Signal TransductionThrough Cytokine Receptors

International Reviews of Immunology

Volumn 17, Issue 42008, 1998, Pages 75-102

  Hibi, Masahiko ^a   Hirano, Toshio ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Cytokine receptor; JAK; MAP kinase; Ras; Signal transduction; STAT

Indexed keywords

CYTOKINE RECEPTOR;

ANIMAL; ARTICLE; HUMAN; IMMUNOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; HUMANS; RECEPTORS, CYTOKINE; SIGNAL TRANSDUCTION;

EID: 0032430523     PISSN: 08830185     EISSN: 15635244     Source Type: Journal    
DOI: 10.3109/08830189809084488     Document Type: Article

References (150)

1. Hirano T., Nakajima K., Hibi M. Cytokine & Growth Factor Reviews. Signaling mechanisms through gp130: a model of the cytokine system. 1997, in press
2. Bazan J. F. Haematopoietic receptors and helical cytokines. Immunol. Today 1990; 11: 350 – 354
3. Miyajima A., Kitamura T., Harada N., Yokota T., Arai K. Cytokine receptors and signal transduction. Annu. Rev. Immunol. 1992; 10: 295 – 331
4. Ihle J. N., Kerr I. M. Jaks and Stats in signaling by the cytokine receptor superfamily. Trends. Genet. 1995; 11: 99 – 74
5. Ihle J. N. Cytokine receptor signalling. Nature 1995; 377: 591 – 594
6. Darnell J. E.J., Kerr I. M., Stark G. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994; 264: 1415 – 1421
7. Schindler C., Darnell J. E.J. Transcriptional responses to polypeptide ligands: the Jak-STAT pathway. Annu. Rev. Biochem. 1995; 64: 621 – 651
8. Ihle J. N. STATs: signal transducers and activators of transcription. Cell 1996; 84: 331 – 334
9. Hiton D. J., Watowich S. S., Kats L., Lodish H. F. Saturation mutagenesis of the WSXWS motif of the erythropoietin receptor. J. Biol. Chem. 1996; 271: 4699 – 4708
10. Murakami M., Narazaki M., Hibi M., Yawata H., Yasukawa K., Hamaguchi M., Taga T., Kishimoto T. Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family. Proc. Natl. Acad. Sci. USA 1991; 88: 11349 – 11353
11. Fukunaga R., Ishizaka-Ikeda E., Pan C. X., Seto Y., Nagata S. Functional domains of the granulocyte colony-stimulating factor receptor. EMBO J. 1991; 10: 2855 – 2865
12. Narazaki M., Witthuhn B. A., Yoshida K., Silvennoinen O., Yasukawa K., Ihle J. N., Kishimoto T., Kishimoto T. Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130. Proc. Natl. Acad. Sci. USA 1994; 91: 2285 – 2289
13. Lebrun J. J., Ali S., Ullrich A., Kelly P. A. Proline-rich sequence-mediated JAK2 association to the prolactin receptor is required but not sufficient for signal transduction. J. Biol. Chem. 1995; 270: 10664 – 10670
14. Wang Y. D., Wood W. I. Amino acids of the human growth hormone receptor that are required for proliferation and Jak-STAT signaling. Mol. Endocrinol. 1995; 9: 303 – 311
15. Avalos B. R., Hunter M. G., Parker J. M., Ceselaki S. K., Drunker B. J., Corey S. J., Mehta V. B. Point mutations in the conserved boxl region inactivate the human granulocyte-colony stimulating factor receptor for growth signal transduction and tyrosine phosphorylation of p75 c-rel. Blood 1995; 85: 3117 – 3126
16. Tanner J. W., Chen W., Woung R. L., Lonmore G. D., Shaw A. S. The conserved boxl motif of cytokine receptor is required for association with JAK kinases. J. Biol. Chem. 1995; 270: 6523 – 6530
17. Mehler M. F., Kessler J. A. Hematolymphopoietic and inflammatory cytokines in neural development. Trends Neurosci. 1997; 20: 357 – 365
18. Hirano T., Matsuda T., Nakajima K. Signal transduction through gp130 that is shared among receptors for the interleukin 6 related cytokine subfamily. Stem Cell Dayt. 1994; 12: 262 – 277
