Genetic analysis of inflammation, cytokine mRNA expression and disease course of relapsing experimental autoimmune encephalomyelitis in DA rats

Journal of Neuroimmunology

Volumn 80, Issue 1-2, 1997, Pages 31-37

  Lorentzen, Johnny C ^a   Andersson, Magnus ^a   Issazadeh, Shohreh ^a   Dahlman, Ingrid ^a   Luthman, Holger ^a   Weissert, Robert ^a   Olsson, Tomas ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

IL 10; Interferon ; MHC; Multiple sclerosis; TGF

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; FREUND ADJUVANT; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TRANSFORMING GROWTH FACTOR BETA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DEMYELINATING DISEASE; DISEASE COURSE; DISEASE PREDISPOSITION; GENETIC ANALYSIS; HAPLOTYPE; INFLAMMATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; RECURRENT DISEASE;

ANIMALS; CROSSES, GENETIC; CYTOKINES; DISEASE PROGRESSION; DISEASE SUSCEPTIBILITY; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENES, MHC CLASS II; INFLAMMATION; MALE; RATS; RATS, INBRED ACI; RATS, INBRED BN; RATS, INBRED LEW; RATS, INBRED STRAINS; RECURRENCE; RNA, MESSENGER; SPECIES SPECIFICITY; SPINAL CORD;

EID: 0031437138     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(97)00131-8     Document Type: Article

References (35)

