Laboratory evaluation of hypercoagulable states

Hematology/Oncology Clinics of North America

Volumn 12, Issue 6, 1998, Pages 1141-1166

  Van Cott, E M ^a   Laposata, M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 8; HEPARIN COFACTOR II; PHOSPHOLIPID ANTIBODY; PLASMINOGEN; THROMBOMODULIN;

ACTIVATED PROTEIN C RESISTANCE; ANTITHROMBIN DEFICIENCY; DISEASE PREDISPOSITION; DYSFIBRINOGENEMIA; GENE MUTATION; HUMAN; HYPERCOAGULABILITY; HYPERHOMOCYSTEINEMIA; LABORATORY TEST; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN C DEFICIENCY; PROTEIN S DEFICIENCY; REVIEW; THROMBOPHILIA;

EID: 0032412683     PISSN: 08898588     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8588(05)70047-2     Document Type: Article

References (117)

1. E. Aadland O.R. Odegaard A. Roseth Free protein S deficiency in patients with chronic inflammatory bowel disease Scand J Gastroenterol 27 1992 957 960
2. M.F. Aillaud K. Pouymayou D. Brunet New direct assay of free protein S antigen applied to diagnosis of protein S deficiency Thromb Haemost 75 1996 283 285
3. M.S. Akhtar A.J. Blair T.C. King Whole blood screening test for factor V Leiden using a Russell viper venom time-based assay Am J Clin Pathol 109 1998 387 391
4. M. Alenc-Gelas M.F. Aillaud M.N. Bonvarlet Specificity of an assay based on a factor V–depleted plasma in patients carrying the Arg 506 Gln mutation [letter] Thromb Haemost 75 1996 976 977
5. C.F. Allaart S.R. Poort F.R. Rosendaal Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect Lancet 341 1993 134 138
6. M. Andrew B. Paes R. Milner Development of the human coagulation system in the full-term infant Blood 70 1987 165 172
7. M. Andrew P. Vegh M. Johnston Maturation of the hemostatic system during childhood Blood 80 1992 1998 2005
8. J. Arnout The pathogenesis of the antiphospholipid syndrome: A hypothesis based on parallelisms with heparin-induced thrombocytopenia Thromb Haemost 75 1996 536 541
9. V.R. Arruda P.M. von Zuben L.C. Chiaparini The mutation Ala677 → Val in the methylene tetrahydrofolate reductase gene: A risk factor for arterial disease and venous thrombosis Thromb Haemost 77 1997 818 821
10. T.A. Bayston D.A. Lane Antithrombin: Molecular basis of deficiency Thromb Haemost 78 1997 339 343
11. D.B. Bellissimo N.E. Kirschbaum P.A. Foster Improved method for factor V Leiden typing by PCR-SSP [letter] Thromb Haemost 75 1996 520
12. J.M. Bensen D.J. Phillips B.P. Holloway Oligonucleotide ligation assay for detection of the factor V mutation (Arg506 → Gln) causing protein C resistance Thromb Res 83 1996 87 96
13. R.M. Bertina B.P.C. Koeleman T. Koster Mutation in blood coagulation factor V associated with resistance to activated protein C Nature 369 1994 64 67
14. K.W.M. Bloemenkamp F.R. Rosendaal F.M. Helmerhorst Enhancement by factor V Leiden mutation of risk of deep-vein thrombosis associated with oral contraceptives containing a third-generation progestagen Lancet 346 1995 1593 1596
15. D. Borgel S. Grandrille M. Aiach Protein S deficiency Thromb Haemost 78 1997 351 356
16. C.J. Boushey S.A.A. Beresford G.S. Omenn A quantitative assessment of plasma homocysteine as a risk factor for vascular disease JAMA 274 1995 1049 1057
17. G. Brandt R. Gruppo C.J. Gluek Sensitivity, specificity, and predictive value of modified assays for activated protein C resistance in children Thromb Haemost 79 1998 567 570
18. J.T. Brandt D.A. Triplett B. Alving Criteria for the diagnosis of lupus anticoagulants: An update Thromb Haemost 74 1995 1185 1190
19. L.C. Chan C. Bourke C.K. Lam Lack of activated protein C resistance in healthy Hong Kong Chinese blood donors—correlation with absence of Arg506-Gln mutation of factor V gene [letter] Thromb Haemost 75 1996 522 523
20. W.P. Chan C.K. Lee Y.L. Kwong A novel mutation of Arg 306 of factor V gene in Hong Kong Chinese Blood 91 1998 1135 1139
