메뉴 건너뛰기




Volumn 42, Issue 1, 1998, Pages 121-128

Mutations in topoisomerase IV and DNA gyrase of Staphylococcus aureus: Novel pleiotropic effects on quinolone and coumarin activity

Author keywords

[No Author keywords available]

Indexed keywords

COUMAMYCIN; COUMARIN ANTICOAGULANT; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); NALIDIXIC ACID; NOVOBIOCIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SITAFLOXACIN; SPARFLOXACIN;

EID: 0031982852     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.42.1.121     Document Type: Article
Times cited : (95)

References (42)
  • 2
    • 0030045003 scopus 로고    scopus 로고
    • Structure and mechanism of DNA topoisomerase II
    • Berger, J. M., S. J. Gamblin, S. C. Harrison, and J. C. Wang. 1996. Structure and mechanism of DNA topoisomerase II. Nature 379:225-232.
    • (1996) Nature , vol.379 , pp. 225-232
    • Berger, J.M.1    Gamblin, S.J.2    Harrison, S.C.3    Wang, J.C.4
  • 4
    • 0031020730 scopus 로고    scopus 로고
    • Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV
    • Breines, D. M., S. Ouabdesselam, E. Y. Ng, J. Tankovic, S. Shah, C. J. Soussy, and D. C. Hooper. 1997. Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV. Antimicrob. Agents Chemother. 41:175-179.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 175-179
    • Breines, D.M.1    Ouabdesselam, S.2    Ng, E.Y.3    Tankovic, J.4    Shah, S.5    Soussy, C.J.6    Hooper, D.C.7
  • 5
    • 0027278035 scopus 로고
    • Cloning, sequencing, and expression of the DNA gyrase genes from Staphylococcus aureus
    • Brockbank, S. M. V., and P. T. Barth. 1993. Cloning, sequencing, and expression of the DNA gyrase genes from Staphylococcus aureus. J. Bacteriol. 175:3269-3277.
    • (1993) J. Bacteriol. , vol.175 , pp. 3269-3277
    • Brockbank, S.M.V.1    Barth, P.T.2
  • 6
    • 0026648204 scopus 로고
    • gyrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by Escherichia coli DNA gyrase
    • Contreras, A., and A. Maxwell. 1992. gyrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by Escherichia coli DNA gyrase. Mol. Microbiol. 6:1617-1624.
    • (1992) Mol. Microbiol. , vol.6 , pp. 1617-1624
    • Contreras, A.1    Maxwell, A.2
  • 8
    • 0027956736 scopus 로고
    • Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: A primary target of fluoroquinolones
    • Ferrero, L., B. Cameron, B. Manse, D. Lagneaux, J. Crouzet, A. Famechon, and F. Blanche. 1994. Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones. Mol. Microbiol. 13:641-653.
    • (1994) Mol. Microbiol. , vol.13 , pp. 641-653
    • Ferrero, L.1    Cameron, B.2    Manse, B.3    Lagneaux, D.4    Crouzet, J.5    Famechon, A.6    Blanche, F.7
  • 9
    • 0029043097 scopus 로고
    • Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus
    • Ferrero, L., B. Cameron, and J. Crouzet. 1995. Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus. Antimicrob. Agents Chemother. 39:1554-1558.
    • (1995) Antimicrob. Agents Chemother. , vol.39 , pp. 1554-1558
    • Ferrero, L.1    Cameron, B.2    Crouzet, J.3
  • 10
    • 0017043747 scopus 로고
    • Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase
    • Gellert, M., M. H. O'Dea, T. Itoh, and J.-I. Tomizawa. 1976. Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase. Proc. Natl. Acad. Sci. USA 73:4474-4478.
    • (1976) Proc. Natl. Acad. Sci. USA , vol.73 , pp. 4474-4478
    • Gellert, M.1    O'Dea, M.H.2    Itoh, T.3    Tomizawa, J.-I.4
  • 11
    • 0028838764 scopus 로고
    • A novel gyrB mutation in a fluoroquinolone-resistant clinical isolate of Salmonella typhimurium
