Tn10 and IS10 transposition and chromosome rearrangements: Mechanism and regulation in vivo and in vitro

Current Topics in Microbiology and Immunology

Volumn 204, Issue , 1996, Pages 49-82

  Kleckner, N ^a   Chalmers, R M ^a   Kwon, D ^a   Sakai, J ^a   Bolland, S ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME REARRANGEMENT; DNA TRANSPOSITION; GENETIC REGULATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRANSPOSON;

EID: 0029655788     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-79795-8_3     Document Type: Review

References (96)

1. Adzuma K, Mizuuchi K (1989) Interaction of proteins located at a distance along DNA: mechanism of target immunity in the Mu DNA strand-transfer reaction Cell 57: 41-47
2. Arciszewska LK, Drake D, Craig NL (1989) Transposon Tn7 cis-acting sequences in transposition and transposition immunity. J Mol Biol 207: 35-52
3. Arthur A, Sherratt D (1979) Dissection of the transposition process: a transposon-encoded site-specific recombination system. Mol Gen Genet 175: 267-274
4. Arthur A, Nimmo E, Hettle S, Sherratt D (1984) Transposition and transposition immunity of transposon Tn3 derivatives having different ends EMBO J 3: 1723-1730
5. Bainton R, Gamas P, Craig NL (1991) Tn7 transposition in vitro proceeds through an excised transposon intermediate generated by staggered breaks in DNA Cell 65: 850-816
6. Bainton RJ, Kubo KM, Feng JN, Craig NL (1993) Tn7 transposition: target DNA recognition is mediated by multiple Tn7-encoded proteins in a purified in vitro system Cell 72: 931-943
7. Baker TA, Luo L (1994) Identification of residues in the Mu transposase essential for catalysis. Proc Natl Acad Sci USA 91: 6654-6658
8. Baker TA, Mizuuchi M, Savilahti H, Mizuuchi K (1993) Division of labor among monomers within the Mu transposase tetramer Cell 74: 723-733
9. Baker TA, Kremenstova E, Luo L (1994) Complete transposition requires four active monomers in the Mu transposase tetramer. Genes Dev 8: 2416-2428
10. Bender J, Kleckner N (1986) Genetic evidence that Tn10 transposes by a nonreplicative mechanism Cell 45: 801-815
11. Bender J, Kleckner N (1992a) Tn10 insertion specificity is strongly dependent upon sequences immediately adjacent to the target site consensus sequence Proc Natl Acad Sci USA 89: 7996-8000
12. Bender J, Kleckner N (1992b) IS10 transposase mutations that specifically alter target site recognition EMBO J 11: 741-750
13. Bender J, Kuo J, Kleckner N (1991) Genetic evidence against intramolecular rejoining of the donor DNA molecular following IS10 transposition. Genetics 128: 687-694
14. Benjamin H, Kleckner N (1989) Intramolecular transposition by Tn10. Cell 59: 373-383
15. Benjamin H, Kleckner N (1992) Tn10 transposase excises Tn10 from flanking donor DNA by flush double-strand cleavages at the transposon termini Proc Natl Acad Sci USA 89: 4648-4652
16. Bennett PM, Robinson MK, Richmond MH (1977) R-factors their properties and possible control. In Drews J, Högenauer G (eds) Topics in infectious diseases, vol 2 Springer, Berlin Heidelberg, New York, p81
17. Berg DE (1983) Structural requirements for IS50-mediated gene transposition. Proc Natl Acad Sci USA 80: 792-796
18. Bolland S, Kleckner N (1995) The two single strand cleavages at each end of Tn10 occur in a specific order during transposition Proc Natl Acad Sci USA (in press)
19. Bushman FD, Craigie R (1992) Integration of human immunodeficiency virus DNA: adduct interference analysts of required DNA sites. Proc Natl Acad Sci USA 89: 3458-3462
20. Casadesus J, Roth JR (1989) Transcriptional occlusion of transposon targets. Mol Gen Genet 216: 204-209
21. Case CC, Roels SM, Jensen PD, Lee J, Kleckner N, Simon RW (1989) The unusual stability of the IS10 anti-sense RNA is critical for its function and is determined by the structure of its stem domain EMBO J 13: 4297-4305
22. Chalmers RM, Kleckner N (1994) Tn10/IS10 transposase purification activation and in vitro reaction. J Biol Chem 269: 8029-8035