21. J. Corral J.A. Iniesta R. Gonzales-Conejero Detection of factor V Leiden from a drop of blood by PCR-SSCP Thromb Haemost 76 1996 735 737
22. S.V. D'Angelo G. Mazzola P.D. Valle Variable interference of activated protein C resistance in the measurement of protein S activity by commercial assays Thromb Res 77 1995 375 378
23. B. Dahlback Resistance to activated protein C, the Arg506 to Gln mutation in the factor V gene, and venous thrombosis. Functional tests and DNA-based assays, pros and cons Thromb Haemost 73 1993 739 742
24. B. Dahlback Factor V gene mutation causing inherited resistance to activated protein C as a basis for venous thromboembolism J Intern Med 237 1995 221 227
25. B. Dahlback M. Carlsson P.J. Svensson Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C Proc Natl Acad Sci USA 90 1995 1004 1008
26. H. de Ronde R.M. Bertina Laboratory diagnosis of APC-resistance: A critical evaluation of the test and the development of diagnostic criteria Thromb Haemost 72 1994 880 886
27. C. Demers J.S. Ginsberg J. Hirsh Thrombosis in antithrombin III–deficient persons. Report of a large kindred and literature review Ann Intern Med 116 1992 754 761
28. C. Demers P. Henderson M.A. Blajchman An antithrombin III assay based on factor Xa inhibition provides a more reliable test to identify congenital antithrombin III deficiency than an assay based on thrombin inhibition Thromb Haemost 69 1993 231 235
29. M. den Heijer H.J. Blom W.B.J. Gerrits Is hyperhomocysteinaemia a risk factor for recurrent venous thrombosis? Lancet 345 1995 882 885
30. M. den Heijer T. Koster H.K. Blom Hyperhomocysteinemia as a risk factor for deep-vein thrombosis N Engl J Med 334 1996 759 762
31. V. DeStefano P. Chiusolo K. Paciaroni Prothrombin G20210A mutant genotype is a risk factor for cerebrovascular ischemic disease in young patients Blood 91 1998 3562 3565
32. D.S. Dizon-Townson L.M. Nelson H. Jang The incidence of the factor V Leiden mutation in an obstetric population and its relationship to deep vein thrombosis Am J Obstet Gynecol 176 1997 883 886
33. E.M. Faioni C. Boyer-Neumann F. Franchi Another protein S functional assay is sensitive to resistance to activated protein C Thromb Haemost 72 1994 648
34. J.A. Fernandez A. Estelles J. Gilabert Functional and immunologic protein S in normal pregnant women and in full-term newborns Thromb Haemost 61 1989 474 478
35. G. Finazzi T. Barbui Different incidence of venous thrombosis in patients with inherited deficiencies of antithrombin III, protein C and protein S Thromb Haemost 71 1994 15 18
36. G. Finazzi V. Brancaccio M. Moia Natural history and risk factors for thrombosis in 360 patients with antiphospholipid antibodies: A four-year prospective study from the Italian Registry Am J Med 100 1996 530 536
37. R.H. Fryer B.D. Wilson D.B. Gubler Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells Arterioscler Thromb 13 1993 1327 1333
38. I.M. Graham L.E. Daly H.M. Refsum Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project JAMA 277 1997 1775 1781
39. J.H. Griffin B. Evatt C. Wideman Anticoagulant protein C pathway defective in majority of thrombophilic patients Blood 82 1993 1989 1993
40. A.B. Guttormsen P.M. Ueland I. Nesthus Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (≥40 μmol/liter) J Clin Invest 98 1996 2174 2183
41. F. Haverkate M. Samama Familial dysfibrinogenemia and thrombophilia. Report on a study of the SCC Subcommittee on fibrinogen Thromb Haemost 73 1995 151 161
42. H. Heijboer D.P.M. Brandjes H.R. Buller Deficiencies of coagulation-inhibiting and fibrinolytic proteins in outpatients with deep-vein thrombosis N Engl J Med 323 1990 1512 1516
43. C.M.A. Henkens V.J.J. Bom W. van der Schaaf Plasma levels of protein S, protein C and factor X: Effects of sex, hormonal state and age Thromb Haemost 74 1995 1271 1275