19. Taga T., Kishimoto T. Signaling mechanisms through cytokine receptors that share signal transducing receptor components. Curr. Opin. Immunol. 1995; 7: 17 – 23
20. Hibi M., Nakajima K., Hirano T. IL-6 cytokine family and signal transduction: a model of cytokine system. J. Mol. Med. 1990; 74: 1 – 12
21. Boulay J. L., Paul W. E. The interleukin-4 family lymphokines. Curr. Opin. Immunol. 1992; 4: 294 – 298
22. Sugamura K., Asao H., Kondo M., Tanaka N., Ishii N., Nakamura M., Takeshita T. The common gamma-chain for multiple cytokine receptors. Adv. Immunol. 1995; 59: 225 – 277
23. Murakami M., Hibi M., Nakagawa N., Nakagawa T., Yasukawa K., Yamanishi K., Taga T., Kishimoto T. IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 1993; 260: 1808 – 1810
24. Davis S., Aldrich T. H., Stahl N., Pan L., Taga T., Kishimoto T., Ip N. Y., Yancopoulos G. D. LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. Science 1993; 260: 1805 – 1808
25. Neddermann P., Graziani R., Ciliberto G., Paonessa G. Functional expression of soluble human interleukin-11 (IL-11) receptor alpha and stoichiometry of in vitro, IL-11 receptor complexes with gp130. J. Biol. Chem. 1996; 271: 30986 – 30991
26. Kawahara A., Minami Y., Miyazaki T., Ihle J. N., Taniguchi T. Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction. Proc. Natl. Acad. Sci. USA 1995; 92: 8724 – 8728
27. Kumanogo A., Marukawa S., Kumanogo T., Hirota H., Yoshida K., Lee I. S., Yasui T., Yoshida K., Taga T., Kishimoto T. Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130. Proc. Natl. Acad. Sci. USA 1997; 94: 2478 – 2482
28. Watowich S. S., Yoshimura A., Longmore G. D., Hilton D. J., Yoshimura Y., Lodish H. F. Homodimerization and constitutive activation of the erythropoietin receptor. Proc. Natl. Acad. Sci. USA 1992; 89: 2140 – 2144
29. Heldin C. H. Dimerization of cell surface receptors in signal transduction. Cell 1995; 80: 213 – 223
30. Noguchi M., Yi H., Rosenblatt H. M., Filipovich A. H., Adelstein S., Modi W. S., McBride O. W., Leonard W. J. Inter Ieukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in human. Cell 1993; 73: 147 – 157
31. Macchi P., Villa A., Gillani S., Sacco M. G., Frattini A., Porta F., Ugazio A. G., Johnston J. A., Candotti F., O'Shea J. J., et al. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 1995; 377: 65 – 68
32. Russell S. M., Taybei N., Nakajima H., Riedy M. C., Roberts J. L., Aman M. J., Migone T. S., Noguchi M., Markert M. L., Buckley R. H., et al. Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 1995; 270: 797 – 800
33. Marrero M. B., Schieffer B., Paxton W. G., Heerdt L., Berk B. C., Delafontaine P., Bernstein K. E. Direct stimulation of Jak/STAT pathway by the angiotensin II ATI receptor. Nature 1995; 375: 247 – 250
34. Danial N. N., Pernis A., Rothman P. B. Jak-STAT signaling induced by the v-abl oncogene. Science 1995; 269: 1875 – 1877
35. Wilks A. F., Harpur A. G., Kurban R. R., Ralph S. J., Zurcher G., Ziemiecki A. Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol. Cell. Biol. 1991; 11: 2057 – 2065
36. Velazquez L., Mogensen K. E., Barbieri G., Fellous M., Uzé G., Pellegrini S. Distinct domains of the protein-tyrosine kinase Tyk2 required for binding of interferon-alpha/beta and for signal transduction. J. Biol. Chem. 1995; 270: 3327 – 3334
37. Fujitani Y., Hibi M., Fukada T., Takahashi-Tezuka M., Yoshida H., Yamaguchi T., Sugiyama K., Yamanaka Y., Nakajima K., Hirano T. An alternative pathway for STAT activation that is mediated by the direct interaction between Jak and STAT. Oncogene 1997; 14: 751 – 761