1. Ben-Nun A., Wekerle H., Cohen I. The rapid isolation of clonal antigen specific lines capable of mediating autoimmune encephalomyelitis. Eur. J. Immunol. 11:1981;195-197.
2. Brideau R.J., Carter P.B., McMaster W.R., Mason D.W., Mason A.F. Two subsets of rat T lymphocytes defined with monoclonal antibodies. Eur. J. Immunol. 10:1980;609-615.
3. Ebers G.C., Kukay K., Bulman D.E., Sadovnik A.D., Rice G., Anderson C., Armstrong H., Cousin K., Bell R.B., Hader W., Paty D.W., Hashimoto S., Oger J., Duquette P., Warren S., Gray T., O'Connor P., Nath A., Auty A., Metz L., Francis G., Paulseth J.E., Murray T.J., Pryse-Phillips W., Nelson R., Freedman M., Brunet D., Bouchard J.-P., Hinds D., Risch N. A full genome search in multiple sclerosis. Nat. Genet. 13:1996;472-476.
4. Greenhouse, D.D., Festing, M.F.W., Hasan, S., Cohen, A.L., 1990. Inbred strains of rats and mutants. In: Hedrich, H.J. (Ed), Genetic Monitoring of Inbred Strains of Rats. Gustav Fischer Verlag, Stuttgart, New York, pp. 410-521.
5. Günther E. Current status of the molecular genetic analysis of the rat major histocompatibility complex. Fol. Biol. Praha. 42:1996;129-145.
6. Hillert J., Olerup O. Multiple sclerosis is associated with genes within or close to the HLA-DR-DQ subregion on normal DR15, DQ6, Dw2 haplotype. Neurology. 43:1993;163-168.
7. Holmdahl R., Moran T., Andersson M. A rapid and efficient immunization protocol for production of monoclonal antibodies reactive with autoantigens. J. Immunol. Methods. 83:1985;379-384.
8. Issazadeh S., Ljungdahl Å., Höjeberg B., Mustafa M., Olsson T. Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: Dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor α and tumor necrosis factor β J. Neuroimmunol. 61:1995;205-212.
9. Issazadeh S., Mustafa M., Ljungdahl Å., Höjeberg B., Elde R., Dagerlind Å., Olsson T. Interferon-γ, interleukin-4 and transforming growth factor-β in experimental allergic encephalomyelitis in Lewis rats: Dynamics of cellular mRNA expression in the central nervous system and lymphoid cells. J. Neurosci. Res. 40:1995;579-590.
10. Issazadeh S., Lorentzen J.C., Mustafa M., Höjeberg B., Müssener Å., Olsson T. Cytokines in relapsing experimental autoimmune encephalomyelitis in DA rats: Persistent mRNA expression of proinflammatory cytokines and absent expression of IL-10 and TGF-β J. Neuroimmunol. 63:1996;193-205.
11. Issazadeh S., Kjellén P., Olsson T., Mustafa M., Holmdahl R. Major histocompatibility complex-controlled protective influences on experimental autoimmune encephalomyelitis are peptide specific. Eur. J. Immunol. 27:1997;1584-1587.
12. Jacob H.J., Lindpaintner K., Lincoln S.E., Kusumi K., Bunker R.K., Mao Y.P., Ganten D., Dzau V.J., Lander E.S. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell. 67:1992;213-224.
13. Kuokkanen S., Sundvall M., Terwilliger J.D., Tienari P.J., Wikström J., Holmdahl R., Pettersson U., Peltonen L. A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus EAE2. Nat. Genet. 13:1996;477-480.
14. Laird P., Zijderveld A., Linders K., Rudnicki M.A., Jaenisch R., Berns A. A simplified mammalian DNA isolation procedure. Nucl. Acids Res. 19:1991;4293.
15. Lassman H., Zimprich F., Rössler K., Vass K. Inflammation in the nervous system. Basic mechanisms and immunological concepts. Rev. Neurol. 147:1991;763-781.
16. Levine S., Sowinski R. Allergic encephalomyelitis in the reputedly resistant Brown Norway strain of rats. J. Immunol. 114:1975;597-601.
17. Lorentzen J.C., Olsson T., Klareskog L. Susceptibility to oil-induced arthritis in the DA rat is determined by MHC and non-MHC genes. Transpl. Proc. 27:1995;1532-1534.
18. Lorentzen J.C., Issazadeh S., Storch M., Mustafa M.I., Lassman H., Linington C., Klareskog L., Olsson T. Protracted, relapsing and demyelinating experimental autoimmune encephalomyelitis in DA rats immunized with syngeneic spinal cord and incomplete Freund's adjuvant. J. Neuroimmunol. 63:1995;193-205.
19. Lublin F.D. Relapsing experimental allergic encephalomyelitis. An autoimmune model for multiple sclerosis. Springer Semin. Immunopath. 8:1985;197-208.
20. McMaster W.R., Williams A.F. Identification of Ia glycoprotein in rat thymus and purification from rat spleen. Eur. J. immunol. 9:1979;426-433.
21. Mustafa M., Vingsbo C., Olsson T., Ljungdahl Å., Höjeberg B., Holmdahl R. The major histocompatibility complex influences myelin basic protein 63-68-induced T cell cytokine profile and experimental autoimmune encephalomyelitis. Eur. J. Immunol. 23:1993;3089-3095.
22. Mustafa M., Vingsbo C., Olsson T., Issazadeh S., Ljungdahl Å., Holmdahl R. Protective influence on experimental autoimmune encephalomyelitis by MHC class I and II alleles. J. Immunol. 153:1994;3337-3344.
23. Olsson T. Immunology of multiple sclerosis. Curr. Opin. Neurol. Neurosurg. 5:1992;195-202.
24. Raine C.S., Traugott U. Experimental autoimmune demyelination. Chronic models and their therapeutic implications for multiple sclerosis. Ann. NY Acad. Sci. 436:1984;33-51.
25. Raine, C.S., 1986. Experimental allergic encephalomyelitis and neuritis. In: Koetsier, J.C. (Ed.), Handbook of Clinical Neurology, vol. 3(47). Elsevier, New York, pp. 429-466.
26. Remmers E.F., Du Y., Zha H., Goldmuntz E.A., Wilder R.L. Ten polymorphic DNA loci, including five in the rat MHC (RT1) region, form a single linkage group on rat chromosome 20. Immunogenetics. 41:1995;316-319.
27. Risch N. Linkage strategies for genetically complex traits. Multilocus models. Am. J. Hum. Gen. 46:1990;222-228.
28. Sawcer S., Jones H.B., Feakes R., Gray J., Smaldon N., Chataway J., Robertson N., Clayton D., Goodfellow P.N., Compston A. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat. Genet. 13:1996;464-468.
29. Sedgwick J., Brostoff S., Mason D. Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. J. Exp. Med. 165:1987;1058-1075.
30. Stepaniak J.A., Gould K.E., Sun D., Swanborg R.H. A comparative study of experimental autoimmune encephalomyelitis in Lewis and DA rats. J. Immunol. 155:1995;2762-2769.
31. Sundvall M., Jirholt J., Yang H.T., Jansson L., Engström Å., Petterson U., Holmdahl R. Identification of murine loci associate with susceptibility to chronic experimental autoimmune encephalomyelitis. Nat. Genet. 10:1995;313-317.
32. The Multiple Sclerosis Genetics Group, 1996. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. Nat. Genet. 13, 469-471.
33. av1 is associated with relapsing/remitting experimental autoimmune encephalomyelitis. Transpl. Proc. 29:1997;1686-1689.
34. Williams A.F., Galfre G., Milstein C. Analysis of cell surface by zenogeneic myeloma hybrid antibodies: Differentiation antigens of rat lymphocytes. Cell. 12:1987;663-673.
35. Williams R.M., Moore M.J. Linkage of susceptibility to experimental allergic encephalomyelitis to the major histocompatibility locus in the rat. J. Exp. Med. 138:1973;775-783.