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Volumn 21, Issue SUPPL. 1, 1997, Pages

Sibutramine: A review of the pharmacology of a novel anti-obesity agent

Author keywords

3 adrenoceptors; 5 hydroxytryptamine; Brown adipose tissue; Expenditure; Intake; Noradrenaline; Satiety; Thermogenesis

Indexed keywords

ANOREXIGENIC AGENT; BETA 2 ADRENERGIC RECEPTOR; NEUROTRANSMITTER; NORADRENALIN; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; SIBUTRAMINE;

EID: 0030942814     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (172)

References (29)
  • 1
    • 0027337616 scopus 로고
    • 3H]5-HT uptake: Effect of administration of various antidepressant treatments
    • 3H]5-HT uptake: effect of administration of various antidepressant treatments. Neuropharmacology 1993; 32: 737-743.
    • (1993) Neuropharmacology , vol.32 , pp. 737-743
    • Cheetham, S.C.1
  • 2
    • 0029670751 scopus 로고    scopus 로고
    • 3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments
    • 3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology 1996; 35: 63-70.
    • (1996) Neuropharmacology , vol.35 , pp. 63-70
    • Cheetham, S.C.1
  • 3
    • 0023814888 scopus 로고
    • The pharmacology of sibutramine hydrochloride (BTS 54 524), a new antidepressant which induces rapid noradrenergic down-regulation
    • Buckett WR, Thomas PC, Luscombe GP. The pharmacology of sibutramine hydrochloride (BTS 54 524), a new antidepressant which induces rapid noradrenergic down-regulation. Prog Neuropsychopharmacol Biol Psychiatry 1988; 12: 575-584.
    • (1988) Prog Neuropsychopharmacol Biol Psychiatry , vol.12 , pp. 575-584
    • Buckett, W.R.1    Thomas, P.C.2    Luscombe, G.P.3
  • 4
    • 0024503310 scopus 로고
    • The contribution of metabolites to the rapid and potent down-regulation of rat cortical β-adrenoceptors by the putative antidepressant sibutramine hydrochloride
    • Luscombe GP, Hopcroft RH, Thomas PC, Buckett WR. The contribution of metabolites to the rapid and potent down-regulation of rat cortical β-adrenoceptors by the putative antidepressant sibutramine hydrochloride. Neuropharmacology 1989; 28: 129-134.
    • (1989) Neuropharmacology , vol.28 , pp. 129-134
    • Luscombe, G.P.1    Hopcroft, R.H.2    Thomas, P.C.3    Buckett, W.R.4
  • 6
    • 8244246880 scopus 로고
    • The effects of sibutramine on serotonin release and metabolism in comparison to other anorectic drugs
    • Martin KF, Heal DJ. The effects of sibutramine on serotonin release and metabolism in comparison to other anorectic drugs. Soc Neuro Abs 1993; 19: A126.2.
    • (1993) Soc Neuro Abs , vol.19
    • Martin, K.F.1    Heal, D.J.2
  • 7
    • 0026510184 scopus 로고
    • A comparison of the effects of sibutramine hydrochloride, bupropion and methamphetamine on dopaminergic function: Evidence that dopamine is not a pharmacological target for sibutramine
    • Heal DJ et al. A comparison of the effects of sibutramine hydrochloride, bupropion and methamphetamine on dopaminergic function: evidence that dopamine is not a pharmacological target for sibutramine. Psychopharmacology 1992; 107: 303-309.
    • (1992) Psychopharmacology , vol.107 , pp. 303-309
    • Heal, D.J.1
  • 9
    • 0026071468 scopus 로고
    • Effects of antidepressant drugs and electroconvulsive shock on pre- and postsynaptic α2-adrenoceptor function in the brain: Rapid down-regulation by sibutramine hydrochloride
    • Heal DJ, Prow MR, Buckett WR. Effects of antidepressant drugs and electroconvulsive shock on pre- and postsynaptic α2-adrenoceptor function in the brain: rapid down-regulation by sibutramine hydrochloride. Psychopharmacology 1991; 103: 251-257.