    • Gensberg, K., Y. F. Jin, and L. Piddock. 1995. A novel gyrB mutation in a fluoroquinolone-resistant clinical isolate of Salmonella typhimurium. FEMS Microbiol. Lett. 132:57-60.
    • (1995) FEMS Microbiol. Lett. , vol.132 , pp. 57-60
    • Gensberg, K.1    Jin, Y.F.2    Piddock, L.3
  • 12
    • 0028363364 scopus 로고
    • The 24kDa N-terminal sub-domain of the DNA gyrase B protein binds coumarin drugs
    • Gilbert, E. J., and A. Maxwell. 1994. The 24kDa N-terminal sub-domain of the DNA gyrase B protein binds coumarin drugs. Mol. Microbiol. 12:365-373.
    • (1994) Mol. Microbiol. , vol.12 , pp. 365-373
    • Gilbert, E.J.1    Maxwell, A.2
  • 13
    • 0025962676 scopus 로고
    • Mutations in DNA gyrase result in novobiocin resistance in halophilic archaebacteria
    • Holmes, M. L., and M.-L. Dyall-Smith. 1991. Mutations in DNA gyrase result in novobiocin resistance in halophilic archaebacteria. J. Bacteriol. 173:642-648.
    • (1991) J. Bacteriol. , vol.173 , pp. 642-648
    • Holmes, M.L.1    Dyall-Smith, M.-L.2
  • 14
    • 0002516115 scopus 로고
    • Mechanisms of quinolone action and bacterial killing
    • D. C. Hooper and J. S. Wolfson (ed.), American Society for Microbiology, Washington, D.C.
    • Hooper, D. C., and J. S. Wolfson. 1993. Mechanisms of quinolone action and bacterial killing, p. 53-75. In D. C. Hooper and J. S. Wolfson (ed.), Quinolone antimicrobial agents. American Society for Microbiology, Washington, D.C.
    • (1993) Quinolone Antimicrobial Agents , pp. 53-75
    • Hooper, D.C.1    Wolfson, J.S.2
  • 18
    • 0025779401 scopus 로고
    • Construction of single-copy integration vectors for Staphylococcus aureus
    • Lee, C. Y., S. L. Buranen, and Z.-H. Ye. 1991. Construction of single-copy integration vectors for Staphylococcus aureus. Gene 103:101-105.
    • (1991) Gene , vol.103 , pp. 101-105
    • Lee, C.Y.1    Buranen, S.L.2    Ye, Z.-H.3
  • 19
    • 0022350299 scopus 로고
    • Mechanism of bacteriophage conversion of lipase activity in Staphylococcus aureus
    • Lee, C. Y., and J. J. Iandolo. 1985. Mechanism of bacteriophage conversion of lipase activity in Staphylococcus aureus. J. Bacteriol. 164:288-293.
    • (1985) J. Bacteriol. , vol.164 , pp. 288-293
    • Lee, C.Y.1    Iandolo, J.J.2
  • 20
    • 0029978822 scopus 로고    scopus 로고
    • The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography
    • Lewis, R. J., O. M. P. Singh, C. V. Smith, T. Skarzynski, A. Maxwell, A. J. Wonacott, and D. B. Wigley. 1996. The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography. EMBO J. 15:1412-1420.
    • (1996) EMBO J. , vol.15 , pp. 1412-1420
    • Lewis, R.J.1    Singh, O.M.P.2    Smith, C.V.3    Skarzynski, T.4    Maxwell, A.5    Wonacott, A.J.6    Wigley, D.B.7
  • 21
    • 0027200479 scopus 로고
    • The interaction between coumarin drugs and DNA gyrase
    • Maxwell, A. 1993. The interaction between coumarin drugs and DNA gyrase. Mol. Microbiol. 9:681-686.
    • (1993) Mol. Microbiol. , vol.9 , pp. 681-686
    • Maxwell, A.1
  • 22
    • 0028981711 scopus 로고
    • Ser-127-to-Leu substitution in the DNA gyrase B subunit of Streptococcus pneumoniae is implicated in novobiocin resistance
    • Muñoz, R., M. Bustamante, and A. de la Campa. 1995. Ser-127-to-Leu substitution in the DNA gyrase B subunit of Streptococcus pneumoniae is implicated in novobiocin resistance. J. Bacteriol. 177:4166-4170.
    • (1995) J. Bacteriol. , vol.177 , pp. 4166-4170
    • Muñoz, R.1    Bustamante, M.2    De La Campa, A.3
  • 24
