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19
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Tumour necrosis factor microsatellites show association with multiple sclerosis
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of special interest. This is a large study exploring the HLA association of MS; it concludes that associations seen with alleles from nearby markers such as that for TNF-α are probably just secondary to the established DR2 association.
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Kirk CW, Droogan AG, Hawkins SA, McMillan SA, Nevin NC, Graham CA. Tumour necrosis factor microsatellites show association with multiple sclerosis. of special interest J Neurol Sci. 147:1997;21-25 This is a large study exploring the HLA association of MS; it concludes that associations seen with alleles from nearby markers such as that for TNF-α are probably just secondary to the established DR2 association.
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Kirk, C.W.1
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Genetic predisposition to multiple sclerosis as revealed by immunoprinting
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of special interest. The authors describe a large study exploring the HLA association of MS; they conclude that the established DR2 association is secondary to that resulting from an association with alleles of the TNF-α marker. This result is in contradiction to that claimed in [19].
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Epplen C, Jäckel S, Santos EJM, D'Souza M, Poehlau D, Dotzauer B, Sindern E, Haupts M, Rüde KP, Weber F, et al. Genetic predisposition to multiple sclerosis as revealed by immunoprinting. of special interest Ann Neurol. 41:1997;341-352 The authors describe a large study exploring the HLA association of MS; they conclude that the established DR2 association is secondary to that resulting from an association with alleles of the TNF-α marker. This result is in contradiction to that claimed in [19].
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Ann Neurol
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Epplen, C.1
Jäckel, S.2
Santos, E.J.M.3
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Dotzauer, B.6
Sindern, E.7
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Weber, F.10
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21
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7344223861
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Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity
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of special interest. This study is an extension of the group's genome screen, that concentrates on the analysis of the HLA region. The authors find increased evidence supporting the notion that a susceptibility gene is encoded in the HLA region. The strongest effect seen in their population is with the DRB1 locus, leading the authors to conclude that this must therefore be the responsible gene - a claim which cannot be supported on the basis of their data.
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Haines JL, Terwedow HA, Burgess K, Pericak-Vance MA, Rimmler JB, Martin ER, Oksenberg JR, Lincoln R, Zhang DY, Banatao DR, et al. Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. of special interest Hum Mol Genet. 7:1998;1229-1234 This study is an extension of the group's genome screen, that concentrates on the analysis of the HLA region. The authors find increased evidence supporting the notion that a susceptibility gene is encoded in the HLA region. The strongest effect seen in their population is with the DRB1 locus, leading the authors to conclude that this must therefore be the responsible gene - a claim which cannot be supported on the basis of their data.
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Hum Mol Genet
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Haines, J.L.1
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22
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DRB1-DQA1-DQB1 loci and multiple sclerosis predisposition in the Sardinian population
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of outstanding interest. This is a very important study, in which the authors definitively establish that the HLA haplotypes associated with MS in the Sardinian population are distinct. They also provide data and discussion which acknowledges that the contribution of the individual alleles within these haplotype cannot be conclusively determined.
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Marrosu MG, Murru MR, Costa G, Murru R, Muntoni F, Cucca F. DRB1-DQA1-DQB1 loci and multiple sclerosis predisposition in the Sardinian population. of outstanding interest Hum Mol Genet. 7:1998;1235-1237 This is a very important study, in which the authors definitively establish that the HLA haplotypes associated with MS in the Sardinian population are distinct. They also provide data and discussion which acknowledges that the contribution of the individual alleles within these haplotype cannot be conclusively determined.
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(1998)
Hum Mol Genet
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Marrosu, M.G.1
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Coraddu, F.1
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The familial nature of multiple sclerosis: Age-corrected empiric recurrence risks for children and siblings of patients
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Sadovnick AD, Baird PA. The familial nature of multiple sclerosis: age-corrected empiric recurrence risks for children and siblings of patients. Neurology. 38:1988;990-991.
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Risks of multiple sclerosis in relatives of patients in Flanders, Belgium
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of special interest. This is a large population-based study of familial recurrence risks in MS. Its results and implications do not differ in any substantial way from those found in previous similar studies, indicating as it does a significant familial incidence of the disease.
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Carton H, Vlietinck R, Debruyne J, DeKeyser J, D'Hooghe MB, Loos R, Medaer R, Truyen L, Yee IM, Sadovnick AD. Risks of multiple sclerosis in relatives of patients in Flanders, Belgium. of special interest J Neurol Neurosurg Psychiatry. 62:1997;329-333 This is a large population-based study of familial recurrence risks in MS. Its results and implications do not differ in any substantial way from those found in previous similar studies, indicating as it does a significant familial incidence of the disease.
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Carton, H.1
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D'Hooghe, M.B.5
Loos, R.6
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Truyen, L.8
Yee, I.M.9
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Haines JL, Ter-Minassian M, Bazyk A, Gusella JF, Kim DJ, Terwedow H, Pericak-Vance MA, Rimmler JB, Haynes CS, Roses AD, et al. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. Nat Genet. 13:1996;469-471.
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44
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