APC resistance in neonates and infants: Adjustment of the aPTT - Based method

Thrombosis Research

Volumn 81, Issue 6, 1996, Pages 665-670

  Nowak Göttl, Ulrike ^b,c   Kohlhase, Bernd ^b   Vielhaber, Heinrich ^b   Aschka, Indre ^a   Schneppenheim, Reinhard ^a   Jürgens, Herbert ^b  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

APCR; APTT based method; Gln 506 Arg; Infancy

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 5; CALCIUM;

ACTIVATED PROTEIN C RESISTANCE; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN EXPERIMENT; INFANT; NEWBORN; NORMAL HUMAN; PRIORITY JOURNAL; THROMBOEMBOLISM;

CASE-CONTROL STUDIES; DRUG RESISTANCE; HUMANS; INFANT; INFANT, NEWBORN; MUTATION; PARTIAL THROMBOPLASTIN TIME; PROTEIN C; SEPSIS; THROMBOEMBOLISM;

EID: 0029872123     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/0049-3848(96)00043-6     Document Type: Article

References (16)

1. DAHLBÄCK, B., CARLSSON, M. Factor VIII defect associated with familial thrombophilia.Thromb Haemostas 65, 658, 1991
2. DAHLBÄCK, B., CARLSSON, M., SVENSSON, P.J. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad of Sci USA 90, 1004-1008, 1993
3. AMER, L., KISIEL, W., SEARLES, R.P., WILLIAMS Jr, R.C. Impairment of the protein C anticoagulant pathway in a patient with systemic lupus crythematosus, anticardiolipin antibodies and thrombosis. Thromb Res 57, 247 - 258, 1990
4. BERTINA, R.M., KOELEMANN, B.P.C., KOSTER, T., ROSENDAAL, F.R., DIRVEN, R.J., DE RONDE, H., VAN DER VELDEN, P.A., REITSMA, P.H. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 369, 64-67, 1994
5. KOSTER, T., ROSENDAAL, F.R., DE RONDE, H., BRIET, E., VANDENBROUCKE, J.P., BERTINA, R.M. Venous thrombosis due to poor anticoagulant response to activated protein C. Leiden Thrombophilia Study. Lancet 342,1503 - 1506, 1993
6. SVENSSON, P.J., DAHLBÄCK, B. Resistance to activated protein C as a basis for venous thrombosis. N Engl J Med 330, 517-522, 1994
7. DAHLBÄCK, B. New molecular insights into the genetics of thrombophilia. Resistance to activated protein C caused by Arg 506 to Gln mutation in factor V as a pathogenetic risk factor. Thromb Haemostas 74, 139 - 148, 1995
8. NOWAK-GÖTTL, U., KOCH, H.G., ASCHKA, I., KOHLHASE, B., VIELHABER, H., KURLEMANN, G., OLESZUK-RASCHKE, K., KEHL, H.G., JÜRGENS, H., SCHNEPPENHEIM, R. Resistance to activated protein C (APCR) in children with venous or arterial thromboembolism. Brit J Haematol 92, in press, 1996
9. ANDREW, M. Developmental Hemostasis: Relevance to thromboembolic complications in pediatric patients.Thromb Haemostas 74, 415 -425, 1995
10. JORQUERA, J.I., MONTORO, J.M., FERNANDEZ, M.A., AZNAR, J.A., J. AZNAR. Modified test for activated protein C resistance. Lancet 344, 1162-1163,1994
11. TROSSAERT, M., CONARD, J., HORELLOU, M.H., SAMAMA, M.M., IRELAND, H., BAYSTON, T.A., LANE, D.A. Modified APC resistance assay for patients on oral anticoagulants. Lancet 344, 1709, 1994
12. D'ANGELO, S.V., MAZZOLA, G., VALLE, D.P., TESTA, S., PATTARINI, E., D'ANGELO, A., COAGULAZIONE, S., RAFFAELE, H.S. Variable interference of activated protein C resistance in the measurement of protein S activity by commercial assays. Thromb Res 77, 375-378, 1995
13. FAIONI, E.M., BOYER-NEUMANN, C., FRANCHI, F., WOLF, M., MEYER, D., MANNUCCI, P.M. Another protein S functional assay is sensitive to resistance to activated protein C. Thromb Haemostas 72, 643-651, 1994
14. MANNUCCI, P.M., TRIPODI, A. Laboratory screening of inherited thrombotic syndromes.Thromb Haemostas 57, 247-251, 1987
15. NOWAK-GÖTTL, U., ASCHKA, I., KOCH, H.G., BOOS, J., DOCK-HORNDWORNICZAK, B., DEUFEL, T., JÜRGENS H., KOHLHASE, B., KUHN, N., LAUPERT, A., RATH, B., WOLFF J.E.A., SCHNEPPENHEIM R. Resistance to activated protein C (APC) in children with acute lymphoblastic leukemia - the utility for a prospective multicenter study. Blood Coagulation & Fibrinolysis: in press 1995
16. VASSE, M., LEDUC, O., BORG, J.Y., CHRETIEN, M.H., MONCONDUIT, M. Resistance to activated protein C: evaluation of three functional assays. Thromb Res 76, 47-59, 1994