Leptin and its receptor in normal human gastric mucosa and in Helicobacter pylori-associated gastritis

Scandinavian Journal of Gastroenterology

Volumn 34, Issue 10, 1999, Pages 954-961

  Breidert, M ^a,b,c,d   Miehlke, S ^a,b,c,d   Glasow, A ^a,b,c,d   Orban, Z ^a,b,c,d   Stolte, M ^a,b,c,d   Ehninger, G ^a,b,c,d   Bayerdorffer E ^a,b,c,d   Nettesheim, O ^a,b,c,d   Halm, U ^a,b,c,d   Haidan, A ^a,b,c,d   Bornstein, S R ^a,b,c,d  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c INSTITUTE OF PATHOLOGY   (Germany)

^d EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Gastritis; Helicobacter pylori; Laser capture microdissection; Leptin; Leptin receptor

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; RECEPTOR PROTEIN;

ADULT; ARTICLE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; DYSPEPSIA; FEMALE; GASTRITIS; GENE EXPRESSION; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH EPITHELIUM; STOMACH MUCOSA;

ANALYSIS OF VARIANCE; BIOPSY; CARRIER PROTEINS; ENDOSCOPY, GASTROINTESTINAL; FEMALE; GASTRIC MUCOSA; GASTRITIS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IMMUNOHISTOCHEMISTRY; LEPTIN; MALE; MIDDLE AGED; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA;

EID: 0032693797     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.1080/003655299750025039     Document Type: Article

References (37)