44. W.C. Hooper A. Dilley M.J.A. Ribeiro A racial difference in the prevalence of the Arg506→Gln mutation Thromb Res 81 1996 577 581
45. A. Inbal G. Kenet A. Zivelin Purpura fulminans induced by disseminated intravascular coagulation following infection in 2 unrelated children with double heterozygosity for factor V Leiden and protein S deficiency Thromb Haemost 77 1997 1086 1089
46. H. Ireland T. Bayston E. Thompson Apparent heterozygous type II protein C deficiency caused by the factor V 506 Arg to Gln mutation Thromb Haemost 73 1995 727
47. J.I. Jorquera J.M. Montoro M.A. Fernandez Modified test for activated protein C resistance Lancet 344 1994 1162 1163
48. B.P.C. Koeleman D. van Rumpt K. Hamulyak Factor V Leiden: An additional risk factor for thrombosis in protein S deficient families? Thromb Haemost 74 1995 580 583
49. H.P. Kohler M. Boothby L. McCormack Incidence of Arg506→Gln mutation (Factor V Leiden) in Pima Indians [letter] Thromb Haemost 78 1997 961
50. T. Koster F.R. Rosendaal F. de Ronde Venous thrombosis due to poor response to activated protein C: Leiden thrombophilia study Lancet 342 1993 1503 1506
51. F. Landgren B. Israelsson A. Lindgren Plasma homocysteine in acute myocardial infarction: Homocysteine-lowering effect of folic acid J Intern Med 237 1995 381 388
52. D.T. Le J.H. Griffin J.S. Greengard Use of a generally applicable tissue-factor–dependent factor V assay to detect activated protein C–resistant factor Va in patients receiving warfarin and in patients with a lupus anticoagulant Blood 85 1995 1704 1711
53. H.A. Leibman D. Sutherland R. Bacon Evaluation of a tissue factor dependent factor V assay to detect factor V Leiden: Demonstration of high sensitivity and specificity for a generally applicable assay for activated protein C resistance Br J Haematol 95 1996 550 553
54. A. Lindgren L. Brattstrom B. Norrving Plasma homocysteine in the acute and convalescent phases after stroke Stroke 26 1995 795 800
55. X. Ling M. Delorme L. Berry α2-macroglobulin remains as important as antithrombin III for thrombin regulation in cord plasma in the presence of endothelial cell surfaces Pediatr Res 37 1995 373 378
56. J. Malm M. Laurell B. Dahlback Changes in the plasma levels of vitamin K–dependent proteins C and S and of C4b-binding protein during pregnancy and oral contraception Br J Haematol 68 1988 437 443
57. M.J. Manco-Johnson R. Nuss N. Key Lupus anticoagulant and protein S deficiency in children with postvaricella purpura fulminans or thrombosis J Pediatr 128 1996 319 323
58. J.R. Martorell A. Munoz-Castillo J.L. Gil False-positive activated protein C resistance test due to anti-phospholipid antibodies is corrected by platelet extract Thromb Haemost 74 1995 796 797
59. M. Marusa F.S. Nolte A. Duncan Prevalence of factor V gene mutation in a healthy Malaysian population [abstract] Am J Clin Pathol 108 1997 347
60. 6, and cardiovascular disease JAMA 279 1998 392 393
61. T.W. Meade S. Dyer D.J. Howarth Antithrombin III and procoagulant activity: Sex differences and effects of the menopause Br J Haematol 74 1990 77 81
62. E. Melissari G. Monte V.S. Lindo Congenital thrombophilia among patients with venous thromboembolism Blood Coagul Fibrinolysis 3 1992 749 758
63. E. Melissari K.H. Nicholaides M.F. Scully Protein S and C4b-binding protein in fetal and neonatal blood Br J Haematol 70 1988 199 203
64. J. Miletich L. Sherman G. Broze Jr Absence of thrombosis in subjects with heterozygous protein C deficiency N Engl J Med 317 1987 991 996
65. C.A. Mitchell J.A. Rowell L. Hau A fatal thrombotic disorder associated with an acquired inhibitor of protein C N Engl J Med 317 1987 1638 1642
66. S.H. Mudd F. Skovby H.L. Levy The natural history of homocystinuria due to cystathionine β-synthase deficiency Am J Hum Genet 37 1985 1 31