23. Chandler M, Clerger M, Galas DJ (1982) The transposition frequency of IS1-flanked transposons is a function of their size. J Mol Biol 154: 229-243
24. Chao L, Vargas C, Spear BB, Cox EC (1983) Transposable elements as mutator genes in evolution Nature 303: 633-635
25. Craigie R, Mizuuchi K (1986) Role of DNA topology in Mu transposition mechanism of sensing the relative orientation of two DNA segments. Cell 45: 793-800
26. Craigse R, Mizuuchi M, Mizuuchi K (1984) Site-specific recognition of the bacteriophage Mu ends by the Mu A protein Cell 39: 387-394
27. Davis MA, Simons RW, Kleckner N (1985) Tn10 protects itself at two levels against fortuitous activation by external promoters. Cell 43: 379-387
28. DeLong A, Syvanen M (1991) Trans-acting transposase mutant from Tn5. Proc Natl Acad Sci USA 88: 6072-2076
29. Derbyshire KM, Grindley NDF (1992) Binding of the IS903 transposase to its inverted repeat in vitro EMBO J 11: 3449-3455
30. Derbyshire KM, Kramer M, Grindley NDF (1990) Role of instability in the cis action of the insertion sequence IS903 transposase Proc Natl Acad Sci USA 87: 4048-4052
31. Doak TG, Doerder FP, Jahn CL, Herrick G (1994) A proposed superfamily of transposase genes: transposon-like elements in ciliated protozoa and a common "D35E" motif Proc Natl Acad Sci USA 91: 942-946
32. Engelman A, Mizuuchi K, Craigie R (1991) HIV-1 DNA integration mechanism of viral DNA cleavage and DNA strand transfer. Cell 67: 1211-1221
33. Fayet O, Ramond P, Polard P, Prére MF, Chandler M (1990) Functional similarities between retroviruses and the 1S3 family of bacterial insertion sequences? Mol Microbiol 4: 1771-1777
34. Flick K (1991) The relationship between element length and transposition frequency of Tn10 in vivo and in vitro. Honor thesis Biochemical Sciences, Harvard University
35. Foster T, Davis MA, Takeshita K, Roberts DE, Kleckner N (1981a) Genetic organization of transposon Tn10. Cell 23: 201-213
36. Foster T, Lundblad V, Hanley-Way S, Hailing S, Kleckner N (1981b) Three Tn10-associated excision events relationship to transposition and role of direct and inverted repeats. Cell 23: 215-227
37. Galas DJ, Chandler M (1989) Bacterial insertion sequences In. Berg DE, Howe MM (eds) Mobile DNA American Society for Microbiology, Washington DC, pp 109-162
38. Grinsted J, Bennett PM, Higginson S, Richmond MH (1978) Regional preference of insertion Tn501 and Tn802 into RP1 and its derivatives. Mol Gen Genet 166: 313
39. Hagemann AT, Craig NL (1993) Tn7 transposition creates a hotspot for homologous recombination at the transposon donor site Genetics 133: 9-16
40. Hallet B, Rezsohazy R, Mahillon J, Delcour J (1994) IS213A insertion specificity: consensus sequence and DNA bending at the target site. Mol Microbiol 14: 131-139
41. Halling SM, Kleckner N (1982) A symmetrical six-basepair target site sequence determines Tn10 insertion specificity Cell 28: 155-163
42. Haniford D, Kleckner N (1994) Tn10 transposition in vivo: temporal separation of cleavages at the two transposon ends and roles of terminal basepairs subsequent to interaction of ends EMBO J 13: 3401-3411
43. Haniford DB, Chelouche AR, Kleckner N (1989) A specific class of IS10 transposase mutants are blocked for target site interactions and promote formation of an excised transposon fragment Cell 59: 385-394
44. Haniford DB, Benjamin HW, Kleckner N (1991) Kinetic and structural analysis of a cleaved donor intermediate and strand transfer product in Tn10 transposition Cell 64: 171-179
45. Harayama S, Oguchi T, Iino T (1984) Does Tn10 transpose via the cointegrate molecule? Mol Gen Genet 194: 444-450
46. Harshey RM, Getzoff ED, Baldwin DL, Miller JL, Chaconas G (1985) Primary structure of phage Mu transposase homology to Mu repressor Proc Natl Acad Sci USA 82: 7676-7680
47. Huisman O, Errada PR, Signon L, Kleckner N (1989) Mutational analysis of IS10's outside end EMBO J 8: 2101-2109