1. 1. Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, et al. Crystal structure of the obese protein leptin-E100. Nature 1997;206-9.
2. 2. Flier JS. Clinical review 94: what's in a name? In search of leptin's physiologic role. J Clin Endocrinol Metab 1998;83: 1407-13.
3. 3. Cohen B, Novick D, Rubinstein M. Modulation of insulin activities by leptin. Science 1996;274:1185-8.
4. 4. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998;395:763-70.
5. 5. Kamohara S, Burcelin R, Halaas JL, Friedman JM, Charron MJ. Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 1997;389:374-7.
6. 6. Barrachina MD, Martinez V, Wang L, Wie JY, Tache Y. Synergistic interaction between leptin and cholecystokinin to reduce short-term intake in lean mice. Proc Natl Acad Sci 1997;94:10455-60.
7. 7. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, et al. Serum immunoreactive-leptin concentration in normal-weight and obese humans. N Engl J Med 1996;334:324-5.
8. 8. Lord GH, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998; 394:897-901.
9. 9. Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, et al. The stomach is a source of leptin. Nature 1998;394:790-3.
10. 10. Lee GH, Proenca R, Montez JM, Caroll KM, Darvishazadeh JG, Lee JI, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996;379:632-5.
11. 11. Sierra-Honigmann MR, Nath A, Murakami C, Garcia-Cardena G, Papapetropoulos A, Sessa WC, et al. Biological action of leptin as an angiogenetic factor. Science 1998;281:1683-6.
12. 12. Tartaglia LA, Demski M, Weng X, Deng N, Culpepper J, Devos R, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995;83:1263-71.
13. 13. Morton NM, Emilsson V, Liu YL, Cawthorne MA. Leptin in intestinal cells. J Biol Chem 1998;273:26194-201.
14. 14. Dixon MF, Genta RM, Yardley JH, Correa P, and the participants in the International Workshop on the Histopathology of Gastritis, Houston 1994. Classification and grading of gastritis: the updated Sydney System. Am J Surg Pathol 1996;20:1161-81.
15. 15. Glasow A, Haidan A, Hilbers U, Breidert M, Gillespie J, Scherbaum WA, et al. Expression of Ob receptor in normal human adrenals: differential regulation of adrenocortical and adrenomedullary function by leptin. J Clin Endocrinol Metab 1998;83:4459-66.
16. 16. Cinti S, Frederich RC, Zingaretti MC, De Matteis R, Flier JS, Lowell BB. Immunhistochemical localization of leptin and uncoupling protein in white and brown adipose tissue. Endocrinology 1997;138:797-804.
17. 17. Emmert-Buck RF, Bonner RF, Smith PD, Chuaqui RF, Zhuang Z, Goldstein SR, et al. Laser capture microdissection. Science 1996;274:998-1001.
18. 18. Päth G, Bornstein SR, Ehrhart-Bornstein M, Scherbaum WA. Interleukin-6 and the interleukin-6 receptor in the human adrenal gland: expression and effects on steroidogenesis. J Clin Endocrinol Metab 1998;82:2343-9.
19. 19. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue [published erratum appears in Nature 1995;374:479]. Nature 1994;372:425-32.
20. 20. Bennett BD, Solar GP, Yuan JQ, Mathias J, Thomas GR, Matthews W. A role for leptin and its cognate receptor in hematopoesis. Curr Biol 1996;274:R204-8.
21. 21. Cioffi JA, Shafer AW, Zupancic TJ, Smith-Crur J, Mikhail A, Platika D, et al. Novel b219/ob receptor isoforms: possible role of leptin in hematopoesis and reproduction. Nat Med 1996;2: 585-9.
22. 22. Hill RA, Margetic S, Pegg GC, Gazzola C. Leptin: its pharmacokinetics and tissue distribution. Int J Obesity 1998;22: 765-70.
23. 23. Buffa R, Solcia E, Go VLM. Immunhistochemical identification of the cholecystokinin cell in intestinal mucosa. Gastroenterology 1976;70:528-32.
24. 24. Matson CA, Wiater MF, Kuijper JL, Weigle DS. Synergy between leptin and cholecystokinin (CCK) to control daily caloric intake. Peptides 1997;18:1275-8.
25. 25. Wang YH, Tache Y, Sheibel AB, Go VL, Wie JY. Two types of leptin-responsive gastric vagal afferent terminals: an in vitro single-unit study in rats. Am J Physiol 1997;273:R833-7.
26. 26. Kaplan LM. Leptin, obesity, and liver disease. Gastroenterology 1998;115:997-1001.
27. 27. McCullough AJ, Bugianesi E, Marchesini G, Kalhan SC. Gender-dependent alterations in serum leptin in alcoholic cirrhosis. Gastroenterology 1998;115:947-953.
28. 28. Hoppin AG, Kaplan LM, Zurakowski D, Leichtner AM, Bousvaros A. Serum leptin in children and young adults with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 1998;26:500-5.
29. 29. Bornstein SR. Is leptin a stress related peptide? Nat Med 1997;3:937.
30. 30. Bornstein SR, Licinio J, Tauchnitz R, Engelmann L, Negrao AB, Gold P, et al. Plasma leptin levels are increased in survivors of acute sepsis: associated loss of diurnal rhythm, in cortisol and leptin secretion. J Clin Endocrinol Metab 1998;83:280-3.
31. 31. Bornstein SR, Preas HL, Chrousos GP, Suffredini AF. Circulating leptin levels during acute experimental endotoxemia and antiinflammatory therapy in humans. J Infect Dis 1998;178:887-90.
32. 32. Sarraf P, Frederich RC, Turner EM, Ma G, Jaskowiak NT, Rivet DJ 3rd, et al. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med 1997;185:171-5.
33. 33. Faggioni R, Fantuzzi G, Fuller J, Dianrello CA, Feingold KR, Grunfeld C. Il-1 beta mediates leptin induction during inflammation. Am J Physiol 1998;274:R204-8.
34. 34. Miell JP, Englaro P, Blum WF. Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects. Horm Metab Res 1996;28:704-7.
35. 35. Janik JE, Curti BD, Considine RV, Rager HC, Powers GC, Alvord WG, et al. Interleukin 1-alpha increases serum leptin concentrations in humans. J Clin Endocrinol Metab 1997;82: 3084-5.
36. 36. Zumbach MS, Boehme MWJ, Wahl P, Stremmel W, Ziegler R, Nawroth PP. Tumor necrosis factor increases serum leptin levels in humans. J Clin Endocrinol Metab 1997;82:4080-2.
37. 37. Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, et al. Leptin regulates proinflammatory immune responses. FASEB J 1998;12:57-65.