67. M. Nesheim W. Wang M. Boffa Thrombin, thrombomodulin and TAFI in the molecular link between coagulation and fibrinolysis Thromb Haemost 78 1997 386 391
68. P. Nguyen J. Reynaud P. Pouzol Varicella and thrombotic complications associated with transient protein C and protein S deficiencies in children Eur J Pediatr 153 1994 646 649
69. L. Norlund B. Zoller A.K. Ohlin A novel thrombomodulin gene mutation in a patient suffering from sagittal sinus thrombosis Thromb Haemost 78 1997 1164 1166
70. U. Nowak-Gottl B. Kohlhase I. Aschka APC resistance in neonates and infants: Adjustment of the aPTT-based method Thromb Res 81 1996 665 670
71. O. Nygard J.E. Nordrehaug H. Refsum Plasma homocysteine levels and mortality in patients with coronary artery disease N Engl J Med 337 1997 230 236
72. K. Okajima M. Uchiba The anti-inflammatory properties of antithrombin III: New therapeutic implications Semin Thromb Hemost 24 1998 27 32
73. T. Ozawa K. Niiya N. Sakuragawa Absence of factor V Leiden in the Japanese [letter] Thromb Res 81 1996 595 596
74. C.H. Pegelow M. Ledford J. Young Severe protein S deficiency in a newborn Pediatrics 89 1992 674 676
75. F. Peyvandi E. Faioni G. Alessandro Moroni Autoimmune protein S deficiency and deep vein thrombosis after chickenpox [letter] Thromb Haemost 75 1996 211 213
76. S.W. Pipe A.H. Schmaier W.C. Nichols Neonatal purpura fulminans in association with factor V R506Q mutation J Pediatr 128 1996 706 709
77. S.R. Poort F.R. Rosendaal P.H. Reitsma A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis Blood 88 1996 3698 3703
78. A.K. Rao S. Niewiarowski J. Guzzo Antithrombin III levels during heparin therapy Thromb Res 24 1981 181 186
79. K. Rasmussen J. Moller M. Lyngbak Age- and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation Clin Chem 42 1996 630 636
80. D.C. Rees M. Cox J.B. Clegg Detection of the factor V Leiden mutation using whole blood PCR [letter] Thromb Haemost 75 1996 520 521
81. D.C. Rees M. Cox J.B. Clegg World distribution of factor V Leiden Lancet 346 1995 1133 1134
82. P.H. Reitsma Protein C deficiency: from gene defects to disease Thromb Haemost 78 1997 344 350
83. P.H. Reitsma F. Bernardi R.G. Doig Protein C deficiency: A database of mutations, 1995 update Thromb Haemost 73 1995 876 889
84. P.M. Ridker R.J. Glynn J.P. Miletich Age-specific incidence rates of venous thromboembolism among heterozygous carriers of factor V Leiden mutation Ann Intern Med 126 1997 528 531
85. P.M. Ridker C.H. Hennekens K. Lindpaintner Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men N Engl J Med 332 1995 912 917
86. P.M. Ridker C.H. Hennekens J. Selhub Interrelation of hyperhomocyst(e)inemia, Factor V Leiden, and risk of future venous thromboembolism Circulation 95 1997 1777 1782
87. P.M. Ridker J.P. Miletich C.H. Hennekens Ethnic distribution of factor V Leiden in 4047 men and women JAMA 277 1997 1305 1307
88. 6 from diet and supplements in relation to risk of coronary heart disease among women JAMA 279 1998 359 364
89. L. Ripoll D. Paulin S. Thomas Multiplex PCR-mediated site-directed mutagenesis for one-step determination of factor V Leiden and G20210A transition of the prothrombin gene [letter] Thromb Haemost 78 1997 960 961
90. F. Rodeghiero A. Tosetto The epidemiology of inherited thrombophilia: The VITA project Thromb Haemost 78 1997 636 640
91. S. Rosen N.E. Andersson M. Andersson Modified Coatest APC resistance assay including V-def plasma with a heparin antagonist: Analysis of heparin and OAC plasmas and influence of preanalytical variables Blood Coagul Fibrinolysis 7 1996 390
92. F.R. Rosendaal T. Koster J.P. Vandenbroucke High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance) Blood 85 1995 1504 1508
93. F.R. Rosendaal D.S. Siscovick S.M. Schwartz Factor V Leiden (resistance to activated protein C) increases the risk of myocardial infarction in young women Blood 89 1997 2817 2821