    • (1991) Psychopharmacology , vol.103 , pp. 251-257
    • Heal, D.J.1    Prow, M.R.2    Buckett, W.R.3
  • 10
    • 0026603572 scopus 로고
    • 2-adrenoceptors exclusively by sibutramine hydrochloride
    • 2-adrenoceptors exclusively by sibutramine hydrochloride. Psychopharmacology 1992; 107: 497-502.
    • (1992) Psychopharmacology , vol.107 , pp. 497-502
    • Heal, D.J.1
  • 11
    • 0026784676 scopus 로고
    • 1A autoreceptor response and its evaluation as a model to selectively identify antidepressants
    • 1A autoreceptor response and its evaluation as a model to selectively identify antidepressants. Br J Pharmacol 1992; 107: 15-21.
    • (1992) Br J Pharmacol , vol.107 , pp. 15-21
    • Martin, K.F.1
  • 12
    • 0000197203 scopus 로고
    • Sibutramine: Weight loss in depressed patients
    • Kelly F, Jones SP, Lee IK. Sibutramine: weight loss in depressed patients. Int J Obes 1995; 19 (Suppl 2): P397.
    • (1995) Int J Obes , vol.19 , Issue.2 SUPPL.
    • Kelly, F.1    Jones, S.P.2    Lee, I.K.3
  • 13
    • 0003135508 scopus 로고
    • Decrease of food intake and weight loss induced by sibutramine in the rat
    • Fantino M et al. Decrease of food intake and weight loss induced by sibutramine in the rat. Obesity Res 1995; 3 (Suppl 4): S628.
    • (1995) Obesity Res , vol.3 , Issue.4 SUPPL.
    • Fantino, M.1
  • 14
    • 0008909631 scopus 로고
    • Sibutramine effects on feeding behaviour: A dose-dependence and microstructural analysis
    • Stricker-Kongrad A, Burlet C, Souquet AM, Courcier A. Sibutramine effects on feeding behaviour: a dose-dependence and microstructural analysis. Obesity Res 1995; 3(Suppl 4): 631S.
    • (1995) Obesity Res , vol.3 , Issue.4 SUPPL.
    • Stricker-Kongrad, A.1    Burlet, C.2    Souquet, A.M.3    Courcier, A.4
  • 15
    • 0000854215 scopus 로고
    • Effects of sibutramine on feeding behaviour in obese and lean Zucker rats
    • Stricker-Kongrad A, Souquet AM, Burlet C. Effects of sibutramine on feeding behaviour in obese and lean Zucker rats. Int J Obes 1995; 19 (Suppl 2): P399.
    • (1995) Int J Obes , vol.19 , Issue.2 SUPPL.
    • Stricker-Kongrad, A.1    Souquet, A.M.2    Burlet, C.3
  • 16
    • 0000854215 scopus 로고
    • Effects of sibutramine on feeding behaviour in dietary-induced obesity: Role of dietary constituents
    • Stricker-Kongrad A, Souquet AM, Burlet C. Effects of sibutramine on feeding behaviour in dietary-induced obesity: role of dietary constituents. Int J Obes 1995; 19(Suppl 2): P398.
    • (1995) Int J Obes , vol.19 , Issue.2 SUPPL.
    • Stricker-Kongrad, A.1    Souquet, A.M.2    Burlet, C.3
  • 17
    • 0000197205 scopus 로고
    • Effects of Metabolites 1 and 2 of sibutramine on the short-term control of food intake in the rat
    • Fantino M, Souquet AM. Effects of Metabolites 1 and 2 of sibutramine on the short-term control of food intake in the rat. Int J Obes 1995; 19(Suppl 2): 400P.
    • (1995) Int J Obes , vol.19 , Issue.2 SUPPL.
    • Fantino, M.1    Souquet, A.M.2
  • 18
    • 0016776704 scopus 로고
    • Cholecystokinin elicits the complete behavioural sequence in rats
    • Antin J et al. Cholecystokinin elicits the complete behavioural sequence in rats. J Comp Physiol Psychol 1975; 84: 784-790.
    • (1975) J Comp Physiol Psychol , vol.84 , pp. 784-790
    • Antin, J.1
  • 19
    • 0001612783 scopus 로고
    • Effects in the rat of sibutramine on food intake and the behavioural satiety sequence
