DNA strand cleavage is required for replication fork arrest by a frozen topoisomerase-quinolone-DNA ternary complex

Journal of Biological Chemistry

Volumn 271, Issue 42, 1996, Pages 26424-26429

  Hiasa, Hiroshi ^a   Yousef, Diana O ^b   Marians, Kenneth J ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE; DOUBLE STRANDED DNA; GYRASE INHIBITOR; MUTANT PROTEIN; NORFLOXACIN; QUINOLONE DERIVATIVE;

ARTICLE; CELL DEATH; DNA CLEAVAGE; DNA DRUG COMPLEX; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; DRUG CYTOTOXICITY; DRUG DNA BINDING; ENZYME ACTIVE SITE; ENZYME DENATURATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA; DNA REPLICATION; DNA TOPOISOMERASE IV; DNA TOPOISOMERASES, TYPE II; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; MUTAGENESIS, SITE-DIRECTED; NORFLOXACIN; NUCLEIC ACID CONFORMATION; QUINOLONES;

EID: 0029859964     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.42.26424     Document Type: Article

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