94. R. Rozen Genetic predisposition to hyperhomocysteinemia: Deficiency of methylenetetrahydrofolate reductase (MTHFR) Thromb Haemost 78 1997 523 526
95. G. Sas D.S. Pepper J.D. Cash Further investigations on antithrombin III in the plasmas of patients with the abnormality of antithrombin III Budapest Thromb Diath Haemorrh 33 1975 564 572
96. P. Simioni P. Prandoni A. Burlina Hyperhomocysteinemia and deep-vein thrombosis. A case control study Thromb Haemost 76 1996 883 886
97. M. Sorice P. Arcieri T. Griggi Inhibition of protein S by autoantibodies in patients with acquired protein S deficiency Thromb Haemost 75 1996 555 559
98. C.P. Stahl C.S. Wideman T.J. Spira Protein S deficiency in men with long-term human immunodeficiency virus infection Blood 81 1993 1801 1807
99. M.J. Stampfer M.R. Malinow W.C. Willet A prospective study of plasma homocysteine and risk of myocardial infarction in US physicians JAMA 268 1992 877 881
100. F.J. Stroble S. Hoffman S. Huber Activated protein C resistance assay performance. Improvement by sample dilution with factor V–deficient plasma Arch Pathol Lab Med 122 1998 430 433
101. P.J. Svensson B. Dahlback Resistance to activated protein C as a basis for venous thrombosis N Engl J Med 330 1994 517 522
102. J.D. Sweeney A.J. Blair T.C. King Comparison of an activated partial thromboplastin time with a Russell viper venom time test in screening for factor V Leiden (FVR506Q) Am J Clin Pathol 108 1997 74 77
103. R.C. Tait I.D. Walker D.J. Perry Prevalence of antithrombin deficiency in the healthy population Br J Haematol 87 1994 106 112
104. R.C. Tait I.D. Walker P.H. Reitsma Prevalence of protein C deficiency in the healthy population Thromb Haemost 73 1995 87 93
105. A. Tripodi V. Chantarangkul B. Negri Standardization of the APC resistance test. Effects of normalization of results by means of pooled normal plasma Thromb Haemost 79 1998 564 566
106. M. Trossaert J. Conard M.H. Horellou Influence of storage conditions on activated protein C resistance assay [letter] Thromb Haemost 73 1995 163
107. M.M. Uttenreuther-Fischer S. Ziemer G. Gaedicke Resistance to activated protein C (APCR): Reference values of APC-ratios for children [letter] Thromb Haemost 76 1996 813 814
108. F.J.M. van der Meer T. Koster J.P. Vandenbroucke The Leiden Thrombophilia Study (LETS) Thromb Haemost 78 1997 631 635
109. R. van Oerle L. van Pampus G. Tans The clinical application of a new specific functional assay to detect the factor V Leiden mutation associated with activated protein C resistance Am J Clin Pathol 107 1997 521 526
110. M. Vasse J.Y. Borg M. Monconduit Protein C: Rouen, a new hereditary protein C abnormality with low anticoagulant but normal amidolytic activities Thromb Res 56 1989 387 398
111. K.V. Voelkerding L. Wu E.C. Williams Factor V R506Q gene mutation analysis by PCR-RFLP Am J Clin Pathol 106 1996 100 106
112. G.N. Welch J. Loscalzo Homocysteine and atherothrombosis N Engl J Med 338 1998 1042 1050
113. D. Williamson K. Brown R. Luddington Factor V Cambridge: A new mutation (Arg306 → Thr) associated with resistance to activated protein C Blood 91 1998 1140 1144
114. E.G.C. Wojcik P. Simioni M.V.D. Berg Mutations which introduce free cysteine residues in the Gla-domain of vitamin K dependent proteins result in the formation of complexes with α1-microglobulin Thromb Haemost 75 1996 70 75
115. J.L. Zehnder R.C. Benson Sensitivity and specificity of the APC resistance assay in detection of individuals with factor V Leiden Am J Clin Pathol 106 1996 107 111
116. B. Zoller A. Berntsdotter P. Garcia de Fruto Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein S Blood 85 1996 3518 3523
117. M. Zuger F.D. Biasiutti M. Furlan Plasminogen deficiency: An additional risk factor for thrombosis in a family with factor V R506Q mutation? Thromb Haemost 76 1996 475 476