    Wyke, A.W.2    Kuroda, R.3    Fisher, L.M.4
  • 6
    • 0031407768 scopus 로고    scopus 로고
    • DNA gyrase, topoisomerase IV, and the 4-quinolones
    • Drlica, K., and X. Zhao. 1997. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol. Mol. Biol. Rev. 61:377-392.
    • (1997) Microbiol. Mol. Biol. Rev. , vol.61 , pp. 377-392
    • Drlica, K.1    Zhao, X.2
  • 7
    • 0027956736 scopus 로고
    • Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: A primary target for quinolones
    • Ferrero, L., B. Cameron, B. Manse, D. Lagneux, J. Crouzet, A. Famechon, and F. Blanche. 1994. Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target for quinolones. Mol. Microbiol. 13:641-653.
    • (1994) Mol. Microbiol. , vol.13 , pp. 641-653
    • Ferrero, L.1    Cameron, B.2    Manse, B.3    Lagneux, D.4    Crouzet, J.5    Famechon, A.6    Blanche, F.7
  • 8
    • 0031982852 scopus 로고    scopus 로고
    • Mutations in topoisomerase IV and DNA gyrase of Staphylococcus aureus: Novel pleiotropic effects on quinolone and coumarin activit
    • Fournier, B., and D. C. Hooper. 1998. Mutations in topoisomerase IV and DNA gyrase of Staphylococcus aureus: novel pleiotropic effects on quinolone and coumarin activity. Antimicrob. Agents Chemother. 42:121-128.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 121-128
    • Fournier, B.1    Hooper, D.C.2
  • 9
    • 0001373485 scopus 로고
    • Nalidixic acid resistance: A second genetic character involved in DNA gyrase activity
    • Gellert, M., K. Mizuuchi, M. H. O'Dea, T. Itoh, and J. I. Tomizawa. 1977. Nalidixic acid resistance: a second genetic character involved in DNA gyrase activity. Proc. Natl. Acad. Sci. USA 74:4772-4776.
    • (1977) Proc. Natl. Acad. Sci. USA , vol.74 , pp. 4772-4776
    • Gellert, M.1    Mizuuchi, K.2    O'Dea, M.H.3    Itoh, T.4    Tomizawa, J.I.5
  • 10
  • 11
    • 0029834825 scopus 로고    scopus 로고
    • Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro
    • Gootz, T. D., R. Zaniewski, S. Haskell, B. Schmieder, J. Tankovic, D. Girard. P. Courvalin, and R. J. Polzer. 1996. Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrob. Agents Chemother. 40:2691-2697.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 2691-2697
    • Gootz, T.D.1    Zaniewski, R.2    Haskell, S.3    Schmieder, B.4    Tankovic, J.5    Girard, D.6    Courvalin, P.7    Polzer, R.J.8
  • 12
    • 0029986580 scopus 로고    scopus 로고
    • Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli
    • Heisig, P. 1996. Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli. Antimicrob. Agents Chemother. 40:879-885.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 879-885
    • Heisig, P.1
  • 14
    • 0342377454 scopus 로고    scopus 로고
    • Bipolar localization of Bacillus subtilis topoisomerase IV, an enzyme required for chromosome segregation
    • Huang, W.-H., J. L. Libbey, P. van der Hoeven, and S. X. Hu. 1998. Bipolar localization of Bacillus subtilis topoisomerase IV, an enzyme required for chromosome segregation. Proc. Natl. Acad. Sci. USA 95:4652-4657.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 4652-4657
    • Huang, W.-H.1    Libbey, J.L.2    Van Der Hoeven, P.3    Hu, S.X.4
  • 15
    • 0031870070 scopus 로고    scopus 로고
    • Nucleotide sequence and chromosomal location of L-lactate dehydrogenase gene of Streptococcus pneumoniae
    • Jado, I., A. Fenoll, J. Casal, and A. Perez. 1998. Nucleotide sequence and chromosomal location of L-lactate dehydrogenase gene of Streptococcus pneumoniae. Curr. Microbiol. 37:77-19.