    • 0028217509 scopus 로고
    • Quinolone resistance mediated by norA: Physiologic characterization and relationship toflqB, a quinolone resistance focus on the Staphylococcus aureus chromosome
    • Ng, E. Y., M. Trucksis, and D. C. Hooper. 1994. Quinolone resistance mediated by norA: physiologic characterization and relationship toflqB, a quinolone resistance focus on the Staphylococcus aureus chromosome. Antimicrob. Agents Chemother. 38:1345-1355.
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 1345-1355
    • Ng, E.Y.1    Trucksis, M.2    Hooper, D.C.3
  • 25
    • 0029824413 scopus 로고    scopus 로고
    • Quinolone resistance mutations in topoisomerase IV: Relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus
    • Ng, E. Y., M. Trucksis, and D. C. Hooper. 1996. Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus. Antimicrob. Agents Chemother. 40:1881-1888.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 1881-1888
    • Ng, E.Y.1    Trucksis, M.2    Hooper, D.C.3
  • 26
    • 0026063124 scopus 로고
    • Inhibitory effects of ciprofloxacin and sparfloxacin on DNA gyrase purified from fluoroquinolone-resistant strains of methicillin-resistant Staphylococcus aureus
    • Okuda, J., S. Okamoto, M. Takahata, and T. Nishino. 1991. Inhibitory effects of ciprofloxacin and sparfloxacin on DNA gyrase purified from fluoroquinolone-resistant strains of methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 35:2288-2293.
    • (1991) Antimicrob. Agents Chemother. , vol.35 , pp. 2288-2293
    • Okuda, J.1    Okamoto, S.2    Takahata, M.3    Nishino, T.4
  • 27
    • 0029794181 scopus 로고    scopus 로고
    • Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae
    • Pan, X.-S., J. Ambler, S. Mehtar, and L. M. Fisher. 1996. Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 40:2321-2326.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 2321-2326
    • Pan, X.-S.1    Ambler, J.2    Mehtar, S.3    Fisher, L.M.4
  • 28
    • 8944237982 scopus 로고    scopus 로고
    • Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: Role in fluoroquinolone resistance
    • Pan, X.-S., and L. M. Fisher. 1996. Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance. J. Bacteriol. 178:4060-4069.
    • (1996) J. Bacteriol. , vol.178 , pp. 4060-4069
    • Pan, X.-S.1    Fisher, L.M.2
  • 29
    • 0031046694 scopus 로고    scopus 로고
    • Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: Selective targeting of gyrase or topoisomerase IV by quinolones
    • Pan, X.-S., and L. M. Fisher. 1997. Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones. Antimicrob. Agents Chemother. 41:471-474.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 471-474
    • Pan, X.-S.1    Fisher, L.M.2
  • 30
    • 0016730194 scopus 로고
    • Transformation analysis of three linkage groups in Staphylococcus aureus
    • Pattee, P. A., and D. S. Neveln. 1975. Transformation analysis of three linkage groups in Staphylococcus aureus. J. Bacteriol. 124:201-211.
    • (1975) J. Bacteriol. , vol.124 , pp. 201-211
    • Pattee, P.A.1    Neveln, D.S.2
  • 31
    • 0030956604 scopus 로고    scopus 로고
    • Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae
    • Périchon, B., J. Tankovic, and P. Courvalin. 1997. Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 41:1166-1167.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 1166-1167
    • Périchon, B.1    Tankovic, J.2    Courvalin, P.3
  • 32
    • 0025633157 scopus 로고
    • DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: Close similarity with quinolone resistance mutations in Escherichia coli
