The self-reactive antibody repertoire of normal human serum IgM is acquired in early childhood and remains conserved throughout life

Scandinavian Journal of Immunology

Volumn 44, Issue 3, 1996, Pages 243-251

  Mouthon, L ^a   Lacroix Desmazes, S ^a   Nobrega, A ^b   Barreau, C ^c   Coutinho, A ^b   Kazatchkine, M D ^a  

^a INSERM   (France)

^b CNRS   (France)

^c INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; BACTERIAL ANTIGEN; IMMUNOGLOBULIN M;

ADULT; AGED; AGING; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CONTROLLED STUDY; DEVELOPMENT; ETIOLOGY; FEMALE; HUMAN; IMMUNOBLOTTING; MALE; NORMAL HUMAN; PRESCHOOL CHILD; PRIORITY JOURNAL;

EID: 0029747129     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1996.d01-306.x     Document Type: Article

References (34)

1. Avrameas S, Guilbert B, Dighiero G. Natural antibodies against tubulin, actin, myoglobin, thyroglobulin, fetuin, albumin and transferrin are present in normal human sera and monoclonal immunoglobulins from multiple myeloma and Waldenström's macroglobulinemia may express similar antibody specificities. Ann Inst Pasteur lmmunol 1981;132C:231-6.
2. Guilbert B, Dighiero G, Avrameas S. Naturally occuring antibodies against nine common antigens in normal human sera. I. Detection, isolation, and characterization. J lmmunol 1982;128:2779-87.
3. Yadin O, Sarov B, Naggan L, Slor H, Shoenfeld Y. Natural autoantibodies in the serum of healthy women- a live year follow-up. Clin Exp lmmunol 1989;75:402-6.
4. Pfueller SL, Logan D, Tran TT, Bilston RA. Naturally occurring human IgG antibodies to intracellular and cytoskeletal components of human platelets. Clin Exp lmmunol 1990;79:367-73.
5. Dighiero G, Lymberi P, Mazie J-C, Rouyre S, Butler-Browne GS, Avrameas S. Murine hybridomas secreting natural monoclonal antibodies reacting with self antigens. J lmmunol 1983;131:2267-72.
6. Dighiero G, Lymberi P, Holmberg D, Lundquist I, Coutinho A, Avrameas S. High frequency of natural autoantibodies in normal newborn mice. J lmmunol 1985;134:765-71.
7. Holmberg D, Wennerström G, Andrade L, Coutinho A. The high idiotypic connectivity of'natural' newborn antibodies is not found in adult mitogen-reactive B cell repertoires. Eur J Immunol 1986;16:82-7.
8. Guigou V, Guilbert B, Moinier D et al. Ig repertoire of human polyspecific antibodies and B-cell ontogeny. J Immunol 1991;146:1368-74.
9. Hurez V, Dietrich G, Kaveri SV, Kazatchkine MD. Polyreactivity is a property of natural and disease-associated human autoantibodies. Scand J Immunol 1993;38:190-6.
10. Holmberg D, Forsgren S, Ivars F, Coutinho A. Reactions amongst IgM antibodies derived from normal, neonatal mice. Eur J Immunol 1984;14:435-41.
11. Kearney J, Vakil M. Idiotype-directed interactions during ontogeny play a major role in the establishment of the adult B cell repertoire. Immunol Rev 1986;94:39-50.
12. Lundkvist I, Coutinho A, Varela F, Holmberg D. Evidence for a functional idiotypic network among natural antibodies in normal mice. Proc Natl Acad Sci USA 1989;86:5074-8.
13. Varela F, Andersson A, Dietrich G et al. The population dynamics of antibodies in normal and autoimmune individuals. Proc Natl Acad Sci USA 1991;88:5917-21.
14. Dietrich G, Kaveri SV, Kazatchkine MD. V region-connected autoreactive subfraction of normal human serum immunoglobulin G. Eur J Immunol 1992;22:1701-6.
15. Jeong HD, Teale JM. Comparison of the fetal and adult functional repertoires by analysis of VH family expression. J Exp Med 1988;168:589-604.
16. Chen C, Stenzel-Poore MP, Rittenberg MB. Natural auto- and polyreactive antibodies differing from antigen-induced antibodies in the H chain CDR3. J Immunol 1991;147:2359-67.
17. Haury M, Grandien A, Sundblad A, Coutinho A, Nobrega A. Global analysis of antibody repertoires. 1. An immunoblot method for the quantitative screening of a large number of reactivities. Scand J Immunol 1994;39:79-87.
18. Nobrega A, Haury M, Grandien A, Malanchére E, Sunblad A, Coutinho A. Global analysis of antibody repertoires. II. Evidence for specificity, self-selection and the immunological 'homunculus' of antibodies in normal serum. Eur J Immunol 1993;23:2851-9.
19. Mouthon L, Nobrega A, Nicolas N et al. Invariance and restriction towards a limited set of self-antigens characterize neonatal IgM antibody repertoires and prevail in autoreactive repertoires of healthy adults. Proc Natl Acad Sci USA 1995:92:3839-44.
20. Moulias R, Proust J, Wang A et al. Age-related increase in autoantibodies. Lancet 1984; i: 1128-9.
21. Manoussakis MN, Tzioufas AG. Silis MP, Fange PJE, Goudevenos J, Moutsopoulos HM. High prevalence of anti-cardiolipin and other autoantibodies in a healthy elderly population. Clin Exp Immunol 1987;69:557-65.
22. Tomer Y, Shoenfeld Y. Aging and autoantibodies, Autoimmunity 1988;1:141-9.
23. Ruffati A, Calligaro A, Ross TD et al. Anti-double-stranded DNA antibodies in the healthy elderly: prevalence and characteristics. J Clin Immunol 1990;10[6]:300-3.
24. Globerson A, Tomer Y, Shoenfeld Y. Aging, natural autoantibodies, and autoimmunity. In: Shoenfeld Y, ed. Natural Autoantibodies 1993.
25. Richmond GW, Zeitz HJ. B-cell and immunoglobulin immunodeficiency in the elderly. Immunology and Allergy Clinics of North America 1993;13:517-33.
26. Belikova VA, Cheverach NV, Kalakoutskii LV. Kurthia sibirica, a new bacterial species of the Kurthia genus. Microbiologia 1986;55:831-5.
27. Jobson JD. Applied multivariate data analysis: categorical and multivariate methods, Vol. (II). New York: Springer-Verlag, 1992.
28. 2 antibodies in relatives of patients with systemic lupus erythematosus. Clin Exp Immunol 1985;60:329-36.
29. Bouanani M, Dietrich G, Hurez V et al. Age-related changes in specificity of human natural autoantibodies to thyroglobulin. J Autoimmunity 1993:6:639-48.
30. Hurez V, Kaveri SV, Kazatchkine MD. Expression and control of the natural autoreactive IgG repertoire in normal human serum. Eur J Immunol 1993;23:783-9.
31. Antonaci S, Jirillo E, Bonomo L. Immunoregulation on aging. Diag Clin Immunol 1987;5:55-61.
32. Lacroix-Desmazes S, Mouthon L, Coutinho A, Kazatchkine MD. Analysis of the natural human IgG antibody repertoire: life-long stability of reactivities towards self antigens contrasts with age-dependent diversification of reactivities against bacterial antigens. Eur J Immunol 1995;25:2598-604.
33. Cohen IR. The cognitive paradigm and the immunological homunculus. Immunol Today 1992;13:490-4.
34. Cohen IR. The cognitive principle challenges clonal selection. Immunol Today 1992;13:441-4.