    • (1998) Curr. Microbiol. , vol.37 , pp. 77-119
    • Jado, I.1    Fenoll, A.2    Casal, J.3    Perez, A.4
  • 16
    • 0029852080 scopus 로고    scopus 로고
    • High-level fluoroquinolone resistance in Streptococcus pneumoniae requires mutations in parC and gyrA
    • Janoir, C., V. Zeller, M.-D. Kitzis, N. J. Moreau, and L. Gutmann. 1996. High-level fluoroquinolone resistance in Streptococcus pneumoniae requires mutations in parC and gyrA. Antimicrob. Agents Chemother. 40:2760-2764.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 2760-2764
    • Janoir, C.1    Zeller, V.2    Kitzis, M.-D.3    Moreau, N.J.4    Gutmann, L.5
  • 17
    • 0025027077 scopus 로고
    • New topoisomerase essential for chromosomal segregation in E. coli
    • Kato, J., Y. Nishimura, R. Imamura, H. Niki, S. Higara, and H. Suzuki. 1990. New topoisomerase essential for chromosomal segregation in E. coli. Cell 63:393-404.
    • (1990) Cell , vol.63 , pp. 393-404
    • Kato, J.1    Nishimura, Y.2    Imamura, R.3    Niki, H.4    Higara, S.5    Suzuki, H.6
  • 18
    • 0032538454 scopus 로고    scopus 로고
    • The mechanism of inhibition of topoisomerase IV by quinolone antibacterials
    • Khodursky, A. B., and N. R. Cozzarelli. 1998. The mechanism of inhibition of topoisomerase IV by quinolone antibacterials. J. Biol. Chem. 273:27668-27677.
    • (1998) J. Biol. Chem. , vol.273 , pp. 27668-27677
    • Khodursky, A.B.1    Cozzarelli, N.R.2
  • 19
    • 0018628599 scopus 로고
    • Escherichia coli mutants thermosensitive for deoxyribonucleic acid gyrase subunit A: Effects on deoxyribonucleic acid replication, transcription, and bacteriophage growth
    • Kreuzer, K. N., and N. R. Cozzarelli. 1979. Escherichia coli mutants thermosensitive for deoxyribonucleic acid gyrase subunit A: effects on deoxyribonucleic acid replication, transcription, and bacteriophage growth. J. Bacteriol. 140:424-435.
    • (1979) J. Bacteriol. , vol.140 , pp. 424-435
    • Kreuzer, K.N.1    Cozzarelli, N.R.2
  • 20
    • 0001913717 scopus 로고    scopus 로고
    • New treatment options for pneumonia
    • Mandell, L. A. 1998. New treatment options for pneumonia. Infect. Med. 15:E34-E43.
    • (1998) Infect. Med. , vol.15
    • Mandell, L.A.1
  • 21
    • 0012127194 scopus 로고
    • DNA gyrase action involves the introduction of transient double strand breaks into DNA
    • Mizuuchi, K., L. M. Fisher, M. H. O'Dea, and M. Gellert. 1990. DNA gyrase action involves the introduction of transient double strand breaks into DNA. Proc. Natl. Acad. Sci. USA 77:1847-1851.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 1847-1851
    • Mizuuchi, K.1    Fisher, L.M.2    O'Dea, M.H.3    Gellert, M.4
  • 22
    • 0021139129 scopus 로고
    • Cloning and simplified purification of Escherichia coli DNA gyrase A and B proteins
    • Mizuuchi, K., M. Mizuuchi, M. H. O'Dea, and M. Gellert. 1984. Cloning and simplified purification of Escherichia coli DNA gyrase A and B proteins. J. Biol. Chem. 259:9199-9201.
    • (1984) J. Biol. Chem. , vol.259 , pp. 9199-9201
    • Mizuuchi, K.1    Mizuuchi, M.2    O'Dea, M.H.3    Gellert, M.4
  • 23
    • 0038782340 scopus 로고
    • DNA gyrase: Subunit structure and ATPase activity of the purified enzyme
    • Mizuuchi, K., M. H. O'Dea, and M. Gellert. 1978. DNA gyrase: subunit structure and ATPase activity of the purified enzyme. Proc. Natl. Acad. Sci. USA 75:5960-5963.