38. Frank S. J., Gilliland G., Kraft A. S., Arnold C. S. Interaction of the growth hormone receptor cytoplasmic domain with Jak2 tyrosine kinase. Endocrinology 1994; 135: 2228 – 2239
39. Zhao Y., Wagner F., Frank S. J., Kraft A. S. The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain. J. Biol. Chem. 1995; 270: 13814 – 13818
40. Kohlhuber F., Rogers N. C., Watling D., Feng J., Guschin D., Briscoe J., Witthuhn B. A., Kotenko S. V., Pestka S., Stark G. R., et al. A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses. Mol. Cell. Biol. 1997; 17: 695 – 706
41. Chen M., Cheng A., Chen Y. Q., Hymel A., Hanson E. P., Kimmel L., Minami Y., Taniguchi T., Changelian P. S., O'Shear J. J. The amino terminus of JAK3 is necessary and sufficient for binding to the common G chain and confers the ability to transmit interleukin 2-mediated signals. Proc. Natl. Acad. Sci. USA 1997; 94: 6910 – 6915
42. Gauzzi M. C., Velazquez L., McKendry R., Mogensen K. E., Fellous M., Pellegrini S. Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. J. Biol. Chem. 1996; 271: 20494 – 20500
43. Feng J., Witthuhn B. A., Matsuda T., Kohlhuber F., Kerr I. M., Ihle J. N. Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop. Mol. Cell. Biol. 1997; 17: 2497 – 2501
44. Mohammadi M., Schlessinger J., Hubbard S. R. Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism. Cell 1996; 86: 577 – 587
45. Harrison D. A., Binari R., Nahreini T. S., Gilman M., Perrimon N. Activation of a Drosophila Janus kinase (Jak) causes hematopoietic neoplasia and developmental defects. EMBO J. 1995; 14: 2857 – 2865
46. Luo H., Hanratty W. P., Dearolf C. R. An amino acid substitution in the Drosophila hop Tum-1 Jak kinase causes leukemia-like hematopoietic defects. EMBO J. 1995; 14: 1412 – 1420
47. Luo H., Rose P., Barber D., Hanratty W. P., Lee S., Roberts T. M., D'Andrea A. D., Dearolf C. R. Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-STAT pathways. Mol. Cell. Biol. 1997; 17: 1562 – 1571
48. Hou X. S., Melnick M. B., Perrimon N. Marelle acts downstream of the Drosophila HOP/Jak kinase and encodes a protein similar to the mammalian STATs. Cell 1996; 84: 411 – 419
49. Hou X. S., Perrimon N. The Jak-STAT pathway in Drosophila. Trends Genet. 1997; 13: 105 – 110
50. Yan R., Small S., Desplan C., Dearolf C. R., Darnell J. E.J. Identification of a Stat gene that functions in Drosophila development. Cell 1996; 84: 421 – 430
51. Yan R., Luo H., Darnell J. E.J, Dearolf C. R. A JAK-STAT pathway regulates wing vein formation in Drosophila. Proc. Natl. Acad. Sci. USA 1996; 93: 5842 – 5847
52. Kawata T., Shevchenko A., Fukuzawa M., Jermyn K. A., Totty N. F., Zhukovskaya N. V., Sterling A. E., Mann M., Williams J. G. SH2 signaling in a lower eukaryote: a STAT protein that regulates stalk cell differentiation in Dictyostelium. Cell 1997; 898: 909 – 916
53. Greenlund A. C., Morales M. O., Viviano B. L., Yan H., Krolewski J., Schindler R. D. Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process. Immunity 1995; 2: 677 – 687
54. Stahl N., Farruggella T. J., Boulton T. G., Zhong Z., Darnell J. E.J, Yancopoulos G. D. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 1995; 267: 1349 – 1353
55. Yamanaka Y., Nakajima K., Nakae H., Kojima H., Kiuchi N., Ichiba M., Kitaoka T., Fukada T., Hibi M., Hirano T. Differentiation and growth arrest signals generate through the cytoplasmic region of gp130 that is essential for Stat3 activation. EMBO J. 1996; 15: 1557 – 1565
