The use of a genetic map of biallelic markers in linkage studies

Nature Genetics

Volumn 17, Issue 1, 1997, Pages 21-24

  Kruglyak, Leonid ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; DNA POLYMORPHISM; GENE MAPPING; GENETIC LINKAGE; GENETIC MARKER; HUMAN; PEDIGREE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ALLELES; CHROMOSOME MAPPING; GENETIC MARKERS; GENETICS, MEDICAL; GENOTYPE; HUMANS; LINKAGE (GENETICS); LOD SCORE; MICROSATELLITE REPEATS; POLYMORPHISM, GENETIC;

EID: 0030861903     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng0997-21     Document Type: Article

References (28)

1. Botstein, D., White, D.L., Skolnick, M. & Davis, R.W. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am. J. Hum. Genet. 32, 314-331 (1980).
2. Wyman, A.R. & White, R.W. A highly polymorphic locus in human DNA. Proc. Natl. Acad. Sci. USA 77, 6754-6758 (1980).
3. Gusella, J.F., et al. A polymorphic DNA marker genetically linked to Huntington's disease. Nature 306, 234-238 (1983).
4. Donis-Keller, H. et al. A genetic linkage map of the human genome. Cell 51, 319-337 (1987).
5. Weber, J.L & May, P.E. Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am. J. Hum. Genet. 44, 388-396 (1989).
6. Cooperative Human Linkage Center. A comprehensive human linkage map with centimorgan density. Science 265, 2049-2054 (1994).
7. Dib, C. et al. A comprehensive genetic map of the human genome based on 5264 microsatellites. Nature 380, 152-154 (1996).
8. Hofker, M.H. et al. The X chromosome shows less genetic variation at restriction sites than the autosomes. Am. J. Hum. Genet. 39, 438-451 (1986).
9. Cooper, D.N., Smith, B.A., Cooke, H.J., Niemann, S. & Schmidtke, J. An estimate of unique DNA sequence heterozygosity in the human genome. Hum. Genet. 69, 201-205 (1985).
10. Nickerson, D.A. et al. Automated DNA diagnostics using an ELISA-based oligonucleotide ligation assay. Proc. Natl. Acad. Sci. USA 87, 8923-8927 (1990).
11. Livak, K.J., Marmaro, J. & Todd, J.A. Towards fully automated genome-wide polymorphism screening. Nature Genet. 9, 341-342 (1995).
12. Saiki, R.K., Walsh, P.S., Levenson, C.H. & Erlich, H.A. Genetic analysis of amplified DNA with immobilized sequence-specific oligonucleotide probes. Proc. Natl. Acad. Sci. USA 86, 6230-6234 (1989).
13. Syvanen, A.-C., Aalto-Setala, K., Harju, L., Kontula, K. & Soderlund, H. A primer-guided nucleotide incorporation assay in the genotyping of apolipoprotein E. Genomics 8, 684-692 (1990).
14. Wu, D.Y., Ugozzoli, L., Pal, B.K. & Wallace, R.B. Allele-specific enzymatic amplification of β-globin genomic DNA for diagnosis of sickle cell anemia. Proc Natl. Acad. Sci. USA 86, 2757-2760 (1989).
15. Wang, D. et al. Toward a third generation genetic map of the human genome based on biallelic polymorphisms. Am. J. Hum. Genet. 59, A3 (1996).
16. Chee, M. et al. Accessing genetic information with high-density DNA arrays. Science 274, 610-614 (1996).
17. Kruglyak, L. & Lander, E.S. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am. J. Hum. Genet. 57, 439-454 (1995).
18. Kruglyak, L., Daly, M.J., Reeve-Daly, M.P. & Lander, E.S. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am. J. Hum. Genet. 58, 1347-1363 (1996).
19. Reed, P.W. et al. Chromosome-specific microsatellite sets for fluorescence-based, semi-automated genome mapping. Nature Genet. 7, 390-395 (1994).
20. Dubovsky, J., Sheffield, V.C., Duyk, G.M. & Weber, J.L. Sets of short tandem repeat polymorphisms for efficient linkage screening of the human genome. Hum. Mol. Genet. 4, 449-452 (1995).
21. Elston, R.C. Designs for the global search of the human genome by linkage analysis. in Proceedings of the 16th International Biometrics Conference 39-51 (Hamilton, New Zealand, 1992).
22. Brown, D.L., Gorin, M.B. & Weeks, D.E. Efficient strategies for genomic searching using the affected-pedigree-member method of linkage analysis. Am. J. Hum. Genet. 54, 544-552 (1994).
23. Terwilliger, J.D., Ding, Y. & Ott, J. On the relative importance of marker heterozygosity and intermarker distance in gene mapping. Genomics 13, 951-956 (1992).
24. Lander, E.S. & Botstein, D. Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children. Science 236, 1567-1570 (1987).
25. O'Connell, J.R. & Weeks, D.E. The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set-recoding and fuzzy inheritance. Nature Genet. 11, 402-408 (1995).
26. Risch, N. & Merikangas, K. The future of genetic studies of complex human diseases. Science 273, 1516-1517 (1996).
27. Lander, E.S. The new genomics: global views of biology. Science 274, 536-539 (1996).
28. Collins, F.S. Positional cloning moves from perditional to traditional. Nature Genet. 9, 347-350 (1995).