    • Sreedharan, S., M. Oram, B. Jensen, L. R. Peterson, and L. M. Fisher. 1990. DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coli. J. Bacteriol. 172:7260-7262.
    • (1990) J. Bacteriol. , vol.172 , pp. 7260-7262
    • Sreedharan, S.1    Oram, M.2    Jensen, B.3    Peterson, L.R.4    Fisher, L.M.5
  • 33
    • 0020537509 scopus 로고
    • Confirmation of protoplast fusion-derived linkages in Staphylococcus aureus by transformation with protoplast DNA
    • Stahl, M. L., and P. A. Pattee. 1983. Confirmation of protoplast fusion-derived linkages in Staphylococcus aureus by transformation with protoplast DNA. J. Bacteriol. 154:406-412.
    • (1983) J. Bacteriol. , vol.154 , pp. 406-412
    • Stahl, M.L.1    Pattee, P.A.2
  • 34
    • 0030005040 scopus 로고    scopus 로고
    • GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin
    • Stieger, M., P. Angehrn, B. Wohlgensinger, and H. Gmünder. 1996. GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin. Antimicrob. Agents Chemother. 40:1060-1062.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 1060-1062
    • Stieger, M.1    Angehrn, P.2    Wohlgensinger, B.3    Gmünder, H.4
  • 35
    • 0018880839 scopus 로고
    • Bacillus subtilis deoxyribonucleic acid gyrase
    • Sugino, A., and K. F. Bott. 1980. Bacillus subtilis deoxyribonucleic acid gyrase. J. Bacteriol. 141:1331-1339.
    • (1980) J. Bacteriol. , vol.141 , pp. 1331-1339
    • Sugino, A.1    Bott, K.F.2
  • 36
    • 0024039558 scopus 로고
    • Cloning and characterization of a DNA gyrase B gene from Streptomyces sphaeroides that confers resistance to novobiocin
    • Thiara, A. S., and E. Cundliffe. 1988. Cloning and characterization of a DNA gyrase B gene from Streptomyces sphaeroides that confers resistance to novobiocin. EMBO J. 7:2255-2259.
    • (1988) EMBO J. , vol.7 , pp. 2255-2259
    • Thiara, A.S.1    Cundliffe, E.2
  • 37
    • 0025998454 scopus 로고
    • A novel locus conferring fluoroquinolone resistance in Staphylococcus aureus
    • Trucksis, M., J. S. Wolfson, and D. C. Hooper. 1991. A novel locus conferring fluoroquinolone resistance in Staphylococcus aureus. J. Bacteriol. 173: 5854-5860.
    • (1991) J. Bacteriol. , vol.173 , pp. 5854-5860
    • Trucksis, M.1    Wolfson, J.S.2    Hooper, D.C.3
  • 38
    • 0028070915 scopus 로고
    • Mechanistic studies of amsacrine-resistant derivatives of DNA topoisomerase II
    • Wasserman, R. A., and J. C. Wang. 1994. Mechanistic studies of amsacrine-resistant derivatives of DNA topoisomerase II. J. Biol. Chem. 269:20943-20951.
    • (1994) J. Biol. Chem. , vol.269 , pp. 20943-20951
    • Wasserman, R.A.1    Wang, J.C.2
  • 39
    • 0026428621 scopus 로고
    • Crystal structure of an N-terminal fragment of the DNA gyrase B protein
    • Wigley, D. B., G. J. Davies, E. J. Dodson, A. Maxwell, and G. Dodson. 1991. Crystal structure of an N-terminal fragment of the DNA gyrase B protein. Nature (London) 351:624-629.
    • (1991) Nature (London) , vol.351 , pp. 624-629
    • Wigley, D.B.1    Davies, G.J.2    Dodson, E.J.3    Maxwell, A.4    Dodson, G.5
  • 40
    • 0027524110 scopus 로고
    • A single point mutation in the DNA gyrase a protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex
    • Willmott, C. J. R., and A. Maxwell. 1993. A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex. Antimicrob. Agents Chemother. 37:126-127.
    • (1993) Antimicrob. Agents Chemother. , vol.37 , pp. 126-127
    • Willmott, C.J.R.1    Maxwell, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.