56. Fujii H., Nakagawa Y., Schindler U., Kawahara A., Mori H., Gouilleux F., Groner B., Ihle J. N., Minami Y., Miyazaki T., Taniguchi T. Activation of Stat S by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor β chain but is not essential for the proliferative signal transmission. Proc. Natl. Acad. Sci. USA 1995; 92: 5482 – 5486
57. Ascherman D. P., Migone T. S., Friedmann M. C., Leonard W. J. lnterleukin-2 (IL-2)-mediated induction of the IL-2 receptor alpha chain gene. Critical role of two functionally redundant tyrosine residues in the IL-2 receptor beta chain cytoplasmic domain and suggestion that these residues mediate more than Stat5 activation. J. Biol. Chem. 1997; 272: 8704 – 8709
58. Schindler U., Wu P., Rothe M., Brasseur M., McKnight S. L. Components of a Stat recognition code: evidence for two layers of molecular selectivity. Immunity 1995; 6: 689 – 697
59. Ryan J. J., McReynolds L. J., Keegan A., Wang L. H., Garfein E., Rothman P., Nelms K., Paue W. E. Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor. Immunity 1996; 4: 123 – 132
60. Choi K. Y., Satterberg B., Lyons D. M., Elion E. A. Ste5 tethers multiple protein kinase the MAP kinase cascade required for mating in S. cerevisiae. Cell 1994; 78: 499 – 512
61. Shuai K., Stark G., Kerr I. M., Darnell J. E.J. A single phosphotyrosine residue of Stat91 required for gene activation by interferon gamma. Science 1993; 261: 1744 – 1746
62. Zhong Z., Wen Z., Darnell J. E.J. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 1994; 164: 95 – 98
63. Akira S., Nishio Y., Inoue M., Wang X. J., Wei S., Matsusaka T., Yoshida K., Sudo T., Naruto M., Kishimoto T. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130- mediated signaling pathway. Cell 1994; 77: 63 – 71
64. Nakajima K., Matsuda T., Fujitani Y., Kojima H., Yamanaka Y., Nakae K., Takeda T., Hirano T. Signal transduction through IL-6 receptor: involvement of multiple protein kinases, stat factors, and a novel H7-sensitive pathway. Ann. N. Y. Acad. Sci. 1995; 762: 55 – 70
65. Lin J. X., Mietz J., Modi W. S., John S., Leonard W. J. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells
66. Kojima H., Nakajima K., Hirano T. IL-6-inducible complexes on an IL-6 response element of the jun B promoter contain Stat3 and 36kDa CRE-like site binding protein(s). Oncogene 1996; 12: 547 – 554
67. Xu X., Sun Y. L., Hoey T. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science 1996; 273: 794 – 797
68. Sotiropoulos A., Moutoussamy S., Renaudie F., Clauss M., Kayser C., Gouilleuz F., Kelly P. A., Finidori J. Differential activation of Stat3 and Stat5 by distinct regions of the growth hormone receptor. Mol. Endocrinol. 1997; 10: 998 – 1009
69. Yoshikawa A., Murakami H., Nagata S. Distinct signal transduction through the tyrosine-containing domains of the granulocyte colony-stimulating factor receptor. EMBO J. 1995; 14: 5288 – 5296
70. Li Z., Leung S., Kerr I. M., Stark G. R. Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Mol Cell. Biol. 1997; 17: 2048 – 2056
71. Sadowski H. B., Oilman M. Z. Cell-free activation of a DNA-binding protein by epidermal growth factor. Nature 1993; 362: 79 – 83
72. Yu C. L., Meyer D. J., Campbell G. S., Larner A. C., Carter-Su C., Schwartz J., Jove R. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 1995; 269: 81 – 83
73. Cao X., Tay A., Guy G. R., Tan Y. H. Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol. Cell. Biol. 1996; 16: 1595 – 1603
74. Wen Z., Zhong Z., Darnell J. E.J. Maximal activation of transcription by Statl and Stat3 requires both tyrosine and serine phosphorylation. Cell 1995; 82: 241 – 250
75. David M., Petricoin E. R., Benjamin C., Pine R., Weber M. J., Lamer A. C. Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins. Science 1995; 269: 1721 – 1723
