The myelin basic protein gene in multiple sclerosis: Identification of discrete alleles of a 1.3 kb tetranucleotide repeat sequence

Acta Neurologica Scandinavica

Volumn 97, Issue 1, 1998, Pages 46-51

  He, B ^a,b   Yang, B ^a   Lundahl, J ^a   Fredrikson, S ^a   Hillert, J ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Genetic susceptibility; Multiple sclerosis; Myelin basic protein gene; Polymorphism

Indexed keywords

AUTOANTIGEN; DNA; MYELIN BASIC PROTEIN;

ALLELE; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DEMYELINATING DISEASE; FAMILY STUDY; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE;

EID: 0031964047     PISSN: 00016314     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0404.1998.tb00608.x     Document Type: Article

References (34)

1. EBERS GC, SADOVNICK AD. The role of genetic factors in multiple sclerosis susceptibility. J Neuroimmunol 1994: 54: 1-17.
2. JERSILD C, FOG T, HANSEN GS, THOMSEN M, SVEJGAARD A, DUPONT B. Histocompatibility determinants in multiple sclerosis, with special reference to clinical course. Lancet 1973: ii: 1221-5.
3. OLERUP O, HILLERT J. HLA class II-associated genetic susceptibility in multiple sclerosis: A critical evaluation. Tissue Antigens 1991: 38: 1-15.
4. KELLAR-WOOD HF, WOOD NW, HOLMANS P, CLAYTON D, ROBERTSON N, COMPSTON DA. Multiple sclerosis and the HLA-D region: linkage and association studies. J Neuroimmunol 1995: 58: 183-90.
5. ALVORD EC, KIES MW, SUCKLING A. Experimental allergic encephalomyelitis: A useful model for multiple sclerosis. New York: Alan R. Liss, Inc., 1984.
6. ALLEGRETTA M, NICKLAS JA, SRIRAM S, ALBERTINI RJ. T cells responsive to myelin basic protein in patients with multiple sclerosis. Science 1990: 247: 718-21.
7. OLSSON T, BAIG S, HÖJEBERG B, LINK H. Antimyelin basic protein and antimyelin antibody-producing cells in multiple sclerosis. Ann Neurol 1990: 27: 132-6.
8. OLSSON T, SUN J-B, HILLERT J et al. Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis. Eur J Immunol 1992: 22: 1083-7.
9. KAMHOLZ J, SPIELMAN R, GOGOLIN K, MODI W, O'BRIEN S, LAZZARINI R. The human myelin basic-protein-gene: chromosomal location and RFLP analysis. Am J Hum Genet 1987: 40: 365-73.
10. PRIBYL TM, CAMPAGNONI CW, KAMPF K et al. The human myelin basic protein gene is included within a 179-kilobase transcription unit: Expression in the immune and central nervous systems. Proc Natl Acad Sci USA 1993: 90: 10695-9.
11. BOYLAN KB, AYRES TM, POPKO B, TAKAHASHI N, HOOD LE, PRUSINER SB. Repetitive DNA (TGGA)n 5′ to the human myelin basic protein gene: a new form of oligonucleotide repetitive sequence showing length polymorphism. Genomics 1990: 6: 16-22
12. BOYLAN KB, TAKAHASHI N, PATY DW et al. DNA length polymorphism 5′ to the myelin basic protein gene is associated with multiple sclerosis. Ann Neurol 1990: 27: 291-7.
13. TIENARI PJ, WIKSTRÖM J, SAJANTILA A, PALO J, PELTONEN L. Genetic susceptibility to multiple sclerosis linked to myelin basic protein gene. Lancet 1992: 340: 987-91.
14. ROSE J, GERKEN S, LYNCH S et al. Genetic susceptibility in familial multiple sclerosis not linked to the myelin basic protein gene. Lancet 1993: 341: 1179-81.
15. GRAHAM CA, KIRK CW, NEVIN NC et al. Lack of association between myelin basic protein gene microsatellite and multiple sclerosis. Lancet 1993: 341: 1596.
16. WOOD NW, HOLMANS P, CLAYTON D, ROBERTSON N, COMPSTON DAS. No linkage or association between multiple sclerosis and the myelin basic protein gene in affected sibling pairs. J Neurol Neurosurg Psychiatry 1994: 57: 1191-4.
17. VANDEVYVER C, STINISSEN P, CASSIMAN J-J, RAUS J. Myelin basic protein gene polymorphism is not associated with chronic progressive multiple sclerosis. J Neuroimmunol 1994: 52: 97-9.
18. EOLI M, PANDOLFO M, MILANESE C, GASPARINI P, SALMAGGI A, ZEVIANI M. The myelin basic protein gene is not a major susceptibility locus for multiple sclerosis in Italian patients. J Neurol 1994: 241: 615-19.
19. IBSEN SN, CLAUSEN J. A repetitive DNA sequence 5′ to the human myelin basic protein gene may be linked to MS in Danes. Acta Neurol Scand 1996: 93: 236-40.
20. SCHUMACHER GA, BEEBE B, KIBLER RF et al. Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis. Ann N Y Acad Sci 1965: 122: 552-68.
21. OLERUP O, ALDENER A, FOGDELL A. HLA-DQB1 and -DQA1 typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours. Tissue Antigens 1993: 41: 119-34.
22. POLYMEROPOULOS M, XIAN H, MERRIL CR. Tetranucleotide repeat polymorphism at the human myelin basic protein gene (MBP). Hum Mol Genet 1992: 8: 658.
23. OTT J. Analysis of human genetic linkage. Baltimore: Johns Hopkins University Press, 1991.
24. WEEKS DE, LANGE K. A multilocus extension of the affected-pedigree-member method of linkage analysis. Am J Hum Genet 1992: 50: 859-68.
25. OTT J. Computer-simulation methods in human linkage analysis. Proc Natl Acad Sci USA 1989: 86: 4175-8.
26. MORELL P. Myelin. New York and London: Plenum Press, 1984: 198-203.
27. KLARESKOG L, OLSSON T. Autoimmunity to collagen II and myelic basic protein: comparative studies in humans and rodents. Immunol Rev 1990: 118: 285-310.
28. SAWCER S, JONES HB, FEAKES R et al. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nature Genet 1996: 13: 464-8.
29. The Multiple Sclerosis Genetics Group. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex. Nature Genet 1996: 13: 469-71.
30. EBERS GC, KUKAY K, BULMAN DE et al. A full genome search in multiple sclerosis. Nature Genet 1996: 13: 472-6.
31. TIENARI PJ, WIKSTRÖM J, KOSKIMIES S, PARTANEN J, PALO J, PELTONEN L. Reappraisal of HLA in multiple sclerosis: close linkage in multiplex families. Eur J Hum Genet 1993: 1: 257-68.
32. FOGDELL A, OLERUP O, FREDRIKSON S, VRETHEM M, HILLERT J. Linkage analysis of HLA class II genes in Swedish multiplex families with multiple sclerosis. Neurology 1997: 48: 758-62.
33. SCHWENGEL DA, JEDLICKA AE, NANTHAKUMAR EJ, WEBER JL, LEVITT RC. Comparison of fluorescence-based semi-automated genotyping of multiple microsatellite loci with autoradiographic techniques. Genomics 1994: 22: 46-54.
34. EBERS GC, SADOVNICK AD, RISCH NJ et al. A genetic basis for familial aggregation in multiple sclerosis. Nature 1995: 377: 150-1.