48. Jain C, Kleckner N (1993) Preferential cis action of IS10 transposase depends upon its mode of synthesis Mol Microbiol 9: 249-260
49. Jilk RA, Makris JC, Borchardt L, Reznikoff WS (1993) Implications of Tn5-associated adjacent deletions. J Bacteriol 175: 1264-1271
50. Joyce CM, Steitz TA (1994) Function and structure relationships in DNA polymerases. Annu Rev Biochem 63: 777-822
51. Junop MS, Hockman D, Haniford D (1994) Intragenic suppression of integration-defective IS1O transposase mutants. Genetics 137: 343-352
52. Kleckner N (1979) DNA sequence analysis of Tn10 insertions: origin and role of 9-bp flanking repetitions during Tn10 translocation. Cell 16: 711-720
53. Kleckner N (1989) Transposon Tn10 In Berg DE, Howe MM (eds) Mobile DNA American Society for Microbiology, Washington DC, pp 227-268
54. Kleckner N (1990a) Regulating Tn10 and IS10 transposition Genetics 124: 449-454
55. Kleckner N (1990b) Regulation of transposition in bacteria Annu Rev Cell Biol 6: 297-327
56. Kleckner N, Reichardt K, Botstein D (1979a) Inversions and deletions of the Salmonella chromosome generated by the translocatable tetracycline-resistance element Tn10. J Mol Biol 127: 89-115
57. Kleckner N, Steele D, Reichardt K, Botstein D (1979b) Specificity of insertion by the translocatable tetracycline-resistance element Tn10 Genetics 92: 1023-1040
58. Kwon D, Chalmers RM, Kleckner N (1995) Structural domains of IS10 transposase and reconstitution of transposition activity from proteolytic fragments lacking an inter-domainal linker. Proc Natl Acad Sci USA (in press)
59. Lee S, Butler D, Kleckner N (1987) Efficient Tn10 transposition into a DNA insertion hot spot in vivo requires the 5-methyl groups of symmetrically disposed thymines within the hot-spot consensus sequence Proc Natl Acad Sci USA 84: 7876-7880
60. Leung PC, Teplow DB, Harshey RM (1989) Interaction of distinct domains in Mu transposase with Mu DNA ends and an internal transpositional enhancer. Nature 338: 656-658
61. Lichens-Park A, Syvanen M (1988) Cointegrate formation by IS50 requires multiple donor molecules. Mol Gen Genet 211: 244-251
62. Machida Y, Machida H, Ohtsubo H, Ohtsubo E (1982) Factors determining frequency of plasmid cointegration mediated by insertion sequence IS1 Proc Natl Acad Sci USA 79: 277-281
63. Mahillion J, Seurinck J, Van Rompuy L, Delcour J, Zabeau M (1985) Nucleotide sequence and structural organization of an insertion sequence element (IS231) from Bacillus thuringiensis strain Berlin 1715. EMBO J 4: 3895-3899
64. Mizzuchi K (1992a) Transpositional recombination: mechanistic insights from studies of Mu and other elements Annu Rev Biochem 61: 1011-1051
65. Mizuuchi K (1992b) Polynucleotidyl transfer reactions in transpositional DNA recombination J Biol Chem 276: 21273-21276
66. Mizuuchi K, Adzuma K (1991) Inversion of the phosphate chirality at the target site of Mu DNA strand transfer evidence for a one-step transesterification mechanism Cell 66: 129-140
67. Mizuuchi M, Mizuuchi K (1989) Efficient Mu transposition requires interaction of transposase with a DNA sequence at the Mu operator implications for regulation Cell 58: 399-408
68. Mizuuchi M, Baker TA, Mizuuchi K (1992) Assembly of the active form of the transposase-Mu DNA complex: a critical control point in Mu transposition Cell 70: 303-311
69. Monsato D, Kleckner N (1984) Transposase promotes double strand breaks and single strand joints at Tn10 termini in vivo Cell 39: 181-190
70. Monsato D, Kleckner N (1987) Tn10 transposition and circle formation in vitro Cell 51: 101-111
71. Monsato D, Way JC, Kim H-J, Kleckner N (1983) Tn10 transposase acts preferentially on nearby transposon ends in vivo. Cell 32: 799-807
72. Navas J, Garcia-Lobo JM, Leon J, Ortiz JM (1985) Structural and functional analyses of the fosfomycin resistance transposon Tn 2921 J Bacteriol 162: 1061-1067
73. Raleigh EA, Kleckner N (1984) Multiple IS10 rearrangements in Escherichia coli J Mol Biol 173: 437-461