76. Boulton T. G., Zhong Z., Wen Z., Darnell J. E.J., Stahl N., Yancopoulos G. D. STAT3 activation by cytokines utilizing gp 130 and related transducers involves a secondary modification requiring an H7-sensitive kinase. Proc. Natl. Acad. Sci. USA 1995; 92: 6915 – 6919
77. Schindler C., Fu X. Y., Improta T., Aebersold R., Darnell J. E.J. Proteins of transcription factor ISGF-3: one gene encodes the 91- and 84-kDa ISGF-3 proteins that are activated by interferon alpha. Proc. Natl. Acad. Sci. USA 1992; 89: 7836 – 7839
78. Wang D., Stravopodis D., Teglund S., Kitazawa J., Ihle J. N. Naturally occurring dominant negative variants of Stat5. Mol. Cell. Biol. 1997; 16: 6141 – 6148
79. Cardenhoven E., Vandijk T. B., Solar R., Armstrong J., Raaijmakers J. A.M., Lammers J. W.J., Koenderman L., DeGroot R. P. STAT3 beta, a splicing variant of transcription factor STAT3, is a dominant negative regulator of transcription. J. Biol. Chem. 1996; 271: 13221 – 13227
80. Schaefer T. S., Sanders L. K., Nathans D. Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3. Proc. Natl. Acad. Sci. USA 1995; 89: 7836 – 7839
81. Sasse J., Hemmann U., Schwartz C., Schniertshauer U., Heesel B., Landgraf C., Schneider-Mergener J., Heinrich P. C., Horn F. Mutational analysis of acute-phase response factor/Stat3 activation and dimerization. Mol. Cell. Biol. 1997; 17: 4677 – 4686
82. Bhattacharya S., Eckner R., Grossman S., Oldread E., Arany Z., D'Andrea A., Livingston D. M. Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature 1996; 383: 344 – 347
83. Horvai A. E., Xu L., Korzus E., Brard G., Kalafus D., Mullen T. M., Rose D. W., Rosenfeld M. G., Glass C. K. Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300. Proc. Natl. Acad. USA 1997; 94: 1074 – 1079
84. Zhang J. J., Vinkemeier U., Gu W., Charkravarti D., Horvath C. M., Darnell J. E.J. Two contact regions between Stat 1 and CBP/p300 in interferon gamma signaling. Proc. Natl. Acad. Sci. USA 1996; 93: 15092 – 15096
85. Sato N., Sakamaki K., Terada N., Arai K., Miyajima A. Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling. EMBO J. 1993; 12: 4181 – 4189
86. Kumar G., Gupta S., Wang S., Nel A. E. Involvement of Janus kinases, p52shc, Raf-1, and MEK-1 in the IL-6-induced mitogen-activated protein kinase cascade of a growth-responsive B cell line. J. Immunol. 1994; 153: 4436 – 4447
87. Friedmann M. C., Migone T. S., Russel S. M., Leonard W. J. Different interleukin 2 receptor β-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation. Proc. Natl. Acad. Sci. USA 1996; 89: 11239 – 11243
88. Wery S., Letourneur M., Bertoglio J., Pierre J. Interleukin-4 induces activation of mitogen-activated protein kinase and phosphorylation of she in human keratinocytes. J. Biol. Chem. 1996; 271: 8529 – 8532
89. Gurney A. L., Wong S. C., Henzel W. J., de-Sauvage F. J. Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and She phosphorylation. Proc. Natl. Acad. Sci. USA 1995; 92: 5292 – 5296
90. Fukada T., Hibi M., Yamanaka Y., Takahashi-Tezuka M., Fujitani Y., Yamaguchi T., Nakajima K., Hirano T. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity 1996; 5: 449 – 460
91. Watanabe S., Itoh T., Arai K. Roles of JAK kinases in human GM-CSF receptor signal transduction. J. Allergv Clin. Immunol. 1996; 98: S183 – 191
92. Bennett A. M., Housdorff S. F., O'Reilly A. M., Freeman R. O., Jr., Neel B. G. Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression. Mol. Cell. Biol. 1996; 16: 1189 – 1202
