Investigation of the binding of isoform-selective inhibitors to prostaglandin endoperoxide synthases using fluorescence spectroscopy

Biochemistry

Volumn 37, Issue 1, 1998, Pages 217-226

  Lanzo, Cheryl A ^a   Beechem, Joseph M ^a   Talley, John ^b   Marnett, Lawrence J ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; ARACHIDONIC ACID; FLURBIPROFEN; HEME; HEMOPROTEIN; ISOENZYME; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; SC 58076; SC 58092; UNCLASSIFIED DRUG;

ANISOTROPY; ARTICLE; CONTROLLED STUDY; ENERGY TRANSFER; ENZYME BINDING; FLUORESCENCE SPECTROSCOPY; MOLECULAR MODEL; PRIORITY JOURNAL;

ANIMALS; APOENZYMES; BINDING, COMPETITIVE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; ENERGY TRANSFER; FLUORESCENCE POLARIZATION; FLURBIPROFEN; HEME; HUMANS; ISOENZYMES; KINETICS; MEMBRANE PROTEINS; MODELS, MOLECULAR; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN BINDING; QUANTUM THEORY; SHEEP; SPECTROMETRY, FLUORESCENCE; THIAZOLES; TITRIMETRY;

EID: 0032488630     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi971691n     Document Type: Article

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