    • Halford JCG, Heal DJ, Blundell JE. Effects in the rat of sibutramine on food intake and the behavioural satiety sequence. Br J Pharmacol 1995; 114: 387P.
    • (1995) Br J Pharmacol , vol.114
    • Halford, J.C.G.1    Heal, D.J.2    Blundell, J.E.3
  • 20
    • 0000979242 scopus 로고    scopus 로고
    • Effects of various monoamine receptor antagonists on the decrease in food intake induced by sibutramine in the rat
    • Stricker-Kongrad A, Souquet A-M, Jackson HC, Burlet C. Effects of various monoamine receptor antagonists on the decrease in food intake induced by sibutramine in the rat. Br J Pharmacol 1996; 117: 167P.
    • (1996) Br J Pharmacol , vol.117
    • Stricker-Kongrad, A.1    Souquet, A.-M.2    Jackson, H.C.3    Burlet, C.4
  • 21
    • 0013469753 scopus 로고    scopus 로고
    • Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and NA reuptake inhibitor sibutramine in the rat
    • Jackson HC et al. Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and NA reuptake inhibitor sibutramine in the rat. Br J Pharmacol 1996; 117: 168P.
    • (1996) Br J Pharmacol , vol.117
    • Jackson, H.C.1
  • 22
    • 0013505918 scopus 로고    scopus 로고
    • Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat
    • Jackson HC et al. Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat. Br J Pharmacol 1996; 117: 323P.
    • (1996) Br J Pharmacol , vol.117
    • Jackson, H.C.1
  • 23
    • 0000115414 scopus 로고
    • A study in rats of the effects of sibutramine on food intake and thermogenesis
    • Connoley IP, Heal DJ, Stock MJ. A study in rats of the effects of sibutramine on food intake and thermogenesis. Br J Pharmacol 1995; 114: 388P.
    • (1995) Br J Pharmacol , vol.114
    • Connoley, I.P.1    Heal, D.J.2    Stock, M.J.3
  • 24
    • 0027103164 scopus 로고
    • Thermogenesis, brown adipose tissue and dexfenfluramine in animal studies
    • Rothwell NJ, Le Feuvre RA. Thermogenesis, brown adipose tissue and dexfenfluramine in animal studies. Int J Obes 1992; 16(Suppl 3): S67-S71.
    • (1992) Int J Obes , vol.16 , Issue.3 SUPPL.
    • Rothwell, N.J.1    Le Feuvre, R.A.2
  • 25
    • 0001071783 scopus 로고    scopus 로고
    • Role of β-adrenoceptors in mediating the thermogenic effects of sibutramine
    • Connoley IP, Frost I, Heal DJ, Stock MJ. Role of β-adrenoceptors in mediating the thermogenic effects of sibutramine. Br J Pharmacol 1996; 117: 170P.
    • (1996) Br J Pharmacol , vol.117
    • Connoley, I.P.1    Frost, I.2    Heal, D.J.3    Stock, M.J.4
  • 26
    • 0028986480 scopus 로고
    • 3-adrenoceptor agonist, BRL 35135, on tissue glucose utilization
    • 3-adrenoceptor agonist, BRL 35135, on tissue glucose utilization. Br J Pharmacol 1995; 114: 888-894.
    • (1995) Br J Pharmacol , vol.114 , pp. 888-894
    • Liu, Y.-L.1    Stock, M.J.2
  • 28
    • 0024997854 scopus 로고
    • α- and β-adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocytes differentiated in culture
    • Rehmark S et al. α- and β-adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocytes differentiated in culture. J Biol Chem 1990; 265: 16464-16471.
    • (1990) J Biol Chem , vol.265 , pp. 16464-16471
    • Rehmark, S.1
  • 29
    • 8244230295 scopus 로고
    • Effects of chronic sibutramine treatment on body composition in adult rats
    • Souquet AM, Courcier S, Stricker-Kongrad A, Burlet C. Effects of chronic sibutramine treatment on body composition in adult rats. Obesity Res 1995; 3(Suppl 4): S631.
    • (1995) Obesity Res , vol.3 , Issue.4 SUPPL.
    • Souquet, A.M.1    Courcier, S.2    Stricker-Kongrad, A.3    Burlet, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.