74. Reif HJ, Saedler H (1977) Chromosomal rearrangements in the gat region of E coli K-12 after integration of IS1 In: Bukhan AI, Shapiro JA, Adhya SL (eds) DNA insertion elements, plasmids, and episomes. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp 81-91
75. Rezsöhazy R, Hallet B, Delcour J, Mahillon J (1993) The IS4 family of insertion sequences: evidence for a conserved transposase motif. Mol Microbiol 9: 1283-1295
76. Roberts D, Kleckner N (1988) Tn10 transposition promotes RecA-dependent induction of a lambda prophage. Proc Natl Acad Sci USA 85: 6037-6041
77. Roberts DE, Hoopes BC, McClure WR, Kleckner N (1985) IS10 transposition is regulated by DNA adenine methylation. Cell 43: 117-130
78. Roberts D, Ascherman D, Kleckner N (1991) IS10 promotes formation of adjacent deletions at low frequency. Genetics 128: 37-43
79. Ross D, Swan J, Kleckner N (1979) Physical structures of Tn10-promoted deletions and inver-sions, role of 1400 basepair inverted repetitions. Cell 16: 721-731
80. Sakai J, Chalmers RM, Kleckner N (1995) Identification and characterization of a precleavage synaptic complex that is an early intermediate in Tn10 transposition. EMBO J (in press)
81. Shapiro JA (1979) Molecular model for the transposition and replication of bacteriophage Mu and other transposable elements. Proc Natl Acad Sci USA 76: 1933-1937
82. Shen M, Raleigh EA, Kleckner N (1987) Physical analysis of IS10-promoted transpositions and rearrangements. Genetics 116: 359-369
83. Signon L, Kleckner N (1995) Negative and positive regulation of Tn10/IS10-promoted recombination by IHF: two distinguishable processes inhibit transposition off of multicopy plasmid replicons and activate chromosomal events that favor evolution of new transposons. Genes Dev 9: 1123-1136
84. Simons RW, Kleckner N (1983) Translational control of IS10 transposition. Cell 34: 683-691
85. Simons RW, Hoopes B, McClure W, Kleckner N (1983) Three promoters near the ends of IS10: p-IN p-OUT and p-III Cell 34: 673-682
86. Starlinger P, Saedler H (1976) IS-elements in microorganisms In: Compans RW, Cooper M, Koprowski H et al. (eds) Current Topics in Microbiology and Immunology, Vol. 75. Springer, Berlin Heidelberg, New York, p111
87. Suck D, Lahm A, Oefner C (1988) Structure refined to 2A of a nicked DNA octanucleotide complex with DNase I. Nature 332: 464-468
88. Surette MG, Chaconas G (1992) The Mu transpositional enhancer can function in trans: requirement of the enhancer for synapsis but not strand cleavage. Cell 68: 1101-1108
89. Surette MG, Buch SJ, Chaconas G (1987) Transpososomes, stable protein-DNA complexes involved in the in vitro transposition of bacteriophage Mu DNA Cell 49: 253-262
90. Surette MG, Harkness T, Chaconas G (1991) Stimulation of the Mu A protein-mediated strand cleavage reaction by the Mu B protein, and the requirement of DNA nicking for stable type 1 transpososome formation. J Biol Chem 266: 3118-3124
91. Thaler DS, Stahl MM, Stahl FW (1987) Tests of the double-strand-break repair model for Red-mediated recombination of phage λ and plasmid λdv Genetics 116: 501-511
92. Waugh DS, Sauer RT (1993) Single amino acid substitutions uncouple the DNA binding and strand scission activities of Fokl endonuclease Proc Natl Acad Sci USA 90: 9596-9600
93. Way J, Kleckner N (1985) Transposition of plasmid-borne Tn10 elements does not exhibit simple length dependence Genetics 111: 705-713
94. Weinert TA, Derbyshire K, Hughson FM, Grindley NDF (1984) Replicative and conservative transpositional recombination of insertion sequences. Cold Spring Harbor Symp Quant Biol 49: 251-260
95. Weigand TW, Reznikoff WS (1992) Characterization of two hypertransposing Tn5 mutants. J Bacteriol 174: 1229-1239
96. Weinreich MD, Gasch A, Reznikoff WS (1994) Evidence that the cis preference of the Tn5 transposase is caused by nonproductive multimenzation. Genes Dev 8: 2363-2374