Mechanism of quinolone action. A drug-induced structural perturbation of the DNA precedes strand cleavage by topoisomerase IV

Journal of Biological Chemistry

Volumn 272, Issue 14, 1997, Pages 9401-9409

  Marians, Kenneth J ^a   Hiasa, Hiroshi ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE; NORFLOXACIN; QUINOLONE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING SITE; CYTOTOXICITY; DNA BINDING; DNA STRAND BREAKAGE; DRUG DNA INTERACTION; DRUG MECHANISM; PRIORITY JOURNAL;

BINDING SITES; DNA; DNA TOPOISOMERASE IV; DNA TOPOISOMERASES, TYPE II; DNA, SUPERHELICAL; ENZYME INHIBITORS; MUTAGENESIS, SITE-DIRECTED; NORFLOXACIN; NUCLEIC ACID CONFORMATION; POTASSIUM PERMANGANATE; THYMINE;

EID: 0030962482     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.14.9401     Document Type: Article

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