Standardization of the APC resistance test. Effects of normalization of results by means of pooled normal plasma

Thrombosis and Haemostasis

Volumn 79, Issue 3, 1998, Pages 564-566

  Tripodi, Armando ^a,b   Chantarangkul, Veena ^a   Negri, Barbara ^a   Mannucci, Pier Mannuccio ^a  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^b NONE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 5; MUTANT PROTEIN;

ACTIVATED PROTEIN C RESISTANCE; ANALYTIC METHOD; ARTICLE; BLOOD CLOTTING TIME; CLINICAL CHEMISTRY; CONTROLLED STUDY; GENE MUTATION; HETEROZYGOTE; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; REPRODUCIBILITY; STANDARDIZATION;

EID: 0031888596     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1614945     Document Type: Article

References (6)

1. Dahlbäck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by a poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993; 90: 1004-8.
2. Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated to activated protein C. Nature 1994; 369: 64-7.
3. de Ronde H, Bertina RM. Laboratory diagnosis of APC-resistance: a critical evaluation of the test and the development of diagnostic criteria. Thromb Haemost 1994; 72: 880-6.
4. Tripodi A, Negri B, Bertina RM, Mannucci PM. Screening for the FV : Q506 mutation. Evaluation of thirteen plasma-based methods for their diagnostic efficacy in comparison with DNA analysis. Thromb Haemost 1997; 77: 436-9.
5. Dahlbäck B. Resistance to activated protein C, the Arg 506 Gln mutation in the factor V gene, and venous thrombosis. Functional tests and DNA-based assay, Pros and Cons. Thromb Haemost 1995; 73: 739-42.
6. Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-4.