    • (1978) Proc. Natl. Acad. Sci. USA , vol.75 , pp. 5960-5963
    • Mizuuchi, K.1    O'Dea, M.H.2    Gellert, M.3
  • 24
    • 0345414745 scopus 로고    scopus 로고
    • The unique equipotency of sitafloxacin against topoisomerase IV and DNA gyrase from Streptococcus pneumoniae
    • Denver, Colo.
    • Morrissey, I. 1998. The unique equipotency of sitafloxacin against topoisomerase IV and DNA gyrase from Streptococcus pneumoniae, p. 55. In Abstracts of the Sixth International Symposium on New Quinolones, Denver, Colo.
    • (1998) Abstracts of the Sixth International Symposium on New Quinolones , pp. 55
    • Morrissey, I.1
  • 25
    • 0029846117 scopus 로고    scopus 로고
    • ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of quinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype
    • Muñoz, R., and A. G. De la Campa. 1996. ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of quinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype. Antimicrob. Agents Chemother. 40:2252-2257.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 2252-2257
    • Muñoz, R.1    De La Campa, A.G.2
  • 26
    • 0001403583 scopus 로고    scopus 로고
    • Mechanisms of quinolone resistance
    • Nakamura, S. 1997. Mechanisms of quinolone resistance. J. Infect. Chemother. 3:128-138.
    • (1997) J. Infect. Chemother. , vol.3 , pp. 128-138
    • Nakamura, S.1
  • 27
    • 0029824413 scopus 로고    scopus 로고
    • Quinolone resistance mutations in topoisomerase IV: Relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus
    • Ng, E. Y., M. Trucksis, and D. C. Hooper. 1996. Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus. Antimicrob. Agents Chemother. 40:1881-1888.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 1881-1888
    • Ng, E.Y.1    Trucksis, M.2    Hooper, D.C.3
  • 30
    • 0029794181 scopus 로고    scopus 로고
    • Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae
    • Pan, X.-S., J. Ambler, S. Mehtar, and L. M. Fisher. 1996. Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 40:2321-2326.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 2321-2326
    • Pan, X.-S.1    Ambler, J.2    Mehtar, S.3    Fisher, L.M.4
  • 31
    • 8944237982 scopus 로고    scopus 로고
    • Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: Role in fluoroquinolone resistance
    • Pan, X.-S., and L. M. Fisher. 1996. Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance. J. Bacteriol. 178:4060-4069.
    • (1996) J. Bacteriol. , vol.178 , pp. 4060-4069
    • Pan, X.-S.1    Fisher, L.M.2
  • 32
    • 0031046694 scopus 로고    scopus 로고
    • Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: Selective targeting of gyrase or topoisomerase IV by quinolones
    • Pan, X.-S., and L. M. Fisher. 1997. Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones. Antimicrob. Agents Chemother. 41:471-474.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 471-474
    • Pan, X.-S.1    Fisher, L.M.2
  • 33
    • 0031784975 scopus 로고    scopus 로고
    • DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae
    • Pan, X.-S., and L. M. Fisher. 1998. DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 42:2810-2816.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 2810-2816
    • Pan, X.-S.1    Fisher, L.M.2
  • 34
    • 0345414743 scopus 로고    scopus 로고
    • Unpublished observations
    • Pan, X.-S., and L. M. Fisher. Unpublished observations.
    • Pan, X.-S.1    Fisher, L.M.2
  • 35
    • 0030956604 scopus 로고    scopus 로고
    • Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae.
    • Perichon, B., J. Tankovic, and P. Courvalin. 1997. Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 41:1166-1167.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 1166-1167
    • Perichon, B.1    Tankovic, J.2    Courvalin, P.3
  • 36
    • 0027976483 scopus 로고
    • New quinolones and gram-positive bacteria
    • Piddock, L. J. V. 1994. New quinolones and gram-positive bacteria. Antimicrob. Agents Chemother. 38:163-169.