93. Noguchi T., Matozaki T., Horita K., Fujioka Y., Kasuga M. Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation. Mol. Cell. Biol. 1994; 14: 6674 – 6682
94. Tang T. L., Freeman R. M., Jr., O'Reilly A. M., Neel B. G., Sokol S. Y. The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development. Cell 1995; 80: 473 – 483
95. Perkins L. A., Larsen I., Perrimon N. Corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso. Cell 1992; 70: 225 – 236
96. Perkins L. A., Johnson M. R., Melnick M. B., Perrimon N. The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathway in Drosophila. Dev. Biol. 1996; 180: 63 – 81
97. Songyang Z., Shoelson S. E., Chaudhuri M., Gish G., Pawson T., Haser W. G., King F., Roberts T., Ratnofsky S., Lechleider R. J., et al. SH2 domains recognize specific phosphopeptide sequences. Cell 1993; 72: 767 – 778
98. Bennett A. M., Tang T. L., Sugimoto S., Walsh C. T., Neel B. G. Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras. Proc. Natl. Acad. Sci. USA 1994; 91: 7335 – 7339
99. Adachi M., Ishino M., Torigoe T., Minami Y., Matozaki T., Miyazaki T., Taniguchi T., Hinoda Y., Imai K. Interleukin-2 induces tyrosine phosphorylation of SHP-2 through IL-2 receptor beta chain. Oncogene 1996; 14: 1629 – 1633
100. Yin T., Shen R., Feng G. S., Yang Y. C. Molecular characterization of specific interactions between SHP-2 phosphatase and JAK. tyrosine kinases. J. Biol. Chem. 1997; 212: 1032 – 1037
101. Herbst R., Carroll R. M., Allard J. D., Schilling J., Raabe T., Simon M. A. Daughter of Sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during Sevenless signaling. Cell 1996; 85: 899 – 909
102. Raabe T., Riesgo-Escovar J., Liu X., Bausenwein B. S., Deak P., Maroy P., Hafen H. DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between Sevenless and Rasl in Drosophila. Cell 1996; 85: 911 – 920
103. Johnston J. A., Wang L. M., Hanson E. P., Sun X. J., White M. F., Oakes S. A., Pierce J. H., O'Shea J. J. Interleukin 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases. J. Biol. Chem. 1995; 270: 28527 – 28530
104. Burfoot M. S., Rogers N. C., Watling D., Smith J. M., Pons S., Ciliberto G., Pellegrini S., White M. F., Kerr I. M. Janus kinase-dependent activation of insulin receptor substrate-1 in response to interleukin-4, oncostatin M and the interferons. J. Biol. Chem. 1997; 272: 24183 – 24190
105. Holgado-Madruga M., Emlet D. R., Mosacatello D. K., Godwin A. K., Wang A. J. Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature 1996; 319: 560 – 564
106. Weidner K. M., Di-Cesare S., Sachs M., Brinkmann V., Behrens J., Birchmeier W. Interaction between Gab1 and c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature 1997; 384: 173 – 176
107. Takahashi-Tezuka M., Yoshida Y., Fukada T., Yamaguchi T., Yamanaka Y., Nakajima K., Hibi M., Hirano T., submitted
108. Wang L. M., Keegan A., Frankel M., Paul W. E., Pierce J. H. Signal transduction through the IL-4 and insulin receptor families. Stem Cells Dayt. 1995; 13: 360 – 8
109. Keegan A. D., Nelms K., White M., Wang L. M., Pierce J. H., Paul W. E. An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth. Cell 1994; 76: 811 – 820
110. Damen J. E., Cutler R. L., Jiao H., Yi T., Krystal G. Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity. J. Biol. Chem. 1995; 270: 23402 – 23408
111. Miura O., Nakamura N., Ihle J. N., Aoki N. Erythropoietin- dependent association of phosphatidylinositol 3-kinase with tyrosine-phosphory- lated erythropoietin receptor. J. Biol. Chem. 1994; 269: 614 – 620
112. Sharfe N., Dadi H. K., Roifman C M. JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3′ kinase. Blood 1995; 86: 2077 – 2085
