Mechanisms for virus-induced liver disease: Tumor necrosis factor- mediated pathology independent of natural killer and T cells during murine cytomegalovirus infection

Journal of Virology

Volumn 71, Issue 12, 1997, Pages 9248-9258

  Orange, Jordan S ^a   Salazar Mather, Thais P ^a   Opal, Steven M ^a   Biron, Christine A ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; LIVER ENZYME; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; FEMALE; HEPATITIS; IMMUNE DEFICIENCY; IMMUNOCOMPETENCE; LIVER INJURY; LIVER NECROSIS; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0030731410     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.12.9248-9258.1997     Document Type: Article

References (61)

1. Adamson, G. M., and R. E. Billings. 1993. Cytokine toxicity and induction of NO synthase activity in cultured mouse hepatocytes. Toxicol. Appl. Pharmacol. 119:100-107.
2. Ando, K., T. Moriyama, L. Guidotti, S. Wirth, R. Schreiber, H.-J. Schlicht, S. Huang, and F. Chisari. 1993. Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis. J. Exp. Med. 178:1541-1554.
3. Bach, N, N. D. Theise, and F. Schaffner. 1992. Hepatic histopathology in the acquired immunodeficiency syndrome. Semin. Liver Dis. 12:205-212.
4. Bancroft, G. J., G. R. Shellam, and J. E. Chalmer. 1981. Genetic influences on the augmentation of natural killer (NK) cells during murine cytomegalovirus infection: correlation with patterns of resistance. J. Immunol. 126: 988-994.
5. Brautigam, A. R., F. J. Dutko, L. B. Olding, and M. B. A. Oldstone. 1979. Pathogenesis of murine cytomegalovirus infection: the macrophage as a permissive cell for cytomegalovirus infection, replication and latency. J. Gen. Virol. 44:349-359.
6. Bukowski, J. F., B. A. Woda, S. Habu, IC Okumura, and R. M. Welsh. 1983. Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo. J. Immunol. 131:1531-1538.
7. Bukowski, J. F., B. A. Woda, and R. M. Welsh. 1984. Pathogenesis of murine cytomegalovirus infection in natural killer cell-depleted mice. J. Virol. 52: 119-128.
8. Burstin, S. J., M. W. Brandriss, and J. J. Schlesinger. 1983. Infection of a macrophage-like cell line, P388D1, with reovirus: effects of immune ascitic fluids and monoclonal antibodies on neutralization and on enhancement of viral growth. J. Immunol. 130:2915-2919.
9. Cohen, J. I., and G. R. Corey. 1985. Cytomegalovirus infection in the normal host. Medicine (Baltimore) 64:100-114.
10. Dindzans, V. J., P. J. MacPhee, L. S. Fung, J. L. Leibowitz, and G. A. Levy. 1985. The immune response to mouse hepatitis virus: expression of monocyte procoagulant activity and plasminogen activator during infection in vivo. J. Immunol. 135:4189-4197.
11. Falagas, M. E., and D. R. Snydman. 1995. Recurrent Cytomegalovirus disease in solid-organ transplant recipients. Transplant. Proc. 27:34-37.
12. Farone, A. L., P. C. O'Brien, and D. C. Cox. 1993. Tumor necrosis factor-alpha induction by reovirus serotype 3. J. Leukocyte Biol. 53:133-137.
13. Haagmans, B., F. Stals, P. Van Der Meide, C. Braggeman, M. Horzinek, and V. Skhijns. 1994. Tumor necrosis factor alpha promotes replication and pathogenicity of rat cytomegalovirus. J. Virol. 68:2297-2304.
14. Henson, D., R. D. Smith, and J. Gehrke. 1966. Non-fatal mouse cytomegalovirus hepatitis: combined morphologic, virologic and immunologic observations. Am. J. Pathol. 49:871-888.
15. Hewett, J., P. Jean, S. Kunkel, and R. Roth. 1993. Relationship between tumor necrosis factor-a and neutrophils in endotoxin-induced liver injury. Am. J. Physiol. 265:G1011-G1015.
16. Horwitz, C. A., W. Henle, G. Henle, D. Snover, H. Rudnick, H. J. Balfour, M. H. Mazur, R. Watson, B. Schwartz, and N. Muller. 1986. Clinical and laboratory evaluation of cytomegalovirus-induced mononucleosis in previously healthy individuals. Report of 82 cases. Medicine (Baltimore) 65:124-134.
17. Jacoby, R., and P. Bhatt. 1987. Mousepox in inbred mice innately resistant or susceptible to lethal infection with ectromelia virus II. Pathogenesis. Lab. Anim. Sci. 37:16-22.
18. Koo, G. C., and J. R. Peppard. 1984. Establishment of monoclonal anti-NK-1.1 antibody. Hybridoma 3:301-303.