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 163-169
    • Piddock, L.J.V.1
  • 37
    • 0344983500 scopus 로고    scopus 로고
    • Cleavage of DNA by quinolone and 2-pyridone antibacterial agents mediated by Staphylococcus aureus DNA gyrase and DNA topoisomerase IV
    • abstr. P31, New York, N.Y.
    • Saiki, A Y. C., L. L. Shen, C.-M. Chen, J. Baranowski, and C. Lerner. 1998. Cleavage of DNA by quinolone and 2-pyridone antibacterial agents mediated by Staphylococcus aureus DNA gyrase and DNA topoisomerase IV, abstr. P31, p. 42. In Ninth Conference on DNA Topoisomerases in Therapy, New York, N.Y.
    • (1998) Ninth Conference on DNA Topoisomerases in Therapy , pp. 42
    • Saiki, A.Y.C.1    Shen, L.L.2    Chen, C.-M.3    Baranowski, J.4    Lerner, C.5
  • 39
    • 0019878168 scopus 로고
    • DNA gyrase: Affinity chromatography on novobiocin-Sepharose and catalytic properties
    • Staudenbauer, W. L., and E. Orr. 1981. DNA gyrase: affinity chromatography on novobiocin-Sepharose and catalytic properties. Nucleic Acids Res. 9:3589-3603.
    • (1981) Nucleic Acids Res. , vol.9 , pp. 3589-3603
    • Staudenbauer, W.L.1    Orr, E.2
  • 40
    • 0030671535 scopus 로고    scopus 로고
    • Inhibitory activities of quinolones against DNA gyrase and topoisomerase IV purified from Staphylococcus aureus
    • Tanaka, M., Y. Onodera, Y. Uchida, K. Sato, and I. Hayakawa. 1997. Inhibitory activities of quinolones against DNA gyrase and topoisomerase IV purified from Staphylococcus aureus. Antimicrob. Agents Chemother. 41: 2362-2366.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 2362-2366
    • Tanaka, M.1    Onodera, Y.2    Uchida, Y.3    Sato, K.4    Hayakawa, I.5
  • 41
    • 0029911379 scopus 로고    scopus 로고
    • Contribution of mutations in the gyrA and parC genes to fluoroquinolone resistance of mutants of Streptococcus pneumoniae obtained in vivo and in vitro
    • Tankovic, J., B. Perichon, J. Duval, and P. Courvalin. 1996. Contribution of mutations in the gyrA and parC genes to fluoroquinolone resistance of mutants of Streptococcus pneumoniae obtained in vivo and in vitro. Antimicrob. Agents Chemother. 40:2505-2510.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 2505-2510
    • Tankovic, J.1    Perichon, B.2    Duval, J.3    Courvalin, P.4
  • 42
    • 0029084656 scopus 로고
    • The pneumococcus at the gates
    • Tomasz, A. 1995. The pneumococcus at the gates. N. Engl. J. Med. 333:314-315.
    • (1995) N. Engl. J. Med. , vol.333 , pp. 314-315
    • Tomasz, A.1
  • 43
    • 0030014783 scopus 로고    scopus 로고
    • DNA topoisomerases
    • Wang, J. C. 1996. DNA topoisomerases. Annu. Rev. Biochem. 65:635-692.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 635-692
    • Wang, J.C.1
  • 44
    • 0025282176 scopus 로고
    • Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli
    • Yoshida, H., M. Bogaki, M. Nakamura, and S. Nakamura. 1990. Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. Antimicrob. Agents Chemother. 34:1271-1272.
    • (1990) Antimicrob. Agents Chemother. , vol.34 , pp. 1271-1272
    • Yoshida, H.1    Bogaki, M.2    Nakamura, M.3    Nakamura, S.4
  • 46
    • 0028858007 scopus 로고
    • Roles of topoisomerase IV and DNA gyrase in DNA unlinking during replication in Escherichia coli
    • Zechiedrich, E. L., and N. R. Cozzarelli. 1995. Roles of topoisomerase IV and DNA gyrase in DNA unlinking during replication in Escherichia coli. Genes Dev. 9:2859-2869.
    • (1995) Genes Dev. , vol.9 , pp. 2859-2869
    • Zechiedrich, E.L.1    Cozzarelli, N.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.