113. Takahashi-Tezuka M., Hibi M., Fujitani Y., Fukada T., Yamaguchi T., Hirano T. Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK. Oncogene 1997; 14: 2273 – 2282
114. Pfeffer L. M., Mullersman J. E., Pfeffer S. R., Murti A., Shi W., Yang C. H. STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor. Science 1997; 276: 1418 – 1420
115. Matsuda T., Yamanaka Y., Hirano T. Interleukin-6-induced tyrosine phosphorylation of multiple proteins in murine hematopoietic lineage cells. Biochem. Biophys. Res. Commun. 1995; 200: 821 – 828
116. Machide M., Mano H., Todokoro K. Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain. Oncogene 1995; 11: 619 – 625
117. Crespo P., Schuebel K. E., Ostrom A. A., Gutkind J. S., Bustelo X. R. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature 1997; 385: 169 – 172
118. Raush O., Marshall C. J. Tyrosine 763 of the murine granulocyte colony-stimulating factor receptor mediates Ras dependent activation the JNK/SAPK mitogen-activated protein kinase pathway. Mol. Cell. Biol. 1997; 17: 1170 – 1179
119. Takeshita T., Arita T., Higuchi M., Asao H., Endo K., Kuroda H., Tanaka N., Marata K., Ishii N., Sugamura K. STAT, signal transducing adapter molecule, is associated with janus kinases and involved in signaling for cell growth and c-myc induction. Immunity 1997; 6: 449 – 457
120. Klingmuller U., Lorenz U., Cantley L. C., Neel B. G., Lodish H. F. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell 1995; 80: 729 – 738
121. Starr R., Willson T. A., Viney E. M., Murray L. J., Rayner J. R., Jenkins B. J., Gonda T. J., Alexander W. S., Metcalf D., Nicola N. A., Hilton D. A family of cytokine inducible inhibitors of signaling. Nature 1997; 387: 917 – 921
122. Endo T. A., Masuhara M., Yokouchi M., Suzuki R., Sakamoto H., Mitsui K., Matusmoto A., et al. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 1997; 387: 921 – 924
123. Naka T., Narazaki M., Hirata M., Matsumoto T., Minamoto S., Aono A., Nishimoto N., Kajita T., et al. Structure and function of a new STAT- induced STAT inhibitor. Nature 1997; 387: 924 – 929
124. Durbin J. E., Hackenmiller R., Simon M. C., Levy D. E. Targeted disruption of the mouse Stat 1 gene results in compromised innate immunity to viral disease. Cell 1996; 84: 443 – 450
125. Meraz M. A., White J. M., Sheehan K. C., Bach E. A., Rodig S. J., Dighe A. S., Kaplan D. H., Riley J. K., Greenlund A. C., Campbell D., et al. Targeted disruption of the Statl gene in mice reveals unexpected physiologic specificity in the Jak-STAT signaling pathway. Cell 1996; 84: 431 – 442
126. Chin Y. E., Kitagawa M., Su W. C., You Z. H., Iwamoto Y., Fu X. Y. Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF/CIP mediated by STAT1. Science 1996; 272: 719 – 722
127. Chin Y. E., Kitagawa M., Kuida K., Flavell R. A., Fu X. Y. Activation of STAT signaling pathway can cause expression of caspase 1 and apoptosis. Mol. Cell. Biol. 1997; 17: 5328 – 5337
128. Takeda K., Noguchi K., Shi W., Tanaka T., Matsumoto M., Yoshida N., Kishimoto T., Akira S. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl. Acad. Sci. USA 1997; 94: 3801 – 3804
129. Nakajima K., Yamanaka Y., Nakae K., Kojima H., Ichiba M., Kiuchi N., Kitaoka T., Fukada T., Hibi M., Hirano T. A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells. EMBO J. 1996; 15: 3651 – 3658
130. Minami M., Inoue M., Wei S., et al. STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc. Natl. Acad. Sci. USA 1996; 93: 3963 – 3966