19. Lai, M. W., M. H. Chang, C. Y. Lee, H. C. Hsu, and C. L. Kau. 1992. Cytomegalovirus-associated neonatal hepatitis. Acta Paediatr. Sin. 33:264-272.
20. Leist, M., F. Gantner, I. Bohlinger, G. Tiegs, P. G. Germann, and A. Wendel. 1995. Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am. J. Pathol. 146:1220-1224.
21. Leist, M., G. Gantner, S. Jilg, and A. Wendel. 1995. Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis and nitrite release. J. Immunol. 154:1307-1316.
22. Levy, G. A., J. L. Leibowitz, and T. S. Edgington. 1981. Induction of monocyte procoagulant activity by murine hepatitis virus type 3 parallels disease susceptibility in mice. J. Exp. Med. 154:1150-1163.
23. Li, C., L. S. Fung, S. Chung, A. Crow, M. N. Myers, M. J. Phillips, J. L. Leibowitz, E. Cole, C. A. Ottaway, and G. Levy. 1992. Monoclonal antiprothrombinase (3D4.3) prevents mortality from murine hepatitis virus (MHV-3) infection. J. Exp. Med. 176:689-697.
24. Lohler, J., J. Gossmann, T. Kratzberg, and F. Lehmann-Grube. 1994. Murine hepatitis caused by lymphocytic choriomeningitis virus. I. The hepatic lesions. Lab. Invest. 70:263-276.
25. Lucin, P., S. Jonjic, M. Messerle, B. Polic, H. Hengel, and U. H. Koszinowski. 1994. Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor. J. Gen. Virol. 75:101-110.
26. MacPhee, P. J., V. J. Dindzans, L. S. Fung, and G. A. Levy. 1985. Acute and chronic changes in the microcirculation of the liver in inbred strains of mice following infection with mouse hepatitis virus type 3. Hepatology 5:649-660.
27. McCordock, H. A., and M. G. Smith. 1936. The visceral lesions produced in mice by the salivary gland virus of mice. J. Exp. Med. 63:303-310.
28. McMichael, A. J., J. R. Pilch, G. Galfre, D. Y. Mason, J. W. Fahre, and C. Milstein. 1979. A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody. Eur. J. Immunol. 9:205-210.
29. Mims, C. 1959. The response of mice to large intravenous injections of ectromelia virus. II. The growth of virus in the liver. Br. J. Exp. Pathol. 40:543-550.
30. Nagaki, M., Y. Muto, H. Ohnishi, S. Yasuda, K. Sano, T. Naito, T. Maeda, T. Yamada, and H. Moriwaki. 1994. Hepatic injury and lethal shock in galactosamine-sensitized mice induced by the superantigen staphylococcal enterotoxin B. Gastroenterology 106:450-458.
31. Olver, S. D., P. Price, and G. R. Shellam. 1994. Cytomegalovirus hepatitis: characterization of the inflammatory infiltrate in resistant and susceptible mice. Clin. Exp. Immunol. 98:375-381.
32. Orange, J. S., and C. A. Biron. 1996. An absolute and restricted requirement for interleukin-12 in natural killer cell interferon-γ production and antiviral defense: studies of NK and T cell responses in contrasting viral infections. J. Immunol. 156:1138-1142.
33. Orange, J. S., and C. A. Biron. 1996. Characterization of early IL-12, IFN-α/β, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection. J. Immunol. 156:4746-4756.
34. Orange, J. S., B. Wang, C. Terhorst, and C. A. Biron. 1995. Requirement for natural killer cell-produced imerferon γ in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration. J. Exp. Med. 182:1045-1056.
35. Parr, R. L., L. Fung, J. Reneker, M. N. Myers, J. L. Leibowitz, and G. Levy. 1995. Association of mouse fibrinogen-like protein with murine hepatitis virus-induced prothrombinase activity. J. Virol. 69:5033-5038.
36. Paya, C. V., P. E. Hermans, R. H. Wiesner, J. Ludwig, T. F. Smith, J. Rakela, and R. A. Krom. 1989. Cytomegalovirus hepatitis in liver transplantation: prospective analysis of 93 consecutive orthotopic liver transplantations. J. Infect. Dis. 160:752-758.
37. Piazza, M. 1969. Experimental viral hepatitis, p. 97-112. Charles C Thomas, Springfield, Ill.
38. Pilaro, A. M., D. D. Taub, K. L. McCormick, H. M. Williams, T. J. Sayers, W. E. Fogler, and R. H. Wiltrout. 1994. TNF-α is a principal cytokine involved in the recruitment of NK cells to liver parenchyma. J. Immunol. 153:333-342.
39. Pope, M., O. Rotstein, E. Cole, S. Sinclair, R. Parr, B. Cruz, R. Fingerote, C. S. R. Gorczynski, L. Fung, J. Leibowitz, Y. Rao, and G. Levy. 1995. Pattern of disease after murine hepatitis virus strain 3 infection correlates with macrophage activation and not viral replication. J. Virol. 69:5252-5260.