131. Shimozaki K., Nakajima K., Hirano T., Nagata S. Involvement of STAT3 in the granulocyte colony stimulating factor-induced differentiation of myeloid cells. J. Biol. Chem. 1997; 272: 25184 – 25189
132. Boeuf H., Hauss C., De Graeve F., Baran N., Kedinger C. Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells. J. Cell. Biology 1997; 138: 1207 – 1217
133. Morese L., Chen D., Franklin D., Xiong Y., Chen-Kiang S. Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18INK4c and IL-6. Immunity 1997; 6: 47 – 56
134. Narimatsu M., Nakajima K., Ichiba M., Hirano T. Association of Stat3-dependent transcriptional activation of p19INK4D with the IL-6-induced growth arrest. Biochem. Biophys. Res. Comm. 1997; 238: 764 – 768
135. Kaplan M. H., Sun Y. L., Hoey T., Grusby M. J. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 1996; 382: 174 – 177
136. Thierfelder W. E., van Deursen J. M., Yamamoto K., Tripp R. A., Sarawar S. R., Carson R. T., Sangster M. Y., Vignali D. A., Doherty P. C., Grosveld G. C., Ihle J. N. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 1996; 382: 171 – 174
137. Liu X., Robinson G. W., Wagner K. U., Garrett L., Wynshaw-Boris A., Hennighausen L. Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev. 1997; 11: 179 – 186
138. Udy G. B., Towers R. P., Snell R. G., Wilkins R. J., Park S.-H., Ram P. A., Waxman D. J., Davey H. W. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc. Natl. Acad. Sci. USA 1997; 94: 7239 – 7244
139. Gobert S., Chretien S., Gouilleux F., Muller O., Pallard C., Dusanter-Fourt I., Groner B., Lacombe C., Gisselbrecht S., Mayeux P. Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation. EMBO J. 1996; 15: 2334 – 2341
140. Quelle F. W., Wang D., Nosaka T., Thierfelder W. E., Stravopodis D., Weinstein Y., Ihle J. N. Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response. Mol. Cell. Biol., 16: 1622 – 1631
141. Muli A. L., Wakao H., Kinoshita T., Kitamura T., Miyajima A. Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation. EMBO J. 1996; 15: 2425 – 2433
142. Kaplan M. H., Schindler U., Smiley S. T., Grusby M. J. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 1996; 4: 313 – 319
143. Shimoda K., van Deursen J., Sangster M. Y., Sarawar S. R., Carson R. T., Trpp R. A., Chu C., Quelle F. W., Nosaka T., Vignali D. A., et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 genes. Nature 1996; 380: 630 – 633
144. Takeda K., Tanaka T., Shi W., Matsumoto M., Minami M., Kashiwamura S., Nakanishi K., Yoshida N., Kishimoto T., Akira S. Essential role of Stat6 in IL-4 signaling. Nature 1996; 380: L627 – 630
145. Binari R., Perrimon N. Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila. Genes Dev. 1994; 8: 300 – 312
146. Kinoshita T., Yokota T., Arai K., Miyajima A. Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors. EMBO J. 1995; 14: 266 – 275
147. Ihara S., Nakajima K., Fukada T., et al. Dual control of neurite outgrowth by STAT3 and MAP kinase in PC 12 cells stimulated with interleukin-6. EMBO J. 1997; 17: 5345 – 5352
148. Nosaka T., van Deursen J. M., Tripp R. A., Thierfelder W. E., Witthuhn B. A., McMickle A. P., Doherty P. C., Grosveld G. C., Ihle J. N. Defective lymphoid development in mice lacking Jak3. Science 1995; 270: 800 – 802
149. Park S. Y., Saijo K., Takahashi T., Osawa M., Arase H., Hirayama N., Miyake K., Nakauchi H., Shirasawa T., Saito T. Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity 1995; 3: 771 – 782
150. Coneway G, Margoliath A., Wong-Madden S., Roberts R. J., Gilbert W. Jakl kinase is required for cell migrations and anterior specification in zebrafish embryos. Proc. Natl. Acad. Sci. USA 1997; 94: 3082 – 3087