40. Quinnan, G. V., and J. E. Manischewitz. 1979. The role of natural killer cells and antibody-dependent cell-mediated cytotoxicity during murine cytomegalovirus infection. J. Exp. Med. 150:1549-1554.
41. Quinnan, G. V., J. E. Manischewitz, and F. A. Ennis. 1978. Cytotoxic T lymphocyte response to murine cytomegalovirus infection. Nature 273:541-543.
42. Reynolds, R. P., R. J. Rahija, D. I. Schenkman, and C. B. Richter. 1993. Experimental murine cytomegalovirus infection in severe combined immunodeficient mice. Lab. Anim. Sci. 43:291-295.
43. Ruzek, M. C., A. H. Miller, S. M. Opal, B. D. Pearce, and C. A. Biron. 1997. Characterization of early cytokine responses and an IL-6-dependent pathway of endogenous glucocorticoid induction during murine cytomegalovirus infection. J. Exp. Med. 185:1185-1192.
44. Ruzek, M. C., B. P. Pearce, A. H. Miller, and C. A. Biron. Unpublished data.
45. Salazar-Mather, T. P., J. S. Orange, and C. A. Biron. Unpublished data.
46. Selgrade, M. J. K., J. G. Nedrud, A. M. Collier, and D. E. Gardner. 1981. Effects of cell source, mouse strain, and immunosuppressive treatment on production of virulent and attenuated murine cytomegalovirus. Infect. Immun. 33:840-847.
47. Senkevich, T. G., E. J. Wolffe, and R. M. Buller. 1995. Ectromelia virus RING finger protein is localized in virus factories and is required for virus replication in macrophages. J. Virol. 69:4103-4111.
48. Stanley, J. 1984. Host genetic factor influence murine cytomegalovirus lung infection and interstitial pneumonitis. J. Gen. Virol. 65:2121-2128.
49. Shanley, J. D., L. Biczak, and S. J. Forman. 1993. Acute murine cytomegalovirus infection induces lethal hepatitis. J. Infect. Dis. 167:264-269.
50. Shanley, J. D., E. L. Pesanti, and K. M. Nugent .1982. The pathogenesis of pneumonitis due to murine cytomegalovirus. J. Infect. Dis. 146:388-396.
51. Shellam, G. R., J. E. Allan, J. M. Papadimitriou, and G. J. Bancroft. 1981. Increased susceptibility to cytomegalovirus infection in beige mutant mice. Proc. Natl. Acad. Sci. USA 78:5104-5108.
52. Smith, M. A., and D. J. Brennessel. 1994. Cytomegalovirus. Infect. Dis. Clin. North Am. 8:427-438.
53. Snover, D. C., and C. A. Horwitz. 1984. Liver disease in cytomegalovirus mononucleosis: a light microscopical and immunoperoxidase study of six cases. Hepatology 4:408-412.
54. Suitters, A. J., R. Foulkes, S. M. Opal, J. E. Palardy, J. S. Emtage, M. Rolfe, S. Stephens, A. Morgan, A. R. Holt, L. C. Chaplin, N. E. Shaw, A. M. Nesbitt, and M. W. Bodmer. 1994. Differential effect of isotype on efficacy of anti-tumor necrosis factor a chimeric antibodies in experimental septic shock. J. Exp. Med. 179:849-856.
55. Tanaka, K., Y. Koga, Y.-Y. Lu, X.-X. Zhang, Y. Wang, G. Kimura, and K. Nomoto. 1994. Murine cytomegalovirus-associated pneumonitis in the lungs free of the virus. J. Clin. Invest. 94:1019-1025.
56. Taylor, F. J. 1994. The inflammatory-coagulant axis in the host response to gram-negative sepsis: regulatory roles of proteins and inhibitors of tissue factor. New Horiz. 2:555-565.
57. Walters, M.-I., R. Joske, P. Leaks, and N. Stanley. 1963. Murine infection with reovirus. I. Pathology of the acute phase. Br. J. Exp. Pathol. 44:427-436.
58. Wang, B., C. Biron, J. She, K. Higgins, M.-J. Sunshine, E. Lacy, N. Lonberg, and C. Terhorst 1994. A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene. Proc. Natl. Acad. Sci. USA 91:9402-9406.
59. Welsh, R. M. 1978. Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. I. Characterization of natural killer cell induction. J. Exp. Med. 148:161-181.
60. Welsh, R. M., J. O. Brubaker, M. Vargas-Cortes, and C. L. O'Donnell. 1991. Natural killer (NK) cell response to virus infections in mice with severe combined immunodeficiency. The stimulation of NK cells and the NK cell-dependent control of virus infections occur independently of T and B cell function. J. Exp. Med. 173:1053-1063.
61. Williams, J. G., G. J. Jurkovich, G. B. Hahnel, and R. V. Maier. 1992. Macrophage priming by interferon gamma: a selective process with potentially harmful effects. J. Leukocyte Biol. 52:579-584.